PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
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2026
·
IF 3.5
Chen Yuan,Chen Yuzhu,Li Yiduo,Wang Luyue,Ma Jie
A multifunctional fluorescence sensor is an important analytical method for detecting water quality. Herein, PCBH-FS, a fluorescence sensor, is first constructed by dispersing a new compound PCBH in THF-H 2 O (fw 60%, v/v). PCBH-FS exhibits a distinct red-shifted emission from 405 to 475 nm and a “turn-on” fluorescence response to Fe 3+ and Al 3+ in the pH range of 5–9, and PCBH-FS exhibits a good fluorescence response to H + in the pH range from 1 to 5. The Al 3+ -PCBH system can be used for F − detection, while the Al 3+ -PCBH and Fe 3+ -PCBH systems can be used for sequential AcO − detection in THF/H 2 O mixed media. The binding ratio and the possible sensing mechanism between cations and PCBH molecules are discussed clearly. The LOD of the PCBH-FS reaches 0.44 µM, 0.36 µM, 2.02 µM, and 1.45 µM for detecting Fe 3+ , Al 3+ , F − , and AcO − in turn. The sensor provides a simple “on-off” & fluorescent-shift co-detection strategy for sequential detection of multiple ions in aqueous solutions.
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Nature Communications
·
2026
·
IF 18.1
Ji Guanrui,Zhang Zhen,Li Juan,Liu Xiaolei,Wang Zeyan,Mao Liang,Chen Xincheng,Wei Wei,Li Baojun,Lou Zaizhu
As a vital industrial feedstock, carbon monoxide (CO) is widely employed in pharmaceutical, electronic and fine chemical synthesis, yet its efficient production in high purity remains challenging. Here we report a solar-driven route to high-purity CO from formic acid using a nonmetallic plasmonic photocatalyst based on aluminum-doped tungsten oxide (Al-W 18 O 49 ). Plasmon-derived hot electrons drive the cleavage of C-H in adsorbed formic acid, while a concomitant photothermal effect markedly accelerates the overall kinetics. This synergistic mechanism lowers the apparent activation energy of HCOOH dehydration to 10.5 kJ mol −1 , substantially below its thermocatalytic barrier of 80.6 kJ mol −1 , and enables a CO production rate of 1.88 mol g −1 h −1 under 1 W cm −2 irradiation. A continuous-flow reactor operated stably for 350 hours, delivering CO at a maximum rate of 2000 L m −2 h −1 under concentrated sunlight. This work develops a practical photocatalytic system for the sustainable production of high-purity CO.
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Food Bioscience
·
2026
·
IF 6.2
Jiawen Lu,Ying Yang,Xingtao Zhou,Qiang Yu,Jianhua Xie,Yi Chen
Acrylamide (AA) and 5-hydroxymethylfurfural (HMF) are common food processing hazards frequently co-existing in thermally processed foods. Although both hazards have been reported to induce oxidative stress and cytotoxicity, their co-exposure effects on intestinal epithelial cells remain unclear. Here, we investigated the co-exposure effects and mechanisms of AA and HMF in intestinal epithelial IEC-6 cells. Co-exposure significantly reduced cell viability, disrupted redox homeostasis, and impaired mitochondrial function, as evidenced by glutathione depletion, increased lipid peroxidation, and mitochondrial membrane potential loss. Multiple lines of evidence supported the involvement of ferroptosis, including glutathione peroxidase 4 (GPX4) downregulation, intracellular iron accumulation, lipid reactive oxygen species (ROS) generation, and the protective effect of ferrostatin-1. Transcriptomic analysis further provided supportive evidence for ferroptosis-related pathways, which was further supported by decreased SLC7A11 expression. In parallel, alterations in autophagy-related markers and lysosomal function were observed, and chloroquine partially attenuated cellular injury, suggesting that impaired autophagic degradation may contribute to the cellular response to AA and HMF exposure. In addition, co-exposure induced nuclear accumulation of Nrf2 together with increased HO-1 expression, indicating activation of an adaptive antioxidant response to oxidative stress. Collectively, AA and HMF co-exposure induced intestinal epithelial injury associated with ferroptosis, accompanied by autophagy-lysosome dysfunction and activation of the Nrf2/HO-1 signaling. These findings improve our understanding of the cellular mechanisms underlying AA and HMF co-exposure in intestinal epithelial cells.
