JOURNAL OF CHROMATOGRAPHY A
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2019
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IF 3.858
Fenqi Ji,Rongrong Jin,Chen Luo,Chunhui Deng,Yaoming Hu,Li Wang,Rongchang Wang,Jiabin Zhang,Guoxin Song
In this paper, a novel core–shell structure magnetic microsphere Fe 3 O 4 @SiO 2 -TPM@StVp(Fe 3 O 4 @SiO 2 -3-(trimethoxysilyl)propyl methacrylate@styrene and n -vinylpyrrolidone) was successfully synthesized and used as a magnetic solid-phase extraction adsorbent for extraction of aristolochic acid I (AAI) in traditional Chinese medicine soup. The prepared Fe 3 O 4 @SiO 2 -TPM@StVp was characterized by transmission electron microscopy (TEM), scanning electron microscopy (SEM), vibrating sample magnetometer (VSM) and Fourier-transform infrared spectroscopy (FT-IR). The microspheres have various advantages of excellent hydrophilicity and π-electron system, which is very suitable for determining target analytes followed by high performance liquid chromatography (HPLC). The main factors, including the pH of samples, amount of adsorbent, adsorption time, elution solvent and desorption time, were optimized. Under optimal conditions, the proposed method showed a wide linear range of 0.4–10 µg/mL and a good correlation coefficient ( R 2 = 0.9918). The pretreatment procedure was achieved within 10 min. The recoveries of aristolochic acid I in real samples range from 80.9% to 89.6% with relative standard deviations less than 4.9%, highlighting the accuracy of this method.
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Small
·
2025
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IF 12.1
Yaoqiu Zheng,Yin Li,Xue Bai,Muzhou Teng,Yiwen Tang,Shuo Zhao,Zihang Ma,Hongbo Liang,Yili Xie,Qing Wan
“Molecular science” has long been regarded as the golden rule to guide the design of organic materials’ performances in the past many years, but some interesting phenomena of conventional aggregation-caused fluorescence quenching and new aggregation-induced emission reflect that materials’ properties would be changed from “molecule” to “aggregate”. Therefore, “molecular science” theory faces certain limitations to guide regulating the performance of materials at aggregation. In this work, it is discovered that the photosensitizer's performances contain fluorescence and reactive oxygen species, which could be affected by changing molecular atoms and aggregation form. The introduction of oxygen and selenium atoms could redshift fluorescence and improve reactive oxygen species (ROS) efficiency. In addition to the atomic effect, the ROS efficiency of photosensitizers could be affected after coating a polymeric shell, that is, the production of type II ROS singlet oxygen ( 1 O 2 ) is suppressed, while the type I ROS of superoxide anion (O 2 −• ) is improved. This work discovers that the fluorescence and ROS efficiency of photosensitizers are relevant to the atomic effect and polymeric aggregation effect, and discussing deeply the influence mechanism, which has important research significance for modulating precisely the performances of photosensitizers and promoting the development of type I photodynamic therapy.
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ANALYST
·
2016
·Vol. 141
·期 8
·2508-2514
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IF 4.033
Meina Wang,Baozhan Zheng,Feng Yang,Juan Du,Yong Guo,Jianyuan Dai,Lei Yan,Dan Xiao
“Amphiphilic” carbon dots (A-CDs) with a strong green fluorescence emission were synthesized by a simple and green method at room temperature. The characterization demonstrated that the synthesized A-CDs have both hydrophilic and hydrophobic properties and could be dispersed well in aqueous and organic solutions. As a fluorescent probe, the fluorescence of A-CDs could be obviously quenched in the presence of iodine (I2) and the quenching rate is proportional to the concentration of I2. Therefore, the A-CDs could be used as fluorophores for the detection of I2 with higher selectivity and sensitivity, and the linear working range for the I2 sensor is 80 nM–10 μM with a detection limit of 3.5 nM (S/N = 3). More interesting is that IO3− and I− could be transformed to I2 with different sample treatment processes, therefore, the I2 sensor based on A-CDs could also be used for the analysis of iodine species (I2, I− and IO3−) in samples. The possible mechanism has also been discussed in this work, and the high selectivity response to I2 can be attributed to the amphiphilic properties of A-CDs, which bring I2 closer to A-CDs and quench their fluorescence. The proposed I2 sensor has been successfully used for the analysis of iodine species in highly saline water, and the satisfactory results of detection and analysis of iodine species in samples demonstrate that the developed I2 sensor based on A-CDs has potential application in the fields of environment and clinical medicine.
