CHEMICAL ENGINEERING JOURNAL
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2026
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IF 12.5
Cancan Yang,Chongyue Bai,Kaixin Yang,Shuo Wang,Yuan Wang,Zhibo Zhang,Faming Gao,Huige Wei
A covalently crosslinked PVA-pCD 2:1 interpenetrating hydrogel network is developed. • The PVA-pCD 2:1 hydrogel enables non‑enzymatic, highly selective sweat cholesterol detection. • The PVA-pCD 2:1 hydrogel exhibits stable strain-sensing performance. • A wireless dual-mode sensing device integrated with smartphone readout is developed for personalized health management. The increasing prevalence of chronic metabolic diseases has highlighted the demand for non-invasive and convenient cholesterol monitoring technologies. However, conventional detection methods are limited by bulky instruments and poor enzyme stability, hindering their application in daily monitoring. This study presents a novel multifunctional hydrogel based on a covalently crosslinked polyvinyl alcohol-polycyclodextrin 2:1 (PVA-pCD 2:1 ) network, which combines excellent mechanical sensing performance with non-enzymatic electrochemical detection of sweat cholesterol. The citrate-crosslinked interpenetrating network endows the hydrogel with desirable mechanical properties (tensile strength: 1.2 MPa), while the excellent strain-responsive behavior ( GF = 4.35) enables motion monitoring. More importantly, the hydrogel achieves highly selective and sensitive cholesterol detection in sweat, with a sensitivity of 0.15 μA·μM −1 ·cm −2 , a linear range of 0–100 μM, and a detection limit of 0.296 μM. A wearable sensor based on this hydrogel is developed, which integrates simultaneous monitoring of sweat biomarkers and mechanical signals. Data are wirelessly transmitted to a smartphone featuring dual modules for cholesterol and mechanical sensing, providing an innovative platform for personalized health management.
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Surfaces and Interfaces
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2026
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IF 6
Suping Jia,Xinyu Chen,Yan Zhou,Jie Jiang,Huinian Zhang,Yujuan Zhang,Qing Chang
The main challenge of applying low-temperature-prepared TiO 2 (LTP-TiO 2 ) to perovskite solar cells lies in its high density of defect states, which adversely affects electron transport at the interface and within the electron transport layer. Through strategic utilization of the ionic liquid 1-ethyl-3-methylimidazolium acetate (EMIMAc), we developed an effective approach to passivate defect states of LTP-TiO 2 and enhance electron transport dynamics in perovskite photovoltaic devices. This ionic liquid additive simultaneously suppresses non-radiative recombination and improves electron extraction efficiency at the perovskite/TiO 2 interface. The EMIMAc-modified TiO 2 demonstrates an optimized electron mobility of 4.16×10 −5 cm²·υ⁻¹·s⁻¹, yielding a higher power conversion efficiency (PCE) of 21.03% with superior stability, thus marking a substantial enhancement over unmodified devices. Download: Download high-res image (212KB) Download: Download full-size image Ionic liquid 1-ethyl-3-methylimidazolium acetate (EMIMAc) possesses an acetate anion that can strongly coordinate with under-coordinated Ti 4+ sites and passivate oxygen vacancies on the TiO 2 surface, while the imidazolium cation interacts with the perovskite to suppress interfacial defects. It can simultaneously suppress non-radiative recombination, improve charge extraction efficiency at the perovskite/TiO 2 interface and enhance the electron mobility of TiO 2 . A high efficiency of 21.03% with negligible hysteresis, improved stability was obtained when used low-temperature-processed TiO 2 as electron transport material in perovskite solar cells.
