ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Yang Tang,Qun Jiang,Rongli Chen,Siqi Wu,Yichang Luo,Xi Huang,Guofang Yu,Cui Shao
Recent advances in immune checkpoint inhibitors (ICIs), particularly those targeting PD-1/PD-L1, have transformed cancer treatment. However, their efficacy is often hampered by the immunosuppressive tumor microenvironment (TME). Here, we developed a cantharidin-loaded nanomedicine (CA@TPGS-AmP), composed of D-α-tocopheryl polyethylene glycol succinate (TPGS) and naturally derived amphiphilic peptides (AmP), designed to enhance PD-1 blockade via induction of immunogenic cell death (ICD). In vitro, CA@TPGS-AmP markedly improved the solubility of cantharidin and exhibited superior penetration in 3D tumor spheroids. It effectively triggered key ICD events, including calreticulin (CRT) surface exposure, ATP release, and HMGB1 translocation, thereby promoting dendritic cell (DC) maturation. In vivo, CA@TPGS-AmP significantly augmented the antitumor efficacy of PD-1 therapy in 4T1 orthotopic breast cancer and LLC lung cancer models. Mechanistically, the combination therapy remodeled the TME into an immunostimulatory state by increasing CD8+ T cell infiltration and activation, leading to enhanced tumor suppression compared to monotherapies. These findings support CA@TPGS-AmP as a promising adjunct to PD-1 blockade and highlight the potential of natural product-based nanomedicine in advancing cancer immunotherapy.
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WATER RESEARCH
·
2026
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IF 12.8
Yunxia Zu,Xueqi Chen,Zimeng Zhang,Aijie Wang,Zhiling Li
Organohalides and heavy metals often co-contaminate groundwater, however, the biotoxicity of heavy metal strongly inhibits microbial reductive dechlorination activity and existing bioremediation strategies seldom achieve simultaneous removal of both types of pollutants. Here, we demonstrated that cysteine amendment enabled synchronous reductive dechlorination and cadmium (Cd(II)) removal in an organohalide-respiring bacterium Pseudomonas sp. CP-1 through cysteine-mediated sulfide bioprecipitation. Batch experiments revealed that cysteine supplementation at a Cd(II):Cys molar ratio of 1:2 achieved an enhanced 2,4,6-trichlorophenol dechlorination kinetics ( k d = 0.28 d -1 ) and 91.20% recovery of Cd(II) as nanocrystalline CdS deposited on the cell surface. In simulated continuous-flow biobarriers, the addition of cysteine sustained high removal efficiencies for both contaminants despite hydraulic fluctuations, with a highest dechlorination rate reaching 120 µM·(L·d) -1 , 9.6 times higher than the pure dechlorination process. Multi-omics analysis revealed the potential coupled metabolic mechanism of dechlorination and Cd(II) removal in which the amendment of cysteine not only activated cysteine desulfurase to produce H 2 S for extracellular precipitation of CdS, but also generated alanine and pyruvate, which likely assimilated into the TCA cycle to augment NADH production and electron supply for reductive dechlorination. This work establishes a unique single-strain based strategy for synergistic remediation of organohalide and heavy metal ions in groundwater, highlighting the potential of cysteine-driven metabolism as an effective bioaugmentation tool for sustainable remediation of organohalide and heavy metal co-contaminated groundwater.
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Food Biophysics
·
2026
·Vol. 21
·期 1
·17
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IF 3.2
Zhang Xinyu,Li Yijie,Lin Hong,He Junbo,Feng Jiangtao,Cai Meng
To improve the lipophilicity and antioxidant potential of ferulic acid (FA), four novel 1- O -alkylglyceryl ferulates (C 8 Gly 1 F, C 12 Gly 1 F, C 16 Gly 1 F, and C 18:1 Gly 1 F) were synthesized via Novozym 435-catalyzed transesterification in n -hexane at 65 °C, achieving high conversion rates and good enzyme reusability. Crystallinity and thermal properties, analyzed by polarized light microscopy and DSC, revealed that C 12 Gly 1 F exhibited optimal crystallinity, while C 18:1 Gly 1 F, due to its unsaturated alkyl chain, was predominantly amorphous, suggesting enhanced solubility. Antioxidant assays (DPPH and ABTS) demonstrated higher radical scavenging activity compared to ethyl ferulate, with C 18:1 Gly 1 F showing the best performance. Density functional theory calculations revealed its high electron affinity, electrophilicity, and a delocalized HOMO–LUMO distribution, supporting its proposed antioxidant mechanism. These findings highlight the potential of 1- O -alkylglyceryl ferulates as effective lipophilic antioxidants for use in functional foods and lipid-based delivery systems.
