CARBOHYDRATE POLYMERS
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2024
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IF 10.7
Jian Zou,Xin Jing,Shitao Li,Yi Chen,Yuejun Liu,Pei-Yong Feng,Xiang-Fang Peng
Large mechanical hysteresis, stemming from the inherent viscoelasticity of the hydrogel networks, seriously affected its service life and application scope. Herein, we introduced a synergistic approach combining MXene nanoconfinement and bridging effect to produce hydrogels with low mechanical hysteresis. The introduced MXene was able to provide an effective nanoconfined effect on the polymerization of acrylamide monomers. By synergizing with the bridging effect—facilitated by strong interactions between chitosan-grafted polyacrylamide and solvent molecules to accelerate stress transfer—we successfully developed a MXene-reinforced conductive hydrogel with mechanical hysteresis as low as 3.17 %. Additionally, the strong electrostatic interactions between the chitosan and MXene further affiliate the dispersion of MXene within the hydrogel. The resulting MXene-reinforced conductive hydrogel demonstrated remarkable temperature sensitivity (TCR = −1.42 %/°C), making it suitable to be used as a health monitoring device. These findings opened up new perspectives for the further expansion of MXene and beyond.
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JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
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2024
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IF 3.6
Xinyu Yang,Dongdong Meng,Ning Jiang,Chaoxing Wang,Jinbo Zhang,Yanqiu Hu,Jiaming Lun,Rui Jia,Xueyun Zhang,Weitong Sun
In this study, the pH-responsive API-CMCS-SA (ACS) polymeric nanoparticles (NPs) based on 1-(3-amino-propyl) imidazole (API), stearic acid (SA), and carboxymethyl chitosan (CMCS) were fabricated for the effective transport of curcumin (CUR) in liver cancer. CUR-ACS-NPs with various degrees of substitution (DS) were employed to prepare through ultrasonic dispersion method. The effect of different DS on NPs formation was discussed. The obtained CUR-ACS-NPs (DSSA=12.4%) had high encapsulation rate (more than 85%) and uniform particle size (186.2 ± 1.42 nm). The CUR-ACS-NPs showed better stability than the other groups. Drug release from the CUR-ACS-NPs was pH-dependent, and more than 90% or 65% of CUR was released in 48 h in weakly acid medium (pH 5.0 or 6.0, respectively). Additionally, the CUR-ACS-NPs increased the intracellular accumulation of CUR and demonstrated high anticancer effect on HepG2 cells compared with the other groups. CUR-ACS-NPs prolonged the retention time of the drug, and the area under the curve (AUC) increased significantly in vivo. The in vivo antitumor study further revealed that the CUR-ACS-NPs exhibited the capability of inhibiting tumor growth and lower systemic toxicity. Meanwhile, CUR, CUR-CS-NPs, and CUR-ACS-NPs could be detected in the evaluated organs, including tumor, liver, spleen, lung, heart, and kidney in distribution studies. Among them, CUR-ACS-NPs reached the maximum concentration at the tumor site, indicating the tumor-targeting properties. In short, the results suggested that CUR-ACS-NPs could act a prospective drug transport system for effective delivery of CUR in cancer treatment.
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SEPARATION AND PURIFICATION TECHNOLOGY
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2024
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IF 8.1
Dongxue Fu,Guifang Wang,Li Zhao,Yuwen Hong,Baoming Yang,Huiling Cheng
Green ion-imprinting technique was applied to construct a Cr(III) ion-imprinted absorbent material from an amino functionalized chitosan derivative. First, nitrogenous organic compounds (GACS) as functional monomer is synthesized by a Schiff base reaction followed by a grafting reaction. In the end, imprinting was completed by cross-linking with epichlorohydrin (ECH) in aqueous media and eluting the coordinated ions with hydrochloric acid to obtain chromium-imprinted polymers (Cr(III)-IIP) with pores. The relevant parameters of the imprinting system were explored, and the superior polymer (Cr(III)-IIP 9 ) has an excellent adsorption capacity 385.89 mg/g, wide pH range adsorption, good adsorption rates and equilibrium times (≤120 min) for Cr(III) ion. Additionally, the kinetic study is best defined in terms of pseudo-second order, while the Freundlich isotherm model fits the data well. Competitive adsorption of the quaternary system of Cr(III)/ Cd(II)/ Ni(II)/ Cu(II) were also investigated, it demonstrated a greater affinity for the Cr(III) ion than other ions. Hence, the imprinting materials prepared by amino functionalized chitosan enhances the adsorption of Cr(III) ions in the simulation of actual water sample. The adsorption mechanism accords with the hard and soft acid and base theory (HSAB), which is expected to be is utilized for the separation of Cr(III) ions in the environment.
