ADVANCED FUNCTIONAL MATERIALS
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2026
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IF 19.9
Liping Bai,Xinyue Wu,Xiaorong Kou,Miaomiao Zhang,Xinchao Li,Ning Wang,Xue Wu,Qinjie Wu,Changyang Gong
The cGAS-STING pathway is an essential element of antitumor immunity. However, its activation triggers immunosuppressive molecules like PD-L1 to feedback upregulate, which limits therapeutic efficacy. Herein, we develop a programmable tumor-activated nanoCRISPR platform (PATROL) that co-delivers CRISPR/Cas13a-CARM1 plasmid and PD-L1 blocking peptide to stimulate the cGAS-STING-IFN-I pathway and diminish its immunosuppressive feedback loop, thereby improving antitumor efficacy. PATROL achieves enhanced circulation longevity, tumor-targeting specificity, and tissue penetration due to surface modifications such as PEGylation, hyaluronic acid, and TAT peptide. At the same time, its PD-L1 blocking peptide on the surface facilitates drug accumulation with the tumor and inhibits PD-L1 activity. Following exposure to tumor-associated hyaluronidase, PATROL undergoes enzyme-triggered disassembly, surface charge reversal, rapid lysosomal escape, and significant CARM1 knockdown, leading to enhanced cGAS-STING signaling. This bifunctional approach cooperatively reprograms the immunosuppressive tumor microenvironment, increases cytotoxic T lymphocyte infiltration, and elicits powerful antitumor immunity by simultaneously blocking PD-1/PD-L1 signaling and activating the cGAS-STING-IFN-I pathway. PATROL exhibits significant antitumor efficacy in B16-F10 melanoma models, successfully inhibiting tumor growth and prolonging survival. As consequently, PATROL presents an innovative therapeutic strategy that achieves effective tumor suppression by enhancing antitumor immunity through dual-pathway activation.
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高影响因子
CHEMICAL ENGINEERING SCIENCE
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2026
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IF 5.1
Yang Liu,Jun Liu,Ming Xie,Jiang Deng,Dengsong Zhang
The design of Passive NO x Adsorbers (PNA) is essential for controlling cold-start emissions, yet Pd-ceria systems often encounter limitations in storage capacity and hydrothermal durability. In this work, we stabilize Pd by incorporating atomically dispersed Zr as neighboring atoms in ceria, establishing a framework for efficient and stable NO x capture. Zr doping in CeO 2 modifies the electronic environment by intensifying Pd-O hybridization and broadening electronic states near the Fermi level. These modifications, alongside emergent Pd-O-Zr interfacial sites, facilitate the dynamic reconfiguration of oxygen vacancies. This process promotes the oxidation of NO to NO 2 , enabling the optimized catalyst to yield a NO x storage capacity of 166.6 µmol/g cat —a value that surpasses the theoretical limit derived from Pd content. Structural stabilization further underpins these performance gains. Zr doping reinforces the CeO 2 lattice, enhancing the thermal resilience of the support. Simultaneously, the atomically dispersed Zr adjacent to Pd sites modulates metal-support interactions to an optimal state, effectively inhibiting Ostwald ripening, particle migration, and coalescence. These combined effects significantly improve hydrothermal stability under rigorous conditions. Our findings provide a mechanistic basis for the rational design of high-performance PNA and offer a viable pathway to mitigate cold-start NO x emissions in advanced after treatment systems.
