APPLIED SURFACE SCIENCE
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2022
·
IF 7.392
Yi Peng,Ying Yan,Jing Wang,Ziyang Xiang,Yanmei Li,Junhui Yang,Jinglin Yin,Wenlei Wang,Hongbo Xiao
In this study, CdSe cluster-modified biogenic α − FeOOH based on macroporous biochar was constructed from rhizosphere iron plaque via pyrolysis. An ultrahigh H 2 O 2 production rate of 655.75 μmol/L was achieved by the photocatalysis-self-Fenton system within 30 min under visible light irradiation. α-FeOOH, with abundant iron ions, can directly activate H 2 O 2 to produce abundant ⋅OH radicals. It was found that As(III) (10 mg/L) could be completely degraded within 20 min. Electron spin resonance spectroscopy (ESR) and density functional theory (DFT) revealed that a suitable energy band structure was achieved by the introduction of CdSe clusters; thus, O 2 was mainly reduced to H 2 O 2 through a two-electron reduction route in the reaction system. The photogenerated electrons promoted the conversion of Fe(III)/Fe(II) by reacting with Fe(III) in α-FeOOH. The presence of H 2 O 2 and Fe 2+ in this system accelerates the oxidation of As(III) by a Fenton-like reaction.
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LWT-FOOD SCIENCE AND TECHNOLOGY
·
2022
·
IF 6.056
Jinzhe Li,Yue Liu,Tianqi Li,Munkh-Amgalan Gantumur,Abdul Qayum,Akhunzada Bilawal,Zhanmei Jiang,Lizhe Wang
Change in conformational and digestive properties of α-lactalbumin (α-LA) induced by safflower yellow (SY) in combination with microwave (MW) heating treatment (70, 80, 90 °C, 10 min) was investigated. Fluorescence study showed that the binding affinity of SY for α-LA increased with temperature. Meanwhile, the quenching mode of SY to α-LA intrinsic fluorescence was static, its binding constant to α-LA was enhanced with increasing temperature. The major interaction forces in α-LA-SY complexation contained hydrophobic force and hydrogen bond. Fourier transform infrared revealed that binding of SY altered α-LA conformation, and increasing MW temperature could have a boost effect on the conversion of α-helix and β-sheet to random coil and β-turn. In addition, SY had a little inhibiting influence on α-LA in vitro digestibility and degree of hydrolysis, while MW heating facilitated those of α-LA-SY complex. Moreover, antioxidant capacities of α-LA-SY complexes was enhanced as a function of temperature. Therefore, increasing MW temperature could facilitate non-covalent interaction (α-LA and SY) and improve α-LA digestibility and antioxidant capacities. These findings were helpful to better recognize α-LA structure and functionality as well as keep SY biological activity by controlling the processing temperature, providing a theoretical data of functional dairy-based products in food industry.
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2023
·
IF 4.2
Guojuan Qu,Tao Jiang,Tao Liu,Xiang Ma
Low color rendering indices (CRIs), distorted chromaticity, and monotonous luminescence seriously hinder the application of luminescent nanomaterials. In this case, Au nanoclusters (Au NCs) are promising candidates for the fabrication of luminescent sensing systems attributed to their excellent luminescent properties and ultrafine size. Here, we synthesized Au@α-CD NCs with blue fluorescence emission adopting the host macrocyclic molecule (6-SH-α-CD) as the ligand and matched it elaborately with orange phosphorescence-emissive Au@GSH NCs to fabricate multicolor tunable ratiometric Au NC luminescent systems. Accordingly, a standard white-light emission was successfully achieved with Commission Internationale de L’Éclairage located at (0.33, 0.33) and a CRI as high as 93. In view of the difference in temperature sensitivity between the lowest excited states of the two Au NCs, the ratiometric blending Au NCs moved from the 3500 K warm light region to 14400 K cold light region when the temperature varied from 0 to 70 °C, which played a role in monitoring temperature changes with the naked eye.
