APPLIED CATALYSIS B-ENVIRONMENTAL
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2024
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IF 20.2
Zezhong Xie,Qiushi Wang,Rongge Yang,Jingnan Zhang,Shanqiang Ou,Gangfeng Ouyang,Mingyang Li,Jianxin Shi,Yexiang Tong
Local pH near the catalyst surface exerts a substantial influence on both catalytic selectivity and activity in electrocatalytic CO 2 reduction (CO 2 RR). While the investigation of local pH remains challenging in the aspect of in-situ imaging and monitoring. In this study, a novel lateral-type surface-enhanced Raman spectroscopy (L-SERS) system with a wide pH testing range from acidic to alkaline, is developed for the in-situ observation of local pH distributions with high spatial and temporal resolution during CO 2 RR. Excellent in-situ imaging of local pH near the catalyst surface is obtained, showing good consistency with simulation results. Besides, the gradual pH elevation and stabilization can be monitored via this time-resolved local pH investigation. This study presents a direct visualization of local pH distribution and variation at the Nernst layer during CO 2 RR, providing direct evidence in local pH for the feasibility of acidic electrolyte and offering theoretical guidance for optimizing CO 2 RR conditions.
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ACS Applied Materials & Interfaces
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2024
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IF 8.3
Chao Yin,Yue Zhang,Cong Fan,Jun Zheng,Yu Yang,Yi Zhang,Jian Jiang
Posterior capsular opacification (PCO) is a common complication following cataract surgery, which can lead to a significant vision loss. This study introduces a facile method for developing a metformin-derived hydrogel (HCM6) stabilized by dynamic covalent bonds among natural polymers. This hydrogel demonstrates antifibrotic properties, on-demand drug release, pH responsiveness, injectability, and self-healing capabilities. Our in vitro experiments confirmed that the HCM6 hydrogel exhibits excellent biocompatibility, inhibiting lens epithelial cell migration, and transforming growth factor-2β (TGFβ2)-induced α-smooth muscle actin (α-SMA) expression in lens epithelial cells. In vivo studies conducted in a rat extracapsular lens extraction (ECLE) model revealed that HCM6 significantly suppressed PCO after 21 days of implantation with no observed pathological effects on surrounding tissues or the optic nerve. According to our experimental results, the inhibitory mechanism of PCO may be attributed to metformin’s suppressive effect on lens cell migration, epithelial–mesenchymal transition (EMT), and lens fiber formation. In summary, the long-acting, controllable, and on-demand release characteristics of the HCM6 hydrogel not only provide an effective strategy for preventing PCO but also offer new avenues for treating undesirable proliferative conditions in ophthalmology and beyond.
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Journal of Environmental Chemical Engineering
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2024
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IF 7.4
Haofu Liu,Zhiqing Huang,Yingyu Shi,Tingyao Cai,Qi Miao,Zideng Gao,Zhenling Cui
Ensuring efficient iron absorption by crops is crucial in terms of high crop yields and food security . Bio-based materials effectively transport nutrients with minimal environmental impacts. Here, highly efficient lightweight iron fertilizers , CSG@Fe was prepared using chitosan hydrogels (CSG) as the adsorption carrier. Iron release from the various CSG@Fe preparations was slow under neutral conditions but rapid under acidic conditions. The effects of various cross-linking agents were investigated; 1.0 wt% genipin chitosan hydrogels iron fertilizer (GE-CSG@Fe) evidenced an excellent iron adsorption rate and a higher iron loading (326.15 mg/g) than the other two iron fertilizers. Iron release from CSG@Fe materials followed the Korsmeyer-Peppas model. Notably, wheat seed germination and tomato pot experiments revealed that GE-CSG@Fe significantly enhanced germination and growth. GE-CSG@Fe appropriately reduced the soil pH, protected ferrous ions from soil oxidation and rapid fixation, activated the soil microenvironment, and improved nutrient absorption by the roots of crops growing. This work provides a simple and effective strategy for overcoming constraints in the development and application of iron fertilizers and provides insights into the development of green and efficient iron fertilizers with intelligent response properties.