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ELECTROCHIMICA ACTA
·
2015
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IF 4.504
Junhua Li,Haibo Feng,Jun Li,Yonglan Feng,Yaqian Zhang,Jianbo Jiang,Dong Qian
In this paper, we are presenting a facile, green and in situ synthesis strategy for the convenient preparation of well-dispersed gold nanoparticles (AuNPs)-decorated reduced graphene oxide (RGO) without the use of any template molecules and poisonous reductant. The as-synthesized nanocomposite has been detailedly characterized by scanning electron microscopy, transmission electron microscopy, energy dispersive X-ray spectroscopy, X-ray powder diffraction, X-ray photoelectron spectroscopy, thermogravimetric analysis as well as electrochemical technologies. The morphological and structural characterizations illustrate that AuNPs can be efficiently decorated on RGO with the Au content of 20.33 wt% in the matrix and the size of the embedded AuNPs vary between 25 and 40 nm. The electrochemical investigations confirm that the small-sized AuNPs on the RGO film can remarkably boost the electrocatalytic activity for the oxidation of Sudan I, which can be used as an enhanced electrochemical sensing platform for the sensitively detection of the toxicant Sudan I. Moreover, the kinetic parameter studies demonstrate that the Sudan I electro-oxidation at the AuNPs/RGO electrode is a diffusion-controlled process which involves two-electron and two-proton transfer. Under the optimal conditions, a wide linear range of Sudan I detection from 0.01 to 70 μmol L −1 with good linearity ( R 2 = 0.9965, 0.9942) and a low detection limit (1.0 nmol L −1 , S/N = 3) were obtained. In comparison with the existing analogues ever reported, the AuNPs/RGO eletrode exhibits overwhelmingly superior comprehensive properties for the sensitive detection of Sudan I. Finally, the newly developed sensor was applied to quantitative determination of Sudan I in food samples such as chilli powder and ketchup sauce with satisfactory sensitivity, selectivity and reversibility.
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Food Chemistry-X
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2024
·
IF 6.5
Haotian Xu,Zeyu Wang,Zhenyang Qin,Minwei Zhang,Yanan Qin
This study investigates the variation of physicochemical, flavonoids, and volatiles during sequential fermentation which Metschnikowia pulcherrima and Issatchenkia terricola as sequential co-fermenters and a single fermentation by Saccharomyces cerevisiae in mulberry wine. Sequential fermentation shown that β-glucosidase activity greater and fermentation time declined to 144 h. In addition, 11 flavonoids (apigenin-5-O-glucoside, aromadendrin-7-O-glucoside, kaempferol-3,7-O-diglucoside, and so on) were significantly increased. Significant differences were found between types of metabolic products enriched in flavone and flavonol biosynthesis and anthocyanins biosynthesis, with an enrichment ratio of 46.15 % and 23.08 %, respectively. 16 apple-scented compounds (2-Buten-1-one, (E)-1-(2,6,6-trimethyl-1,3-cyclohexadien-1-yl)-, Butanoic acid, (Z)-3-hexenyl ester, 3-methyl-1-methylethyl-Butanoic acid ester, and so on), 5 rose-scented (e.g. benzyl alcohol, ethyl geranate, hydrocinnamic acid), and 4 balsamic-scented compounds ((−)-myrtenol, benzoic acid 1-methylethyl ester, benzyl alcohol, p-cymen-7-ol) were distinctively present. Interestingly, tryptophan metabolism and indole alkaloid biosynthesis are only enriched in sequential fermentation.