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APPLIED SURFACE SCIENCE
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2026
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IF 6.6
Qiang Ren,Jiongliang Yuan,Donglin Song,Xinlu Xiong,Jianjun Wei,Xu Xiang
Pd/NiFe LDH heterointerfaces are constructed for electrooxidation of EG to GA. • Pd/NiFe LDH/NF reaches 100 mA cm −2 at 0.58 V vs. RHE for EGOR. • Pd/NiFe LDH heterointerface enhances OH – adsorption and weakens GA adsorption. The electrooxidation of ethylene glycol (EG) to glycolic acid (GA) is limited by poor OH – adsorption on Pd-based catalysts. In this work, a Pd/NiFe LDH/NF heterostructured catalyst was constructed by depositing Pd on NiFe layered double hydroxide (LDH) supported on nickel foam (NF) for efficient ethylene glycol electrooxidation (EGOR). The Pd/NiFe LDH heterointerface regulates the electronic structure of Pd sites, thereby enhancing the adsorption and activation of EG on Pd sites. And the heterointerface facilitates OH – adsorption, which promotes the conversion of C2 oxygenated intermediates toward GA. Moreover, Pd/NiFe LDH/NF shows relatively weak adsorption toward GA, which favors GA release from active sites and suppresses its further oxidation. Through this interfacial electronic modulation, Pd/NiFe LDH/NF delivers excellent EGOR performance, reaching 100 mA cm −2 at 0.58 V vs. RHE and achieving a maximum GA Faradaic efficiency of 95.7%. This work provides an interfacial design strategy for regulating EGOR over Pd-based catalysts and improving GA selectivity. Download: Download high-res image (98KB) Download: Download full-size image
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Cell Communication and Signaling
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2026
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IF 11.6
Yang Minghan,Chen Jinlin,Huang Yi,Zheng Bowen,Cheng Yunying,Chen Jianming,Chen Ming
Programmed death ligand 1 (PD-L1) antibodies have achieved significant success in cancer immunotherapy. However, their roles beyond tumor treatment are not fully understood. In this study, we developed a shark-derived variable new antigen receptor targeting PD-L1, named 3P17, and investigated its role in promoting hair growth in C57BL/6J mice. The intravenous administration of 3P17 increased the proliferation of hair matrix cells, promoted hair shaft elongation, and accelerated hair follicle entry into anagen phage. Moreover, transcriptomic analysis showed that 3P17 increased leptin expression in mouse dorsal skin. Intravenous leptin phenocopied the hair shaft-elongating effect of 3P17. In contrast, the leptin receptor antagonist Allo-aca abrogated 3P17-induced hair shaft elongation. PD-L1, leptin, and phosphorylated STAT3 were co-expressed in hair matrix cells, and both 3P17 and leptin increased STAT3 phosphorylation in mouse dorsal skin. 3P17 also increased the expression of the proliferation-associated genes cyclin D1 and c-Myc in hair follicles. These results collectively indicated that the involvement of leptin-STAT3 signaling in the hair-growth-promoting effect of 3P17. To enhance drug delivery efficiency and patient compliance, we further evaluated the transdermal delivery of leptin using hollow sponge Haliclona sp. spicules (oSHS). oSHS-mediated delivery increased the proportion of leptin penetrating the skin to 43.69 ± 3.66% of the applied dose, representing a 3.28 ± 0.26-fold increase compared with leptin alone. Consistent with this enhanced uptake, oSHS increased leptin deposition into the viable epidermis and dermis, compared with microneedling and SHS, and promoted hair shaft elongation and hair growth in a mouse model of androgenetic alopecia. We propose oSHS-mediated transdermal delivery of leptin as a promising strategy to stimulate hair growth. Graphical abstract
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高影响因子
ACS Applied Electronic Materials
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2026
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IF 4.7
Mingzhi Jiao,Liangsong Duan,Jiade Zhang,Wei Peng,Chenyu Wen
To address the demands for efficient detection of combustible gas, such as hydrogen (H2), ethylene (C2H4), and acetylene (C2H2), in complex gas environments relevant to environmental monitoring, industrial safety, and smart homes, we developed zinc oxide (ZnO) gas sensors featuring bimetallic surface decoration with palladium (Pd) and gold (Au). Electron microscopy reveals the surface morphology of the sensing film and Pd/Au codecoration conformation, while X-ray photoelectron spectroscopy supports that codecoration modulates the distribution of surface oxygen species on ZnO. Gas sensing measurements demonstrate that Pd/Au decoration enhances both sensitivity and selectivity toward H2, C2H4, and C2H2. Specifically, a sensor decorated with 0.6 nm Pd and 2.3 nm Au exhibits a 178-fold increase in response to 160 ppm H2. Furthermore, by combining particle swarm optimization algorithm for feature selection with a support vector machine classifier, a recognition accuracy of 96.07% is achieved across seven different pure and mixture gas samples. This study presents a high-accuracy ZnO-based gas sensing platform optimized through both material engineering and machine learning algorithm, providing a reliable solution for real-world applications in industrial safety and environmental monitoring.