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INDUSTRIAL CROPS AND PRODUCTS
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2024
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IF 5.6
Jingmei Li,Xin Liu,Shuangli Zhang,Luying Chen,Yujie Jiang,Rongyu Li,Xianhui Yin,Youhua Long,Yue Ma,Zhuo Chen
Liquid mulch, as a novel biodegradable mulch, can keep soil temperature and moisture, and also has the advantages of being applied without terrain restriction and biodegradable. However, the biodegradation of ordinary liquid mulch is not controllable and cannot meet the needs of different crop growth periods. In this study, we formulated a liquid mulch film (LMF) with pH-controllable degradation based on furfural and carboxymethyl chitosan, with polyvinyl alcohol , xanthan gum , and biochar added to improve the resistance to water solubility. The resulting LMF exhibited better mechanical strength and decreased light transmittance , air permeability , and water vapor permeability than commercial liquid mulch film (CLF). Compared with bare soli, LMF effectively reduced soil moisture evaporation and increased soil temperature , resulting in the growth promotion of cowpeas and maize with longer and thicker roots. Moreover, citric acid spraying could promote the degradation of LMF (9.26±1.64 %) and increase the abundance of beneficial bacteria in the soil. Overall, our study designed the controlled degradable LMF, which not only enhances crop growth but also fosters sustainable agricultural development .
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SENSORS AND ACTUATORS A-PHYSICAL
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2024
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IF 4.1
Ziyu Yuan,Zesen Li,Yipu Zheng,Yunlu Du,Yining Wang,Xu Yue,Yan Ding,Yang Ran,Bai-Ou Guan
The tumor microenvironment (TME) is a complex system. Temperature, pH, oxygen content, and other biomarkers comprehensively reflect the growth state of the tumor, necessitating a multi-parameter detection strategy to garner the precise status of tumor for treatment guidance. Fluorescence imaging technology is a promising tool for realizing this goal due to its advantages of low cost, real-time responses, and high sensitivity. However, several limitations, including the shallow penetration depth of fluorescence signals in biological tissues and the potential crosstalk between multiple fluorescence signals, hinder the practical application of current fluorescence imaging technology. In this paper, a dual-mode optical fiber sensor consisting of a fiber fluorescence pH sensor and a fiber Bragg grating (FBG) temperature sensor is presented. The compact sensor uses different principles for pH and temperature monitoring, thus effectively eliminating potential crosstalk between different signals. In addition, its small size allows it to be inserted into deep tissues for detection. The sensor responds quickly to changes in pH.Moreover, the temperature sensitivity of FBG packaged with PDMS is 34 % higher than the uncoated FBG. In vivo experiments confirmed that the sensor can accurately distinguish normal tissues and tumor tissues. The proposed sensor provides a novel way to realize multi-parameter monitoring of tumor microenvironment and improve the specificity of tumor detection.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
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IF 7.7
Jianlan Peng,Chang Liu,Meilan Mo,Yu Huang,Yeqing Lu,Mengjie Xiao,Xin Zhao,Qijun Ruan,Huihui Ti
Nanozymes have become promising alternative antibacterial agents for bacteria-infected wounds. In this study, fucoidan-confined gold nanoparticles (Fuc@AuNPs) are developed by in situ reduction, and stabilized by sulfate groups of fucoidan. Fuc@AuNPs exhibit pH-responsive catalytic activity that can mimic oxidase (OXD) under acidic bacterial infection conditions and mimic superoxide dismutase (SOD) under normal physiological conditions. The OXD-like catalytic activity of Fuc@AuNPs generates active singlet oxygen ( 1 O 2 ), exhibiting effective antibacterial properties against both Gram-negative E. coli and Gram-positive S. aureus . Fuc@AuNPs and aldehyde grafted saponin incorporate with chitosan to form a hybrid hydrogel. This hydrogel exhibits superior mechanical, adhesive, and self-healing properties due to electrostatic complex coacervation networks and dynamic covalent Schiff base reactions. Animal experiments show that the hydrogel aids S. aureus -infected skin wound healing by reducing bacterial infection and promoting granulation tissue formation without causing excessive ROS-induced inflammation. This study presents the design of multifunctional nanozymes and bioactive hydrogels as a promising wound healing dressing for biomedical applications.