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ACS Applied Energy Materials
·
2024
·
IF 5.4
Zixuan Huang,Xin Ge,Zhen Liu,Biao Shi,Pengyang Wang,Ying Zhao,Xiaodan Zhang
Wide-band-gap perovskite solar cells (PSCs) are considered an important part of multijunction tandem solar cells and have attracted extensive research in related fields. For blade-coated inverted wide-band-gap PSCs, nonradiative recombination losses in the perovskite/charge transport layer interface are serious. The performance of blade-coated wide-band-gap perovskite solar cells has hindered the industrialization of tandem solar cells, especially for two-terminal perovskite/silicon tandem solar cells (TSCs). To reduce these losses as much as possible, the choice of hole transport layers and perovskite films post-treatment is extremely important. Herein, we used two strategies: a hybrid self-assembled monolayer as the hole transport layer and surface passivation post-treatment to obtain highly efficient and stable PSCs by the blade-coating method. The champion device demonstrated an efficiency of 21.30% for p-i-n PSCs, which is one of the highest efficiencies for band gaps above 1.67 eV among all of the scalable preparation methods employed.
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ACS Omega
·
2024
·
IF 3.7
Jinfu Wang,Yan Guo,Huifen Zhou,Yanjie Hua,Haitong Wan,Jiehong Yang
Objective: Cardiac ischemia-reperfusion (I/R) injury has negative effects on the brain and can even lead to the occurrence of ischemic stroke. Clinical evidence shows that Danhong injection (DHI) protects the heart and brain following ischemic events. This study investigated the mechanisms and key active compounds underlying the therapeutic effect of DHI against brain damage induced by cardiac I/R injury. Methods: The gene expression omnibus database provided GSE66360 and GSE22255 data sets. The R programming language was used to identify the common differentially expressed genes (cDEGs). Gene ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analysis were performed, and protein–protein interaction network was constructed. Active compounds of DHI were collected from the Traditional Chinese Medicine Systems Pharmacology database. Molecular docking and molecular dynamics simulations were performed. The MMPBSA method was used to calculate the binding-free energy. The pkCSM server and DruLiTo software were used for Absorption, Distribution, metabolism, excretion, and toxicity (ADMET) analysis and drug-likeness analysis. Finally, in vitro experiments were conducted to validate the results. Results: A total of 27 cDEGs had been identified. The PPI and enrichment results indicated that TNF-α was considered to be the core target. A total of 80 active compounds were retrieved. The molecular docking results indicated that tanshinone I (TSI), tanshinone IIA (TSIIA), and hydroxyl safflower yellow A (HSYA) were selected as core active compounds. Molecular dynamics verification revealed that the conformations were relatively stable without significant fluctuations. MMPBSA analysis revealed that the binding energies of TSI, TSIIA, and HSYA with TNF-α were −36.01, −21.71, and −14.80 kcal/mol, respectively. LEU57 residue of TNF-α has the highest contribution. TSI and TSIIA passed both the ADMET analysis and drug-likeness screening, whereas HSYA did not. Experimental verification confirmed that DHI and TSIIA reduced the expression of TNF-α, NLRP3, and IL-1β in the injured H9C2 and rat brain microvascular endothelial cells. Conclusion: TNF-α can be considered to be a key target for BD-CI/R. TSIIA in DHI exerts a significant inhibitory effect on the inflammatory damage of BD-CI/R, providing new insights for future drug development.
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Journal of Cleaner Production
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2024
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IF 9.7
Shuai Han,Zhe Wang,Junjian Yu,Fei Wang,Xiangwei Li
Low-silica SOD zeolites are among the most promising inorganic materials for mixed matrix membranes (MMMs). However, the gas separation performance is severely hindered by the non-selective voids formed by both the zeolite and polymer membranes, as well as the rigid layer. In this work, SOD-liquid-M2070 PL type I porous liquid was synthesized and subsequently filled into an Amidoxime-functionalized polymer of intrinsic microporosity (AO-PIM) to prepare MMMs. The fillers and MMMs were characterized using FTIR, SEM, TGA, XRD, and gas permeation techniques. SOD-liquid-M2070 PL facilitates the rapid diffusion of CO 2 and H 2 gas molecules for efficient gas separation. The liquid-like fluidity of SOD-liquid-M2070 PL improves the formation of non-selective pores in the SOD and polymer matrix membranes to enhance gas permeability and selectivity. The CO 2 , H 2 permeability and CO 2 /N 2 , H 2 /N 2 selectivity of MMMs composed of 5 wt% SOD-liquid-M2070 PL with optimal filling ratio were increased by 248%, 246%, and 173%, 222%, respectively, compared with pure membranes. It exceeds the 2008 Robeson limit for H 2 /N 2 and approaches much closer to the 2019 Robeson limit for CO 2 /N 2 . The field of green environment presents a promising development prospect for low silica SOD zeolite, which exhibits high separation efficiency.
