Nature Communications
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2026
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IF 18.1
Guo Xuewen,Hu Yongji,Wu Xiaoyi,Shen Yuesong
H 2 O and SO 2 poisoning of cerium-manganese oxide catalysts remains a critical challenge for low-temperature selective catalytic reduction of nitrogen oxides by NH 3 . Here we show that Ti doping of CeO 2 induces lattice contraction and structural distortion, promoting the generation of oxygen vacancies, active oxygen species, and stable Ce-O-Ti interfaces. These strain-engineered structural modifications enhances surface Lewis acidity and triggers a downshift of the d-band center, collectively improving low-temperature catalytic activity and resistance to H 2 O/SO 2 poisoning. The optimized Ce 8 MnTi 2.5 O x catalyst achieves over 90% nitrogen oxides removal across a 150–335 °C temperature range. Under 5 vol.% water and 100 ppm SO 2 , it maintains over 98% efficiency for 12 h at 210 °C. Furthermore, during stepwise heating from 150 °C to 240 °C with 5 vol.% H 2 O and 200 ppm SO 2 , initial activity suppression below 180 °C is fully reversed at or above 210 °C, demonstrating temperature-driven regeneration. This study introduces a strain-engineering strategy for designing robust catalysts for low-temperature nitrogen oxides removal.
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Scientific Reports
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2026
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IF 4.9
Qin Yong,Xu Shengqian,Ye Hailin,Wang Chaojun,Pan Wenjuan
Hepatocellular carcinoma remains a leading cause of cancer-related mortality worldwide. Although lenvatinib is widely deployed as a frontline systemic therapy for advanced disease, its clinical utility is frequently subverted by primary or adaptive non-responsiveness. Evasion of ferroptosis, an iron-dependent form of regulated cell death driven by lipid peroxidation, has emerged as a key survival mechanism for tumor cells under therapeutic stress. While the RNA-binding protein RBMS1 is known to participate in oncogenic progression and ferroptotic regulation across several malignancies, whether it modulates lenvatinib sensitivity in hepatocellular carcinoma by intersecting with the SLC7A11-dependent antioxidant pathway has not been established. Expression profiles of RBMS1 and SLC7A11 were interrogated in paired clinical tissue samples and public transcriptomic datasets. Stable lentiviral overexpression or short hairpin RNA-mediated knockdown was executed in HepG2 and Huh7 cells to modulate candidate gene abundance. Cellular phenotypes, comprising viability, clonogenicity, migration, invasion, and drug sensitivity, were mapped via cell counting kit-eight, colony formation, wound healing, and transwell migration assays. Ferroptotic kinetics and oxidative shifts were tracked by measuring intracellular reactive oxygen species and lipid peroxidation using fluorescent probes. Finally, a subcutaneous xenograft model was established to validate the synergistic potential of RBMS1 depletion with lenvatinib therapy in vivo. In clinical specimens, SLC7A11 was markedly upregulated and tied to shortened overall survival, while RBMS1 expression exhibited a strong upward trend that correlated robustly with SLC7A11 abundance in broader transcriptomic cohorts. Functionally, overexpressing RBMS1 accelerated malignant behaviors, expanded SLC7A11 protein levels, neutralized reactive oxygen species, and shielded cells from lipid peroxidation, ultimately lowering lenvatinib sensitivity. Conversely, silencing RBMS1 yielded opposite phenotypes, aggravating ferroptotic oxidative damage and amplifying lenvatinib responsiveness. Epistatic rescue experiments demonstrated that SLC7A11 knockdown completely abrogated the anti-ferroptotic defense and drug tolerance conferred by RBMS1 hyperactivation. In vivo animal models corroborated these dynamics, showing that RBMS1 knockdown significantly potentiated the antitumor efficacy of lenvatinib. These findings position RBMS1 as a novel upstream post-transcriptional regulator of SLC7A11-dependent ferroptosis susceptibility and lenvatinib responsiveness in hepatocellular carcinoma. By reinforcing the SLC7A11 antioxidant network, RBMS1 shields malignant cells from drug-induced oxidative catastrophe. Targeting this newly uncovered post-transcriptional axis represents a viable therapeutic strategy to overcome lenvatinib tolerance in advanced disease.
