JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
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2024
·
IF 4.5
Guohao Mu,Fang Peng,Ziyin Zhang,John M. Brameld,Peter Rose,Xiaogang Yang,Zhi-jiang Jiang,Xi He,Bencan Tang
This study designed and developed a novel three-layer electrostatic, slow-releasing nanoparticle drug delivery system for the treatment of ulcerative colitis. The nanoparticles were composed of layers of zein-based polydopamine, chitosan and cellulose acetate phthalate to form a polyelectrolyte multilayer core−shell nanoparticle structure. The anti-inflammatory natural product magnolol was chosen to be the model drug for the study. The nanoparticles (260.50 ± 23.90 nm) were prepared with layer-by-layer coating and then assessed in vitro and in vivo using a mouse model of ulcerative colitis. The in vitro data confirmed the slow-releasing and pH-dependent characteristics of particles. Quantitative analysis of the in vivo distribution of Mag in mice showed significantly higher concentrations in colonic tissue than in the upper gastrointestinal tract (854.6 ng/g vs 291.5–351.1 ng/g, respectively). Histological and pro-inflammatory cytokine analysis indicated that the nanoparticles had a significant anti-inflammatory effect and were protective against DSS-induced structural damage of the colonic mucosal structure. These results confirm that this nano-delivery system could increase the levels of Mag reaching the colon, resulting in greater efficacy than free Mag in treating UC in this mouse model.
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Sustainable Energy & Fuels
·
2024
·
IF 5
Fuqiang Zhang,Zhiqiang Qi,Xiangsheng Han,Hongzhen Cai,Keyan Yang
Interfacial solar steam generation (ISSG) is an effective method to produce clean water through evaporating seawater actuated by solar energy. Nevertheless, developing a solar evaporator that is simultaneously simple in process and maintains good stability and high efficiency is still difficult but in great demand. Herein, an aerogel solar evaporator was prepared by cross-linking chitosan (CS) and two-dimensional transition metal carbide/nitride (MXene) nanosheets with excellent properties via a simple freeze-drying strategy. The unique three-dimensional network structure and good biocompatibility could facilitate quick transport of water from the bottom up to the evaporation surface by capillary force. MXene nanosheets combined a broad spectral response with strong solar absorption capacity, enabling the CS/MXene aerogel solar evaporator to exhibit strong light absorption, light-to-heat conversion, and water transport capabilities. The results showed that the water evaporation rate under one sun was as high as 1.80 kg m−2 h−1, with an energy conversion efficiency of 75.2%. Notably, the stability of the solar evaporator ensured stable solar water evaporation over a long period compared with most CS-based solar evaporators. Meanwhile, clean water could be continuously produced from acidic, alkaline and organic dye solutions, and saline brines. These tactics pave a new way for developing solar absorbers for solar-driven desalination.
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CARBOHYDRATE POLYMERS
·
2019
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IF 6.044
Hang Xue,Liangcong Hu,Yuan Xiong,Xiangwei Zhu,Congying Wei,Faqi Cao,Wu Zhou,Yun Sun,Yori Endo,Mengfei Liu,Yi Liu,Jing Liu,Abudula Abududilibaier,Lang Chen,Chenchen Yan,Bobin Mi,Guohui Liu
Hydrogels could be promising wound healing dressings that maintain a moist environment in the wound site and accelerate wound healing. However, the lack of antibacterial effect, suitable mechanical property and adhesiveness limits their applications. Here, we designed a quaternized chitosan-Matrigel-polyacrylamide (QCS-M-PAM) hydrogel with multi-functions. The morphology, swelling ratio, mechanical test, antimicrobial property, hemostatic performance and biocompatibility of the hybrid hydrogel were investigated in vitro and vivo. The hybrid hydrogel showed a three-dimensional (3D) microporous structure, high swelling ratio, excellent stretchable and compressive property, similar modulus to human skin, good adhesiveness, and low cytotoxicity. The results of histology and molecular testing in vivo demonstrated that the hybrid hydrogel could significantly enhance wound healing, collagen deposition, and induce skin adnexal regeneration by upregulating anti-inflammatory factors, and downregulating proinflammatory factors. Together, the present antibacterial hydrogels with hemostatic and adhesive properties are considered to have promising potential used as wound dressings for full-thickness skin defect.
