BIOCHEMICAL PHARMACOLOGY
·
2022
·
IF 6.1
Mengmeng Wang,Xuqin Guo,Man Yang,Yawen Zhang,Fanyi Meng,Yinshuang Chen,Mengxi Chen,Tian Qiu,Jiawei Li,Zhi Li,Qi Zhang,Fang Xu,Haiyang Zhang,Weipeng Wang
Clinically, 5-fluorouracil (5-Fu) is a first-line drug for the treatment of patients with colorectal cancer (CRC). However, chemoresistance to 5-Fu-based chemotherapy is a leading obstacle in achieving effective treatment for CRC, especially microsatellite stable (MSS) CRC. Since the cytotoxicity of 5-Fu is negatively correlated with oxytocin receptor (OXTR) expression in MSS CRC cell lines, our current study aimed to investigate the synergistic antitumor activity of 5-Fu combined with atosiban , an antagonist of OXTR. Our results suggested that atosiban remarkably potentiated the inhibitory effect of 5-Fu on the growth of MSS-type CRC cells in vitro and in vivo . Moreover, 5-Fu induced GATA3 in MSS CRC cells and tumors, which were eradicated by atosiban. Further investigation showed that atosiban strengthened the antitumor activity of 5-Fu through eradiation of 5-Fu-induced GATA3 in MSS-type CRC cells. Taken together, our findings suggest that atosiban potentiates the antitumor effect of 5-Fu by abolishing 5-Fu-induced GATA3, which provides a novel therapeutic strategy for MSS-type CRC via the combination of atosiban and 5-Fu.
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PubMed
高影响因子
MICROPOROUS AND MESOPOROUS MATERIALS
·
2021
·
IF 5.455
Tao Jiang,Fumin Wang,Xubin Zhang,Yi Zhai,Guojun Lv,Yu Shen,Yuzhou Wu
Mesocrystal zeolite with well-defined morphology owns mesoporous channels and single crystal characteristics, which could promote diffusion efficiency, stability and catalytic activity. Thus, we performed the controllable synthesis of ZSM-5 mesocrystal without special additives and complex methods. Selected area electron diffraction (SAED) and fast Fourier transform (FFT) showed diffraction spots regardless of crystallization time, which indicated the well oriented feature of synthesized ZSM-5 zeolites. The crystallization process was further investigated. The oriented particle attachment (OPA) effectively guided the synthesis process of mesocrystals, which followed the nonclassical crystallization mechanism. The crystallinity curve exhibited valley-like shape, which manifested that the crystallization pathway went through three stages: fast precipitation, deconstruction and reorganization. The plausible formation mechanism was proposed, which might be useful for the fabrication of ZSM-5 mesocrystal. The prepared zeolites showed superior catalytic performance in aldol condensation reaction between benzaldehyde and 2-hydroxyacetophenone, obtaining 93% of the conversion.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2019
·
IF 6.361
Fei Li,Huanshun Yin,Yan Chen,Siyu Wang,Jingyan Li,Yuemei Zhang,Chunxiao Li,Shiyun Ai
DNA formylation (5-formylcytosine, 5fC) is a major epigenetic modification involved in alterations in the DNA double helix structure and protein identification. Due to the low amount in all mammalian tissues and cells, it is necessary to develop a rapid, sensitive and efficient method for detecting 5fC for further understanding the biological functions of 5fC. Thus, a novel PEC biosensor was constructed using P-g-C 3 N 4 -WS 2 nanocomposite as photoactive material. Firstly, AuNPs/P-g-C 3 N 4 -WS 2 /ITO electrode was prepared as substrate electrode. Secondly, the probe DNA and complementary DNA (containing 5fC base) was modified to the electrode surface based on the formation of Au-S bonds between AuNPs and thiol group on the probe DNA and hybridization, respectively. Finally, the amino functionalized MnO 2 nanoflowers were further modified to the electrode surface by covalent interaction between the aldehyde group on the 5fC and the amino group on MnO 2 nanoflowers. The sensitive and specific detection of 5fC can be achieved by oxidizing ascorbic acid with MnO 2 nanoflowers and quenching the photoactivity of P-g-C 3 N 4 -WS 2 nanocomposite. The sensor has a detection range of 0.01–200 nM and a detection limit of 3.8 pM. Moreover, this sensor has excellent detection specificity, stability and reproducibility.