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JOURNAL OF CHEMICAL AND ENGINEERING DATA
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2026
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IF 2.4
Zhen Chang,Yaxuan Zhen,Chunying Zhu,Taotao Fu,Youguang Ma
The densities and dynamic viscosities of pure components, binary solutions and ternary solutions of 2-amino-2-methyl-1-propanol (AMP), 2-ethylaminoethanol (EAE) and water were systematically measured at (293.15–323.15) K. Based on experimental findings, calculations were made for the excess molar volume, thermal expansion coefficient, dynamic viscosity deviation, and solution viscous activation energy to assess intermolecular interactions. The negative excess molar volumes of binary and ternary aqueous solutions indicate significant hydrogen bonding interaction and a filling effect within the solutions. The negative excess molar volumes of binary and ternary aqueous solutions indicate significant hydrogen bonding interactions and a filling effect within the solutions. For the AMP–EAE system, the hydrogen bonding interaction and filling effect are weakened due to the similar volume and steric hindrance effect.
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INTERNATIONAL IMMUNOPHARMACOLOGY
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2026
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IF 5.6
Yaqi Pu,Tianxin Li,Zihe Zhao,Qian Xu,Yi Jin,Huan Dou,Zhao Liu
Background Abdominal aortic aneurysm (AAA) is a prevalent and potentially fatal cardiovascular disease, yet the precise therapeutic mechanism of the bioactive compound Senkyunolide I (SEI) against AAA is not fully understood. Methods Utilizing an elastase/BAPN-induced AAA mouse model, this study employed integrated network pharmacology, proteomics (LiP-MS), and biophysical validation (molecular docking, MST) to identify and confirm PARP-1 as a direct target of SEI. The therapeutic effect of SEI was evaluated in vivo by monitoring aortic dilation and histopathology, and its inhibitory effect on TNF-α-induced macrophage migration was assessed in vitro . The functional role of the SEI-PARP-1 axis was further verified using PARP-1 inhibitors and macrophage-targeted PARP-1 overexpression. Results In the elastase/BAPN-induced AAA model, which mimics human AAA progression and rupture risk, SEI treatment attenuated disease progression by reducing aortic dilation, collagen deposition, and elastin degradation. SEI directly bound to and downregulated PARP-1 expression in both AAA tissues and large peritoneal macrophages (LPMs). It dose-dependently suppressed TNF-α-induced LPMs migration in vitro and restored the AAA-induced reduction in peritoneal LPMs proportion in vivo , an effect also seen with pharmacological PARP-1 inhibition. In contrast, macrophage-specific PARP-1 overexpression abolished SEI's protection and promoted LPMs migration into aortic lesions. Conclusion This study demonstrates that SEI attenuates AAA progression by targeting PARP-1 and inhibiting the migration of LPMs from the peritoneal cavity to the aortic lesion. These findings elucidate a novel pharmacological mechanism of SEI and underscore PARP-1 as a promising therapeutic target for AAA.
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JOURNAL OF ENVIRONMENTAL MANAGEMENT
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2026
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IF 9.2
Ubong J. Etim,Peng Bai,Waheed Iqbal,Ziyi Zhong
Supported palladium (Pd) catalysts are known for their exceptional catalytic activity in methane combustion; however, they often undergo rapid deactivation due to sintering under practical reaction conditions. This study aims to develop highly active and stable catalysts for CH 4 combustion by investigating the effect of guest elements within silicalite-1 (S-1) zeolite as supports for Pd. Various transition metals (TMs) were introduced into the S-1 gel to modify its structural properties. The TMs were incorporated into both framework and extra-framework positions, as demonstrated for iron (Fe) and titanium (Ti), resulting in the formation of FeS-1 and TS-1, respectively. The structures were confirmed by Fourier transform infrared (FTIR) and ultraviolet-visible diffused reflectance (UV-vis DR) spectroscopy. Following Pd impregnation, the resulting Pd/FeS-1 and Pd/TS-1 exhibited high activity in CH 4 combustion. Compared to 1Pd/S-1, both 1Pd/FeS-1 and 1Pd/TS-1 achieved excellent low-temperature catalytic performance (T 90 < 400 °C), along with high reaction rates, turnover frequency (TOF) and stability. Characterization of the catalysts confirms the stabilizing effects of Fe and Ti on Pd species, primarily attributed to the formation of PdO x nanoclusters. Fe 3+ maintained PdO x in a more oxidized state, facilitated the activation of gas-phase oxygen, and provided anchoring sites for CH 4 activation into CH 3 ∗ , which combined with activated oxygen species. The reaction follows the Langmuir-Hinshelwood (L-H) mechanism, in which both CH 4 and oxygen are first adsorbed on the catalyst surface. Adsorbed and activated CH 4 species are sequentially oxidized by active oxygen species, leading to the formation of chemisorbed CO species, which are transformed into CO 2 and H 2 O as the final products.
