CHEMICAL ENGINEERING JOURNAL
·
2021
·
IF 13.273
Yi Han,Chenfang Xu,Huihui Shi,Fei Yu,Yanlin Zhong,Zuguo Liu,Xian Jun Loh,Yun-Long Wu,Zibiao Li,Cheng Li
Even though fungal keratitis is a severe corneal disease that can lead to permanent vision loss, its therapeutic management is still problematic. This limitation is in part attributable to the fact that tear film renewal curtails exposure time of drug containing eye drops to the ocular surface. Accordingly, anti-microbial therapy needs to be performed repeatedly. Efforts to resolve this hindrance include developing formulations that prolong drug retention on the ocular surface which can in turn improve therapeutic efficacy as well as reduce administration frequency. To extend drug residence time on the ocular surface, we designed a novel organic-inorganic hybrid consisting of a PEG-PPG copolymer modified with polyhedral oligomeric silsesquioxane (POSS) groups. Its tailored POSS-micelles possess both good biocompatibility and bio-adhesiveness, which improve ocular delivery of poorly soluble drugs. We describe here use of mouse fungal keratitis model to determine the effects of this formulation encapsulating amphotericin B (AMB) on this condition. The results show that POSS-micelles significantly prolonged AMB retention time on the ocular surface, leading to improved resolution of this disease. Moreover, this treatment strategy had no toxic effects during ocular administration either in vitro or in vivo. Therefore, this POSS formulation bearing AMB has the potential to prolong drug retention time and improve its therapeutic efficacy in managing fungal keratitis.
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JOURNAL OF BIOMATERIALS APPLICATIONS
·
2023
·
IF 2.9
Tian Yi Wu,Wen Jie Cao,Zi Ling Li,Yan Chun Gong,Xiang Yuan Xiong
Drugs with different solubility can be selectively embedded into polymersomes with the hydrophilic core and hydrophobic bilayer. Novel folate-targeted Pluronic/poly (D,L-lactide-b-glycolide) polymersomes were constructed and used for the co-delivery of paclitaxel (PTX) and doxorubicin (DOX) to improve their inhibitory effect over cancer cells. The particle size of blank polymersomes was mainly distributed below 125 nm. The release of PTX and DOX from polymersomes showed an initial burst release followed by a sustained and slow release. The in vitro cytotoxicity data showed that the targeted co-loaded polymersomes (PTX&DOX FA-Ps) exhibited better inhibitory effect than single-loaded polymersomes and free drugs did. Furthermore, PTX&DOX FA-Ps showed the synergistic therapeutic effect over OVCAR-3 cancer cells. The cellular uptake results also showed that folate modified polymersomes had excellent targeting performance. Therefore, the folate-targeted Pluronic/poly (D,L-lactide-b-glycolide) polymersomes have potential application value as novel drug carriers to co-deliver PTX and DOX.
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PubMed
高影响因子
Materials
·
2025
·Vol. 18
·期 23
·5313
·
IF 3.2
Shasha Hong,Yuan Jiao,Ruyu Li,Peng Lei,Chuan Dong,Shang Guo,Shaomin Shuang
Synergetic therapeutic study using multifunctional nanoplatforms has been developed as an innovative modality for effective cancer treatment to improve the clinical efficiency of anticancer drugs and reduce severe off-target side effects. Herein, an artificial nanoplatform (denoted as PPy-RhB-PDA-CD-LA) was prepared by grafting β-cyclodextrin (β-CD) derivatives and lactobionic acid (LA) on the surface of rhodamine B (RhB)-doped polypyrrole nanoparticles (PPy-RhB NPs) using polydopamine (PDA) as the intermediate linker. Doxorubicin (DOX) was selected and successfully loaded onto the nanoplatforms with a high loading content of 327 mg/g. Furthermore, significant NIR light-triggered release of DOX was observed in a weak acidic tumor microenvironment. The nanoplatform exhibited superior photostability with a high photothermal effect of 51.7% under irradiation by a 808 nm laser and a competent temperature sensitivity (SR is 1.44% °C−1) under a single wavelength excitation. MTT assay against SMMC-7721 cells clearly illustrated that the nanoplatform had low cytotoxicity at a high level (200 μg/mL) after 24 h and high therapeutic efficacy of chemo-phototherapy. Thus, it is highly promising for use in biomedical applications.
