JOURNAL OF POROUS MATERIALS
·
2022
·Vol. 30
·期 3
·881-887
·
IF 2.523
Liu Debao,Xue Yahui
SiOC ceramic aerogels (SiOC CAs) were successfully fabricated through vacuum freeze-drying method combined with PDC process. The microstructure, phase composition and thermal conductivity of the as-prepared samples were systematically investigated. The results showed that the as-prepared SiOC CAs were composed of amorphous phase with three-dimensional network porous structure. In addition, the as-prepared SiOC CAs demonstrated high specific surface area of 635.72 m 2 /g, low density of 0.19 g/cm 3 , large pore volume of 0.49 cm 3 /g, and ultra-low thermal conductivity of 0.031 ± 0.0015 W/(m K). The present developed work provided a new thought to produce other porous Si-based ceramic aerogel materials.
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Genes & Genomics
·
2022
·Vol. 45
·期 1
·1-11
·
IF 2.164
Cao Qingfei,Ma Jiaji,Li Weitao,Hong Peng,Shen Tong,Tong Ming
Background Guanine nucleotide-binding protein 2 (GNBP2) is a GTPase that has critical roles in host immunity and some types of cancer, but its function in clear cell renal cell carcinoma (ccRCC) is not fully understood. Objective This work explored the role of GNBP2 in ccRCC progression and the underlying molecular mechanism. Methods Two public human cancer databases TNMplot and TISIDB were employed to analyze the expression pattern of GNBP2 during ccRCC progression and the correlation between GNBP2 expression and clinical features of ccRCC patients. GNBP2 functions in ccRCC cells were determined by EdU staining, flow cytometry, scratch wound assay, transwell assay, and xenograft model. Gene expression was evaluated using qPCR, Western blot, immunofluorescence staining, and immunohistochemical staining. Results GNBP2 expression was significantly elevated in ccRCC tissues and increased gradually with the increasing tumor grades. Patients with higher GNBP2 expression had shorter overall survival times. Knockdown of GNBP2 suppressed tumor cell proliferation and cell cycle progression and reduced the capability of migration and invasion, while GNBP2 overexpression exhibited protumor effects. GNBP2 silencing by RNA interference significantly inhibited the tumor growth of tumor-bearing nude mice and decreased the proliferation marker Ki67. Mechanistically, GNBP2 downregulation suppressed the STAT3 signaling transduction, as it reduced the phosphorylation of STAT3 and modulated the expression of the target genes, including c-Myc, MMP2, N-cadherin, and E-cadherin. Conclusion These findings reveal that GNBP2 promotes ccRCC progression by regulating STAT3 signaling transduction, indicating that GNBP2 might be a promising molecular target for ccRCC therapy.
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JOURNAL OF POROUS MATERIALS
·
2022
·Vol. 30
·期 1
·311-325
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IF 2.523
Li Zhengjie,Zhang Lu,Li Yunlong,Zhou Lilong,Han Jilong,Xu Hong,Yun Jimmy,Shen Shufeng,Liu Runjing
In the present work, functionalized MIL-101(Cr)-X (X = –Br, –CH 3 , –HSO 3 , –NO 2 ) materials with mesoporous pores were synthesized and used for tannic acid (TA) adsorption from aqueous solutions. In comparison with MIL-101(Cr), NO 2 -substituted MIL-101(Cr) was found to have positive surface charge and only slight reduction in its specific surface area, resulting in higher TA adsorption capacity than the parent MIL-101(Cr) and the others. Effect of operating parameters such as adsorption time, temperature, pH and ionic strength on the adsorption performance of MIL-101(Cr)-NO 2 was investigated. The TA adsorption capacity remarkably increases with increasing ionic strength adjusted by CaCl 2 . MIL-101(Cr)-NO 2 exhibits an adsorption capacity of 1619 mg/g, higher than that of the reported adsorbents, probably due to electrostatic interaction, π–π stacking interaction and Cr–O complexation interaction between MOF framework and TA. Adsorption isotherms and kinetic results are in accordance with Freundlich model and pseudo-second-order model, respectively. Moreover, the thermodynamics of TA adsorption on MIL-101(Cr)-NO 2 suggests an endothermic process.
