Theranostics
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2026
·Vol. 16
·期 13
·7571
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IF 14.9
Linlin Song,Meixu Chen,Huiling Wang,Xin Wang,Tianyue Xu,Heqing Zhang,Shuwen Ran,Liwen Huang,Yingying Ma,Zhihui Liu,Zihan Xu,Yujie Zhao,Zichang Liu,Yong Luo,Xiujun Yu,Yulan Peng,Hubing Shi,Jing Jing,Xiujing He
Rationale Triple-negative breast cancer (TNBC) remains one of the most aggressive subtypes due to its poor immunogenicity and resistance to systemic therapies. Methods Here, we report a multifunctional NIR-II light-triggered theranostic nanoplatform, termed LQPO, that integrates liposome, Ti 3 C 2 quantum dots (QDs), perfluorohexane (PFH), and ozone to enable multimodal imaging-guided photo-gas synergistic therapy. The QDs, embedded within the liposomal bilayer, act as highly efficient NIR-II photothermal transducers, while the PFH core serves as a liquid-gas phase-change medium capable of dissolving and releasing ozone under localized heating. Results Upon NIR-II irradiation, LQPO produced strong photothermal and photoacoustic signals for real-time photoacoustic (PA) and contrast-enhanced ultrasound (CEUS) imaging, accompanied by vaporization of the PFH core and burst release of ozone. This spatiotemporally coordinated cascade induced potent oxidative stress and hyperthermia, synergistically driving GSDME-dependent pyroptosis and immunogenic cell death (ICD). The resulting “in situ vaccination” effect remodeled the tumor immune microenvironment and primed tumors for PD-1 blockade therapy. In vivo , NIR-II-activated LQPO achieved efficient tumor accumulation, strong PA/CEUS imaging contrast, and pronounced inhibition of both primary and abscopal tumors when combined with αPD-1 therapy. No significant systemic toxicity was observed, confirming its favorable biosafety. Conclusions Overall, this study establishes a single-laser-activated nanoplatform that unifies real-time multimodal imaging and photo-gas synergistic therapy, and converts localized treatment into a systemic antitumor immune response upon integration with checkpoint inhibition.
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高影响因子
ChemSusChem
·
2026
·Vol. 19
·期 12
·e70812
·
IF 5.9
Mengyao Guo,Jinxiong Wan,Jihuai Wu,Ying Wang,Weichun Pan,Shen Zhang,Guohua Chen,Yiming Xie,Xuping Liu,Zhang Lan
Power conversion efficiency (PCE) is limited by the high density of defects and poor energy level alignment of the SnO 2 /perovskite (PVK) buried interface in perovskite solar cells (PSCs). Herein, a synergistic molecular interface engineering strategy is designed by using an ionic liquid, 1-dodecyl-3-methylimidazolium bis(trifluoromethanesulfonyl) imide salt (DMIMTFSI) to modify this critical interface. The strong electron-withdrawing TFSI − anion induces a downward shift of the conduction band of SnO 2 , thereby optimizing energy level alignment and facilitating electron extraction. Meanwhile, the DMIM + cation passivates interfacial defects through robust chemical interactions with Pb 2+ and I − ions. Furthermore, the long alkyl chain of DMIMTFSI templates the formation of an ordered porous PbI 2 morphology, which improves the crystallinity of the overlying PVK film. The DMIMTFSI modification reduces the trap-state density by 31.86%, prolongs the carrier lifetime by 39.42%, and increases the built-in potential from 0.95 to 1.02 V. Therefore, the DMIMTFSI-modified device achieves a PCE of 24.14%, significantly outperforming the pristine device of 22.34%. The unencapsulated modified device retained 87% of its initial PCE after being stored for 1000 h under ambient conditions, demonstrating excellent environmental stability. This work provides a viable multifunctional interface engineering pathway toward high-performance and stable PSCs. Graphical The insertion of the ionic liquid of 1-dodecyl-3-methylimidazolium bis(trifluoromethanesulfonyl) imide (DMIMTFSI) into the interface of perovskite/tin oxide significantly improves the power conversion efficiency of perovskite solar cells from 22.34% to 24.14%. This is due to the synergistic effect of defect passivation, energy level modulation, and crystal growth promotion of DMIMTFSI.