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MICROCHEMICAL JOURNAL
·
2023
·
IF 4.8
Congyi Zhao,Yaxu Zhao,Lianqi Wang,Ke Lu,Wei Guo,Xiong Lu,Faming Gao
In this experimental study, a highly sensitive electrochemical acetylcholinesterase (AChE) biosensor for the detection of organophosphorus pesticides (OPs) based on three-dimensional α-Fe 2 O 3 nanoflowers decorated with Au nanoparticles (AuNPs) and carbon nanotube (CNTs) (α-Fe 2 O 3 NFs-AuNPs-CNTs) was developed. With the blooms structure, the α-Fe 2 O 3 NFs not only provided an excellent microenvironment for the loading of AChE, but also increased the contact specific surface area. Meanwhile, AuNPs dispersed uniformly on the α-Fe 2 O 3 nanosheets and CNTs further enhanced the conductivity of the nanocomposites. Under the optimized conditions, the biosensor was made to exhibit favorable linear relationship with the logarithm of the concentration of omethoate from 1 × 10 −13 -1 × 10 −7 M, with the detection limit of 1.9 × 10 −15 M. In addition, the biosensor also possessed good repeatability, stability and practicality, proved to be a valuable tool for the detection of pesticides in environment.
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ANALYTICAL CHEMISTRY
·
2021
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IF 6.986
Stanislas Nsanzamahoro,Wei-Feng Wang,Ying Zhang,Cheng-Bo Wang,Yan-Ping Shi,Jun-Li Yang
Designing analytical approaches for enzymatic activity monitoring with high sensitivity and selectivity is of critical value for the diagnosis of diseases and biomedical studies. In this study, we have created a facile one-step synthetic route to prepare orange-red color and yellow fluorescent silicon-containing nanoparticles (Si CNPs) by mixing 3(2-aminoethylamino) propyl (dimethoxymethylsilane) and hydroquinone (HQ) in an aqueous solution. Inspired by the HQ-regulated facile synthetic step and the generation of HQ from α-glucosidase (α-Glu)-catalyzed hydrolysis of 4-hydroxyphenyl-α-d-glucopyranosyl (4-HPαDG), we have designed a straightforward colorimetric and fluorometric α-Glu activity assay using a commercially available 4-HPαDG as the α-Glu substrate. Fluorescent and colorimetric assays for α-Glu activity measurement have been thereby established and exhibited detection limits as low as 0.0032 and 0.0046 U/mL, respectively. Under single excitation at 370 nm, the prepared Si CNPs emitted yellow fluorescence at 520 nm and exhibited an absorbance peak at 390 nm. In addition, the proposed approach reveals various advantages including easy operation, time-saving, and good anti-interference ability. Hence, it could improve the progress of fluorometric and colorimetric enzymatic activity assays with high sensitivity and simplicity. Moreover, the proposed approach was applied for α-Glu inhibitor screening, and its feasibility in real samples was measured by detecting the α-Glu activity in human serum samples.
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JOURNAL OF ORGANIC CHEMISTRY
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2021
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IF 4.354
Qian Chen,Xuanming Zheng,Fang Guo,Kun Liang,Fanrui Zhou
α-Aminophosphonate analogues containing a phthalazine skeleton were efficiently obtained by a new transition-metal-free addition of dialkyl phosphites to phthalazin-2-ium bromide under mild conditions. A mechanistic study using isotope labeling and radical inhibition experiment revealed that the present transformation passes through a nucleophilic addition of dialkyl phosphates, rather than an insertion of P-H to carbenes.