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产品关联
DOI
PubMed
高影响因子
BMC PLANT BIOLOGY
·
2019
·Vol. 19
·期 1
·1-16
·
IF 3.67
Cao Yunpeng,Meng Dandan,Han Yahui,Chen Tianzhe,Jiao Chunyan,Chen Yu,Jin Qing,Cai Yongping
Background Studies have demonstrated that BBX (B-BOX) genes play crucial roles in regulatory networks controlling plant growth, developmental processes and stress response. Nevertheless, comprehensive study of BBX genes in orchids (Orchidaceae) is not well studied. The newly released genome sequences of Dendrobium officinale and Phalaenopsis equestris have allowed a systematic analysis of these important BBX genes in orchids. Results Here we identified 19 ( DoBBX01 – 19 ) and 16 ( PeBBX01–16 ) BBX genes from D. officinale and P. equestris , respectively, and clustered into five clades (I-V) according to phylogenetic analysis. Thirteen orthologous, two DoBBXs paralogous and two PeBBXs paralogous gene pairs were validated. This gene family mainly underwent purifying selection, but five domains experienced positive selection during evolution. Noteworthy, the expression patterns of root, root_tips, stem, leaf, speal, column, lip, and flower_buds revealed that they might contribution to the formation of these tissues. According to the cis-regulatory elements analysis of BBX genes, qRT-PCR experiments were carried out using D. officinale PLBs (protocorm-like bodies) and displayed that these BBX genes were differentially regulated under AgNO 3 , MeJA (Methyl Jasmonate), ABA (abscisic acid) and SA (salicylic acid) treatments. Conclusions Our analysis exposed that DoBBX genes play significant roles in plant growth and development, and response to different environmental stress conditions of D. officinale , which provide aid in the selection of appropriate candidate genes for further functional characterization of BBX genes in plants.
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高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2025
·
IF 6.2
Changsheng Zhang,Shuang Liang,Haijun Liu,Yuxuan Hu,Xinzhong Zhang,Fengjian Luo,Zhengyun Lou,Li Zhou,Mei Yang
Mercury (Hg2+) and thiophanate-methyl (TM) are recognized as widespread pollutants in the environment and food. Here, a novel ratiometric fluorescent sensor has been developed for the detection of Hg2+ and TM using nitrogen-doped carbon dots (N-CDs) and Rhodamine B (RhB). In the presence of Hg2+, the fluorescence quenching of N-CDs was caused by photoinduced electron transfer, while the fluorescence recovery was triggered by the competitive binding of TM and N-CDs to Hg2+. However, the RhB fluorescence in the system was unaffected by Hg2+ and acted as a reference for internal calibration. Under optimized conditions, the sensor displayed a favorable linear dependence on Hg2+ and TM within the concentration ranges of 0.50–50 μM and 0.50–3.0 mg/L, with detection limits of 0.15 μM and 0.017 mg/L, respectively. And the sensor exhibited remarkable selectivity, with insignificant interference from coexisting metal ions or pesticides. This work presents a novel dual-functional ratiometric sensor for cascade detection of Hg2+ and TM in diverse environments, such as water, cucumber, and rice, highlighting its potential in practical applications.
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PubMed
高影响因子
ACS Applied Energy Materials
·
2022
·
IF 6.959
Feng Li,Jin-Da Luo,Le Tang,Xiaobin Cheng,Guozhen Zhang,Yi-Chen Yin,Te Tian,Hongsheng Mo,Jing-Tian Yang,Hong-Bin Yao
Although oxide- and sulfide-type fast Li-ion conductors employing various crystal structures have been extensively investigated over the past decades, the intrinsic disadvantages including the poor mechanical deformability of oxides and the narrow electrochemical window of sulfides limited their applications in all-solid-state lithium metal batteries. Metal halide-type fast Li-ion conductors have recently attracted intensive attention due to their prominent ductility, excellent interface compatibility, and wide electrochemical window. Here, we report a metal halide perovskite (HP)-type Li-ion conductor, Cs2LiYCl6, which crystallizes in a double perovskite structure, with Cs+ residing in the cuboctahedral spaces formed within the LiCl65– and YCl63– octahedron-connected frameworks. We unravel that this metal halide fast Li-ion conductor has a unique octahedral B-site vacancy Li-ion migration pathway, exhibiting an ionic conductivity of 0.015 mS cm–1 and a low Li-ion migration energy barrier of ∼0.40 eV. Our reported Cs2LiYCl6 lithium-ion conductor represents the first metal HP-type solid electrolyte, and the proposed B-site vacancy migration mechanism in this double perovskite structure will open a promising avenue for the exploration of metal HP-type Li-ion conductors.
