INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2019
·
IF 4.784
Xuemin Shen,Zhenfeng Liu,Junhui Li,Dongmei Wu,Meng Zhu,Lufeng Yan,Guizhu Mao,Xingqian Ye,Robert J. Linhardt,Shiguo Chen
Low molecular weight heparins (LMWHs) are currently used as an anticoagulant agent since unfractionated heparin (UFH) can cause serious adverse drug reactions. LMWHs are commercially prepared using different methods such as nitrous acid cleavage and β-elimination under strong reaction conditions or with harsh chemicals, which may cause the saccharide units within the polysaccharide backbone to be decomposed and noticeably modified. This study demonstrates an effective method for depolymerizing heparin via the production of large amounts of free radicals from H 2 O 2 /ascorbic acid and ultrasonic power; this results in highly pure products because ascorbic acid can decompose during the reaction, which is different from the previously reported H 2 O 2 /Cu 2+ method. The reaction conditions—including concentration of ascorbic acid, reaction temperature and intensity of ultrasonic power—were investigated and optimized. We found that the degradation behavior of heparin in this combined physicochemical process conformed to first-order reaction kinetics . The chemical composition and structures of different LMWHs were analyzed. The results showed the primary structure and sulfate esters were well preserved after the depolymerization , the major repeat units are (1–4)-linked glucosamine and iduronic acid . The further in vitro assays indicated that the LMWHs produced by H 2 O 2 /ascorbic acid with ultrasonic power have an anti-metastatic effect in A549 cells, which suggested the LMWHs rapidly prepared in this physicochemical way have a potential for anti-tumor metastatic function.
研究领域:
药理学
·
生物化学
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2022
·Vol. 33
·期 29
·23187-23195
·
IF 2.779
Yi Junhui,Li Minghao,Xie Runkun,Liao Xiaoying,You Jinfeng,Chen Beifang,Liu Qiqi,Huang Weili
CuBi 2 O 4 is widely used in photocatalytic degradation for pollutants in water due to its strong visible light response characteristics, excellent chemical stability, non-toxic, and low cost. Here, stone-shaped CuBi 2 O 4 was prepared with CuO and Bi 2 O 3 as raw materials by high temperature solid phase. The effect of calcined temperature and time on the product was discussed. This material was analyzed and discussed by XRD, SEM, XPS, and DRS, and the visible light activity of degradation for Orange II was explored. The results showed that the absorption edge of prepared CuBi 2 O 4 expands to the visible region, and the band gap was about 1.77 eV. The photocatalytic degradation rate of Orange II was 42.6% under the optimal conditions. After H 2 O 2 assisted, the degradation rate was more than 2 times, and repeated experiments verified that the prepared catalysts had high stability. Finally, a reasonable mechanism of H 2 O 2 assisted degradation enhancement is proposed. This work gives new ideas for the preparation of new and efficient catalytic materials.
研究领域:
材料科学
·
环境科学
✓ 已验证
DOI
高影响因子
RSC Advances
·
2015
·Vol. 5
·期 44
·35338-35345
·
IF 3.84
Junwei Ding,Wei Sun,Gang Wei,Zhiqiang Su
We report here a facile one-step green synthesis of cuprous oxide microspheres (Cu2OMS) on reduced graphene oxide (RGO) by reducing Cu2+ ions and GO with sodium ascorbate synchronously in the presence of sodium hydroxide. Cu2OMS with different sizes on the surface of RGO were successfully synthesized by adjusting the mass ratio of GO to CuSO4·5H2O in this reaction system. It was found that uniform Cu2OMS were formed on RGO by increasing the mass ratio from 1 : 20 to 1 : 80. The synthesized Cu2OMS–RGO composites with different structures were immobilized onto glassy carbon electrodes and applied to construct electrochemical hydrogen peroxide (H2O2) and glucose sensors. The results indicate that the Cu2OMS–RGO composite created with the mass ratio of 1 : 80 presents the best sensor performances. The fabricated H2O2 sensor exhibits a fast amperometric response to H2O2 with a linear detection range from 0.005 to 2.775 mM and a detection limit of 0.0108 mM, and the glucose sensor has a linear detection range from 0.001 to 0.419 mM and a detection limit of 7.288 × 10−4 mM. The superior performance is ascribed to the unique structure of the synthesized Cu2OMS and the excellent conductivity of the RGO content. In addition, the synthesized Cu2OMS–RGO composites exhibited improved electrochemical stability. Such novel Cu2OMS–RGO hybrid materials represent promising non-enzymatic electrochemical glucose and H2O2 sensors with high sensitivity and selectivity, improved stability, and fast amperometric response.