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Nature Communications
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2026
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IF 18.1
Tang Yu,Li Jiale,Li Yanfang,Ran Pan,Zou Weixin,Yan Shicheng,Dong Lin
Achieving stable and selective electrocatalytic nitrate reduction (NO 3 RR) at high current densities demands a fundamental understanding of the hydrogenation mechanism. We demonstrate that alloying cobalt with ruthenium (RuCo) switches the dominant hydrogenation pathway from the Eley-Rideal (E-R) mechanism, involving solvated protons, to the Langmuir-Hinshelwood (L-H) mechanism, utilizing adsorbed protons. Microkinetic modeling, in situ spectroscopy and density functional theory (DFT) calculations reveal that the competitive E-R pathway on pure Co causes sluggish hydrogenation kinetics and low Faradaic efficiency. In contrast, the L-H pathway on RuCo sustains high hydrogen coverage ( θ H ≈ 0.45), enabling efficient hydrogen-atom transfer for high-rate and deep hydrogenation. Leveraging this mechanistic insight, we achieve a satisfactory ammonia yield rate of 135.53 ± 1.18 mg h −1 cm −2 with 100% Faradaic efficiency and robust 1000-h stability at 1 A cm⁻². This work provides critical understanding of electrochemical hydrogenation pathways for designing efficient catalysts operating under industrially relevant conditions.
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RENAL FAILURE
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2026
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IF 3.8
Jia Wang,Jin-Wei E.,Jiong Zhang
Roxadustat (ROX) has a protective action against contrast-induced acute kidney injury (CI-AKI). Excessive production of reactive oxygen species (ROS) plays a significant role in exacerbating the deterioration of renal function. Notably, activation of Nrf2/HO-1 signaling can reduce ROS production. We constructed a mouse model of CI-AKI by iohexol injection. The effect of ROX on CI-AKI was assessed by measuring serum blood urea nitrogen (BUN) and creatinine (Cr), evaluating renal histopathology, and analyzing the expression level of Nrf2 and HO-1. Additionally, levels of ROS, malondialdehyde (MDA), proinflammatory cytokines (IL-6, TNF-α, and IL-1β), as well as the activities of antioxidant kinases superoxide dismutase (SOD) and glutathione (GSH), were examined. The results showed that ROX significantly suppresses the iohexol-induced decline in the activity of antioxidant enzymes, increases the levels of ROS, MDA, Cr, IL-6, IL-1β, BUN and TNF-α, and attenuates renal pathological injury. Furthermore, ROX enhanced the iohexol–induced increase in Nrf2 and HO-1 expression. However, these effects of ROX on CI-AKI were abolished by ML-385, a Nrf2 inhibitor. Our findings indicate ROX attenuates CI-AKI by down-regulating inflammation and restoring the balance between oxidative stress and anti-oxidant defenses. This may involve the activation of the Nrf2/HO-1 signaling pathway to clear excessive ROS.