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ChemCatChem
·
2026
·Vol. 18
·期 12
·e70879
·
IF 4.1
Minjie Hu,Chan Wu,Hui Yue,Sichun Yang,Xu Hou,Enxian Yuan,Jiancheng Zhou
Dry reforming of methane (DRM) offers a promising route to convert greenhouse gases into syngas, although fabricating Ni-based catalysts with long-term stability during reaction conditions remains challenging. Unlike the conventional H 2 pretreatment typically required for activating Ni-based catalysts prior to DRM, we herein reported a one-pot hydrothermal encapsulation strategy to directly synthesize Ni-Mo bimetallic catalysts confined within silicalite-1 (Ni x Mo@S-1) under CH 4 /CO 2 atmosphere for catalyst activation. In contrast to the conventional impregnation Ni 5 Mo/S-1 catalyst, this structural encapsulation approach effectively improved nickel dispersion and enhanced catalytic performance. XRD and TEM revealed that the encapsulated Ni 5 Mo@S-1 exhibited ultra-small nanoparticle size (∼2.3 nm) and Mo promoted high dispersion of Ni nanoparticles. Furthermore, XPS and XANES confirmed that Ni 5 Mo@S-1 facilitated the direct reduction of NiO to metallic Ni under CH 4 /CO 2 atmosphere, thereby inducing active Ni 0 sites and Ni-O-Si bond formation with reinforced metal-support interaction. Graphical The CH 4 /CO 2 atmosphere-induced strategy of encapsulation of Ni x Mo@S-1 enhances DRM performance. Pretreatment with different atmosphere revealed the distinct roles of CH 4 /CO 2 in fabricating the confinement structure of Ni 5 Mo@S-1 for DRM. The CH 4 /CO 2 pretreatment atmosphere directly drives the formation of both active Ni 0 and stabilizing Ni─O─Si bonds with the promotion of Mo, remarkably reinforcing metal-support interaction.
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PHYTOMEDICINE
·
2026
·
IF 11.3
Hansheng Wang,Keyi Li,Haomou Pu,Yaoyao Xiong,Dan Luo,Jinjie Song,Hongjie Jiang,Xiaoping Yu,Tao Deng
Background The molecular basis of retinal photochemical damage remains incompletely understood, limiting the development of targeted therapeutic strategies. Delphinidin, an anthocyanidin with reported protective effects, represents a promising candidate, but its direct molecular target and mechanism of action are unclear. Methods The molecular target of delphinidin was identified using Activity-Based Protein Profiling (ABPP), DARTS-MS, SPR, and CETSA. Its functional effects were investigated in 661W photoreceptor cells and in a light-induced retinal damage model in Sprague-Dawley rats. Protein carbonylation was assessed via an alkynylaniline probe, and Voltage-Dependent Anion Channel 1 (VDAC1) oligomerization was examined by chemical crosslinking. Mitochondrial function, cGAS-STING pathway activation, and ferroptosis markers were evaluated to delineate the underlying mechanism. Results VDAC1 was identified as a direct target of delphinidin. Light exposure induced VDAC1 carbonylation and oligomerization, leading to mitochondrial dysfunction characterized by cytochrome c release and mitochondrial DNA (mtDNA) leakage into the cytosol. Cytosolic mtDNA activated cGAS-STING pathway, which in turn promoted loss of the ferroptosis suppressor GPX4 and triggered ferroptosis. Delphinidin interrupted this cascade by binding to VDAC1 and inhibiting its carbonylation and oligomerization, thus limiting mtDNA leakage, attenuating cGAS-STING activation, preserving GPX4 abundance, and inhibiting ferroptosis. In vivo , delphinidin intervention conferred significant protective effects, as evidenced by preservation of retinal histoarchitecture and reduced oxidative damage and ferroptosis, Conclusion This study identifies a novel mechanistic axis in RPD linking VDAC1 dysregulation to mtDNA-driven innate immune activation and ferroptosis. It further establishes delphinidin as a direct VDAC1 targeting compound and highlights its therapeutic potential for the prevention of RPD. Download: Download high-res image (219KB) Download: Download full-size image
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PHYTOMEDICINE