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ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
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2024
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IF 6.2
Wenchao Zhang,Lu Shen,Ruyue Xu,Xue Dong,Shurui Luo,Huajie Gu,Fenju Qin,Hengwei Liu
Microbially induced carbonate precipitation (MICP), as an eco-friendly and promising technology that can transform free metal ions into stable precipitation, has been extensively used in remediation of heavy metal contamination. However, its depressed efficiency of heavy metal elimination remains in question due to the inhibition effect of heavy metal toxicity on bacterial activity. In this work, an efficient, low-cost manganese (Mn) elimination strategy by coupling MICP with chitosan biopolymer as an additive with reduced treatment time was suggested, optimized, and implemented. The influences of chitosan at different concentrations (0.01, 0.05, 0.10, 0.15 and 0.30 %, w/v) on bacterial growth, enzyme activity, Mn removal efficiency and microstructure properties of the resulting precipitation were investigated. Results showed that Mn content was reduced by 94.5 % within 12 h with 0.15 % chitosan addition through adsorption and biomineralization as MnCO 3 (at an initial Mn concentration of 3 mM), demonstrating a two-thirds decrease in remediation time compared to the chitosan-absent system, whereas maximum urease activity increased by ∼50 %. Microstructure analyses indicated that the mineralized precipitates were spherical-shaped MnCO 3 , and a smaller size and more uniform distribution of MnCO 3 is obtained by the regulation of abundant amino and hydroxyl groups in chitosan. These results demonstrate that chitosan accelerates nucleation and tunes the growth of MnCO 3 by providing nucleation sites for mineral formation and alleviating the toxicity of metal ions, which has the potential to upgrade MICP process in a sustainable and effective manner. This work provides a reference for further understanding of the biomineralization regulation mechanism, and gives a new perspective into the application of biopolymer-intensified strategies of MICP technology in heavy metal contamination.
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POLYMER DEGRADATION AND STABILITY
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2025
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IF 7.4
Qian Li,Jing Zheng,Zejie Huang,Libo Hu,Yanqiao Jin,Lei Xiong
In order to overcome the performance barriers of polylactic acid (PLA), a multifunctional layered chitosan derivative, DAMC-Al, is synthesised and used as an intumescent flame retardant. The acid sources used in this work are 9,10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide and amino trimethylene phosphonic acid, which act synergistically to facilitate the conversion of chitosan to carbon. The combustion tests demonstrate that the PLA/5DAMC-Al exhibits excellent flame-retardancy with a limiting oxygen index of 30.3 % and a UL-94 flammability rating of V-0. The heat release rate and total heat release are significantly reduced compared to pure PLA, and the residual carbon expands rapidly. In addition, the composite has improved toughness while maintaining the stiffness of the PLA substrate, with a 31.0 % increase in elongation at break. DAMC-Al can also effectively block the transmission of 95 % of ultraviolet lights, protecting the PLA macromolecular chain from high-energy ultraviolet damage. Actually, the ultraviolet protection factor of PLA/5DAMC-Al is determined to be as high as 51.43. Furthermore, the soil degradation tests show that PLA/5DAMC-Al has the same excellent natural degradation properties as PLA.