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PubMed
高影响因子
Journal of Environmental Chemical Engineering
·
2025
·Vol. 14
·期 1
·120635
·
IF 7.2
Nan Xiang,Huajun Sun,Guifeng Tang,Na Zhang,Chuanhui Gao,Yuetao Liu,Chuanxing Wang,Junwei Ding,Li Ding
Photocatalytic conversion of CO 2 into solar fuels presents a promising strategy for mitigating greenhouse gas emissions. The reduction of CO 2 to methanol not only enables carbon resource recycling but also facilitates the production of sustainable fuels. In this study, a litchi-shell-like TiO 2 /WO 3 -5 hollow heterojunction catalyst was constructed, featuring surface alkalization and abundant oxygen vacancies. This unique architecture provides a high specific surface area and plentiful active sites, thereby significantly enhancing CO 2 adsorption capacity. Under neutral conditions (pH = 7), the TiO 2 /WO 3 -5 catalyst achieves a remarkable methanol production rate of 780 μmol·g⁻¹ ·h⁻¹ with a high selectivity of 88.6 %, substantially outperforming its individual counterparts, pure TiO 2 and WO 3 . Furthermore, the catalyst demonstrates excellent stability over multiple reaction cycles. A series of characterizations, including EPR, PL, TRPL, and in situ DRIFTS, collectively verify the formation of a Z-type heterojunction, which effectively promotes the spatial separation of photoinduced charge carriers and suppresses the formation of CO and CH 4 . This work underscores the crucial synergy between Z-type heterojunction engineering and surface defect manipulation in enhancing reaction selectivity and efficiency. The TiO 2 /WO 3 -5 catalyst offers a prospective platform for CO 2 -to-fuel conversion and provides valuable guidance for the design of advanced photocatalysts.
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高影响因子
Catalysts
·
2025
·Vol. 15
·期 11
·
IF 4
Juan Du,Wanting Qiu,Sunbal Ayaz,Jian Long,Wenze Guo,Ling Zhao,Zhenhao Xi
2,5-furandicarboxylic acid (FDCA), a high-value biomass-derived monomer, serves as a crucial building block for sustainable polymers including polyesters, polyamides, and polyurethanes. This study systematically investigated the catalytic oxidation of 5-hydroxymethylfurfural (HMF) to FDCA over Pt/Al2O3and Pt–Bi/Al2O3catalysts. The 5Pt/Al2O3catalyst yielded 60.6% FDCA after 12 h under optimized conditions (80 °C, 0.1 MPa O2, 1 equiv. Na2CO3). Remarkably, Bi-modified 5Pt–1Bi/Al2O3catalyst dramatically enhanced catalytic performance, achieving 94.1% FDCA yield within 6 h under optimized conditions (80 °C, 1.5 MPa O2, 2 equiv. Na2CO3). Comprehensive characterization revealed that the exceptional activity originates from Bi–O–Pt interactions that modulate the electronic structure and oxidation state of Pt active sites, which facilitates the oxidation of intermediate 5-formyl-2-furancarboxylic acid (FFCA) to FDCA, the rate-limiting step of HMF oxidation. This work demonstrates an efficient Bi-promoted Pt catalytic system for FDCA production with significant potential for industrial application.
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高影响因子
BRITISH JOURNAL OF NUTRITION
·
2015
·Vol. 114
·期 6
·866-872
·
IF 3.453
Xihong Zhou,Jingqing Chen,Weiche Wu,Xinxia Wang,Yizhen Wang
n-3 Long-chain PUFA up-regulate intestinal lipid metabolism. However, whether these metabolic effects of PUFA on intestine are mediated by AMP-activated protein kinase (AMPK) remains to be elucidated. To determine the effects of α-linolenic acid (ALA) on intestinal fatty acid (FA) metabolism and whether these effects were affected by AMPK deletion, mice deficient in the catalytic subunit of AMPKα1 or AMPKα2 and wild-type (WT) mice were fed either a high-fat diet (HF) or HF supplemented with ALA (HF-A). The results showed that ALA supplementation decreased serum TAG content in WT mice. ALA also increased mRNA expression of genes (carnitine palmitoyltransferase 1a, acyl-CoA oxidase 1, medium-chain acyl-CoA dehydrogenase, cytochrome P450 4A10 and pyruvate dehydrogenase kinase isoenzyme 4a) involved in intestinal lipid oxidation and mRNA expression of TAG synthesis-related genes (monoacylglycerol O-acyltransferase 2, diacylglycerol O-acyltransferases 1 and 2) in WT mice. Consistent with these, expression levels of phosphorylated AMPKα1 and AMPKα2 were also increased in WT mice after ALA addition. However, in the absence of either AMPKα1 or AMPKα2, ALA supplementation failed to increase intestinal lipid oxidation. In addition, no significant effects of either diet (HF and HF-A) or genotype (WT, AMPKα1–/– and AMPKα2–/–) on FA uptake in the intestine and faecal TAG output were observed. Our results suggest that AMPK is indispensable for the effects of ALA on intestinal lipid oxidation.
