Food & Function
·
2022
·Vol. 13
·期 13
·7062-7074
·
IF 6.317
Fengwei Ma,Qingfang Deng,Huayong Lou,Jinyu Li,Su Xu,Wenneng Wu,Qihua Wen,Lei Tang,Xin Wang,Weidong Pan
Self-heal (Prunella vulgaris L.) is a perennial edible plant that is widely distributed across the world and is traditionally consumed as a food additive in soft drink beverages. In this study, to explore the functional components of P. vulgaris, an investigation of its ethanol extracts has been conducted by our group. As a result, twelve (1–12) vulgarisin-type diterpenoids with a special 5/6/4/5-fused ring skeleton, including six new ones (1–6), were obtained. Their structures including the absolute configuration were elucidated based on comprehensive spectroscopic evidence, ECD calculations, as well as single-crystal X-ray diffraction analyses. All the isolates were tested for neuroprotective effects against ischemia/reperfusion (I/R) on primary neuron cells through the oxygen and glucose deprivation and reperfusion (OGD/R) induced injury model. The results showed that all twelve vulgarisin-type diterpenoids possess promising neuroprotective activity at a concentration of 10 μM. Among them, compound 3 can significantly suppress cell apoptosis by regulating Bax/Bcl-2 protein expression and inhibiting cleaved caspase-3 and caspase-9 expression with a western blotting assay. Further research revealed that compound 3 could improve mitochondrial function by inhibiting mitochondrial cytochrome c release, reducing ROS levels, and maintaining the membrane potential. This work firstly reports vulgarisin-type diterpenoids possessing neuroprotective activity. These findings also suggest that daily consumption of P. vulgaris might prevent cerebral disorders via a mitochondria-related pathway.
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INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
·
2023
·Vol. 58
·期 12
·6386-6398
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IF 3.3
Zi-wei Liu,Jun-ru Qi,Ya-ting Song,Cheng-wei Ruan,Jin-song Liao
Summary The properties of pectin extracted by enzyme-assisted nitric acid (EAE-N) and pectin extracted by enzyme-assisted oxalic acid (EAE-O) were analysed and compared with pectin extracted by nitric acid (AE-N) and pectin extracted by oxalic acid (AE-O) systematically. The yield of pectin obtained by the enzyme-assisted acid method (23.73% ~ 25.60%) was significantly higher than that by acid extraction method (19.75% ~ 20.60%). Monosaccharide analyses demonstrated that the enzyme-assisted acid method was able to attain more branched rhamnogalacturonan I (RG-I) regions (36.59% ~ 42.06%) than using acid solely (31.01% ~ 34.58%). Fourier transform infrared spectroscopy (FT–IR) and nuclear magnetic resonance ( 1 H NMR) analyses indicated that there was no obvious difference in the characteristic structure of pectin. The atomic force microscopy (AFM) images revealed that EAE-N and EAE-O had more short side chains and cross-link compared with AE-N and AE-O. Thermogravimetric analysis (TGA) shows that EAE-N and EAE-O have good thermal stability. All pectin samples showed a shear-thinning fluid flow behaviour and an elastic gel-like behaviour. The results suggested that enzyme-assisted acid provided a viable alternative method for the extraction of pectin.
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Advanced Optical Materials
·
2021
·Vol. 9
·期 11
·2100012
·
IF 9.926
Yao Tong,Qin Wang,Enrou Mei,Xiaojuan Liang,Wei Gao,Weidong Xiang
All-inorganic perovskite (CsPbX 3 , X = Cl, Br, I) nanocrystals (NCs) with promising optical properties are recognized as a rising star among photoelectric materials, but their inevitable instabilities limit extensive application. Herein, a new one-step strategy for encapsulating CsPbX 3 NCs with porous zeolite via the hot injection method is explored. By altering the mole ratio of PbX 2 , the emission wavelength of CsPbX 3 @zeolite is found to be regularly modulated from blue-emission (CsPbCl 2 Br@zeolite, 436 nm) to red-emission (CsPbBrI 2 @zeolite, 648 nm), thus enabling full spectrum adjustment. Due to the surface passivation of zeolite to CsPbX 3 NCs, CsPbX 3 @zeolite possess an outstanding quantum yield and display excellent thermal/photo/air stability. Subsequently, white light-emitting diodes based on green-CsPbBr 3 @zeolite and red-CsPbBrI 2 @zeolite are constructed and applied to the backlit display, achieving a wide color gamut of 134.2% for NTSC 1953 and 99.8% for Rec. 2020. The CsPbX 3 @zeolite implanted with a polymethyl methacrylate film is used to realize upconversion emission under an 800 nm laser at room temperature. Furthermore, amplified spontaneous radiation based on CsPbBr 3 @zeolite films is achieved. These results convincingly indicate broad application prospects for CsPbX 3 @zeolite prepared via this simple method.