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CARBOHYDRATE POLYMERS
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2010
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IF 3.167
Hua Zheng,Yan Rao,Yihua Yin,Xiong Xiong,Peihu Xu,Bo Lu
A series of 6-mercaptopurine-carboxymethyl chitosans (6-MP-CMC) were prepared and structurally characterized. Their in vitro drug release behaviors in the buffer solutions containing glutathione (GSH) were investigated. 6-MP-CMC did not release any 6-MP in the media without GSH and containing 2 μM GSH. By comparison, the obvious 6-MP release could be observed within an hour in the media containing 2 mM and 10 mM GSH. And the maximum cumulative release rates were 65.1% and 74.4%, respectively. The buffer pH and the 6-MP content in 6-MP-CMC had obvious influences on the 6-MP release. At 10 mM GSH, the maximum cumulative release rate at pH 5 was higher than that at pH 7.4. 6-MP-CMC in pH 7.4 PBS could self-assemble into nanoparticles. Their mean hydrodynamic diameter determined by dynamic light scattering (DLS) was 155.8 ± 6.0 nm. The particles observed by transmission electron microscopy (TEM) were spherical in shape and had the size of about 100 nm.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
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IF 7.7
Hang Wu,Liang Zhu,Lei Xie,Taiyu Zhou,Tengbo Yu,Yingze Zhang
Bacterial infections, excessive reactive oxygen species (ROS) accumulation and a persistent inflammatory response severely impede the wound healing process. In this study, we developed a novel multifunctional hydrogel dressing (LCPN) based on lipoic acid modified chitosan (LAMC), polypyrrole nanoparticles (PPy NPs) and nicotinamide mononucleotide (NMN) for accelerated healing of infected wounds. The synthesized LCPN hydrogel has several properties. Modification of lipoic acid significantly enhances the water solubility of chitosan making it easier to dissolve and absorb wound secretions. Interestingly, owing to the breaking and restructuring of disulfide bonds, LCPN can be quickly bonded under UV light without relying on photoinitiators. In addition, the incorporation of PPy NPs not only enhances the electrical conductivity of LCPN hydrogel, but also confers photothermal antimicrobial capability to LCPN hydrogel. More importantly, the sustained release of NMN in LCPN hydrogel can significantly enhance cell proliferation, migration and antioxidant capacity, which is conducive to accelerated wound healing. In vivo and in vitro experiments have shown that LCPN hydrogel has excellent biocompatibility and the ability to promote wound healing. Therefore, the prepared multifunctional hydrogel is expected to be used as a novel dressing to accelerate wound healing.
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EUROPEAN POLYMER JOURNAL
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2024
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IF 5.8
Ze Xu,Jun Gao,Hongyu Zhang,Guojun Zheng,Jihong Hu,Junyao Li,Laidi Xu,Yong Kong
A thermosensitive hydrogel based on 6-deoxy-6-arginine grafted chitosan (DAC) and poloxamer 407 (P407) is prepared for wound repair. Since P407 is a thermosensitive polymer, the resultant DAC/P407-gel exhibits thermo-responsive sol–to–gel phase transition behaviors with a phase transition temperature (T sol/gel ) of ∼ 26.5 °C, making it an appropriate material for wound healing. The DAC/P407-gel has a three-dimensional (3D) network structure with large amounts of pores, and the good air permeability of the hydrogel makes it an attractive candidate as wound dressing. The introduction of DAC can not only increase the mechanical strength of the hydrogel but also significantly enhance its biological indexes including antibacterial activity, blood-clotting index (BCI) and hemocompatibility. The cytotoxicity test reveals that the developed DAC/P407-gel also shows outstanding cytocompatibility.
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FOOD HYDROCOLLOIDS
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2025
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IF 12.4
Baoyi Zhang,Haifeng Mai,Xinqi Liang,You Liu,Weijuan Huang
This study presents a general approach for fabricating polysaccharide-based self-healing emulsion gels with superior physical stability. The emulsion gels were synthesized by crosslinking carboxymethyl chitosan (CMC)-stabilized emulsions with oxidized sodium alginate (OSA). The self-healing properties of the gels were attributed to the formation of reversible imine bonds between the primary amino groups (-NH 2 ) of CMC and the aldehyde groups (-CHO) of OSA. Gelation occurred rapidly (20–60 s) upon mixing the CMC-stabilized emulsion with the OSA solution. Microstructural analysis revealed that the dispersed oil droplets were tightly encapsulated within an interconnected gel network. The compressive strength and rheological properties of the CMC-OSA emulsion gels were influenced by the mass ratio of CMC to OSA and the preparation parameters of OSA. Furthermore, the CMC-OSA emulsion gels demonstrated rapid self-healing at room temperature without external stimuli, along with excellent injectability. Owing to the 3D gel-like network structure and reversible interactions at the oil/water interface and within the continuous phase, the emulsion gels exhibited exceptional physical stability, including storage stability, freeze-thaw stability, pH and ionic stability, thermal stability, and centrifugal stability. This study provides a promising strategy for developing injectable self-healing emulsion gels with tunable mechanical properties and enhanced physical stability for multifunctional applications.