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JOURNAL OF NANOBIOTECHNOLOGY
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2026
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IF 15
Hanjing Lu,Min Li,Wenxuan Fan,Zhao Li,Ji Cheng,Rui Liu,Pan Xu,Ding Luo,Jinghua Li,Xiaoran Liu
Sepsis-associated acute lung injury (ALI) is a critical clinical problem owing to the complex interactions between inflammation and oxidative stress. It is often associated with high mortality rates and a lack of therapeutic options. To simultaneously combat the interconnected inflammatory and oxidative stress pathways in sepsis-associated ALI, we designed near-infrared (NIR)-responsive nanomedicine by co-loading ferroptosis inhibitor Ferrostatin-1 (Fer-1) with Prussian blue nanozymes (denoted as Fer-1@PB) to achieve synergistic therapy and enhanced efficacy. Fer-1@PB combines the multi-enzyme mimetic properties of PB nanoparticle-based nanozyme (PBzyme) for reactive oxygen species (ROS) scavenging and the ferroptosis-inhibitory function of Fer-1 with spatiotemporally controlled burst release under NIR irradiation. The 0.05), and the conclusion of colloidal stability remains completely unchanged. All the above revisions are limited to typographical adjustments, wording accuracy, and minor typo corrections. No experimental data, results, figures, or cistance. Sincerely, Xiaoran Liu (on behalf of all authors) Corresponding author"?> Fer-1@PB nanozymes exhibited strong therapeutic efficacy in cellular and animal sepsis-related ALI models, with an increased survival rate, reduced pulmonary edema and histopathological damage, and recovery of lung function. Mechanistic investigations using transcriptomic analysis (RNA-seq) and experimental validation revealed that the therapeutic effects were mediated by the modulation of the CXCL2/ARF6/NCF1 signaling axis. This study introduces Fer-1@PB as a highly efficient and biosafe nanotherapeutic approach for ALI via synergistic anti-oxidative and anti-inflammatory effects. It also outlines a new molecular mechanism of action, yielding new insights into the precise nanomedicine for inflammatory lung disease.
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eScience
·
2026
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IF 52.9
Donglei Zhao,Kaiwen Shi,Shuang Wu,Xinyi Liu,Haoxiang Sun,Jinze Hou,Diantao Li,Siyuan Shao,Xingwei Sun,Lihong Zhang,Youxuan Ni,Zhenhua Yan,Yong Lu,Jun Chen
The quasi-solid-state gel electrolytes (QSEs) fabricated through free-radical in situ polymerization show great promise for energy-dense solid-state lithium batteries, paving the way for next-generation electric vehicles and the low-altitude economy. However, the high-voltage-resistant QSEs were obtained under strict conditions within batteries, causing highly non-uniform electrolyte and poor compatibility with electrodes. Here we propose a universal C=C bond activation strategy by introducing activators with high maximum molecular surface electrostatic potential (ESP max ) to improve the condensed local softness of C=C bonds in a series of acrylate-based monomers. The activated C=C bonds result in decreased polymerization reaction energy barrier, and thus realize room-temperature free-radical polymerized QSE (RT-QSE). The RT-QSE effectively suppresses harmful interfacial reactions, maintains electrode structure stability and improves electrolyte uniformity, enabling high-areal-capacity cathodes. As a result, the 4 mAh cm −2 cathode remains 95.1% capacity after 100 cycles. Moreover, the 9.53 Ah pouch battery with an areal capacity cathode >10 mAh cm −2 shows a record high energy density of 656.6 Wh kg –1 . This work establishes a general design criterion for selecting activators and monomers to achieve uniform and compatible RT-QSEs for energy-dense solid-state lithium batteries.
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CORROSION SCIENCE
·
2025
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IF 8.5
Zhihao Hong,Rong Liu,Yongjin Feng,Sifan Zong,Fantao Meng,Baoping Gong,Juemin Yan,Long Wang,Jijun Yang
The corrosion kinetics and deuterium permeation behavior of reduced activation ferritic/martensitic (RAFM) CLF-1 steel exposed to Li 2 ZrO 3 under high-temperature breeding blanket conditions were systematically investigated. The study revealed the corrosion kinetics of a bilayer corrosion structure that evolves with corrosion cycles, comprising a porous Fe-rich outer layer and a dense Cr-rich inner layer·H 2 O play a significant role in interfacial corrosion reactions, accelerating the degradation of the Fe-rich oxide through pore formation and delamination, resulting in enhanced deuterium permeation. Thermodynamic modeling confirmed that the interfacial reaction mechanism involves sequential structural transformations involving LiFeO 2 , Li 2 Fe 3 O 4 , Fe and LiCrO 2 phase. TEM reveals the dynamic microstructural evolution underlying the deterioration of the bilayer. A time-dependent corrosion model is proposed to elucidate the correlation between structural evolution and permeation resistance. With extended exposure, the Cr-rich LiCrO 2 phase dominates, acting as a passivating barrier that significantly impedes hydrogen isotope transport. Arrhenius analysis further substantiates the effectiveness of this evolving oxide structure in suppressing tritium permeation, highlighting the critical influence of H 2 O in corrosion-driven transport mechanisms.