研究领域:
材料科学
·
分析化学
✓ 已验证
DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2018
·
IF 3.927
Yalei Ding,Jiejie Wang,Shanshan Xu,Kun-Yi Andrew Lin,Shaoping Tong
In order to completely mineralization of contaminants, it is necessary to develop new methods which can effectively degrade final products of chemical oxidation. Acetic acid (HAc) has been considered one of the typical end products of chemical oxidation of pollutants and thus chosen as a representative target pollutant in the study. Nano-cerium oxide (CeO 2 ), an environment-friendly rare-earth material, was prepared to catalytic ozonation of HAc in acidic solutions. Experimental results show that the prepared CeO 2 could greatly enhance efficiency of H 2 O 2 /O 3 , and also have good stability and recyclability. The Raman spectra indicate that H 2 O 2 interacts with oxygen vacancies of CeO 2 to form peroxide-like species, which could effectively initiate the decomposition of ozone to produce hydroxyl radicals. A mechanism is proposed to explain the activity of peroxide-like species for the decomposition of ozone. The effects of different parameters such as initial pH value, catalyst dosage, and the concentration of H 2 O 2 are also investigated. The results indicate that the CeO 2 /H 2 O 2 /O 3 may provide a convenient and effective method for degrading refractory organic pollutants in acidic wastewaters.
研究领域:
环境科学
·
催化化学
✓ 已验证
DOI
高影响因子
Journal of Energy Chemistry
·
2022
·
IF 13.599
Yang Ding,Soumyajit Maitra,Chunhua Wang,Runtian Zheng,Meiyu Zhang,Tarek Barakat,Subhasis Roy,Jing Liu,Yu Li,Tawfique Hasan,Bao-Lian Su
Graphitic carbon nitride (g-C 3 N 4 ) has attracted great interest in photocatalysis and photoelectrocatalysis. However, their poor hydrophilicity poses a great challenge for their applications in aqueous environment . Here, we demonstrate synthesis of a hydrophilic bi-functional hierarchical architecture by the assembly of B-doped g-C 3 N 4 nanoplatelets . Such hierarchical B-doped g-C 3 N 4 material enables full utilization of their highly enhanced visible light absorption and photogenerated carrier separation in aqueous medium , leading to an excellent photocatalytic H 2 O 2 production rate of 4240.3 μM g −1 h −1 , 2.84, 2.64 and 2.13 times higher than that of the bulk g-C 3 N 4 , g-C 3 N 4 nanoplatelets and bulk B doped g-C 3 N 4 , respectively. Photoanodes based on these hierarchical architectures can generate an unprecedented photocurrent density of 1.72 mA cm −2 at 1.23 V under AM 1.5 G illumination for photoelectrochemical water splitting. This work makes a fundamental improvement towards large-scale exploitation of highly active, hydrophilic and stable metal-free g-C 3 N 4 photocatalysts for various practical applications.
研究领域:
材料科学
·
环境科学
✓ 已验证
DOI
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2019
·
IF 4.175
Wenning Yang,Jia Li,Jie Yang,Yong Liu,Zhipeng Xu,Xiaofan Sun,Fudong Wang,Dickon H.L. Ng
Biomass-derived hierarchically porous CoFe-LDH (layered double hydroxides)/CeO 2 hybrid possessing an inherent peroxidase-like activity was first fabricated employing kapok as bio-template. The CeO 2 fibers not only exhibited peroxidase-like activity, but also served as a support and guided the deposition of CoFe-LDH nanosheets on their surface to form a hierarchically porous network. The resultant CoFe-LDH/CeO 2 hybrid acted as a peroxidase mimic to catalyze 3,3′,5,5′- tetramethylbenzidine (TMB) with H 2 O 2 to generate a typical blue colored product. Furthermore, CoFe-LDH/CeO 2 hybrid displayed superior peroxidase-like catalytic property compared to the pristineCeO 2 and CoFe-LDH, which was attributed to the presence of more effective active sites of unique hierarchical-porous architecture and the synergistic effect between CoFe-LDH and CeO 2 . A facile and sensitive sensing system for H 2 O 2 and glucose determination was successfully proposed, which exhibited a sensitive response to glucose ranging from 0.05–2 mM with a detection limit of 0.015 mM based on the accelerated electron transfer between TMB and H 2 O 2 with the assistance of CoFe-LDH/CeO 2 . This paper offered a feasible way or the fabrication of materials with hierarchical structure and provided a new insight into seeking novel peroxidase mimics with boosted catalytic activities.