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Carbon Energy
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2026
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IF 21.4
Liangmeng Ni,Aiyue Huang,Xin Feng,Zhijia Liu
Proton exchange membrane (PEM) electrolysis demands hydrogen evolution reaction (HER) cathodes that minimize precious-metal usage while remaining durable in strongly acidic media, yet improving Pt utilization and stability under reduced PGM loading remains challenging. Here, we develop a programmable nucleation pathway that uses in situ H* from formic acid (HCOOH) dehydrogenation at a Ru–Pd interface to gate reducing equivalents during nucleation. This enables site-confined Pt nucleation/immobilization and stabilizes a hydrogen-management interface for H* generation, relay, and recombination. The resulting Ru–Pd–Pt/C comprises uniformly dispersed ternary nanodomains (~2.46 nm). In 0.5 M H 2 SO 4 , Ru–Pd–Pt/C delivers η 10 = 12.24 mV, an apparent Tafel slope of 29.9 mV dec −1 from a unified 20–50 mV fitting window, and a PGM mass activity of 6.58 A mg PGM −1 at η = 50 mV. More importantly, membrane electrode assembly tests under identical assembly conditions show lower cell voltages than commercial 40 wt% Pt/C over 1–4 A cm −2 and stable operation at 1 A cm −2 . Density functional theory calculation shows Ru/Pd neighbors tune Pt toward near-thermoneutral H adsorption (ΔG H* = −0.19 eV), consistent with density of states/d-band shifts and the improved apparent HER response. This formation-stage programming offers a transferable framework for durable, low-PGM HER cathodes in acidic water electrolysis.
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高影响因子
Nature Communications
·
2025
·Vol. 16
·期 1
·1-24
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IF 15.7
Liu Chuqi,Liu Dexiang,Zheng Xiang,Guan Jiali,Zhou Xinyan,Zhang Haikun,Wang Shen,Li Qiubai,Lu Gan,He Jun,Ma Cong
Tumor-derived exosomes carry programmed death-ligand 1 (PD-L1), which binds programmed cell death protein 1 (PD-1) on T cells, suppressing immune responses locally and systemically. However, the mechanisms governing exosomal PD-L1 sorting and secretion remain elusive. Here, we identify Munc13-4 as a crucial regulator of this process. Deletion of Munc13-4 in breast tumors enhances T cell-mediated anti-tumor immunity, suppresses tumor growth, and improves the efficacy of immune checkpoint inhibitors. Mechanistically, Munc13-4 collaborates with hepatocyte growth factor-regulated tyrosine kinase substrate (HRS), Rab27, and SNAREs to facilitate PD-L1 sorting and secretion via exosomes. Cryogenic electron microscopy (cryo-EM) analysis of the Munc13-4–Rab27a complex provide structural insights into exosome secretion. Importantly, PD-L1 sorting relies on a ternary complex composed of Munc13-4, PD-L1 and HRS, which is regulated by interferon gamma (IFNγ) signaling. A designed peptide that disrupts Munc13-4–PD-L1 interaction impedes PD-L1 sorting, enhances antitumor immunity, and suppresses tumor growth, highlighting the therapeutic potential of targeting this pathway.