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Advanced Fiber Materials
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2026
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IF 22.6
Li Rui,Liao Xinyue,Liu Yige,Bae Juyeol,Wu Ronghui,LINGHU Changhong,Hong Xinghua
Electronic textiles (E-textiles) provide remarkable potential for next-generation personalized healthcare. However, the limitations in skin adhesion, underwater stability, and air permeability severely hinder their broader application, especially in dynamic and aquatic environments during sweating, showering, or underwater conditions. Here, we reported a highly skin-adhesive, underwater-stable, and breathable E-textile enabled by a graphene oxide–aqueous polyurethane (GAWPU) intermolecular network integrated with a macroscopic knitting structure. Mechanical testing on porcine skin demonstrates an exceptional shear adhesion strength (665 kPa), outperforming previously reported E-textile self-adhesive materials. Benefiting from its multi-scale architecture design, the knitted E-textile also exhibits high stretchability (> 300%) together with breathable waterproofness (466 ± 5 mm/s). The intrinsic water resistance and strong adhesiveness of the GAWPU network allow the E-textile to adhere firmly to biological tissues in wet environments, even for under-water scenarios. As a proof of concept, the E-textile is successfully used as a water-resistant electrode sensor for monitoring diverse human electrophysiological signals, such as surface electromyography (sEMG) and electrocardiography (ECG). Moreover, GAWPU's extraordinary biocompatibility and antibacterial properties enable prolonged skin contact without irritation. This E-textile forms a unified platform integrating tissue adhesion, environmental stability, and biosensing, paving the way for deploying textile-based electronics in real-world biomedical and interactive applications.
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POLYMER BULLETIN
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2026
·Vol. 83
·期 11
·593
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IF 4.2
Tang Zhong-Xiang,Wu Bin,Shi Ying-Jia,Jin Meng,Yu Tian,Ren Hui,Ma Ning,Zhan Xue-Qing,Tsai Fang-Chang
Efficient wound management remains a critical challenge in clinical medicine and public health. Hydrogel-based wound dressings have garnered significant attention due to exceptional moisture retention and inherent cooling analgesia effects. This study develops an electrically triggered PVA/Cu-BTC@Aloe composite hydrogel for advanced wound healing. By incorporating Cu-BTC@Aloe nanocomposites (synthesized via Aloe adsorption onto Cu-BTC followed by freeze-thaw crosslinking with polyvinyl alcohol), the material achieves enhanced mechanical properties (tensile strength: 438.9 ± 42.7 kPa, + 47% vs. pure PVA) and dual functional capabilities. Under 3 V electrical stimulation, the cumulative release of Aloe at 3 h increased from 47% to 62%. Meanwhile, the hydrogel achieved antibacterial efficiencies of 97.8 ± 2.2% against Staphylococcus aureus and 99.9 ± 0.1% against Escherichia coli, while maintaining favorable cytocompatibility and promoting directional cell migration toward the anode of fibroblasts. The integration of electroresponsive materials, natural bioactive constituents, and electrical stimulation provides a promising multifunctional platform for electrically assisted wound management.