研究领域:
材料科学
·
分析化学
·
纳米技术
·
生物化学
✓ 已验证
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2017
·
IF 3.671
Jing-yi Zhang,Ying Guo,Jin-ping Si,Xiao-bo Sun,Gui-bo Sun,Jing-jing Liu
Dendrobium officinale is one valuable traditional Chinese medicine, which has skyscraping medicinal value. Polysaccharide is the main active ingredient in D. officinale ; its antioxidant activity is a hot research topic nowadays. Oxidative stress plays an important role in the pathological progress of a variety of cardiovascular disease, as one of key factors of cardiomyocyte apoptosis. This research adopts a model of H 2 O 2 induction-H9c2 cardiomyocytes apoptosis, aiming to study the effect of Dendrobium officinale Polysaccharide (DOP-GY) for cardiomyocyte apoptosis caused by oxidative stress and its possible mechanism. Our results showed that pretreatment of DOP-GY (low dose: 6.25 μg/mL, medium dose: 12.5 μg/mL, high dose: 25 μg/mL) followed by a 2 h incubation with 200 μM H 2 O 2 elevated the survival rate, cutted the LDH leakage, reduced lipid peroxidation damage, improved the activity of the endogenous antioxidant enzymes. In addition, the pretreatment of DOP-GY significantly inhibited the production of ROS, declined of the mitochondrial membrane potential, down-regulated pro-apoptosis protein and up-regulated anti-apoptosis protein. The protective effect was correlated with the PI3K/Akt and MAPK signal pathway. Collectively, these observations suggest that DOY-GY has the potential to exert cardioprotective effects against H 2 O 2 -induced H9c2 cardiomyocyte apoptosis.
研究领域:
药理学
·
心脏病学
·
分子生物学
✓ 已验证
DOI
PubMed
高影响因子
WATER RESEARCH
·
2025
·
IF 12.4
Yuanna Zhang,Wenjun Sun,Wenxuan Yin
The widespread application of UV/H 2 O 2 is limited by the empirical operational practices, which can lead to excessive energy, chemical input and the generation of uncontrollable by-products. This study presents a precise regulation approach based on the characteristics of free radical generation/reaction and the chemical transformation of organics, assessed through a pilot experiment. The findings indicated that increasing H 2 O 2 dosage was more effective than increasing UV dose in enhancing •OH generation and pollutant removal. As the H 2 O 2 dosage and UV dose increased, the relative influence of water quality on pollutant removal gradually diminished. Dissolved organic matter (DOM) in the water quality background accounted for the largest proportion of •OH scavenging (76.4 %) and the most complex component. Moreover, changes in operating conditions were accompanied by the uncontrollable production of low-molecular-weight (LMW) DOM. Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) revealed the chemical transformation of LMW DOM at the molecular level. Higher H₂O₂ dosages triggered more extensive oxidative degradation, resulting in more complex effluent compositions. Considering treatment efficiency, energy consumption, and effluent product composition, H₂O₂ dosages of 5–10 mg/L and UV doses of 350–450 mJ/cm² were identified as optimal. This research contributes to the efficient purification of organic micropollutants in water using UV/H 2 O 2 technology with low energy consumption, minimal chemical input, and relatively controllable by-products.
研究领域:
环境科学
·
水处理技术
·
化学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Xiaofan An,Yuhong Liu,Yunxue Sun,Xuetao Zhang,Yuhua Liu,Yuanyuan Tao,Longsuo Guo,Xiaoping Jiang,Meng Gao
The development of portable flexible sensors for sensitive gas detection with antibacterial activity is of great significance for protecting human health and environment safety. In this paper, we designed a ratiometric sensing platform (PLA@RPEG@TBSN) for reliable and visual monitoring of gaseous H 2 O 2 by electrospinning technology, which reveals self-antibacterial function and highly photostability simultaneously. By employing the aggregation-induced emission (AIE) active nanoparticles (TBSN) as fluorescent responder and Rose Bengal modified photosensitive polymer (RPEG) as reference unit, accurate ratiometric sensing process of PLA@RPEG@TBSN film was realized based on the specific peroxide-mediated reaction between TBSN and H 2 O 2 . The flexible film system demonstrated superior sensing performance toward H 2 O 2 vapor, including excellent selectivity, visualized color change and low detection limit (7 ppb). Additionally, benefitting from the photodynamic activity of RPEG , the PLA@RPEG@TBSN film exhibited highly effective antibacterial performance (killing 84 % of bacteria). Moreover, the multifunctional wearable potential is supported by employing film sensor onto the protective mask, which reveals dual capabilities of ratio sensing and resistance bacteria aerosols, encouraging the application of the sensor in complex practical scenario.