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Advanced Composites and Hybrid Materials
·
2022
·Vol. 5
·期 3
·2106-2115
·
IF 11.806
Wang Yan,Yang Dandan,Hessien Mahmoud M.,Du Kang,Ibrahim Mohamed M.,Su Yao,Mersal Gaber A. M.,Ma Rong,El-Bahy Salah M.,Huang Mina,Yuan Qibin,Cui Bin,Hu Dengwei
The introduction of high-permittivity inorganic ceramic materials into organic polymer-based dielectric materials can effectively increase the energy density of film capacitors. In this study, polydopamine (PDA) was coated on BaTiO 3 (BT) nanoparticles through a condensation reaction to form a core–shell structure of BT@PDA. Then it is introduced into the polyvinylidene fluoride/polymethyl methacrylate (PVDF/PMMA) matrix, and the BT@PDA/PVDF-PMMA nanocomposite flexible energy storage films are prepared by the solution casting method. When BT@PDA is 5%, the breakdown strength of the nanocomposite film is 378 MV/m, and the maximum energy density is 11.15 J/cm 3 . Excellent comprehensive electrical properties are due to the enhanced interface coupling between the BT nanofiller and the PVDF macromolecular chain. The introduction of PMMA can suppress the increase in residual polarization. Utilizing the respective advantages of BT@PDA nanocomposite and PVDF-PMMA blending, while improving the breakdown strength and polarization difference, this work provides feasible strategy for improving the energy density and discharge efficiency of flexible PVDF-based films capacitors. Graphical abstract The energy density of the nanomaterials with 5% BT@PDA filler was 11.15 J/cm 3 at 378 MV/m electric field intensity.
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ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2022
·Vol. 30
·期 5
·12138-12151
·
IF 5.19
Kong Wenwen,Huang Suiliang,Shen Boxiong,Ekaterina Priakhina,Khatoon Zobia,Yun Huigwang
Single exposure toxicity tests of herbicides like prometryn are commonly applied in studying ecological and environmental issues, but they are more likely exposed to microalgae through multiple applications of irrigation and water flow. The toxicity of prometryn towards Microcystis aeruginosa ( M. aeruginosa ) at different growth stages (different exposure period) was determined by single and multiple exposures (different exposure mode) through 39-day batch-experiment comparison study. Inhibition rates showed that M. aeruginosa growth was greatly inhibited by exposure to prometryn in a final concentration of 80 and 160 μg·L −1 ( p < 0.05). Specifically, with the same prometryn exposure periods (lag or exponential phase) and concentrations, a single exposure displayed larger toxicity on M. aeruginosa than repetitive additions of prometryn in general according to inhibition rates. Moreover, with the same prometryn exposure modes and concentrations, inhibitory effect was higher with prometryn exposure in lag phase than that in exponential phase according to M. aeruginosa densities and inhibition rates. In general, variations of total dissolved phosphorus (TDP) and total dissolved nitrogen (TDN) with time responded negatively to M. aeruginosa growth, and added prometryn inhibits the utilization rate of both P and N. Logistic function was well used to describe algae densities ( R 2 = 0.979 ~ 0.995), growth rates ( R 2 = 0.515 ~ 0.731), specific growth rates ( R 2 = 0.301 ~ 0.648) and inhibition rates ( R 2 = 0.357 ~ 0.946) along with its combination with Monod function. In addition, results showed that shifts of limiting nutrients could be prompted by not only M. aeruginosa growth but also prometryn exposure scenarios. This study provides a basis for studying the potential harm of prometryn to the ecological environment.
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Biomass Conversion and Biorefinery
·
2023
·
IF 4
Ye Haiyang,Yu Kun,Li Bing,Guo Jianzhong
Heavy metal pollution and organic wastewater treatment have attracted extensive attention of researchers. Adsorption method is widely used in wastewater treatment because of its low price and high efficiency. As a natural, cheap biomass material, bamboo powder is of great significance to develop it into an economical and efficient biochar for wastewater treatment. A new type of ball-milled biochar (BMBC) adsorbent was prepared by pyrolysis of bamboo powder under an inert atmosphere, activated with sodium hydroxide solution and ball milling. The specific surface area of BMBC increased from 29.21 to 60.49 m 2 /g, and the carboxyl and hydroxyl groups on the pyrolyzed carbon surface also obviously increased after ball milling. The results of bath adsorption experiments showed that BMBC exhibited excellent adsorption capacity towards both Pb(II) (170.52 mg/g) and methylene blue (MB, 419.11 mg/g) at 308 K. Based on a systematic study on the effect of various working conditions (including concentration, temperature, pH value, and ionic strength), it was demonstrated that pseudo-second-order kinetic equation might match the adsorption process ( R 2 > 0.9934) and Langmuir model ( R 2 > 0.9924); adsorptions were thermodynamically endothermic and occurred spontaneously. The ball milled alkalization-modified bamboo biochar can potentially be applied to remove heavy metal and cationic pollutants from wastewater.