·
2026
·
IF 11.3
Li Song,Yue Li,Wenjing Li,Bingfeng Lin,Wenlong Xiao,Yuzhen Xia,Feida Wang,Mingli Ye,Wei Wang,Nani Wang
Background Sarcopenia is a prevalent disorder among postmenopausal women, representing a debilitating condition with limited treatment options. Icariin (ICA), a prenylated flavonol glycoside, is commonly used in conditions associated with estrogen deficiency; however, its efficacy and mechanism in postmenopausal sarcopenia remain undefined. Purpose This study aimed to evaluate the therapeutic effect of ICA on postmenopausal sarcopenia and to elucidate its underlying mechanism, with a focus on the estrogen receptor α/fatty acid transport protein 1 (ERα/FATP1) pathway. Study design An integrated approach was employed, combining in vivo pharmacological evaluation, multi-omics analyses, and in vitro mechanistic validation. Methods The in vivo therapeutic effect of oral ICA was assessed by evaluating muscle function, histology, and senescence markers. Human muscle transcriptome datasets and mouse single-cell RNA sequencing data were analyzed. In vitro validation was performed in D-galactose-induced senescent C2C12 myoblasts. Target engagement was confirmed by molecular docking, cellular thermal shift assay, and surface plasmon resonance, and mechanistic validation was performed via FATP1 knockdown. Results Oral administration of ICA significantly improved muscle mass, function, and fiber cross-sectional area, while attenuating lipid deposition and cellular senescence. Single-cell RNA sequencing revealed a diminished myoblast pool with downregulated ERα in aged muscle. This finding aligns with human transcriptome data, linking reduced ERα/FATP1 signaling and dysregulated fatty acid metabolism to sarcopenia. Metabolomic analysis identified FATP1 as a critical transporter of eicosapentaenoic acid and docosapentaenoic acid, which activated the protein kinase B/ mammalian target of rapamycin pathway to promote myogenesis. Importantly, ICA functioned as a dual-target agonist, directly binding to and upregulating both ERα and FATP1, thereby elevating eicosapentaenoic/ docosapentaenoic acid levels and reactivating the protein kinase B/ mammalian target of rapamycin/ myogenic differentiation 1 axis. The specificity of this pathway was confirmed, as FATP1 knockdown completely abrogated the protective effects of ICA. Conclusion This study identifies the ERα/FATP1 axis as a pivotal therapeutic target for sarcopenia. ICA, acting as a first-in-class dual agonist of this pathway, represents a promising candidate for sarcopenia treatment by synchronously modulating estrogen signaling and fatty acid metabolism. Download: Download high-res image (181KB) Download: Download full-size image
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高影响因子
Nature Communications
·
2026
·
IF 18.1
Tang Yu,Li Jiale,Li Yanfang,Ran Pan,Zou Weixin,Yan Shicheng,Dong Lin
Achieving stable and selective electrocatalytic nitrate reduction (NO 3 RR) at high current densities demands a fundamental understanding of the hydrogenation mechanism. We demonstrate that alloying cobalt with ruthenium (RuCo) switches the dominant hydrogenation pathway from the Eley-Rideal (E-R) mechanism, involving solvated protons, to the Langmuir-Hinshelwood (L-H) mechanism, utilizing adsorbed protons. Microkinetic modeling, in situ spectroscopy and density functional theory (DFT) calculations reveal that the competitive E-R pathway on pure Co causes sluggish hydrogenation kinetics and low Faradaic efficiency. In contrast, the L-H pathway on RuCo sustains high hydrogen coverage ( θ H ≈ 0.45), enabling efficient hydrogen-atom transfer for high-rate and deep hydrogenation. Leveraging this mechanistic insight, we achieve a satisfactory ammonia yield rate of 135.53 ± 1.18 mg h −1 cm −2 with 100% Faradaic efficiency and robust 1000-h stability at 1 A cm⁻². This work provides critical understanding of electrochemical hydrogenation pathways for designing efficient catalysts operating under industrially relevant conditions.