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BIOPROCESS AND BIOSYSTEMS ENGINEERING
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2026
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IF 4.3
Shen Ji-Dong,Zhang Meng,Li Meng-Yang,Dong Yu-Qi,Liu Zhi-Qiang,Zheng Yu-Guo
Omega-3 polyunsaturated fatty acids (n-3 PUFAs) offer therapeutic benefits, including triglyceride reduction and management of cardiovascular and neurological disorders. This study investigates the use of fish oil processing by‑products, which consist mainly of fatty acid methyl and ethyl esters, as novel substrates for n‑3 PUFAs production. To overcome the low efficiency of conventional chemical methods and the vulnerability of free lipase to alcohol toxicity and poor reusability, we developed a stable immobilized lipase system. The target enzyme (CALB) was immobilized onto macroporous resin LXTE‑1000 via adsorption‑crosslinking, and optimal hydrolysis conditions were determined. The resulting immobilized enzyme (LXTE‑1000@CALB) showed markedly enhanced thermal and operational stability, retaining approximately 64.21% of its initial hydrolysis degree over ten consecutive batches. This work provides an efficient, green, and sustainable approach for valorizing fish oil by‑products and producing n‑3 PUFAs. Graphical abstract
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JOURNAL OF NANOBIOTECHNOLOGY
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2026
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IF 15
Huang Sijia,Yang Menglan,Ding Chen,Du Wenfang,Yang Shengyuan,Xi Qiang,Xiao Fubing
Bacterial-infected wounds present a critical clinical challenge due to persistent inflammation, impaired angiogenesis, and the lack of real-time treatment monitoring. To address these issues, we developed an innovative colloidal crystal hydrogel microneedle (CT MNs) patch based on CuS nanoparticles (CuS NPs) and tannic acid-berberine nanoparticles (TB NPs). This system integrates synergistic antibacterial/antioxidant therapy with structural color-based drug release self-reporting capability. Specifically, the CT MNs combine photothermal CuS NPs for near‑infrared (NIR)-triggered hyperthermia and temperature‑controlled drug release, the release of TB NPs for potent antibacterial/antioxidant activities, and the color changes of the inverse opal colloidal crystal for real‑time monitoring of drug release. In vitro assays demonstrated strong antibacterial effects (95.65% and 95.92% against E. coli and S. aureus , respectively) and outstanding ROS‑scavenging capacity (92.93% for DPPH and 97.36% for ABTS⁺). In infected rat models, the CT MNs + NIR group achieved rapid wound closure (94.41% by day 10), significantly outperforming the controls. This accelerated healing was attributed to the synergistic effects of photothermal ablation, TB NPs-mediated bacterial clearance, and ROS-scavenging-driven inflammation alleviation. Therefore, this work presents a theranostic dressing that merges targeted combination therapy with non‑invasive optical monitoring of drug release, offering a promising strategy for intelligent wound management. Graphical
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JOURNAL OF NANOBIOTECHNOLOGY
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2026
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IF 15
Wenya Li,Xiyao Zhang,Ying Huang,Yangyang Guo,Hao Zhang,Weiying Ge,Yuxin Xie,Yiming Li,Zhen Zhou,Wenjie Ni,Zhe Zheng,Jianmin Li,Yang Zhao
Background: Prostate cancer (PCa) is characterized by a unique metabolic dependency on the hyperactivated tricarboxylic acid (TCA) cycle, creating a distinct vulnerability to cuproptosis-a copper-dependent form of regulated cell death. However, metabolic plasticity allows tumor cells to evade single-pathway inhibition through compensatory glycolysis, limiting the efficacy of copper-based therapies. Therefore, there is an urgent need to develop integrated nanoplatforms capable of orchestrating a dual-pathway metabolic blockade to overcome this therapeutic resistance. Results: Herein, we engineered a self-assembling copper-epigallocatechin gallate (EGCG) nanoreactor (Cu-EQ NP) designed to execute a synchronized dual-metabolic assault. The Cu-EQ NPs leverage the tumor microenvironment to release copper ions that trigger TCA-dependent cuproptosis, while the EGCG component simultaneously inhibits key glycolytic enzymes to prevent metabolic escape. Mechanistically, this lethality is self-amplified by EGCG-quinone-mediated depletion of glutathione (GSH) and the downregulation of the ATPase copper-transporting beta (ATP7B) efflux pump, leading to irreversible intracellular copper accumulation. Furthermore, we demonstrate that this metabolic collapse is highly immunogenic. In a syngeneic RM-1 mouse model, Cu-EQ NP-induced immunogenic cell death (ICD) released damage-associated molecular patterns (DAMPs) that successfully transformed the immunologically "cold" tumor microenvironment. This remodeling was characterized by enhanced dendritic cell maturation, M2-to-M1 macrophage repolarization, and robust infiltration of cytotoxic CD8 + T cells, resulting in potent tumor regression. Conclusions: The Cu-EQ nanoreactor represents a precision nanomedicine strategy that converts the specific metabolic vulnerabilities of PCa into a fatal weakness. By integrating dual-metabolic disruption with robust immune activation, this platform offers a promising therapeutic paradigm for overcoming resistance in advanced prostate cancer.