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Theranostics
·
2026
·Vol. 16
·期 7
·3408
·
IF 13.3
Binbin Ji,Hui Guo,Rong Xing,Miaomiao Sun,Yu Cheng,Chen Yao,Hanyong Zhu,Xuerong Wang,Ruihan Jiang,Xin Chen,Zimeng Liu,Suyan Wang,Fei Xu,Fangyu Zhang,Fuxing Dong,Xiucheng Pan,Jing Yang,Yuchen Pan
Rationale: Macrophage phagocytosis is essential for pathogen clearance during sepsis. We previously demonstrated that the glycolytic enzyme 6-phosphofructokinase, muscle type (PFKM), modulates macrophage functions and its deficiency alleviates sepsis in mice. However, the function of PFKM in regulating macrophage phagocytosis remains unclear. Methods: CD14 + monocytes were sorted by flow cytometry from healthy volunteers and septic patients, and the subcellular localization of PFKM was assessed by immunofluorescence. Nuclear translocation mechanisms and PFKM-p53 interaction were identified by Co-immunoprecipitation coupled with mass spectrometry (Co-IP/MS) and validated by Co-IP. Transcriptomic sequencing was used to identify the downstream target of the PFKM-p53 complex. Inflammatory cytokine levels were detected by ELISA and real-time RT-PCR, and the phagocytosis of macrophages was assessed by flow cytometry. Dual-luciferase reporter assays and ChIP were employed to investigate whether PFKM acts as a co-regulator of p53 in mediating Pdcd1 transcription. Nanobodies targeting PFKM-p53 were screened and subsequently synthesized according to the sequences. The effect of nuclear PFKM and the therapeutic effect of nanobodies were evaluated on the well-established sepsis mouse models induced by Escherichia coli or cecal ligation and puncture. Results: PFKM translocated to the macrophage nucleus during sepsis. Nuclear accumulation of PFKM impaired phagocytosis through a non-glycolytic “moonlighting” function and exacerbated sepsis. Mechanistically, PFKM interacts with p53, which facilitates its nuclear translocation. Subsequently, PFKM promotes p53 acetylation at K120, enhancing p53 binding to the Pdcd1 promoter and driving its transcription, thereby suppressing macrophage phagocytosis. Blocking the PFKM-p53 interaction with a nanobody, Nb07, restored phagocytosis of macrophages and alleviated sepsis in mice. Conclusion: Our data reveal the PFKM-p53-PD-1 axis that suppresses macrophage phagocytosis in sepsis and highlight the therapeutic potential of targeting this pathway with nanobody-based strategies.
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JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY
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2016
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IF 1.112
Jianbin Qin,Guangcheng Zhang,Xuetao Shi
The viscoelasticity of shear thickening fluid (STF), a crucial property in the protective composite applications, with different silica nanoparticle concentrations in ionic liquid, 1-butyl-3-methylimidizolium tetrafluoroborate ([C4min]BF4), was studied at different temperatures and with shear frequencies through oscillatory shear, respectively. All STFs present strain thickening behavior. With increasing silica nanoparticle concentration, the critical shear strain for the onset of strain thickening decreased, while the complex viscosity, storage modulus, and loss modulus increased significantly. The critical shear strain increased with an increase of temperature, while the complex viscosity, storage modulus, and loss modulus decreased notably. The critical shear strain was constant with increasing the frequency of strain, while the complex viscosity decreases slightly. The storage modulus and loss modulus were independent with frequency in the strain thickening region. Nanoparticle clusters leading to strain thickening were demonstrated. The viscoelastic response of STFs to varying silica nanoparticle content, temperature, and frequency investigated here will help to design the specific application of STFs in soft protective composites and damping devices.
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JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL
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2015
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IF 3.615
Lian-wei Shan,Gui-lin Wang,Li-zhu Liu,Ze Wu
In order to develop low-cost photocatalyst, commercial Bi 2 O 3 was utilized as raw material to prepare α-Bi 2 O 3 /BiOCl core-shell heterojunction via a facile in situ chemical transformation method. To clarify experimentally the band alignment relationships between the α-Bi 2 O 3 and BiOCl (0 0 1), the α-Bi 2 O 3 /BiOCl (0 0 1) core–shell heterojunction band offsets were analyzed by X-ray photoelectron spectroscopy (XPS). Here based on energy gaps, valence band values of α-Bi 2 O 3 and BiOCl (0 0 1), core levels difference of Bi 4f in α-Bi 2 O 3 /BiOCl (0 0 1) heterojunction , we demonstrate that band alignment of ∼0.28 eV exists between α-Bi 2 O 3 and BiOCl with α-Bi 2 O 3 possessing the higher valence band potential or electron affinity which is a driving force of valence band holes from α-Bi 2 O 3 to BiOCl (0 0 1). While, the electrons in conduction band were driven to migrate through conduction band potential difference (0.49 eV) from BiOCl (0 0 1) to α-Bi 2 O 3 .