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JOURNAL OF ALLOYS AND COMPOUNDS
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2025
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IF 6.3
Xia Wei,Pengcheng Huan,Xiaming Chen,Guang Ji,Song Li
The interfacial electron interactions in heterogeneous catalysts are critical determinants of their catalytic efficiency. In this study, a Ni-Co alloy coating with a precisely controlled Ni/Co of 6:4 was synthesized on nickel foam (denoted as Ni-Co-6–4/NF) using NaH 2 PO 2 as a reducing agent. The resulting surface exhibited negligible phosphorus incorporation. The Ni-Co-6–4 coating featured a unique crystalline-amorphous interfacial structure. As expected, Ni-Co-6–4/NF demonstrated outstanding catalytic activity toward hydrazine oxidation, achieving a current density of 169.1 mA·cm −2 at 0.3 V versus the reversible hydrogen electrode (RHE) without i R compensation. Moreover, it maintained 100 % of its catalytic performance over 24 h of continuous electrolysis, placing it among the most durable non-noble Ni-based electrocatalysts reported for hydrazine oxidation. Density functional theory (DFT) calculations revealed that this improved performance stems from electron redistribution at the crystalline-amorphous interface, which enhances N 2 H 4 adsorption. These findings highlight the effectiveness of crystalline-amorphous interface engineering as a powerful strategy for the rational design and optimization of high-performance electrocatalysts.
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CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Ziting Liu,Heting Chen,Panpan Qiao,Qin Mi,Qinyi Liu,Juan Zhang
The acidogenic capacity of oral cariogenic bacteria is closely related with the occurrence and development of dental caries. In this work, a novel strategy is innovatively proposed to evaluate the acidogenic capacity of cariogenic bacteria in virtue of coaggregation recognition between bacteria to accelerate acid production. Taking Streptococcus mutans as an example of oral bacteria, it has been found to co-aggregate with Bacillus camelliae 7578-1 T , a fermentation bacterium from Pu’er tea. Based on co-aggregation interaction, a metabolic substrate of S. mutans , 7578-1 T @PDBA@Mal, is prepared to load maltose (Mal) onto 7578-1 T with 1, 4-phenylenediboronic acid (PDBA) as a linker and it exhibits an initial rate of acid production that is 3.26 times higher, in comparison with that of the free Mal with the same amount. By using 7578-1 T @PDBA@Mal as metabolic substrate, the method has been established to evaluate acidogenic capacity of S. mutans with a linear range from 10 2 to 10 8 CFU/mL and a detection limit of 656 CFU/mL. The established method gives an area under the ROC curve of 0.99 by analyzing clinical saliva samples treated through centrifugation and resuspension. At the same time, Bland-Altman analysis also demonstrates high consistency with qPCR results. Moreover, the established method significantly reduces equipment dependency and saves detection time. With the ingenious usage of bacterial co-aggregation recognition to construct metabolic substrates, this strategy demonstrates a cost-effective, rapid, and simple approach that holds significant potential for precise risk assessment of dental caries.
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Advanced Healthcare Materials
·
2025
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IF 9.6
Weijian Zhao,Siyu Sun,Xuesong He,Yiran Liu,Jing Meng,Qin Hu,Wang Sheng,Runqing Jia
Nanovaccines represent a promising strategy for colon cancer immunotherapy, with the potential to elicit potent, tumor-specific immune responses. However, the efficacy of these vaccines is often compromised by the presence of cancer stem cells (CSCs) in the tumor microenvironment (TME). Nanoliposome (NLP) is a widely used delivery system in nucleic acid and drug delivery research. In this study, we enriched MC38-derived CSCs (MCSCs) and developed a manganese-CpG-nanoliposome (Mn@CpG@NLP) nanocomplex using MC38 colon carcinoma tumor lysates as antigens to induce immune responses against MCSCs-derived tumors. Manganese NLPs (Mn@NLP) are initially engineered by incorporating manganese ions to enhance their positive surface charge, thereby optimizing their interaction with cellular membranes and activating the STING signaling pathway to promote bone marrow-derived dendritic cells (BMDCs) maturation. Subsequently, these liposomes are co-assembled with the CpG oligonucleotides (CpG ODNs) 1826 adjuvant, a Toll-like receptor 9 agonist, through electrostatic interactions to form the Mn@CpG@NLP nano-adjuvant complex. The Mn@CpG@NLP complex is efficiently taken up by dendritic cells (DCs), leading to their maturation and activation. This nanocomplex also effectively stimulated cytotoxic T lymphocytes and promoted the secretion of cytokines. In vivo treatment with Mn@CpG@NLP significantly inhibited tumor growth and prolonged survival in a mouse model. This study highlights the potential of nano-adjuvant platforms in immunotherapy targeting cancers driven by colon CSCs.