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BMC MICROBIOLOGY
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2026
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IF 5.4
Yuan Junjie,Wang Jing,Wang Hui,He Zhenzhen,Chen Zhongju,Hu Yating,Zhou Xuan,Yan Shaozhen,Wei Lijie,He Mengzhou,Jiang Yi,Su Rui,Yu Huihui,Wang Shaoshuai,Tan Weidong,Ding Wencheng,Feng Ling,Wang Zerui
Background Members of the genus Corynebacterium are widely distributed across human mucosal surfaces and are increasingly recognized as important components of the female reproductive tract microbiota. However, their diversity is underestimated due to limitations of conventional cultivation approaches. Results In this study, a novel bacterial strain, designated TJG_1 T , was isolated from vaginal swab samples of a pregnant woman with preeclampsia (PE) using droplet-based microfluidic single-cell cultivation. Strain TJG_1 T was characterized as a Gram-positive, non-spore-forming, non-motile short rod. Phylogenetic analysis based on the 16 S rRNA gene sequence placed the strain within the genus Corynebacterium , with the highest sequence similarity to Corynebacterium coyleae (97.39%). Whole-genome sequencing revealed a genome size of 2,481,283 bp with a G + C content of 61.52 mol%. Average nucleotide identity (ANI) and digital DNA–DNA hybridization (dDDH) values between strain TJG_1 T and its closest relatives were below the accepted species thresholds, supporting its classification as a novel species. Functional genome annotation identified genes associated with metabolism, transport systems, putative antimicrobial resistance, and predicted host interaction-related traits. In vitro assays showed that neither bacterial metabolites nor live cells significantly affected trophoblast cell viability or oxidative stress-related gene expression under the tested conditions. Although alterations in cell migration behavior were observed following exposure to live bacteria, these changes were not accompanied by significant differences in migration-related gene expression. Conclusions Strain TJG_1 T represents a novel species within the genus Corynebacterium . This study highlights the utility of droplet-based cultivation for recovering previously underrepresented vaginal bacteria and expands current knowledge of Corynebacterium diversity in the female reproductive tract.
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Science China-Chemistry
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2026
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IF 9.8
Xu Lei,Dong Runmin,Mu Xijiao,Cao Jing,Tang Yu
Photocatalytic water splitting offers a sustainable pathway for hydrogen production. Lanthanide (Ln), with unique 4f electron configurations and strong spin-orbit coupling, exhibits superior catalytic properties. However, their practical deployment is hindered by severe aggregation due to weak meta-ligand interactions and thermodynamic instability. Herein, we report a dual-stabilization strategy combining interlayer confinement and robust Ln–O coordination within a coordination-driven self-assembly framework. This approach enables uniform dispersion of Ln atoms in layered self-assembled carbon nitride (S-CN), effectively suppressing aggregation and enhancing atomic stability. The Sm@S-CN catalyst exhibits an eightfold enhancement in hydrogen evolution activity relative to its undoped counterparts and demonstrates remarkable stability over a duration of 100 h. Additional π - π stacking with conjugated porphyrin molecules broadens light absorption and facilitates charge transfer, achieving a high hydrogen evolution rate of 200.5 mmol g −1 h −1 . This scalable strategy provides a universal platform for stabilizing the Ln single-atom charge modulation center and offers promising prospects for solar-driven hydrogen production.