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BIOSENSORS & BIOELECTRONICS
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2025
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IF 10.5
Jiuhong Zhao,Jinnan Zhao,Xiaoyu Zhang,Guixia Ling,Peng Zhang
The level of dopamine (DA) in the human body has a certain correlation with neurological diseases. However, most detection methods of DA are complex and expensive. In this study, laccase-like DNAzyme@MOF with improved pH stability was successfully prepared. DNAzyme@MOF could catalyze the chromogenic substrate to change the color of the solution for the detection of DA in ISF. The addition of DNAzyme made DNAzyme@MOF possess higher stability and enzyme-like activity. The operation process was simple, rapid, and intuitive. In addition, the in vivo DA content in skin interstitial fluid (ISF) was analyzed by an off-line method. The swelling hydrogel microneedles (MNs) were prepared to extract skin ISF. DA in skin ISF was recovered and detected by laccase-like DNAzyme@MOF. This study realized the minimally invasive detection of DA. The proposed detection method of biomarkers in ISF based on DNAzyme@MOF would provide a new dimension towards the future development for the detection of other biomarkers in ISF.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2024
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IF 4.9
Junjie Fan,Jianpeng Cui,Tianhao Zhang,Jianwen Hu,Ziqi Wu,Mingshuo Chi,Wenqing Xie,Shuangqing Sun,Songqing Hu
In this study, we successfully synthesized silica coated Fe 3 O 4 nanoparticles (Fe 3 O 4 @SiO 2 NPs) and further animated their surface to create amino modified Fe 3 O 4 @SiO 2 (Fe 3 O 4 @SiO 2 -NH 2 ) NPs. By taking advantage of the pH-responsive dynamic (covalent) imine bond between the hydrophilic Fe 3 O 4 @SiO 2 -NH 2 NPs and the hydrophobic cinnamaldehyde molecule (R), we developed dynamic covalent Fe 3 O 4 @SiO 2 (Fe 3 O 4 @SiO 2 -R) NPs with switching wettability . These NPs were then utilized to form Pickering emulsions , and whose stability and pH/magnetic response were thoroughly investigated. As the NPs concentration in the emulsion increased, the emulsion stability initially improved but then subsequently slightly decreased. Emulsifiers exhibited emulsifying effect on various oil phases, with paraffin oil demonstrating the best effect. By adding Hydrochloric acid to the emulsion, we successfully broke the imine bond at a pH value of 2.8, resulting in demulsification. Applying a magnetic field also achieved demulsification. After five cycles of pH or magnetic response-induced emulsification and demulsification, a stable Pickering emulsion could still be obtained. Stimuli-responsive Pickering emulsions have been extensively studied, but there is limited research on double-responsive Pickering emulsions. This study presents a novel design of Pickering emulsions with pH/magnetic dual responsiveness, offering great potential for oil-water separation applications.
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Materials Today Communications
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2024
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IF 3.7
Chensi Zeng,Yanfang Gong,Chenxi Qi,Xianghua Zeng,Ni Tan
Capecitabine (CAP) is a kind of prodrug that can be metabolized into 5-fluorouracil (5-FU) in vivo, so it is usually classified as the antimetabolite fluoropyrimidine deoxynucleoside analog. In this paper, CAP, upconversion nanoparticles (UCNPs), 3,5-dicarboxy-4-methacrylate-based azobenzene (MAPDIA)/acrylic acid-functionalized gelatin, N,N′-methylene bisacrylamide (MBA), and ammonium persulfate (APS) were used as template, light trigger, bifunctional monomers, cross-linking agent and initiator, respectively. By using the free-radical polymerization and the molecular imprinting technique, the potential drug delivery nanocontainer CAP-MIP with the dual-responsive performance to pH/near infrared light (NIR) was successfully prepared. Furthermore, the characterization of CAP-MIP was also carried out by the modern instrumental analysis such as FTIR, XRD, TGA, BET and so on. The stimulus-responsive release experiment in vitro indicated the maximum cumulative release rate of CAP changed from 1.71 % to 89.54 % when the pH value in medium varied from 1.2 to 8.3, and the equilibrium release time point also greatly prolonged to 420 min from 40 min, respectively. When irradiated by 980 nm monochromatic NIR light in the same solution of pH 6.8, the maximum release rate of the sample could reach 96.21 % at 180 min, which respectively corresponded to the data of 41.84 % at 420 min under the condition of the absence of additional NIR light. In addition, CAP-MIP also had the excellent specific adsorption for CAP with the selectivity factor of 2.904 and the maximum CAP-loaded capacity of 7 mg•g −1 . The above information denoted the target material should be of some potential in drug delivery system application.