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Scientific Reports
·
2025
·Vol. 15
·期 1
·1-10
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IF 3.9
Mo Fei,Hong Min,Chen Xiao,Wang Qiye,Dong Chao
The accumulation of regulatory T cells (Tregs) in the tumor microenvironment is a key factor for immunosuppression and immune escape of cancer cells. Genistein is a natural isoflavonoid in soybeans, possessing a wide range of pharmacological bioactivities. However, the immunomodulatory potential of genistein remains largely unexplored. This study investigated the synergistic efficacy of genistein with anti-PD-1 therapy in a mouse model of melanoma. The regulatory role of genistein in Treg differentiation and functional stability was also examined in this study. The antitumor effects of genistein, alone or in combination with anti-PD-1 therapy, were evaluated in the mouse B16-F10 melanoma model. The profiles of intratumoral Tregs and CD8 + cytotoxic T cells were profiled using flow cytometry. The impact of genistein on the suppressive function and differentiation of Tregs was also studied in vitro. RT-qPCR, Western blotting and flow cytometry were conducted to characterize the functional phenotype of Tregs under genistein treatment. Genistein showed a synergistic effect with anti-PD-1 therapy in B16-F10 melanoma models, achieving enhanced immune infiltration and functional reprogramming of the tumor microenvironment. This combinatorial strategy not only reduced intratumoral Tregs but also elevated the CD8 + /Treg ratio. At the mechanistic level, genistein effectively suppressed critical Treg surface markers, which are indispensable for Treg-mediated immunosuppression. Furthermore, it disrupted Treg differentiation by attenuating PI3K/AKT signaling phosphorylation. Our data demonstrated that genistein boosts the antitumor effect of anti-PD-1 therapy by impairing the immunosuppressive function and differentiation of Tregs, indicating that genistein has the potential to enhance the treatment outcome of the immune checkpoint inhibitor.
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Materials
·
2025
·Vol. 18
·期 12
·2770
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IF 3.2
Qianqian Zheng,Yanwen Ren,Cuicui He,Jingjing Nie,Binyang Du
The transition to renewable energy makes energy storage crucial. Aqueous organic redox flow batteries (AORFBs) show great potential in large-scale energy storage due to their outstanding safety compared to conventional systems. Derivatives of 2,2,6,6-tetramethylpiperidin-1-oxyl (TEMPO) show significant promise as catholyte materials in AORFBs. In this work, a bipyridine-ester dual-modified TEMPO derivative, (2,2,6,6-tetramethyl-1-piperidinyloxy)carbonyl-ethyl-(4-(pyridin-4-yl)benzyl) ammonium bromide (TEMP-BPy) was successfully synthesized via a two-step functionalization. The synthesized compound was experimentally confirmed to possess excellent electrochemical stability. The electron-withdrawing effect of the 4,4′-bipyridine moiety elevates the redox potential by 60 mV. When implemented as a catholyte paired with methyl viologen (MV) as the anolyte in AORFB, the TEMP-BPy/MV system demonstrates excellent performance: achieving a cell voltage of 1.28 V and an energy density of 14.5 Wh L−1at a 0.6 M (16.08 Ah L−1) concentration with 71.3% material utilization. Notably, it demonstrates exceptional cycling stability with an average capacity retention of 99.86% per cycle over 200 cycles, and it exhibits particularly impressive initial stability, with an average capacity retention of 99.997% per cycle during the first 100 cycles.
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