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BIOSENSORS & BIOELECTRONICS
·
2020
·
IF 10.257
Guihua Zhang,Li Zhang,Ying Yu,Bixia Lin,Yumin Wang,Manli Guo,Yujuan Cao
Diversified determination of cardiac troponin I (cTnI) in serum is of great significance for the clinical diagnose and daily monitoring of acute myocardial infarction. Herein, an electrochemical-colorimetric dual-mode imprinted sensing strategy was proposed. Firstly, the aptamer-functionalized Fe 3+ -polydopamine ( [email protected] 3+ -PDA) was constructed as the self-sacrifice beacon. Furthermore, an epitope magnetic molecularly imprinted polymer was prepared to recognize cTnI. Once the cTnI was captured, the beacon was then bound to it through the aptamer , which formed a sandwich-like complex. Under acidic condition, the [email protected] 3+ -PDA was disintegrated to release large amount of Fe 3+ , and further converted to Prussian blue (PB). On one hand, the electrochemical response of the PB was sensitive to the cTnI amount. On the other hand, the addition of the yellow K 3 [Fe(CN) 6 ] into different amounts of the produced PB was able to result in different colors, which enabled the visual detection of cTnI. Under the optimal condition, the sensing strategy exhibited a linear range from 1.0 × 10 −2 to 1.0 × 10 3 ng mL −1 , and the detection limits were 3.2 and 7.4 pg mL −1 for the electrochemical and colorimetric modes, respectively. Besides, It is demonstrated that the dual-mode strategy shows favorable selectivity and stability in the assays, indicating a diversified application prospect in both clinic analysis and daily care.
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2020
·
IF 5.774
Longqian Xu,Linghui Zhao,Yunfeng Mao,Zhen Zhou,Deli Wu
Copper-iron bimetallic material shows a high reactive activity in dioxygen activation processes (DOAs) but presents a significant challenge for enhancing superoxide radical ( • O 2 − ) generation. In this study, a practical strategy was developed to enhance • O 2 − generation for BPA degradation using a zeolite-supported Cu-Fe bimetallic system (called Cu/Fe@zeolite), which was simply prepared by impregnation method. The results verified that the Cu(I) regeneration at the zeolite surface contributes • O 2 − generation and the H 2 O 2 that is further generated induces • OH production via a further Fenton reaction. In the reaction process, the initial generation of • O 2 − was primarily enhanced by the Cu(I) loaded onto the zeolite surface and the adsorbed BPA was easily degraded by the •OH. Under optimal operating conditions (i.e., Cu/Fe@zeolite = 3 g/L, Cu:Fe = 1:2, pH = 5, t = 120 min), it was found that 87% of BPA can be removed from wastewater. It is also important to note that the weak alkali buffering property of zeolite not only provides BPA adsorption sites under acidic conditions but also accelerates the precipitation efficiency for metallic ions and reduced the adverse effect of metallic residue on the effluent quality.
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Journal of Materials Chemistry B
·
2020
·Vol. 8
·期 47
·10854-10866
·
IF 5.344
Cuifu Fang,Zhiwei Zhong,Teng Zhang,Shuang Jia,Xingwei Ding,Weimin Zhou,Xiaolei Wang
Problems such as massive hemorrhage caused by uncontrolled drug dosage are the main significant obstacles in clinical thrombolytic therapy, which are prominently due to the lack of targeting and controlled release ability of efficient thrombolytic drug systems. In recent years, our team demonstrated that the photothermal effect can facilitate the thrombolytic effect of urokinase plasminogen activator (uPA). However, conventional photothermal agents are relatively expensive or contain heavy metals. If drug delivery systems with low toxicity, minimized heavy metal elements and easy accessibility (preferably provided by human self) can be developed, they will be of value in the future related applications. Herein, uPA-loaded human black hair derived nanoparticles with gelatin capsules (uPA@HBHNP@GNCs) were applied for the first time as a thrombolytic system. Upon irradiation by near-infrared I window (NIR-I) laser or II window (NIR-II) laser, the photothermal effect of HBHNP was triggered to promote the melting of the gelatin encapsulated around the outer layer, thereby realizing the targeted release of uPA. The in vitro and in vivo experiments demonstrated that the deep response to NIR (especially II window) of this system exhibited a satisfactory thrombolytic effect with ideal biosafety. Briefly, the proposed hair derived drug delivery system has the characteristics of human source, low cost, minimum heavy metal components, deep response to NIR (II window) laser, and good biocompatibility, which is expected to be expanded to the treatment for some diseases, even in deep tissue areas.