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ACS Catalysis
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2024
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IF 11.3
Ting Zhu,Junnan Han,Teng Sun,Jingjie Zhao,Xiaodong Pi,Jun Xu,Kunji Chen
In order to broaden the applications of water splitting for hydrogen production, it is highly desired to develop an ideal catalyst, which can operate in a wide pH range. In this work, we proposed amorphous RuSex nanoparticles (NPs) with a highly disordered structure to introduce abundant surface defects, which contribute to the enhanced HER activity. The optimized RuSe1.5 NPs exhibited the pH-universal activity, which only require an overpotential of 24, 30, and 12 mV to reach a current density of 10 mA cm–2 in 0.5 M H2SO4 (pH = 0), 1 M PBS (pH = 7), and 1 M KOH (pH = 14), respectively. By capitalizing on the synergistic effect between Ru and Se, we have successfully achieved a balance in the strong adsorption of reaction intermediates on Ru sites and significantly improved the performance of HER. This work highlights the crucial role of understanding and harnessing the elemental synergies in the development of optimized HER catalysts and paves the way for the advancement of hydrogen production.
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FOOD CHEMISTRY
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2024
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IF 8.5
Linlin Li,Li Xia,Feng Xiao,Yewen Xiao,Wei Ji,Baocai Xu,Hualin Wang
Using novel active food packaging has gradually become a daily necessity in terms of impeding microbial contamination. Here, an antimicrobial photodynamic inactivation (PDI) pH-responsive film is developed by incorporating aloe-emodin (AE) into a vehicle of gelatin/chitosan (GC). Besides enhancement in hydrophobicity, the well-dispersed crystals of AE in the GC matrix by hydrogen bonding can upgrade the film's mechanical strength and barrier. The matrix is capable of regulating the release of AE in response to acidic stimuli by a combination mechanism of diffusion and polymer relaxation. Being benefitted from the inherent bioactivity of AE and the PDI activity under visible light irradiation (i.e., 456 nm), the target film of GC-AE2 has excellent antibacterial effect towards Staphylococcus aureus and Escherichia coli , showing bacterial viability of 9.93 ± 1.33 % and 14.85 ± 1.16 %, respectively. Furthermore, the film can effectively thwart Botrytis cinerea infection in cherry tomatoes, demonstrating its potential in preventing the microbial spoilage of postharvest fruits.
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International Journal of Nanomedicine
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2020
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IF 5.115
Dan-Li Hao,Ran Xie,Ge-Jing De,Hong Yi,Chen Zang,Mi-Yi Yang,Li Liu,Hai Ma,Wei-Yan Cai,Qing-He Zhao,Feng Sui,Yan-Jun Chen
Purpose In this study, pH-sensitive poly(2-ethyl-2-oxazoline)-poly(lactic acid)-poly(β-amino ester) (PEOz-PLA-PBAE) triblock copolymers were synthesized and were conjugated with an antimalaria drug artesunate (ART), for inhibition of a colon cancer xenograft model. Methods The as-prepared polymer prodrugs are tended to self-assemble into polymeric micelles in aqueous milieu, with PEOz segment as hydrophilic shell and PLA-PBAE segment as hydrophobic core. Results The pH sensitivity of the as-prepared copolymers was confirmed by acid-base titration with p K b values around 6.5. The drug-conjugated polymer micelles showed high stability for at least 96 h in PBS and 37°C, respectively. The as-prepared copolymer prodrugs showed high drug loading content, with 9.57%±1.24% of drug loading for PEOz-PLA-PBAE-ART4. The conjugated ART could be released in a sustained and pH-dependent manner, with 92% of released drug at pH 6.0 and 57% of drug released at pH 7.4, respectively. In addition, in vitro experiments showed higher inhibitory effect of the prodrugs on rodent CT-26 cells than that of free ART. Animal studies also demonstrated the enhanced inhibitory efficacy of PEOz-PLA-PBAE-ART2 micelles on the growth of rodent xenograft tumor. Conclusion The pH-responsive artesunate polymer prodrugs are promising candidates for colon cancer adjuvant therapy.
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