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International Journal of Minerals Metallurgy and Materials
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2026
·Vol. 33
·期 5
·1574-1584
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IF 8.8
Liu Ting,Xu Hao,Liu Shuai,Cai Shixia,Wang Weimin,Song Kaikai,Hu Lina,Sui Kunyan
Lithium metal batteries have been widely used in energy storage applications owing to their high theoretical energy density. However, the unstable solid electrolyte interphase (SEI) in the batteries lead to the formation of lithium dendrites and “dead lithium”, thus affecting the safety and cycle life of the battery. To address this issue, an artificial SEI was prepared using a polymer coating strategy. The introduction of succinonitrile (SN) accelerates ion transport by promoting the dissociation of lithium salts. The solid electrolyte Li 6.5 La 3 Zr 1.5 Ta 0.5 O 12 (LLZTO) enhances the mechanical strength of artificial SEIs and promotes ion conduction. Furthermore, the competitive coordination between LLZTO and SN inhibits lithium anode corrosion, forming SEI rich in LiF and Li 3 N. Therefore, the lithium metal anode modified with an artificial SEI can be stably plated/stripped for more than 10000 h. The LiFePO 4 full cell assembled with the modified anode exhibited a discharge specific capacity of 133 mAh·g −1 and a capacity retention of 97% after 1000 cycles at 2 C (1 C = 170 mA·g −1 ). Notably, the anode modified with the artificial SEI exhibited excellent electrochemical performance even at low temperatures.
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RHEOLOGICA ACTA
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2026
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IF 2.7
Jiang Qin,Li Zhixin,Sun Peiyu,Yang Ruizhu,Xu Zhicheng,Zhang Lei,Zhang Lu
To clarify the influence of molecular structure on interfacial behaviors of extended surfactants, interfacial rheological properties of three extended surfactants with different ionic heads (C 8 P 10 E 5 C and C 8 P 10 E 5 S) and different hydrophobic tails (C 8 P 10 E 5 C and phP 10 E 5 C) were investigated by the droplet analysis method. The effects of adsorption time, interfacial pressure, oscillating frequency, and concentration on the dilational modulus and phase angle of C 8 P 10 E 5 C, C 8 P 10 E 5 S, and phP 10 E 5 C were determined. Results indicate that interfacial films of these three extended surfactants exhibit predominantly elastic behavior. The modulus and phase angle of C 8 P 10 E 5 C and C 8 P 10 E 5 S with different ionic heads exhibit little variation at variable experimental conditions, indicating that different ionic heads have a negligible effect on interfacial film properties. At low interfacial pressures, the adsorption layer is in a local thermodynamic quasi-equilibrium state with negligible intrinsic relaxation processes. At high interfacial pressures, the diffusion exchange process may play a more important role in the interfacial film of C 8 P 10 E 5 C. Compared to C 8 P 10 E 5 C, phP 10 E 5 C with a different hydrophobic group maintains a higher dilational modulus over a wider concentration range due to its rigid phenyl groups. Compared to ionic heads, hydrophobic tails exert a more pronounced influence on the interfacial rheological behavior of extended surfactants. These findings are expected to contribute to the rational design of extended surfactants with a short hydrophobic group.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
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2026
·Vol. 37
·期 14
·1112
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IF 3.2
Wei Zehao,Liu Jing,Wang Xihe,Li Jun
Electrochromic materials undergo reversible color changes through redox reactions involving the insertion and extraction of electrons and ions under an applied electric field. In this study, we systematically investigate the photo-assisted electrochromic behavior of Bi 2 O 2 Se nanosheets, which exhibit a color transition from gray to yellow under light modulation. Bi 2 O 2 Se nanosheets were successfully synthesized via a hydrothermal method and characterized in a three-electrode system using photoelectrochemical measurements. During the tests, an external bias of 0.6 V was applied while the samples were illuminated with monochromatic light in the wavelength range of 400–650 nm. The results show that illumination across this wavelength range can promote the coloration process.Upon further reducing the applied voltage, it is found that shorter-wavelength light effectively lowers the threshold voltage for electrochromic switching, exhibiting a nonlinear increase in threshold voltage with increasing incident wavelength. Compared with white-light illumination, the coloration process under monochromatic light is slower and mainly results in partial coloration. The colored samples were subsequently discharged at 0 V, during which the electrode color gradually recovered, and the photocurrent returned to approximately 0.42 µA cm⁻ 2 , close to its initial value. These results indicate that the system exhibits a certain degree of reversibility in both electrochromic behavior and electrochemical function.Overall, the findings demonstrate that photon energy can modulate the threshold voltage and kinetics of electrochromic processes in Bi 2 O 2 Se nanosheets, providing new experimental insights and potential applications for photo-responsive electrochromic devices.
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