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Advanced Composites and Hybrid Materials
·
2023
·Vol. 6
·期 1
·1-9
·
IF 20.1
Chen Cheng,Wang Xi,Wang Yan,Gu Hongxi,Zhao Weixing,Zhang Wenxiong,Sewvandi Galhenage Asha,Wang Bo,Ma Chunrui,Liu Ming,Hu Dengwei
Digital light processing (DLP) 3D printing technology is widely applied in the fabrication of ceramics owing to the good printing precision and printing speed. Barium titanate (BaTiO 3 , BT) has attracted extensive attention of researchers due to the good piezoelectric constant, strong dielectric constant, and ease of integration. Therefore, DLP 3D printing technology is combined with the production of BaTiO 3 /1,6-ethylene glycol diacrylate/Polyethylene glycol (400) diacrylate (BT/HDDA/PEG(400)DA) nanocomposites to improve the electrical properties. A preparation method for composite slurry with high fluidity, high solid content, and low viscosity is proposed by comparing the electrical properties of BT/HDDA/PEG(400)DA nanocomposite fabrication with different solid content. The work demonstrates that 67 wt% BT/HDDA/PEG(400)DA nanocomposites are better solid content to DLP 3D printing technology and the printed nanocomposite has the excellent electric properties. After a post-processing, the 67 wt% nanocomposite slurry shows the higher relative density (91.69%) and exhibits piezoelectric constant, remnant polarization, and dielectric constant of 151 pC/N, 17.4 μC/cm 2 , and 7712, respectively. The results suggest that the DLP 3D printing technology provides an alternative method for the fabrication of complex functionality nanocomposite piezoelectric elements. Graphical Abstract
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2023
·Vol. 34
·期 2
·1-10
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IF 2.8
Zhang Zhen,Li Jinglong,Liu Tao,Tian Wenhuai,Li Zhipeng
Conducting films are becoming increasingly crucial for the electronics industry with applications in various technologies including high-power microelectronic packaging, photovoltaics, and flexible displays. The films with high conductivity were normally fabricated by sintering of printed inks with micrometer size particles. However, the resolution of printed pattern and high sintering temperature limit its application due to the particle size. Herein, we report a stable bimetallic alloy nanoparticle (Au–Ag) sintering inks with low sintering temperature (450 °C). The fabricated films have low resistivity (4.13 × 10 –8 Ω·m), which is similar with that of bulk Au films (2.4 × 10 –8 Ω·m) and show great adhesion on glass substrates. Film porosity is extremely low, with a maximum transmittance of only 0.1% in the wavelength range of 340 nm-870 nm. The Au–Ag nanoparticles sintering behavior was also characterized systematically by both scanning electron microscopy (SEM) and transmission electron microscopy (TEM). It was observed that the sintering process could be divided into three stages. This work indicates that this preparation approach of conductive film shows potential in the fabrication of highly integrated electronic devices by ink printing method.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
·
2023
·Vol. 34
·期 1
·1-14
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IF 3.7
Tao Zhou-Shan,Li Tian-Lin,Wei Shan
Magnesium (Mg) and Selenium (Se) are essential elements for bone health and have been studied extensively for its powerful osteogenesis and promoting bone regeneration. The purpose was to observe whether Co-modified 3D-printed β-tricalcium phosphate with Mg and Se could promote bone defect regeneration in an ovariectomized(OVX) rat model. The MC3T3-E1 cells were co-cultured with the leachate of β-TCP, Mg-TCP, and Mg/Se-TCP and induced to osteogenesis, and the cell viability, ROS, and osteogenic activity were observed by Cell Count Kit-8(CCK-8), fluorescent probe 2′, 7′-dichlorofluorescin diacetate, Alkaline phosphatase (ALP) staining, Alizarin Red(RES) staining, western blotting(WB), and immunofluorescence. Then the β-TCP, Mg-TCP, and Mg/Se-TCP were implanted into the femoral epiphysis bone defect model of OVX rats for 12 weeks. Micro-CT and histology analysis were used to observe the therapeutic effect. In vitro results show that the cell mineralization and osteogenic activity of the Mg/Se-TCP group is significantly higher than the β-TCP group and Mg-TCP group. Protein expressions such as FOxO1, SIRT1, SOD2, Runx-2, Cola1a, and OC of the Mg/Se-TCP group are significantly higher than the Con group and the β-TCP group. The results of intracellular ROS and SIRT1 and SOD2 immunofluorescence showed that Mg/Se-TCP can restore the oxidative stress balance of osteoblasts. Micro-CT and histology analysis showed that treatment with Mg/Se-TCP showed the largest amount of bone tissue in the defect area ( p < 0.05), and exhibited lower values of residual biological material ( p < 0.05), compared to that of the β-TCP group and Mg-TCP group. Our research results confirm that Mg/Se-TCP can improve the activity and function of osteoblasts and enhance bone regeneration mediated by reducing intracellular ROS in OVX rat models. Graphical Abstract