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PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
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2025
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IF 13.2
Xiangdong Cao,Jihua Tang,Chenchen Xu,Jiaqi Wang,Youfu Geng,Duo Yi,Xuejin Li,Yu Du,Xiaoqing Tian
Triethylamine (TEA) is a kind of flammable and pungent gas, which extensively exists in our daily life. It is paramount important to monitor ppb-level TEA rapidly and selectively at low temperatures. Herein, tungsten oxide hollow microspheres were successfully co-modified by different amount of Pd and N719, and were used to construct semiconductor gas sensor. TEA sensing properties were tested for the N719-Pd/WO 3 and Pd/WO 3 composites under various light illumination conditions. It is exciting to observe that the 0.3 wt% N719-Pd/WO 3 sensor exhibits excellent TEA detectability in terms of ultra-high response (1410, 50 ppm), low operating temperature (100 °C), fast response speed (25 s) and low detection limit (27 ppb) under white light illumination, which are superior to WO 3 sensors loaded with other Pd and N719 concentration as well as upon other light illumination conditions. This excellent sensing performance indicates that the proposed dual-effect improved sensitization by combining noble metal functionalization with visible light excitation offers an effective design for highly sensitive and efficient gas sensors based on wide-band gap semiconductors.
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高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
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2025
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IF 6.3
Qian Wang,Hanyu Shi,Sihan Fang,Chengchen Wang,Jiming Zeng,Guobin Yang,Jun Li,Giuseppe Mele,Chen Wang
Photocatalytic technology, as an environmentally friendly and sustainable approach for hydrogen production, demonstrates significant market potential，where bimetallic single-atom catalysts (SACs) demonstrate superior performance compared to monometallic counterparts through heteronuclear synergistic effects, establishing them as a critical research focus in modern catalytic science. In this investigation, TiO₂ nanosheets were employed as catalytic supports, with oxygen vacancy defects being strategically introduced via H₂-Ar atmosphere thermal reduction to immobilize both monometallic Pt and bimetallic Pt-Pd single atoms. The hydrogen evolution rates were quantified as 1956.45 μmol·h⁻¹ ·g cat ⁻¹ for Pt-loaded catalysts and 3522.65 μmol·h⁻¹ ·g cat ⁻¹ for Pt-Pd-loaded systems, corresponding to 72.3-fold and 130.2-fold improvements relative to unmodified TiO₂. This performance enhancement is attributed to optimized charge carrier separation facilitated by oxygen vacancies and the complementary electronic interactions between Pt and Pd atoms in bimetallic configurations, which collectively promote efficient surface reactions and hydrogen generation kinetics. The remarkable advantages of bimetallic systems in photocatalytic hydrogen evolution are demonstrated through these findings, with Density Functional Theory (DFT) revealing that Pd incorporation not only modulates charge density and band structure through its role as a cocatalyst but also actively participates in the hydrogen evolution reaction as catalytic sites. The formation of Ti-Pt-Ti and Ti-Pd-Ti configurations is observed to effectively reduce reaction energy barriers while suppressing competitive adsorption at isolated metal sites, resulting in enhanced catalytic performance. A strategy for designing efficient photocatalysts is established through this work, supported by mechanistic insights into energy barrier reduction and adsorption regulation, which provides critical theoretical foundations with both scientific and practical significance.