研究领域:
生物医学工程
·
材料科学
·
分析化学
✓ 已验证
产品关联
DOI
高影响因子
Inorganic Chemistry Frontiers
·
2024
·
IF 6.1
Suhua Mao,Xin Li,Bingshuang Li,Jin Li,Xiaoxi Huang
Oxygenated groups functionalized carbon materials are promising catalysts for the electrochemical production of hydrogen peroxide (H2O2) via two-electron oxygen reduction reaction (ORR). Electrochemical activation of carbon materials to introduce oxygenated groups has exhibited attractive features compared with chemical oxidation method. However, the knowledge is limited as to how electrochemical treatment influences the resulting ORR performance. Herein, we describe the synthesis of carbon electrodes modified with oxygenated groups at both anodic and cathodic sides by using potential cycling in neutral Na2SO4 solution. Composition analysis based on XPS and electrochemical FTIR indicates the successful modification of oxygenated groups. The production rate of H2O2 is significantly enhanced after potential cycling. The oxidized carbon electrode can catalyze ORR at an industrial-current-density to produce H2O2 with selectivity close to 100% in a flow cell. Density functional theory (DFT) calculations demonstrate that the binding energy of *OOH is promoted after modification of oxygenated groups. These findings highlight the advantages of the electrochemical method on carbon surface functionalization and provide some guidelines for catalyst design.
研究领域:
材料科学
·
电化学
·
催化科学
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Shuang Zhao,Najun Li,Qingfeng Xu,Hua Li,Jianmei Lu,Dongyun Chen
Pyrene units are grafted on a D-A polymer by amidation to construct a D + -A structure and improve H 2 O 2 production. Experimental results show that the H 2 O 2 generation rate of this D + -A polymer (PTM-PY) is 2.94 mmol g −1 h −1 , which is higher than the original D-A polymer (PTM) under the same conditions. Mechanistic studies reveal that the increased photocatalytic performance of PTM-PY is attributed to the enhanced light-harvesting capacity and electron push-pull interactions after grafting pyrene as a donor. Therefore, grafting the appropriate small organic molecules on the D-A polymer skeleton can improve their performance further, in addition to the routine methods of optimizing the donor/acceptor ratio and reaction conditions. This is the first report of small organic molecules grafted on a D-A polymer to construct a D + -A polymer for photocatalytic H 2 O 2 generation.
研究领域:
材料科学
·
环境科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2024
·Vol. 48
·期 26
·11776-11782
·
IF 2.7
Yuwei Yan,Hongyan Li,Songnan Li,Jiawei Zhang,Jingxiang Zhao,Qinghai Cai
Copper, iron–chloride ionic liquids (ILs) were immobilized on SBA-15 via N-methylimidazole grafting with C–Cl in chloropropylsilane pre-anchored on SBA-15, followed by FeCl3 and CuCl2 coordination to imidazolium chloride to generate a double metal IL-supported mesoporous composite (SIL-CuFe). The prepared composite exhibited an effective catalytic performance for the solvent-free oxidation of styrene to benzaldehdye (BzH) with H2O2 oxidant, offering 51% conversion, a turnover number (TON) of 330.5 mol molFe+Cu−1, and a selectivity of 71% at a reaction temperature of 70 °C. The composite catalyst can be easily recovered and effectively reused without a significant loss in activity and selectivity. The quenching experiments by adding tert-butanol (TBA), 1,4-benzoquinone (p-BQ) and L-histidine (L-HIS) in the reaction system were conducted to identify the type of reactive O species, specifically ˙OH, ˙O2−, and 1O2, produced by catalyst activation with H2O2 and played a main role in the oxidation. The reaction mechanism of the oxidation process is also proposed.
研究领域:
化学工程
·
催化材料
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）