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MATERIALS LETTERS
·
2019
·
IF 3.019
Junfei Ou,Bo Wu,Fajun Wang,Mingshan Xue
Textile with Janus wetting properties, viz., one side super-nonwetting (abridged as SNW) and the other side super-wetting (SW), was fabricated via copper (Cu) deposition and subsequent chemical vapor deposition (CVD) of 1-dodecanethiol (DT). To facilitate or hinder the deposition of DT molecules onto the SNW or SW side, three measures were taken. Firstly, less Cu particles were electroless deposited onto the adhered side of the textile to the vessel bottom. Secondly, the side with less Cu particles were adhered to the bottom of the vessel in the CVD process and was wetted by water. Thirdly, the DT molecules on the cap of the vessel spread downward and deposited on the exposed side and could not go through the textile and deposit on the bottom side due to the water sealing and evaporating.
研究领域:
材料科学
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表面化学
·
功能纺织品
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Journal of Environmental Chemical Engineering
·
2026
·
IF 7.2
Yingfeng Wang,Ming Huang,Maoli Yin,Wei Li,Xun Zhang,Xiaojuan Li,Gang Li
Bacterial adhesion and proliferation on the surface of solar energy evaporator lead to contamination of the evaporation water and reduce the efficiency of photothermal evaporation. In this work, the metal-organic framework (MOF), HKUST-1 was in situ synthesized onto the surface of MXene, and CuS was sulfurized onto the Cu 2+ sites to form MX/HK@CuS nanosheets. The morphology, microstructure, and crystallinity of MX/HK@CuS were characterized using SEM, EDS, FTIR, XRD, and XPS. Results shows that MX/HK@CuS exhibited fair photothermal water evaporation capabilities, with a photothermal evaporation efficiency exceeding 30% in aqueous solution under irradiation. The photothermal water evaporation efficiency of MX/HK@CuS-3 thin sheets was 86%, demonstrating significant photothermal water evaporation performance. The antibacterial properties of the MX/HK@CuS series were attributed to Cu 2+ release, photothermal and photodynamic conditions via sulfurization times. Interestingly, MX/HK@CuS-3 shows over 99.9% of inactivation to E. coli and S. aureus within 20 min of exposure under NIR and simulated sunlight illumination. Meanwhile, MX/HK@CuS-3 demonstrated improved efficacy in biofilm eradication, with weak bacterial adhesion. The MX/HK@CuS series showed impressive blood compatibility, indicating its biocompatibility and environmental safety. In conclusion, this study provides a novel multifunctional platform for solar-energy evaporator materials, combining triple functional antibacterial properties with high photothermal conversion efficiency.
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ANALYTICA CHIMICA ACTA
·
2026
·
IF 6
Mengxue Tang,Jiale Zhang,Qixuan Mu,Keyan Chen,Yibing Ji
Background Enantiomers may have differences in biological effects, pharmacological activity, and toxicity. Currently, global regulatory authorities are imposing increasingly stringent approval requirements for single-enantiomer drugs. Coupled with the continued growth of the chiral pharmaceutical market, this makes the development of chiral separation technology an urgent scientific task. Therefore, the separation and analysis of chiral drug enantiomers are directly related to human health. Enzyme-based chiral stationary phase (CSP) is a promising platform. Unfortunately, the fragility of natural enzymes, as well as the complexity and low efficiency of the preparation process, hinder their practical application in chiral separation. Results Metal organic frameworks (MOFs), which have enormous potential in the fields of enzyme immobilization and capillary electrochromatography (CEC) separation, were explored as support materials with good enzyme immobilization performance and CSP with separation abilities. Lipase (from porcine pancreatic) was encapsulated into a metal organic framework (MOF) under the concept of "in situ". Effective enzyme loading capacity enables composite materials (Lipase@HKUST-1) to inherit lipase's natural chiral recognition ability. On this basis, inspired by the same concept, Lipase@HKUST-1 was directly grown in the open column for capillary electrochromatography (CEC). By optimizing the interface combination method and simplifying the column preparation steps, the efficiency and performance of capillary column preparation have been effectively improved. Enantiomer separation of multi-chiral drugs such as naproxen and chlorpheniramine has been achieved. Theoretical calculations further explore potential chiral recognition mechanisms. Significance The effective combination of cost-effective lipase (from porcine pancreatic) and MOF materials enriches the library of chiral materials for enantioseparation. The understanding of the chiral recognition mechanism inspires the design of ideal performance materials. The highly stable MOF separation platform for biological functions has introduced a pioneering research paradigm for the CSP development of OT-CEC.