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INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2026
·
IF 9.2
Shijie Cao,Quanquan Li,Hui Yun,Boyu Zhang,Zhixue Wang,Xiaowen Wang,Jing Bai,Xiaodong Wang,Yunhua Xu
Magnesium Hydride (MgH 2 ) is a promising hydrogen storage material but suffers from a high dehydrogenation temperature and sluggish sorption kinetics, which hinder its practical application. Accordingly, we report the use of a Cu-based metal-organic framework (HKUST-1) derived carbon material as a catalyst for optimizing the MgH 2 hydrogen storage performance. The MgH 2 containing 10 wt% HKUST-1 (denoted as MgH 2 -HKUST-1) exhibits a maximum dehydrogenation temperature of 50 °C, much lower than pure MgH 2 . Additionally, it demonstrates enhanced hydrogenation dynamics: it adsorbs 6.4 wt% H 2 within 240 s when heated to 350 °C, and even at 200 °C, it still captures 5.7 wt% H 2 in 60 min. Moreover, the dehydrogenation activation energy is 85.01 kJ per mole of H 2 , showing a marked reduction compared to pure MgH 2 . Furthermore, the excellent H 2 storage performance perhaps stems from the synergistic interaction of Cu 2+ /Cu + redox reactions, mechanochemical size effects, and in situ carbon scaffolding.
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CARBON
·
2026
·
IF 12.7
Xiaoqi Mao,Qichao Wei
The conventional approach of enhancing the strength of titanium alloys and their composites through mechanical processing to induce dislocations often leads to compromised ductility. In recent years, structural design strategies have stimulated the exploration of the material community towards deformation mechanisms and their impact on mechanical properties. Herein, we introduce the {10 1 ‾ 2} twinning to the B@Gr/TC4 composites, which were synthesized using ball milling, spark plasma sintering, hot rolling, and heat treatment processes. These composites are reinforced by in-situ formed TiC and TiB hybrid phases, achieving a high ultimate tensile strength (UTS) of 1424 MPa and fractured elongation (FE) of 13%, which are superior to those of TC4 alloy (with its UTS of 984 MPa and FE of 12%) and Gr/TC4 composite (with its UTS of 1325 MPa and FE of 12%). The enhanced strength of the composite is primarily attributed to the grain refinement and dislocation strengthening effects contributed by the high percentage of small-angle grain boundaries pinned by TiC and TiB hybrid phases. Furthermore, the twinning-induced strain softening effect is identified as the key mechanism for maintaining exceptional ductility. This study provides an effective structural strategy to simultaneously improve the strength-ductility of Ti matrix composites.
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产品关联
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高影响因子
eScience
·
2026
·
IF 52.9
Donglei Zhao,Kaiwen Shi,Shuang Wu,Xinyi Liu,Haoxiang Sun,Jinze Hou,Diantao Li,Siyuan Shao,Xingwei Sun,Lihong Zhang,Youxuan Ni,Zhenhua Yan,Yong Lu,Jun Chen
The quasi-solid-state gel electrolytes (QSEs) fabricated through free-radical in situ polymerization show great promise for energy-dense solid-state lithium batteries, paving the way for next-generation electric vehicles and the low-altitude economy. However, the high-voltage-resistant QSEs were obtained under strict conditions within batteries, causing highly non-uniform electrolyte and poor compatibility with electrodes. Here we propose a universal C=C bond activation strategy by introducing activators with high maximum molecular surface electrostatic potential (ESP max ) to improve the condensed local softness of C=C bonds in a series of acrylate-based monomers. The activated C=C bonds result in decreased polymerization reaction energy barrier, and thus realize room-temperature free-radical polymerized QSE (RT-QSE). The RT-QSE effectively suppresses harmful interfacial reactions, maintains electrode structure stability and improves electrolyte uniformity, enabling high-areal-capacity cathodes. As a result, the 4 mAh cm −2 cathode remains 95.1% capacity after 100 cycles. Moreover, the 9.53 Ah pouch battery with an areal capacity cathode >10 mAh cm −2 shows a record high energy density of 656.6 Wh kg –1 . This work establishes a general design criterion for selecting activators and monomers to achieve uniform and compatible RT-QSEs for energy-dense solid-state lithium batteries.