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CARBOHYDRATE POLYMERS
·
2020
·
IF 7.182
Yangmei Ren,Lanmei Huang,Yuelong Wang,Lan Mei,Rangrang Fan,Min He,Chao Wang,Aiping Tong,Haifeng Chen,Gang Guo
Skin damage, especially the extensive full-thickness wound, is seriously affecting people’s daily life and health. Meanwhile, wound healing is always challenged by bacterial infection. In this study, for the purpose of developing a disinfectant wound dressing, we designed a novel multi-functional nanofiber mats via electrospinning combining chitosan derivations and stereocomplex crystallite (SC). The SC membrane of poly (lactic acid)/chitosan derivatives were prepared via warming at 80 °C for 1 h. The thermal and mechanical properties of the heated mats were strengthened owing to the formation of SC, which restricted the lactide chains mobility. I n vivo wound healing test revealed that the SC mats have better wound repair ability than the control group with a wound healing rate of 100 % within 15 days. In a word, the biomass-based mats with enhanced thermal and mechanical properties, antibacterial effect and antioxidant activity, providing a potential multi-functional platform for designing of disinfectant wound dressings.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Shuhan Liu,Jianing Wang,Xin Wang,Lintongqing Tan,Tao Liu,Yudie Wang,Yihan Shi,Zhuoran Zhang,Sheng Ding,Kexin Hou,Wen Zhang,Fan Li,Xin Meng
Timely healing of acute wounds and stopping wound chronicity are current and future priorities in wound therapy. It is urgent and relevant to develop a wound dressing that has antimicrobial and monitors the wound microenvironment in real time. In this study, quaternary ammonium chitosan (HTCC) was selected as the antimicrobial agent and CS/PEO/HTCC nanofiber membranes (CPHs) were prepared by electrostatic spinning technique. The nanofiber membrane (CPH91) with the best antimicrobial performance was screened by the disk diffusion method and drug susceptibility testing by dilution method, and its antimicrobial effect on S. aureus was better than that of E. coli . Subsequently, functional carbon dots (CDs) were synthesized by solvothermal method and doped into CPH91 nanofibers by electrospinning. A good linear relationship between pH value (5.0–8.0) and the fluorescence intensity of CDs was observed. In addition, the nanofibers (CPH91@CDs) had good morphology, hydrophilicity, and biocompatibility. Changes in fluorescence intensity of CPH91@CDs at different pH (5.0–8.0) were monitored and converted into RGB values that were linearly fitted to pH value. Finally, the potential of CPH91@CDs of improving wound healing and instantaneously controlling wound healing process was confirmed by an infected wound model ( S. aureus ) on the back of SD rats.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Ke Jian,Liming Fu,Yujie Zhang,Hongmei Zhang,Xiangjun Guo,Xihui Zhao
Yellow fluorescent carbon dots (Y-CDs) were prepared via microwave method using chitosan and o -phenylenediamine as the main raw materials. The obtained Y-CDs possesses good water solubility, excellent biocompatibility and luminous stability. During the microwave pyrolysis carbonization process, the surface of Y-CDs was modified with the functional groups such as amino and carboxyl, which can bind to Al 3+ by forming complexes, further improving the selectivity and sensitivity of the Al 3+ detection. And the fluorescence of Y-CDs was quenched by Al 3+ by static quenching process. More importantly, Y-CDs as fluorescent sensor was further applied for the determination of Al 3+ in the real water samples with high reliability and accuracy. In addition, Y-CDs present potential application in biological imaging. The cultivated zebrafish embryos with Y-CDs displayed clearly in vivo uptake and metabolic fluorescence images, further confirming its low toxicity and excellent biocompatibility.