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高影响因子
ACS Applied Materials & Interfaces
·
2023
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IF 9.5
Min Song,Ming Chen,Chang Zhang,Jingjing Zhang,Wei Liu,Xiao Huang,Jingwen Li,Guang Feng,Deli Wang
The atomic ensemble effect will affect the catalysis on catalyst surfaces and determine the selectivity of multielectron reactions, which is an effective potential strategy to modulate the oxygen reduction reaction (ORR) selectivity for hydrogen peroxide (H2O2) production. Here, we reported the investigation of the ensemble effect on Pt/Pd chalcogenides for the two-electron ORR. A series of Pt/Pd chalcogenides were synthesized via introducing chalcogens into Pt/Pd, resulting in catalysts with isolated Pt/Pd active site. X-ray adsorption spectroscopy reveals the change of the electronic structure. Their ORR selectivity transformed from a four-electron process to a two-electron one, which was attributed to the isolated active sites changing the adsorption mode and the tunable electronic property weakening the adsorption energy. Density functional theory calculations revealed that Pt/Pd chalcogenides possessed a lower binding energy of OOH* and inhibited the breakage of the O–O bond, and PtSe2/C with an optimal adsorption energy of OOH* showed 91% selectivity toward H2O2 production. This work provides a design principle for synthesizing highly selective Pt group catalysts for H2O2 production.
研究领域:
催化化学
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材料科学
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理论计算
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高影响因子
Molecular Catalysis
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2018
·
IF 0
Fengwei Zhang,Chunlan Ma,Shuai Chen,Jianfei Zhang,Zhihong Li,Xian-Ming Zhang
Chemoselective hydrogenation of quinolines is often subjected to the problems of leaching and poisoning of catalytic active site as well as harsh reaction conditions. Developing a novel and high-performance heterogeneous catalyst is of paramount importance yet a huge challenge. Herein, we report a facile and efficient strategy for preparing the large surface area and highly N-doped hierarchical porous carbon anchored tiny Pd NPs catalyst, in which the low-cost chitosan, nitrogen-rich ionic liquids are served as composite precursors and KZ molten salt as friendly pore-forming agent. And a series of Pd@CIL-T (C refers to chitosan, IL refers to ionic liquid, T = 600–900 °C) catalysts are successfully fabricated via pyrolyzing aforesaid composites at different temperatures followed by anchoring the highly dispersed and small-sized Pd NPs on their surface. Among all the prepared catalysts, Pd@CIL-900 exhibits the optimal catalytic performance towards the selective hydrogenation of quinoline under extremely mild conditions (0.6 mol% Pd, 0.1 MPa H 2 and 50 °C). The kinetic experiments further reveal that such hydrogenation is subject to a pseudo-first order reaction and the apparent activation energy is as low as 41.1 kJ/mol, demonstrating excellent hydrogenation reaction rate. Moreover, the catalytic activity and selectivity are well maintained even after being reused for fifth reaction cycles.
研究领域:
化学
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催化材料
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纳米技术
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2026
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IF 5.4
Dongdong Chen,Siting Hu,Zhenzhen Jia,Huibin Liu,Bo Zhang,Shasha Liu,Wuwan Xiong,Xiang Li
The integration of lubricant oil additives or biofuels compels the Passive NO x Adsorber (PNA) within automotive exhaust after-treatment systems to withstand chemical poisoning from contaminants such as phosphorus (P). For the first time, lanthanum (La) has been employed to enhance the operational efficacy of Pd-loaded small-pore SSZ-13 zeolite (i.e., Pd-SSZ-13) in the presence of phosphorus species. Our findings reveal that La modification significantly bolsters the resilience of Pd-SSZ-13 against P-induced deactivation during the cold-start phase. Furthermore, we have elucidated a pronounced reduction in the degradation of active cationic Pd 2 + ions and Brønsted acid sites within the Pd-SSZ-13 framework upon the introduction of La. Notably, La not only exerts a stabilizing influence on the framework aluminum at the Brønsted acid sites but also effectively mitigates the interaction between the active Pd 2+ species and phosphorus, thereby preventing the formation of metaphosphate and its subsequent conversion into bulk PdO x aggregates. This research offers profound insights, particularly concerning the utilization of La to augment the resistance of Pd-SSZ-13 zeolite catalysts against poisoning by various chemical poisons (such as alkali metals or sulfur) and to enhance their high-temperature hydrothermal stability.
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高影响因子
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