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FASEB JOURNAL
·
2024
·Vol. 38
·期 17
·e70019
·
IF 4.4
Yuxue Xu,Yue Peng,Xiaojun Wu,Feixue Ni,Daxi Sun,Pengfei Zhang,Yang Yang,Miao Yan,Jia Mi,Geng Tian
Non-proliferative diabetic retinopathy (NPDR) is the early stage of diabetic retinopathy (DR) and is a chronic oxidative stress-related ocular disease. Few treatments are approved for early DR. This study aimed to investigate the pathogenic mechanisms underlying the retinal micro-vasculopathy induced by diabetes and to explore an early potential for treating early DR in a mouse model. The mouse model of type 1 diabetes was established by intraperitoneal injection of streptozotocin (STZ, 180 mg/kg), which was used as the early DR model. The body weight and blood glucose mice were measured regularly; The retinal vascular leakage in the early DR mice was determined by whole-mount staining; Label-free quantitative proteomic analysis and bioinformatics were used to explore the target proteins and signaling pathways associated with the retinal tissues of early DR mice; To detect the effects of target protein on endothelial cell proliferation, migration, and tube formation, knockdown and overexpression of VEGF-B were performed in human retinal vascular endothelial cells (HRECs); Western blotting was used to detect the expression of target proteins in vitro and in vivo; Meanwhile, the therapeutic effect of VEGF-B on vascular leakage has also been evaluated in vitro and in vivo. The protein expressions of vascular endothelial growth factor (VEGF)-B and the Rho GTPases family member CDC42 were reduced in the retinal tissues of early DR. VEGF-B upregulated the expression of CDC42/ZO1/VE-cadherin and prevented hyperglycemia-induced vascular leakage in HRECs. Standard intravitreal VEGF-B injections improved the retinal vascular leakage and neurovascular response in early DR mice. Our findings demonstrated, for the first time, that in diabetes, the retinal vessels are damaged due to decreased VEGF-B expression through downregulation of CDC42/ZO1/VE-cadherin expression. Therefore, VEGF-B could be used as a novel therapy for early DR.
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PubMed
高影响因子
POLYMERS FOR ADVANCED TECHNOLOGIES
·
2018
·Vol. 29
·期 6
·1684-1696
·
IF 2.137
Xiaoyu Chen,Xiaomeng Wu,Zhongyong Fan,Qinghua Zhao,Qing Liu
The macroinitiator of poly(1,3-trimethylene carbonate) (PTMC) with number-average molecular weight ( ) of 9.6 × 10 3 g mol −1 was synthesized by ring-opening polymerization at 120°C. Then, the novel terpolymer P(TMC- b -( L LA- ran -GA)) consisting of PTMC homopolymer segment attached with various monomer molar ratios of L -lactide ( L LA) and glycolide (GA) random copolymerization block was prepared with about 5.0 × 10 4 g mol −1 by ring-opening polymerization in bulk at 140°C. The tailored molecular structures of P(TMC- b -( L LA- ran -GA)) were characterized by 1 H nuclear magnetic resonance, 13 C NMR, FTIR, and gel permeation chromatography, and chain microstructure analysis was performed in detail with 13 C NMR spectroscopy. The effect of GA units on the thermal and crystallization behaviors, mechanical properties, as well as biodegradability of terpolymers was investigated by differential scanning calorimetry, wide-angle X-ray diffraction, stress-strain measurements, and in vitro tests in comparison with corresponding poly(trimethylene carbonate- block - L -lactide) copolymer P(TMC- b - L LA). The results show that amorphous PTMC segments have a significant effect on condensed state behavior of the terpolymers, and the incorporation of GA units strongly decreases the crystallinity and crystallization ability of L LA segment within terpolymers because of more random L LA-GA sequence and shorter average L LA block length. Meanwhile, the toughness of materials is greatly improved, and in vitro degradation is also accelerated. Peripheral vascular stents were 3D printed for the first time and met the requirements for application. The results show totally biodegradable terpolymers with unique molecular structure, and modifiable properties are promising new biomaterials with advanced performance for biomedical application.