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JOURNAL OF POLYMER RESEARCH
·
2025
·Vol. 32
·期 3
·1-12
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IF 2.8
Liu Qingshan,Ji Lei,Lin Wenjing,Sun Yingjuan,Lin Xiaofeng,Xie Yanqing,Xie Jinting,Yi Guobin
Superabsorbent polymers (SAPs) with improved absorbency under mechanical load (AUL) and enhanced antimicrobial properties in hygiene applications are still challenging. In this study, chitosan was modified to prepare quaternized carboxymethyl chitosan (QCMC) to improve water solubility and antimicrobial properties and then used it as backbone to obtain a novel type of superabsorbent polymers (P(AA-AMPS/QCMC)) by introducing acrylic acid (AA) and 2-acryloylamino-2-methylpropanesulfonic acid (AMPS) monomers through grafted copolymerization. FT-IR, XRD, SEM, and TG were used to analyze and characterize the structure of samples. Different factors influencing the absorption capacity, such as neutralization degree, monomer concentration, and crosslinker content, were optimized. Conventional SAPs exhibited low AUL and slow absorption rates due to gel blockage. To overcome these limitations, surface crosslinking was applied to improve both AUL and absorption rates. The SAPs showed absorption capacities of 634 g/g in deionized water and 78.8 g/g in 0.9 wt.% NaCl solution, and reached swelling equilibrium within 30 min. With only a 3% QCMC dosage, the inhibition rates against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) were 88.9% and 87.7%, respectively. Exploratory biodegradability tests indicated that these polymers possess degradable properties. This study demonstrates the potential applications of these polymers in hygiene.
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MOLECULES
·
2025
·Vol. 30
·期 6
·1334
·
IF 4.6
Yina He,Xiaojun Zhang,Zhan Zhang,Bing Lin,Haitao Yu
Using chitosan and polyvinyl alcohol (PVA) as substrates, active packaging composite (VPC) films based on vanillin-crosslinked PVA/chitosan with different concentrations of added vanillin were prepared and characterized. The results show that the VPC films exhibited higher tightness and hydrophobicity, lower water content and water vapor permeability, as well as better UV resistance. The potential interactions between the film groups were analyzed by SEM, FTIR, and XRD, and the results showed that the formation of Schiff base and hydrogen bond interactions affected the properties of the films. The VPC films also showed excellent antioxidant activity. Therefore, vanillin-crosslinked PVA/chitosan active films have broader application prospects as packaging materials for food preservation.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Kun Lin,Yu-zhang Zhu,Hua-wei Ma,Jincheng Wu,Chao-nan Kong,Yang Xiao,Hong-cun Liu,Li-lan Zhao,Xiao-lin Qin,Li-fang Yang
In this study, an active film composed of gallic acid (GA), chitosan (CS), and cellulose nanocrystals (CNC) was prepared using a solution casting method and synergistic photodynamic inactivation (PDI) technology. Characterization of the film showed that the CS-CNC-GA composite film had high transparency and UV-blocking ability. The addition of GA (0.2 %–1.0 %) significantly enhanced the mechanical properties, water resistance, and thermal stability of the film. The tensile strength increased up to 46.30 MPa, and the lowest water vapor permeability was 1.16 × e −12 g/(cm·s·Pa). The PDI-treated CS-CNC-GA1.0 composite film exhibited significantly enhanced antibacterial activity, with inhibition zone diameters of 31.83 mm against Staphylococcus aureus and 21.82 mm against Escherichia coli. The CS-CNC-GA composite film also showed good antioxidant activity. Additionally, the CS-CNC-GA 1.0 composite film generated a large amount of singlet oxygen under UV-C light irradiation. It was found that using the CS-CNC-GA 1.0 composite film for packaging and storage of oysters at 4 °C effectively delayed the increase in pH, total colony count, and lipid oxidation in oysters. In conclusion, the CS-CNC-GA composite film based on PDI technology has great potential for applications in the preservation of aquatic products.