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高影响因子
Catalysts
·
2025
·Vol. 15
·期 12
·1160
·
IF 4
Liya Zheng,Yongshui Qu,Yibing Li,Yuanxin Cao,Quanyuan Wei,Ming Fang
To address the challenges of difficult recovery, significant environmental hazards associated with homogeneous catalysts, and insufficient catalytic activity of heterogeneous supports in the catalytic dehydration of fructose to produce 5-hydroxymethylfurfural (5-HMF), this study employs a straightforward nitric acid modification method to prepare an acid-activated silica gel catalyst for application in this reaction system. Through systematic investigation of the influence of modification conditions on catalyst performance and economic benefits, optimal reaction conditions were determined: DMSO as the solvent, nitric acid-modified silica gel as the catalyst, a reaction temperature of 120 °C, a solid–liquid ratio of 1:30 (g∙mL−1), and a fructose-to-catalyst mass ratio of 1:1. Under these conditions, the maximum 5-HMF yield reached 91.6%. Characterization via specific surface area, pore size analysis, and acid/base site characterization (NH3-TPD) revealed that nitric acid modification preserved the silica gel’s pore structure. Through oxidative cleaning, etching to expose silanol groups, and inducing surface defects, this process significantly increased the number of acid sites on the silica gel surface, thereby enhancing catalytic activity. This study presents a low-cost, easily recoverable, and environmentally friendly heterogeneous catalytic strategy for the efficient conversion of fructose into 5-HMF. It also provides experimental guidance for the targeted functionalization of silica-based catalytic materials, holding significant implications for advancing the high-value utilization of biomass resources.
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高影响因子
Bioresource Technology Reports
·
2022
·
IF 0
Jiali Mi,Simin Liu,Yan Du,Haishan Qi,Lei Zhang
Cadaverine (1,5-diaminopentane) has widespread applications in industry, agriculture and medicine. Cadaverine can be biotransformed from l -lysine by lysine decarboxylasey which is a pyridoxal 5′-phosphate (PLP)-dependent enzyme. Herein, barium alginate microspheres were fabricated by electro-dripping and employed as immobilized metal ion affinity chromatography matrix to purify and immobilize engineered lysine decarboxylase CadA-EK. Besides, polyethyleneimine (PEI) was employed for co-immobilizing PLP and enzymes (cCadA-EK-PEI/PLP). The cCadA-EK-PEI/PLP can produced 184.53 g/L cadaverine with yield of 90.03% in 2 mol/L lysine solution. And the stability of co-immobilized CadA-EK was 1–4 times higher than that of iCadA-EK + PLP in environmental factors, and the catalytic efficiency k cat / K m was increased by 3.4-fold. Furthermore, a continuous flow microreactor with the co-immobilized enzymes and cofactors was developed to catalyze lysine, with 14.28 g/(L·h) productivity of cadaverine, which displayed great potential for cadaverine biosynthesis. This work provides alternative strategy for the one-step purification and co-immobilization of enzyme and cofactor.
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APPLIED SURFACE SCIENCE
·
2022
·
IF 7.392
Yu-Xuan Dai,Wen-Li Xin,Lian-Hua Xu,Ji Li,Yi-Xuan Li,Junji Li,Serge Cosnier,Xue-Ji Zhang,Robert S. Marks,Dan Shan
Rational design highly active transition metal or transition metal oxides/nanocarbon hybrids is one of the feasible way to deliver a cooperative oxygen reduction (ORR) with a synergistic effect of the hybrid interface. Herein, based on benzimidazole-5-carboxylate (BIMC), CoO/Co-N-C nanocomposites are fabricated via 2-methylimidazole (2-MeIm)-tuned “4-Self” strategy, namely, self-templating, self-adapting, self-assembly and self-catalysis. As a base competitive ligand with N and C sources, 2-MeIm modulates the dispersion of BIMC in methanol to generate collodial-like BIMC tiny particles, the coordination ability of BIMC to Co(II), the composition and morphology of the self-assembled precursor (Co-BM), and as well as the conductivity of the resultant electrocatalyst. Impressing, carbonization of Co-BM at 800 °C under N 2 atmosphere endows the pyrolysis product (Co-BM-800) with the well-dispersed Co/CoO riveted on nitrogen-doped carbon, as well as the enhanced ORR performance in terms of positive onset-potential (0.890 V vs. RHE), large diffusion limiting current density (5.21 mA cm −2 ), and high stability.