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Analytical Methods
·
2020
·Vol. 12
·期 17
·2237-2243
·
IF 2.596
Yujiao Tu,Suping Wang,Xiaotian Yuan,Pengfei Song,Yunlin Wei,Kunhao Qin,Qi Zhang,Xiuling Ji
Novel fluorescent nitrogen and phosphorus-doped carbon dots (Aa N,P-CDs) derived from Auricularia auricula were successfully prepared via a simple hydrothermal method. The Aa N,P-CDs showed high selectivity and sensitivity in detection of 4-nitrophenol (4-NP) and Ag(I) and good linear ranges of 4-NP (0–37.5 μM, R2 = 0.9967) and Ag(I) (0–25 μM, R2 = 0.9934). The low detection limits were 198 nM and 74.35 nM, respectively. This showed that static quenching dominated in Ag(I) quenching of the Aa N,P-CD fluorescence, while that of 4-NP was the inner filter effect. The Aa N,P-CDs were successfully used to detect 4-NP and Ag(I) in real water and soil samples. Cell imaging indicated that Aa N,P-CDs showed low biotoxicity and good biocompatibility, which provided a new insight into bioimaging application and environmental pollutant detection.
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Nanomaterials
·
2020
·Vol. 10
·期 6
·1112
·
IF 4.324
Wenjuan Guo,Ahmad Umar,Yankai Du,Luyan Wang,Meishan Pei
Poly(2-(dimethylamino)ethyl methacrylate)-grafted bentonite, marked as Bent-PDMAEMA, was designed and prepared by a surface-initiated atom transfer radical polymerization method for the first time in this study. Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM) and thermal gravimetric analysis (TGA) were applied to characterize the structure of Bent-PDMAEMA, which resulted in the successful synthesis of Bent-PDMAEMA. As a cationic adsorbent, the designed Bent-PDMAEMA was used to remove dye Orange I from wastewater. The adsorption property of Bent-PDMAEMA for Orange I dye was investigated under different experimental conditions, such as solution pH, initial dye concentration, contact time and temperature. Under the optimum conditions, the adsorption amount of Bent-PDMAEMA for Orange I dye could reach 700 mg·g−1, indicating the potential application of Bent-PDMAEMA for anionic dyes in the treatment of wastewater. Moreover, the experimental data fitted well with the Langmuir model. The adsorption process obeyed pseudo-second-order kinetic process mechanism.Keywords:PDMAEMA;polymer brushes;Orange I;dyes removal;water treatment
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MICROCHIMICA ACTA
·
2020
·Vol. 187
·期 8
·1-13
·
IF 6.232
Min Jie,Qu Xiang-Long,Yan Bing
A novel fluorescent and electron-deficient hybrid, N -methylated [Eu (pddb)phen(ox) 0.5 ] n (Eu-MOF-Me) has been prepared via post-synthetic modification. Considering its special luminescent properties and cationic framework, Eu-MOF-Me is developed as a visualized fluorescent probe. Notably, water-stable Eu-MOF-Me exhibits advantages like good structural and fluorescent stability in a wide range of pH value (3.39–10.86), excellent identification ability for F − , I − , and S 2− (it can easily distinguish F − and I − from other halogen ions and can realize naked eye identification of F − , I − , and S 2− ), relatively low detection limits (6.61 μM for S 2− , 7.57 μM for F − ), and reusability. More importantly, it has been utilized for the construction of a Boolean logic gate system. In this system, Eu-MOF-Me serves as the gate, by taking F − , I − , and S 2− as the inputs and fluorescence emission bands (UV380, B437, and R612) as the outputs; some primary logic gates (NOR, IMP, YES, NOT) and the combination of them have been realized. Moreover, we achieved a cascaded logic gate (NOR+OR). For further application, a molecular computing keypad-lock security system has been obtained.