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PubMed
高影响因子
npj Science of Food
·
2025
·Vol. 9
·期 1
·1-8
·
IF 7.8
Luo Yingting,Li Yuxin,Song Xuening,Wang Yuzhuo,Liu Simiao,Ren Fazheng,Zhang Hao
Coenzyme Q10 (CoQ10) plays a vital role in aerobic respiration and cardiovascular diseases; however, its application is limited owing to poor water solubility. In this study, equimolar CoQ10 and stevioside (STE) formed a co-amorphous (CM) system by lyophilization, and its solubility was approximately 63 times higher than that of CoQ10. Through crystal, thermodynamic, and morphological characterization of the formula, the formation of the CM system was confirmed. The intermolecular interactions were investigated by spectroscopies. The relationship of 8 intermolecular interaction sites between the two was confirmed via molecular dynamics simulation, firmly indicating the strong intermolecular forces. Further, CM products remained stable even under accelerated storage conditions, equivalent to 1 year at room temperature. Meanwhile, the area under curve (AUC) values increased by 5 times in the in vivo bioavailability study. In conclusion, the CoQ10 was transformed into an amorphous structure by initially employing STE through intermolecular interactions to enhance solubility.
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JOURNAL OF FLUORESCENCE
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2026
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IF 3.4
Su Qian,Huang Li,Zhang Youjin,Yang Zhiyong
Carbon dots (CDs) have been broadly employed in many fields due to their excellent fluorescence property, especially in pharmaceutical analysis. Herein, we developed a simple and rapid method to prepare the phosphorus-nitrogen (P, N) co-doped carbon dots via a 3-minute 50-second microwave-assisted synthesis, using N-butyldiethanolamine as the carbon source with phosphoric acid accelerating the CDs formation reaction. The prepared CDs (termed CD1) were characterized by TEM, FT-IR, XPS, XRD and fluorescence spectroscopy. P, N co-doped CDs exhibited notable water solubility, a quantum yield of 19.7% and good photobleaching resistance. Taking advantage of their superior fluorescence, these CDs served as a bright-blue probe for tigecycline detection through fluorescence quenching. The sensor displayed excellent selectivity and anti-interference ability against common coexisting drugs (e.g., voriconazole, ceftazidime, amikacin). Under optimized conditions, a wide linear range (1-936 µM) between F 0 / F and Tigecycline concentration was established, with a correlation coefficient (R) of 0.984, and the detection limit (LOD) was calculated to be 1.10 µM. Furthermore, we clarified the fluorescence quenching mechanism of CD1 toward tigecycline, which was attributed to the internal filtration effect (IFE). Thus, this work demonstrated a novel P, N co-doped CD-based sensing strategy for rapid tigecycline monitoring.
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Nano-Micro Letters
·
2026
·Vol. 18
·期 1
·227
·
IF 36.3
Li Na,Cheng Weiren,Liu Yuying,Liu Ruiqi,Feng Sihua,Wang Huijuan,Lv Liyang,Liu Chenglong,Ma Jin,Wang Chao,Yan Wensheng
Monodisperse and substitute Co were doped into edge-sharing [IrO 6 ] octahedra of Ca 2 IrO 4 model catalyst, which usually present the intrinsic and strong stability for acid oxygen evolution reaction (OER)
The optimized Janus Co–Ir local structure triggers spin balance effect with optimal e g 1 orbital and uneven t 2g orbital despite the large crystal field of Ir, which co-promote the OER activity with a relatively stable crystal structure.
Different from the slowly kinetics of adsorbates evolution mechanism on Ca 2 IrO 4 , superoxide path mechanism occurs on Co doped Ca 2 IrO 4 based on the assignment of *OO on dual active sites of Ir and Co.