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APPLIED CATALYSIS A-GENERAL
·
2026
·
IF 4.8
Shengnan Xu,Yu Yu,Fuxin Wang,Jiande Hu,Zixiang Li,Guojun Lv
Cobalt-doped zeolite catalysts have been identified as a potentially viable non-precious metal alternative for toluene oxidation, exhibiting characteristics reminiscent of noble metals, such as the ability to activate C-H bonds, abundance, and minimal adverse environmental impact. However, the catalytic activity is greatly reliant on the diversity of cobalt species embedded within the zeolite framework. To address this, a ligand-engineering strategy was utilized to precisely control the coordination environment of the cobalt precursor, thereby regulating the resulting cobalt species and accordingly the catalytic activity of cobalt-doped zeolite catalysts. Four distinct Co@S-1 zeolites were synthesized with disparate ligands including ethylenediamine, water, ammonia water and acetylacetone, and meanwhile applied as heterogeneous catalysts for the selective oxidation of toluene with molecular oxygen as oxidant. Among them, the Co@S-1(EDA) zeolite catalyst synthesized with ethylenediamine demonstrated superior catalytic reaction performance, achieving a toluene conversion of 63.8 % with a benzaldehyde selectivity of 68.5 % within 6 h of reaction. This eminent catalytic oxidation ability for Co@S-1(EDA) zeolite catalyst is mainly ascribed to its largest Co 2+ /Co 3+ ratio, its most oxygen vacancy amount and its largest external surface area. Furthermore, the Co@S-1(EDA) zeolite catalyst exhibited excellent re-usability, maintaining its activity over five consecutive catalytic cycles. This study emphasizes ligand engineering as an effective approach to create highly efficient and stable cobalt-based zeolite catalysts for selective hydrocarbon oxidation reactions.
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MICROCHEMICAL JOURNAL
·
2026
·
IF 5.1
Mengfei Xu,Ziyi Ren,Xinyao Huo,Xiyu Zhang,Fang Yang,Feifei Peng,Geng Zhang,Xuerong Chen,Wei Wu
Regulating the morphology of composite materials and simplifying their preparation processes are critical for enhancing material performance and broadening application prospects, especially for metal-organic framework (MOF)-based nanocomposites. Conventional synthesis methods for MOF/graphene composites (e.g., solvothermal methods) often suffer from high energy consumption (high temperature), long reaction times (up to 24 h), and large MOF particle sizes (micrometer scale), which limit active site exposure, electron transfer efficiency, and practical applicability. Herein, we report a low-energy, efficient strategy to fabricate nanosized HKUST-1 decorated graphene nanosheet (nano-HKUST-1@GS) composites via in situ growth, which requires only 15 min at room temperature. This strategy yields uniformly distributed nano-HKUST-1 particles (∼46 nm) with intimate interfacial contact with GS. Benefiting from the synergistic interplay between nanosized HKUST-1 (abundant exposed active sites) and conductive GS (accelerated electron transfer), the nano-HKUST-1@GS composite exhibits superior electrochemical performance compared to individual components or their physical mixtures. When applied as an electrocatalyst for glucose oxidation, the constructed non-enzymatic sensor achieves a high sensitivity of 2065 μA mM −1 cm −2 , a wide linear range (0.5–2607 μM), and an ultralow detection limit of 0.11 μM (S/N = 3), outperforming most reported counterparts. Furthermore, this sensor successfully quantifies glucose in human serum samples, validating its practical utility. This work not only provides a low-energy, efficient approach for constructing nanosized MOF/graphene heterostructures but also develops a sensitive, reliable enzyme-free glucose detection platform, holding promise for advancing MOF-based composite synthesis and clinical diagnostics.
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CARBON
·
2026
·
IF 12.7
Xiaoqi Mao,Qichao Wei
The conventional approach of enhancing the strength of titanium alloys and their composites through mechanical processing to induce dislocations often leads to compromised ductility. In recent years, structural design strategies have stimulated the exploration of the material community towards deformation mechanisms and their impact on mechanical properties. Herein, we introduce the {10 1 ‾ 2} twinning to the B@Gr/TC4 composites, which were synthesized using ball milling, spark plasma sintering, hot rolling, and heat treatment processes. These composites are reinforced by in-situ formed TiC and TiB hybrid phases, achieving a high ultimate tensile strength (UTS) of 1424 MPa and fractured elongation (FE) of 13%, which are superior to those of TC4 alloy (with its UTS of 984 MPa and FE of 12%) and Gr/TC4 composite (with its UTS of 1325 MPa and FE of 12%). The enhanced strength of the composite is primarily attributed to the grain refinement and dislocation strengthening effects contributed by the high percentage of small-angle grain boundaries pinned by TiC and TiB hybrid phases. Furthermore, the twinning-induced strain softening effect is identified as the key mechanism for maintaining exceptional ductility. This study provides an effective structural strategy to simultaneously improve the strength-ductility of Ti matrix composites.
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危险品化学品经营许可证（带存储）