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AQUACULTURE NUTRITION
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2021
·Vol. 27
·期 6
·2749-2758
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IF 3.497
Yan-Yu Zhang,Jun-Xian Wang,Jiong Ren,Jie Wang,Fang Qiao,Mei-Ling Zhang,Zhen-Yu Du
In aquaculture, excess lipid deposition in liver is a health damage in largemouth bass ( Micropterus salmoides ). Activation of peroxisome proliferator-activated receptor-α (PPARα) has been proved to stimulate lipid catabolism and alleviate fatty liver in rodents and human. Our present study was conducted to investigate the effects of Pparα activation via dietary fenofibrate stimulation on hepatic lipid catabolism in largemouth bass. Total 240 fish (10.7 ± 0.2 g) were randomly divided into eight tanks and fed two diets (control and control containing 5 g/kg fenofibrate), respectively, for 4 weeks. Dietary fenofibrate increased Pparα protein and mitochondrial DNA amounts. The weight gain rate and carcass ratio of fish with Pparα activation decreased, but viscerosomatic index and hepatosomatic index were higher in the fenofibrate-fed fish than the control. Pparα activation significantly reduced triglyceride levels in the serum and liver but did not change the lipid composition in liver. Moreover, hepatic glycogen accumulation was found in the fish with Pparα activation. The Pparα activation also had health benefits for liver, as reflected by reducing serum ALT and AST activities, and increasing antioxidative ability in liver. Our results showed that in largemouth bass, Pparα can be activated and the Pparα activation could efficiently stimulate lipid catabolism and reduce hepatic fat deposition, and promote health in liver.
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ACTA PHYSIOLOGIAE PLANTARUM
·
2023
·Vol. 46
·期 2
·1-17
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IF 2.6
Kumari Monika,Singh Hidam Bishworjit,Khan Mohammad Imtiyaj
Betalains are health-promoting plant pigments accumulated in non-anthocyanic plants. Owing to its limited distribution in nature, metabolic trade-offs of inhibiting them are poorly understood. The aim of this study was to investigate the effects of inhibition of betalains in Amaranthus tricolor seedlings to gain insights into the relationship of betalain biosynthesis with other biosynthetic pathways in betalain-accumulating plants. Phenylalanine (Phe; 12.5, 25, and 50 mmol L −1 ) and 3-methyl-2-benzothiazolinone hydrazone (MBTH) (25 mmol L −1 ) were treated to inhibit betalain biosynthesis in ten-day-old A. tricolor (red) seedlings. After two and six days of treatment, target (betalain-related metabolites) and non-target metabolites were analyzed. In two days, Phe content increased by 2.6, 8.5, and 17.4-fold in Phe (12.5, 25, and 50 mmol L −1 )-treated seedlings, respectively, compared to control, indicating the uptake of Phe by the seedlings. Phe treatment led to a 10.1–18% decrease in betacyanins, while MBTH caused an 18.3% decrease in two days. In both treatments, cyclo -DOPA formation, which is essential for betacyanin biosynthesis, seems to be inhibited, albeit through different mechanisms. Betalain biosynthetic precursors and intermediates, viz., tyrosine, L-DOPA, and dopamine decreased differentially. Ascorbic acid, α -tocopherol, and retinol contents increased in both treatments concomitant with the reduction in betalains, total phenols, and antioxidant enzymes. Therefore, Phe treatment is beneficial in enhancing antioxidant metabolites in betalain-accumulating plants. However, the mechanism of increasing ascorbic acid on inhibiting betalains needs further investigation in other betalain-producing plants also to understand if ascorbic acid is involved in regulating betalain biosynthesis.
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JOURNAL OF MEDICINAL CHEMISTRY
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2020
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IF 6.205
Jinhao Liang,Yi-You Huang,Qian Zhou,Yuqi Gao,Zhe Li,Deyan Wu,Si Yu,Lei Guo,Zhen Chen,Ling Huang,Steven H. Liang,Xixin He,Ruibo Wu,Hai-Bin Luo
To validate PDE4 inhibitors as novel therapeutic agents against vascular dementia (VaD), 25 derivatives were discovered from the natural inhibitor α-mangostin (IC50 = 1.31 μM). Hit-to-lead optimization identified a novel and selective PDE4 inhibitor 4e (IC50 = 17 nM), which adopted a different binding pattern from PDE4 inhibitors roflumilast and rolipram. Oral administration of 4e at a dose of 10 mg/kg exhibited remarkable therapeutic effects in a VaD model and did not cause emesis to beagle dogs, indicating its potential as a novel anti-VaD agent.