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CARBOHYDRATE POLYMERS
·
2024
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IF 10.7
Yilong Wang,Xingyu Zhou,Junhui Jiang,Tianhao Zhao,Junbo Dang,Ruibo Hu,Chen Shen,Qiaochu Fan,Dahui Sun,Mei Zhang
Critical-sized bone defects (CSBDs) necessitate interventions like bone grafts or tissue engineering scaffolds to surpass the body's limited spontaneous healing capacity and ensure effective bone regeneration. A multi-level microstructured composite hydrogel 3D scaffold was fabricated for enhanced bone defect repair, integrating a 3D-printed macroporous polylactic acid (PLA) scaffold with polydopamine treatment and filled with a sodium alginate/nano hydroxyapatite/carboxymethyl chitosan (SA/nHA/CMCS) micrometer-scale porous composite hydrogel. The incorporation of nano hydroxyapatite (nHA) nanoparticles enhanced hydrogel crosslinking and osteogenic activity. A systematic evaluation of CMCS concentration demonstrated its pivotal role in enhancing hydrogel cross-linking and mineralization, regulating degradation rate adapted to the osteogenic cycle, endowing the scaffold with a bioactive micrometer-scale porous structure. In vitro studies confirmed the osteogenic effectiveness of the composite hydrogel 3D scaffold, particularly those with CMCS, which boosted bone mesenchymal stem cells (BMSCs) adhesion, proliferation, and differentiation. The rabbit tibial bone defect model further confirmed that, compared to the DAPLA (dopamine modified PLA) scaffold, the bone trabecular number of the DSHC (DAPLA-SA/nHA/CMCS) scaffold increases 2.06-fold. In conclusion, this study expanded the application of hydrogel scaffolds in bone tissue engineering and provided an effective strategy for the development of hydrogel implant materials.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
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IF 7.7
Xiaoyao Wang,Haizhi Huang,Siyao Zhong,Xuping Shentu,Zihong Ye,Xiaoping Yu
Fenpropathrin residues in grain are potentially harmful to humans. Therefore, a fluorimetric lateral flow immunoassay using a zirconium-based organic skeleton (UiO-66) as a signal marker was developed for detecting fenpropathrin. Herein, carboxymethyl chitosan (CMCS) was used to modify UiO-66 and improve its water solubility to facilitate stable binding with sodium fluorescein (NaFL). This resulted in formation of a new fluorescent probe that is more suitable for lateral flow immunoassay (LFIA). The materials were characterized via electron microscopy , Fourier-transform infrared spectroscopy, and powder X-ray diffraction. CMCS and NaFL were successfully bound to UiO-66. Under optimized conditions, the constructed NaFL/UiO-66@CMCS-LFIA exhibited a good linear relationship within the range of 0.98–62.5 μg/L, with a detection limit of 3.91 μg/L. This probe was fourfold more sensitive than traditional colloidal gold nanoparticle-based LFIA. Finally, NaFL/UiO-66@CMCS-LFIA was successfully applied to detect fenpropathrin in wheat and maize samples. The detection limit was 1.56 μg/kg and recoveries ranged from 96.58 % to 118.56 %. This study provides a sensitive, stable, and convenient method for the rapid detection of pesticide residues .
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
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IF 8.5
Mingzhu Xie,Jing Zhao,Xiaokai Feng,Xu Gao,Wenwen Cheng,Lingheng Kong,Fei Liang
Conventional chemotherapy is challenged by its inherent limitations. As an emerging drug delivery system, nanoparticles are easily eliminated by the immune system due to their exogenous nature. Moreover, the lack of long-circulation and tumor-targeting greatly limits their application. In our research, to address this problem, the biomimetic nanocarriers combine cell membranes, targeting ligand and nanoparticles into one system. Firstly, an active ester monomer and three terpolymers PMAN containing different proportions of phosphorylcholine, sulfonic acid and active ester group were successfully synthesized. Subsequently, aminated-folate was synthesized and grafted onto the terpolymers to prepare the folate-targeted polymers FA-PMAN. Finally, cell membrane biomimetic and folate-targeted chitosan nanoparticles (FA-PMAN/CS) with average particle size of 100 to 200 nm were prepared through electrostatic interactions. The in vivo blood circulation results showed that the long-circulating properties of PMAN/CS nanoparticles were significantly enhanced, compared with TPP/CS nanoparticle as a control. The half-life extended from 2.71 h to 12.95 h, with five-fold increase. Additionally, the uptake efficiency of FA-PMAN/CS nanoparticles by rat breast cancer cells (MADB-106) was 5–6 times greater than that of nanoparticles without folate. The biological distribution in mice demonstrated that the signal intensity in tumors treated with FA-PMAN/CS nanoparticle was substantially higher than in other organs, indicating that folate on the surface of nanoparticles increased the uptake into cancer cells. This work aims to design more efficient nanocarriers through biomimetic simulation of cell membranes, reduce recognition and clearance by the immune system, prolong blood circulation time and achieve tumor-targeted drug delivery. It is expected to significantly improve efficacy and provide an innovative strategy for clinical treatment.
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