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2026
·
IF 3.9
Bingjie Sun,Pengjun Duan,Yuxin Yu,Jiajun Xie,Xiaozheng Han,Qiaomei Sun,Jianzhong Zheng,Zhaoxiang Zhong
Developing catalysts with superior electron transfer capabilities has emerged as a key challenge in the activation of peroxymonosulfate (PMS). Herein, the morphology and electronic structure of CeO2 catalysts were modulated through Co doping, thereby generating a higher concentration of oxygen vacancies (Ovs) and providing additional active sites for PMS activation. At a Co doping level of 25%, the two-dimensional (2D) nanosheet-structured CeO2 achieved 93.6% degradation of Tetracycline hydrochloride (TC) within 60 min, with a rate constant (k) of 0.042 min–1. Quenching experiments and electron spin resonance (ESR) analyses elucidated the involvement of both radical and nonradical pathways in the TC degradation process. Density functional theory (DFT) calculations demonstrated that Co-doped CeO2 with Ovs not only reduced the energy barrier for PMS activation but also enhanced the generation of reactive radicals. This study offers novel insights and technical support for the treatment of wastewater contaminated with recalcitrant organic pollutants.
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Journal of Energy Storage
·
2026
·
IF 9.8
Ting Liu,Menghui Yin,Beibei Li,Salifu Nasir,Qiang Chen
The accelerating demand for sustainable, high-rate, and durable energy storage underscores the need for carbon electrodes that simultaneously offer balanced micro–mesoporosity for rapid ion transport and robust heteroatom functionalities for enhanced interfacial chemistry. In the present work, we convert bitumen asphaltenes and recycled cellulose acetate into N/S co-doped hierarchical carbons via ammonium persulfate-assisted co‑carbonization and KOH activation. The optimized carbon combines an ultrahigh specific surface area of 3527 m 2 g −1 , balanced micro–mesoporosity, and uniformly distributed electroactive N/S species (pyridinic/pyrrolic N, C S, SO x ), enhancing conductivity and pseudocapacitance. In three-electrode tests, the electrode delivered 382.5 F g −1 at 0.5 A g −1 with 74% retention at 10 A g −1 . The symmetric aqueous device achieved a specific capacitance of 288.2 F g −1 at 0.5 A g −1 , energy densities of 10.01 Wh kg −1 at 257.4 W kg −1 and 5.42 Wh kg −1 at 6728.3 W kg −1 , and 108.7% capacitance retention after 10,000 cycles at 5 A g −1 . This study advances sustainable energy storage by enabling low-cost, high-performance supercapacitors and promoting solid-waste recycling.
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Materials Today Bio
·
2026
·
IF 10.2
Zhiyang Huang,Xiong Cai,Yibo Ying,Jiamen Shen,Zhenwen Xie,Jiali Lv,Yuchao Zhang,Yujun Mo,Hongli Lv,Lihua Luo,Xiaojun Cai,Sipin Zhu,Ping Wu,Zhouguang Wang
Spinal cord injury (SCI) initiates a cascade of pathological events in which neuroinflammation and hypoxia critically impair functional recovery. Although exogenous carbon monoxide (CO) exhibits anti-inflammatory potential, its translation has been hindered by the lack of a safe and effective delivery strategy. Here, we report the development of a multifunctional therapeutic platform (COPH), composed of CO-releasing molecules-401 (CORM-401) as the CO donor, peptide dendrimer nanogels (PDNs) as the carrier, and hyaluronic acid (HA) as a microglia-targeting ligand. COPH selectively accumulates in microglia, where it responds to elevated reactive oxygen species (ROS) by releasing CO and simultaneously scavenging excessive ROS. In vitro and in vivo studies demonstrate that COPH suppresses pro-inflammatory mediators such as IL-1β and CD86 via inhibition of the NF-κB/p65 pathway, while promoting M1-to-M2 microglial polarization. Moreover, CO released from COPH alleviates local hypoxia by modulating hemoglobin-oxygen binding dynamics, thereby enhancing oxygen availability to neurons and vascular cells in ischemic regions. Through activation of the Nrf2/HO-1 antioxidant pathway, COPH further mitigates oxidative stress and reduces neuronal apoptosis. Collectively, these findings highlight COPH as a targeted CO delivery system that attenuates inflammation, relieves hypoxia, and protects neurons after SCI, providing a promising strategy for CO-based therapeutics in neurotrauma.
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