A novel fluorescent and electron-deficient hybrid named Eu-MOF-Me has been prepared via post-synthetic methylation. Considering its special luminescent properties and cationic framework, Eu-MOF-Me was developed as a fluorescent probe for the visual monitoring of important anions. In addition, it was used for the construction of Boolean logic library and a keypad-lock system was achieved
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CHEMICAL ENGINEERING JOURNAL
·
2021
·
IF 13.273
Yao Tong,Qin Wang,Xiaoting Liu,Enrou Mei,Xiaojuan Liang,Weidong Xiang
All-inorganic CsPbX 3 (X = Cl, Br, I) perovskite nanocrystals (PNCs) hold tremendous prospect in optoelectronics. Different from the previous method of preparing perovskite glass, the self-crystallization of CsPbX 3 (X = Cl, Br, I) PNCs glasses were successfully synthesized by introducing TiO 2 into the glass matrix without subsequent annealing and heat treatment engineering. The effective realization of self-crystallization was attributed to the nucleating agent changing the glass structure which has been confirmed by DSC, XPS, FTIR tests. As a nucleating agent, TiO 2 reduced the crystallization temperature of BSZ glasses and promoted controlled nucleation of PNCs. Surprisingly, the self-crystallized glass with high Photoluminescence quantum yield (PLQY) of 41.2% showed strong hydrothermal stability. After soaking in water for 30 days, the Pb 2+ escaped did not change significantly. The green-emitting LEDs made of BSZ-xTi achieved tunable colour coordinates of (0.1038–0.1177, 0.7376–0.7386). Furthermore, combining BSZ-2Ti with BrI 2 -2Ti on InGaN chip, the wide-color-gamut covering 93.15% of the Rec. 2020 standard was achieved. This study has an important role in guiding the synthesis of time-saving, environment-friendly and low-cost PNCs glasses, which made a contribution to deepening the understanding of the promoting effect of related nucleating agents on nucleation of PNCs.
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JOURNAL OF CHROMATOGRAPHY A
·
2019
·
IF 3.858
Fenqi Ji,Rongrong Jin,Chen Luo,Chunhui Deng,Yaoming Hu,Li Wang,Rongchang Wang,Jiabin Zhang,Guoxin Song
In this paper, a novel core–shell structure magnetic microsphere Fe 3 O 4 @SiO 2 -TPM@StVp(Fe 3 O 4 @SiO 2 -3-(trimethoxysilyl)propyl methacrylate@styrene and n -vinylpyrrolidone) was successfully synthesized and used as a magnetic solid-phase extraction adsorbent for extraction of aristolochic acid I (AAI) in traditional Chinese medicine soup. The prepared Fe 3 O 4 @SiO 2 -TPM@StVp was characterized by transmission electron microscopy (TEM), scanning electron microscopy (SEM), vibrating sample magnetometer (VSM) and Fourier-transform infrared spectroscopy (FT-IR). The microspheres have various advantages of excellent hydrophilicity and π-electron system, which is very suitable for determining target analytes followed by high performance liquid chromatography (HPLC). The main factors, including the pH of samples, amount of adsorbent, adsorption time, elution solvent and desorption time, were optimized. Under optimal conditions, the proposed method showed a wide linear range of 0.4–10 µg/mL and a good correlation coefficient ( R 2 = 0.9918). The pretreatment procedure was achieved within 10 min. The recoveries of aristolochic acid I in real samples range from 80.9% to 89.6% with relative standard deviations less than 4.9%, highlighting the accuracy of this method.
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ELECTROCHIMICA ACTA
·
2018
·
IF 5.116
Chao Wang,Liuyi Hu,Kang Zhao,Anping Deng,Jianguo Li
Herein, a novel ultrasensitive competition-type electrochemiluminescent (ECL) immunosensor for detecting Sudan I was constructed using palladium/aurum core-shell nanocrystallines (Pd/Au CSNs) and CdSe@CdS QDs as signal bioprobe. The Pd/Au CSNs as outstanding nanocarrier equipped with superior performance like highly catalytic activity, good biocompatibility and large specific surface area, which enhanced ECL intensity significantly. The surface of electrode was coated with gold nanorods functionalized graphene oxide (GNRs/GO) nanocomposite film as the substrate, which provided an effective matrix to immobilize more coating antigen but also facilitated the electronic transmission to increase the ECL signal. The proposed immunoassay based on the synergistic effect of Pd/Au CSNs and GNRs/GO for determining Sudan I exhibited good stability, high sensitivity and wide linearity with a lower detection limit of 0.3 pg mL −1 (S/N = 3) and the wide range from 0.001 to 500 ng mL −1 . Furthermore, the developed immunosensor was successfully applied in determination of real samples with acceptable accuracy, and initiated a new route for detecting other small molecule in the future.
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