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JOURNAL OF NUTRITIONAL BIOCHEMISTRY
·
2023
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IF 5.6
Siyu Xia,Feifei Xi,Kunlin Ou,Ying Zhang,Huizhen Ni,Chonggang Wang,Qin Wang
Tea and tea products are widely used as the most popular beverage in the world. EGCG is the most abundant bioactive tea polyphenol in green tea, which has positive effects on the prevention and treatment of diabetes. However, the impact of EGCG exposure on glucose homeostasis and islets in adult mice have not been reported. In this study, we studied glucose homeostasis and the morphological and molecular changes of pancreatic islet α and β cells in adult male mice after 60 d of exposure to 1 and 10 mg/kg/day EGCG by drinking water. Glucose homeostasis was not affected in both EGCG groups. The expression of pancreatic duodenal homebox1 (Pdx1) in β cells was upregulated, which might be related to increased insulin level , β cell mass and β cell proliferation in 10 mg/kg/day EGCG group. The expression of aristaless-related homeobox (Arx) in α cells did not change significantly, which corresponded with the unchanged α-cell mass. The significant reduction of musculoaponeurotic fibrosarcoma oncogene homolog B (MafB) positive α-cells might be associated with decreased glucagon level in both EGCG groups. These results suggest that EGCG supplementation dose-dependent increases β cell mass of adult mice and affects the levels of serum insulin and glucagon. Our results show that regular tea drinking in healthy people may have the possibility of preventing diabetes.
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Artificial Cells Nanomedicine and Biotechnology
·
2023
·
IF 5.8
Yanhai Xi,Wenming Pan,Yanyan Liu,Ji Liu,Guohua Xu,Yanguo Su,Daquan Chen,Xiaojian Ye
Osteoporosis is a common disease among the ageing society. Oxidative stress caused by excessive accumulation of reactive oxygen species (ROS) is the aetiology of osteoporosis. α-Lipoic acid (ALA) is an antioxidant in the body, which can eliminate excess ROS in the body and inhibits levels of oxidative stress in cells. Herein, we designed PEGylated hollow gold nanoparticles (HGNPs) loaded with ALA (mPEG@HGNPs-ALA) to remove ROS in the treatment of osteoporosis. First, mPEG@HGNPs with a particle size of ∼63 nm has been successfully synthesized. By comparing the drug loading of mPEG@HGNPs, it was concluded that the optimal mass ratio of mPEG@HGNPs (calculated by the amount of gold) to ALA was ∼1:2. ABTS antioxidant assay showed that free radical removal ability. In vitro results revealed that the preparation had good biocompatibility. At the gold concentration of 1–150 μg/mL, the cell viability of mPEG@HGNPs was more than 100%, which indicated that it could promote the proliferation of osteoblasts. What’s more, mPEG@HGNPs-ALA could effectively remove the ROS caused by H2O2 injury and improve the cell viability. According to these results, it can be considered that mPEG@HGNPs-ALA has the potential to treat osteoporosis.
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CERAMICS INTERNATIONAL
·
2023
·
IF 5.2
Hang Qin,Liangcheng Tong,Qisi Dai,Xinyi Zhou,Zhiwei Liu,Wenming Guo,Pengzhao Gao,Hanning Xiao
α-Al 2 O 3 exhibits excellent physical and chemical stabilities and thus has a wide range of applications in various fields, however the potential application are often called off because of the grains coarsening and vermiculite structures originated from the high-temperature calcination process. In this paper, the calcination temperature has been significantly reduced by selecting the chelating anhydrous aluminium sols as the precursor. It was found that when the chelating agent was malic acid and the addition amount was 0.06 mol, the chelated structure had the highest content of [AlO 6 ] octahedra, which was more favourable for the low-temperature synthesis of α-Al 2 O 3 . Kinetic analysis showed that the activation energy for the conversion of γ-Al 2 O 3 to α-Al 2 O 3 in this work was 398.09 kJ mol −1 , which has been reduced by nearly 100 kJ mol −1 and thus the complete conversion of γ-Al 2 O 3 to α-Al 2 O 3 was achieved by holding at 900 °C for 2 h. The obtained spherical α-Al 2 O 3 nanoparticles, with a particle size of about 67.2 nm and a uniform morphology. After further extending the holding time to 30 h, the complete conversion of α-Al 2 O 3 was achieved at 825 °C, while the initial nucleation temperature was lower than 760 °C.
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