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高影响因子
ChemCatChem
·
2016
·Vol. 8
·期 23
·3636-3643
·
IF 4.724
Zhenyou Gui,Wenrong Cao,Shunmugavel Saravanamurugan,Anders Riisager,Lifang Chen,Zhiwen Qi
Graphical Efficient noble alloy : Au–Pd supported on zinc hydroxycarbonate (ZOC) catalysts shows high activity for 5-hydroxymethylfurfural oxidation. The basicity of ZOC can play a crucial role in enhancing the yield of FDCA. Moreover, Au–Pd/ZOC can be recycled at least six times without significant loss of its activity. Bimetallic catalysts with Au–Pd supported on zinc hydroxycarbonate (ZOC) were synthesized by a simple deposition–precipitation method and analyzed by transmission electron microscopy to have a narrow-size distribution of predominantly 1–2 nm. The prepared Au–Pd/ZOC catalysts exhibited excellent activity towards 5-hydoxymethylfurfural (HMF) oxidation in water in the presence of the base NaHCO 3 at benign conditions of 80 °C and 3 bar O 2 , resulting in quantitative yield of 2,5-furandicarboxylic acid (FDCA). The addition of base not only enhanced the yield of FDCA but also stabilized the support ZOC by preventing ZOC from the reaction with formed carboxylic acid intermediates/products, thus allowing Au–Pd/ZOC to be recycled for at least six times without significant loss of activity. The basicity of ZOC could play an important role in obtaining the improved yield of FDCA as compared to other supports.
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高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2023
·
IF 4.2
Xuemin Cao,Kun Zhang,Yu Wang,Peng He
The carbonylation of formaldehyde offers a promising, cost-effective, and environmentally friendly method for synthesizing glycolic acid, a crucial monomer in biodegradable plastics. This study highlights the development and optimization of a bifunctional PdO/ZSM-5 zeolite catalyst for this process. Investigations via various spectroscopic techniques reveal that Pd species, predominantly in the form of PdO, enhance the CO activation, thereby boosting the formaldehyde carbonylation reaction rate significantly. The optimal catalytic performance was observed with a Pd-loading of 2 wt %. Notably, excessive Pd loading was found to impede the catalytic performance by overoccupying acid sites, thereby reducing its capacity to activate formaldehyde. The concurrent activation of formaldehyde and CO at the Brønsted acid site and the PdO site, respectively, through a Langmuir–Hinshelwood mechanism is key to the enhanced catalytic performance. These findings underscore the importance of CO activation in improving the formaldehyde carbonylation process, offering vital insights for catalyst optimization.
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高影响因子
ENERGY
·
2019
·
IF 5.537
Lin Long,Weixing Zhou,Yunfeng Qiu,Zhenzhong Lan
Endothermic hydrocarbon fuel of active thermal protection has great potential in cooling system. The bottlenecks for the practical application are the unsatisfied heat sink and severe coking issue. Here, NiO nanoparticle/nanosheet hybrid thin layers were successfully wrapped on the commercial HZSM-5 (denoted as ZSM-5@Ni M ), and showing significant modulation ability for the acidity properties of HZSM-5 to boost supercritical cracking of n-decane. The as-prepared catalysts make the NiO and HZSM-5 show synergistic effect which dramatically lowers the overall acidity of composite, thus changes the cracking path of n-decane, and results in effective anti-coking properties. ZSM-5@Ni M decelerated many additional free radicals and generated more gases products by monomolecular beta cleavage reaction. Gases products also show positively correlating with the heat sink. The catalysts improve the heat sink of n-decane from 3.77 MJ/kg at 728 °C to 4.59 MJ/kg at 780 °C. Present work demonstrates that the introduction of nanostructured metal oxides into HZSM-5 will synergistically adjust the acidity of composite, leading to the manipulation of catalytic cracking path and extent, gas products, heat sink, coking behavior of supercritical n-decane, finally providing deep insights for the design and fabrication of catalysts for hydrocarbon fuel cracking.
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