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FOOD CHEMISTRY
·
2026
·
IF 10.4
Tianyu Hu,Fang Zou,Jie Yu,Siqian He,Shiyun Lai,Yuanjie Teng,Zaifa Pan
UNCA employs upconversion nanoparticles as signal probes for specific IGF-1 recognition. • Single-molecule counting enables IGF-1 detection with a low LOD of 6.04 pg/mL. • This method exhibits low cross reactivity and good recovery rates in milk products. There is rapidly growing interest in food nutrition assessment, particularly for nutrients present at low abundance. Here, an upconversion nanoprobe counting analysis (UNCA) is designed for ultra-sensitive detection of insulin-like growth factor-1 (IGF-1). The high sensitivity is attributed to the strong fluorescent intensity of upconversion nanoparticles (UCNPs) and highly specific antibody-antigen binding. Core–shell structured UCNPs are synthesized via co-precipitation followed by layer-by-layer epitaxial growth, and detection probes are constructed through hydrophilic ligand exchange and antibody conjugation. Two detection methods, traditional fluorescent intensity detection and single-molecule counting, are established with linear working ranges of 0.05–5000 ng/mL, which reach limit of detections (LODs) of 21.23 and 6.04 pg/mL, respectively. UNCA is further employed for analyzing three representative milk products, achieving recovery of 73.90%–107.09% with coefficients of variation (CVs) between 2.24% and 7.57%. This method demonstrates quantitative detection of trace-level IGF-1, especially via single-molecule counting. Download: Download high-res image (111KB) Download: Download full-size image
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高影响因子
Frontiers in Microbiology
·
2026
·
IF 5.8
Huiqin Li,Zhiyi Zhao,Mingqi Wu,Chunlan Shi,Tao Zhu,Xi Gao,Chun Xiao,Mehboob Hussain,Deqiang Qin,Guoxing Wu,Junfu Yu
This study examined the interaction between Fusarium solani KMZW-1 and adult Bactrocera dorsalis, with emphasis on cuticular colonization, adult-stage pathological effects, and candidate metabolite-mediated toxicity. KMZW-1 showed Fusarium-like colony and conidial morphology and colonized mainly tarsal setae, joints, and recessed cuticular regions, where fungal conidia and hyphae progressively accumulated over time. Fungal treatment reduced adult survival in a concentration-dependent manner (P < 0.001) and lowered egg production per female, likely due to reduced male survival and fewer mating opportunities, whereas egg hatchability, larval pupation, and adult emergence of offspring were not significantly affected (P > 0.05). Untargeted LC-MS/MS profiling annotated 3073 metabolites, and candidate secondary metabolites were prioritized using pathway assignment, CAS-confirmed identity, normalized peak-area abundance, reported biological activity and commercial availability. Among coumarin, umbelliferone and podophyllotoxin, podophyllotoxin showed the lowest 24 h LC50 values against adult flies, at 24.33 μg mL−1 for females and 21.03 μg mL−1 for males. These results indicate that KMZW-1 produces a reproducible surface-colonization-associated adult-stage phenotype in B. dorsalis. Podophyllotoxin should be interpreted as a prioritized candidate with confirmed topical toxicity, not as a confirmed in vivo virulence determinant. Further work is required to confirm metabolite identity with authentic standards, quantify metabolite production during infection, determine internal invasion dynamics, and evaluate mode of action and non-target safety.
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高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2026
·
IF 6.7
Peng Deng,Yang Chen,Xing Shen,Qiuming Chen,Zhaojun Wang,Zhiyong He,Jie Chen,Maomao Zeng
Abstract CaSR has been recognized as a potential receptor involved in kokumi peptide perception. However, the molecular basis underlying kokumi-peptide-induced cellular responses remains insufficiently understood. Herein, CaSR-associated responses induced by kokumi peptides were investigated in STC-1 cells. Compared with MSG stimulation alone, MSG combined with γ-glutamyl peptides enhanced intracellular Ca2+ mobilization and CCK secretion, with response trends consistent with sensory evaluation. MSG+γEγEV elicited the strongest cellular response, increasing CCK secretion from 31.38 ± 3.18 pg/mL in the MSG group to 60.84 ± 4.45 pg/mL, while Ca2+ fluorescence intensity increased by 133.60% relative to MSG treatment alone (p < 0.05). Pretreatment with the CaSR antagonist NPS-2143 reduced MSG+γEγEV-induced Ca2+ mobilization and CCK secretion by 51.09 and 42.90%, respectively, supporting the involvement of CaSR in these cellular responses. Metabolomic and transcriptomic analyses revealed alterations in signaling-associated metabolites and pathways, including calcium signaling, MAPK signaling, PI3K-Akt signaling, cAMP signaling, phosphoinositide-related metabolism, and glycerophospholipid metabolism. These findings suggest that signaling responses associated with CaSR involvement in STC-1 cells share certain features with taste-related signal transduction processes. Collectively, the results provide insights into kokumi-peptide-induced cellular responses and their potential relevance to umami enhancement.
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