The release of Mg and Se during the degradation of Mg/Se-TCP can improve the local bone repair ability. At the same time, it can also inhibit cell ROS, and ultimately greatly promote local bone repair.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2023
·Vol. 415
·期 10
·1855-1863
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IF 4.3
Fang Xiaoting,Wang Jing,Chen Jiamin,Guo Hongyu,Yang Fafu
Although various fluorescent sensors for biomolecules had been extensively reported, the effective fluorescent sensor was seldom reported for detecting oleanolic acid up to now. This work reports the first color-change fluorescence sensor for oleanolic acid based on a bridging bis-cyanostilbene derivative with chiral camphanic groups ( C-BCS ). C-BCS possessed the chartreuse fluorescence in aqueous media, which transferred to strong blue fluorescence in the presence of oleanolic acid. This sensing ability of C-BCS for oleanolic acid exhibited the high selectivity among all kinds of biomolecules and ions. The good linearity between the fluorescence intensity and concentration of oleanolic acid was acquired in the range of 0.2 × 10 −6 to 8.0 × 10 −6 M with the detecting limitation of 0.0582 μM. The 1:1 binding process was clarified as oleanolic acid located in the opening cavity composed of two bridging cyanostilbene units and two chiral camphanic groups based on multiple hydrogen bonds and hydrophobic interaction. The detecting ability of C-BCS was applied on sensing oleanolic acid in thin-layer chromatography analysis, imprinting experiment, tap water, and tea samples, suggesting the effective on-site sensing abilities of C-BCS for oleanolic acid in real samples and daily life. Graphical Abstract
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BIOPROCESS AND BIOSYSTEMS ENGINEERING
·
2023
·Vol. 46
·期 4
·589-597
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IF 3.8
Jiang Wenfei,Dai Lin,Tan Xin,Zhou Xin,Xu Yong
Pre-hydrolysate liquor, as an inevitable by-product, contains a large amount of xylose, and is therefore an inexpensive feedstock that can be upgraded to value-added chemical xylonic acid. However, inhibitors, simultaneously formed in lignocellulose pretreatment process, are regarded as the major obstacle for effectively bio-converting xylose in pre-hydrolysate into xylonic acid. In this study, Gluconobacter oxydans , with highly selective and efficient, was employed for xylonic acid production; the impacts of five typical toxic inhibitory compounds on xylonic acid productivity and the activity of the membrane-bound dehydrogenase were evaluated. The results revealed that the inhibitors showed different degrees of influence toward xylonic acid production, and the order of inhibitory effect for acidic inhibitors was formic acid > acetic acid > levulinic acid; the inhibitory effect of aldehyde inhibitors was furfural > 5-hydroxymethyl-furfural. This study provides an important basis of metabolic modification and detoxification process for enhancing inhibitor tolerance and xylonic acid productivity. Graphical abstract
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JOURNAL OF FLUORESCENCE
·
2023
·Vol. 33
·期 3
·849-858
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IF 2.7
Hu Qingqing,Yu Weihua,Fan Yucong,Kuang Jianhua,Cheng Zhengjun
In the study, silicon doped carbon quantum dots (Si-CQDs) was prepared by one-pot hydrothermal method with (3-aminopropyl) triethoxysilane (APTES) and o-phenylenediamine (OPD) as raw materials. Then a new ratiometric fluorescent probe (RF-probe) was successfully established for sensitively and selectively monitoring proanthocyanidins (PAs) with a linear range of 10–500 nM and limit of detection (LOD) of 5.6 nM. that is, the fluorescence (FL) intensity of Si-CQDs at 570 nm was used as the built-in reference, while dopamine (DA) reacting with 4-hexylresorcinol (4-HR) could produce a new fluorescent substance (named as azamonardine, AZMON), and its FL intensity at 480 nm was reduced because Cr(VI) could oxidize DA to generate quinone without fluorescence. In the presence of PAs, Cr(VI) was reduced to Cr(III), which caused that the amount of DA reacting with 4-HR was increased, thus the FL intensity of AZMON was recovered. Furthermore, the RF-probe was successfully used for the determination of PAs in black goji berry from two different areas and PAs capsule with satisfactory results compared to the standard HPLC method.
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