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CARBOHYDRATE POLYMERS
·
2025
·
IF 12.5
Luning He,Shuyi Xing,Weikang Zhang,Ying Wang,Yian Li,Jinghao Chen,Jinghai Zhang,Siling Wang,Qinfu Zhao
Traditional wound care methods are less effective for infectious and diabetic wounds, highlighting an urgent need for effective strategies. The study aimed to design a self-healing hydrogel with antibacterial, antioxidant, and photothermal capabilities to treat infectious and diabetic wounds. Silver nanoparticles (AgNPs) were loaded into mesoporous polydopamine (MPDA) nanoparticles to form Ag@MPDA nanoparticles. Ag@MPDA was incorporated into the cationic guar gum-chitosan-boric acid (CCB) hydrogel to obtain the PA-CCB hydrogel. PA-CCB hydrogel exhibited excellent self-healing and adhesive properties, adapting well to the dynamic wound environment. PA-CCB hydrogel combined with photothermal therapy (PTT) could effectively eradicated E. coli (99.9 %) and S. aureus (99.7 %). The PA-CCB hydrogel reduced excessive reactive oxygen species and promoted the migration of fibroblasts in vitro. In the infected mouse wound models, the PA-CCB hydrogel effectively inhibited bacteria. After combining with PTT, the antibacterial ability of the PA-CCB hydrogel was further enhanced. In the diabetic mouse wound models, the PA-CCB hydrogel reduced the inflammatory level of wound tissue. In both models, after combining with PTT, the PA-CCB hydrogel exhibited further improvements in angiogenesis, collagen deposition, and re-epithelialization. By integrating multifunctional hydrogel with PTT, the PA-CCB hydrogel exhibited broad application potential for infectious and diabetic wounds.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Ting Liang,Cuntao Lu,Maofang Zhao,Xiaoying Cao,Jingwen Hao,Xinyue Zhang,Hailan Fu,Qinghe Cao,Ludan Li,Jihong Jiang
Wound infections are a growing public health issue, worsened by drug-resistant strains. Quercetin (Que) has shown anti-inflammatory, antioxidant, and antimicrobial properties, but its limited bioavailability hinders therapeutic use. This study introduces a multifunctional self-assembly nanoplatform, QHCNPs, encapsulating quercetin with hordein/chitosan to enhance stability and bioavailability. Transmission electron microscopy and particle size analysis revealed that QHCNPs are spherical structures with a diameter of 435.5 ± 2.9 nm and a Zeta potential of +11.0 mV. QHCNPs demonstrated excellent stability, low cytotoxicity, and MIC values of 512 ppm against Staphylococcus aureus ( S. aureus ) and 256 ppm against methicillin-resistant Staphylococcus aureus (MRSA) . In a bacterial wound model, QHCNPs outperformed quercetin alone by accelerating wound healing, eliminating bacteria, reducing inflammatory markers, scavenging reactive oxygen species (ROS), and promoting collagen and blood vessel regeneration. These results establish QHCNPs as a promising non-antibiotic therapy for treating drug-resistant wound infections, supporting further exploration for clinical applications.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Bingbing Xu,Yue Zhang,Jia Li,Boxiang Wang,Ruoxin Li,Dehong Cheng,Guangtao Chang
Conductive hydrogels have attracted intensive attention for their promising applications in flexible electronics, sensors, and electronic skins. However, extremely poor adaptability under cold or dry environmental conditions along with inferior repairability seriously hinders the development of hydrogels in wearable electronics. Here, a triple network conductive hydrogel (PBCP A -MXene) was prepared by proportionally mixing polyvinyl alcohol (PVA), borax, chitosan (CS), phytic acid (PA), and MXene. The prepared triple network hydrogels composed of robust chitosan polysaccharide as the first network, tough PVA biopolymer gel as the second network, and MXene nanosheets as the third network. Facilitated by triple networks, multiple hydrogen bonds, and electrostatic interactions of CS and PA, the obtained hydrogels not only exhibited outstanding mechanical properties (tensile strain of ∼1580 %, stress of ∼280 kPa) and electrical properties (∼ 2.72 S/m), but also possessed excellent self-healing, self-adhesion, anti-freezing and anti-drying properties. This work presents a strategy for the development of biopolysaccharide hydrogels for applications in the field of sensors.
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