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INTERNATIONAL JOURNAL OF POLYMER ANALYSIS AND CHARACTERIZATION
·
2019
·
IF 1.426
Yan Zhang,Qihang Zhou,Yujian Liu
Polymethylene-b-poly(ethylene glycol) (PM-b-PEG) with different block length ratio was synthesized by a combination of polyhomologation and coupling reaction. The effect of hydrophilic and hydrophobic block length on the crystallization process and self-assembly behavior of PM-b-PEG was self-assembled were investigated. The results showed that with the increase of methylene units, the crystallization temperature of PM block raised from 54.59 °C to 70.93 °C gradually, while that of the PEG block reduced from 17.54 °C to 15.23 °C. In addition, the amphiphilic PM-b-PEG was self-assembled into star-like micelles in water, and its diameter extended from 98.2 nm to 151.9 nm as the block length of hydrophobic PM increased from 30 to 70. And the micelles also exhibit super stability when the concentration of copolymer precursor is 0.50 ∼ 0.90 mg/ml and the storage temperature lies in the range of 25 ∼ 60 °C.
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高影响因子
ACS Omega
·
2022
·
IF 4.132
Zhiwei Liu,Na Li,Ping Liu,Zhihui Qin,Tifeng Jiao
Detection of iron ions in aqueous solutions is of significant importance because of their important role in the environment and the human body. Herein, a fluorescent rhodamine B-functionalized chitosan nanoparticles probe is reported for the efficient detection of iron ions. The chitosan nanospheres-rhodamine B (CREN) was prepared by grafting rhodamine B onto the surface of chitosan nanospheres through an amidation reaction. The as-prepared CREN fluorescent probes exhibit high fluorescence intensity under ultraviolet light. When iron ions are added to the CREN solution, they can be coordinated with weak-field ligands such as N and O on the surface of chitosan nanoparticles (CSNP) by a high-spin method. The self-assembly of Fe3+ on the surface of the CREN led to the generation of single electrons and the presence of high paramagnetism, resulting in fluorescence quenching. The quenching effect of Fe3+ on the CREN fluorescent probe can achieve the efficient detection of Fe3+, and the detection limit reaches 10–5 mol/mL. Moreover, this fluorescence quenching effect of Fe3+ on the CREN fluorescent probe is specific, which could not be disturbed by other metal ions and counteranions.
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高影响因子
Reaction Kinetics Mechanisms and Catalysis
·
2022
·Vol. 136
·期 1
·449-463
·
IF 1.843
Wang Jiaqi,Cheng Tiexin,Zhou Guangdong
In this work, calcium nitrate and sodium silicate were employed as the sources of calcium and silicon, respectively, to synthesize sheet calcium silicate hydrate (CSH) by simple chemical precipitation. The obtained sheet CSH exhibited fast adsorption rate and large adsorption capacity, the maximum adsorption capacity is 556.3 mg g −1 , for Cu(II) ions. The CSH after adsorption of Cu(II) ions (CSH-Cu) was characterized by XRD, FTIR, SEM, N 2 adsorption and XPS, and which could be converted into a catalyst for rhodamine B (RhB) degradation by a simple high-temperature activation process. The results showed that the catalyst give the excellent reusability, and after four cycles of the catalyst, more than 90% of the RhB could still be degraded within 240 min. The free radical trapping experiments showed that all of the ·OH, ·O 2 − and h + generated on the surface of the catalyst played an essential role in the degradation process, while h + made the largest contribution. Based on this, the degradation mechanism of RhB is also proposed.
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Journal of Materials Chemistry C
·
2024
·Vol. 12
·期 47
·19086-19093
·
IF 5.7
Xiaowei Zhu,Wei Liu,Guobin Zhu,Siyu Xiong,Deqin Chen,Xiuyun Lei,Laijun Liu,Chunchun Li
The present study reports on entropy-engineered perovskite ceramics (Ca1/3Sr1/3Ba1/3)(SnxTi1−x)O3 (CSBTO-xSn) with varying Sn-doping levels (x = 0.1, 0.2, 0.3), achieved through synergistic compositional design in both the A-sites and B-sites of the perovskite. Increasing the Sn-doping content induces a transition in configuration entropy from medium to high values. Notably, at an optimal composition of x = 0.1, the ceramic exhibits exceptional energy storage characteristics including an ultrahigh recoverable energy density (Wrec) of 5.05 J cm−3 and a high efficiency (η) of 82.56% at an electric field strength (Eb) of 540 kV cm−1 over a wide temperature range spanning from 30 to 100 °C and frequencies ranging from 1 Hz to 200 Hz. Furthermore, this ceramic demonstrates remarkable charge–discharge properties with a discharge energy density (Wdis) of 2.94 J cm−3 and a rapid discharge rate of t0.9 ∼ 67 ns. This study underscores the effectiveness of entropy engineering as a viable approach for developing advanced energy storage capacitors.
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