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ACS Sensors
·
2024
·
IF 8.2
Linge Nian,Wenhua Li,Chunxia Zhang,Lu Li,Guangrui Zhang,Jianxi Xiao
Hepatic fibrosis, the insidious progression of chronic liver scarring leading to life-threatening cirrhosis and hepatocellular carcinoma, necessitates the urgent development of noninvasive and precise diagnostic methodologies. Denatured collagen emerges as a critical biomarker in the pathogenesis of hepatic fibrosis. Herein, we have for the first time developed 3D-printed collagen capture chips for highly specific surface-enhanced Raman scattering (SERS) detection of denatured type I and type IV collagen in blood, facilitating the early diagnosis of hepatic fibrosis. Employing a novel blend of denatured collagen-targeting peptide-modified silver nanoparticle probes (Ag@DCTP) and polyethylene glycol diacrylate (PEGDA), we engineered a robust ink for the 3D fabrication of these collagen capture chips. The chips are further equipped with specialized SERS peptide probes, Ag@ICTP@R1 (S–I) and Ag@IVCTP@R2 (S–IV), tailored for the targeted detection of type I and IV collagen, respectively. The SERS chip platform demonstrated exceptional specificity and sensitivity in capturing and detecting denatured type I and IV collagen, achieving detection limits of 3.5 ng/mL for type I and 3.2 ng/mL for type IV collagen within a 10–400 ng/mL range. When tested on serum samples from hepatic fibrosis mouse models across a spectrum of fibrosis stages (S0–S4), the chips consistently measured denatured type I collagen and detected a progressive increase in type IV collagen concentration, which correlated with the severity of fibrosis. This novel strategy establishes a benchmark for the multiplexed detection of collagen biomarkers, enhancing our capacity to assess the stages of hepatic fibrosis.
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Advanced Science
·
2021
·Vol. 8
·期 14
·2100524
·
IF 16.806
Miaomiao Kang,Zhijun Zhang,Wenhan Xu,Haifei Wen,Wei Zhu,Qian Wu,Hongzhuo Wu,Junyi Gong,Zhijia Wang,Dong Wang,Ben Zhong Tang
Photodynamic therapy (PDT) has long been recognized to be a promising approach for cancer treatment. However, the high oxygen dependency of conventional PDT dramatically impairs its overall therapeutic efficacy, especially in hypoxic solid tumors. Exploration of distinctive PDT strategy involving both high-performance less-oxygen-dependent photosensitizers (PSs) and prominent drug delivery system is an appealing yet significantly challenging task. Herein, a precise nuclear targeting PDT protocol based on type-I PSs with aggregation-induced emission (AIE) characteristics is fabricated for the first time. Of the two synthesized AIE PSs, TTFMN is demonstrated to exhibit superior AIE property and stronger type-I reactive oxygen species (ROS) generation efficiency owing to the introduction of tetraphenylethylene and smaller singlet–triplet energy gap, respectively. With the aid of a lysosomal acid-activated TAT-peptide-modified amphiphilic polymer poly(lactic acid)12k–poly(ethylene glycol)5k–succinic anhydride-modified TAT, the corresponding TTFMN-loaded nanoparticles accompanied with acid-triggered nuclear targeting peculiarity can quickly accumulate in the tumor site, effectively generate type-I ROS in the nuclear region and significantly suppress the tumor growth under white light irradiation with minimized systematic toxicity. This delicate “Good Steel Used in the Blade” tactic significantly maximizes the PDT efficacy and offers a conceptual while practical paradigm for optimized cancer treatment in further translational medicine.
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CHEMICAL PHYSICS
·
2025
·
IF 2.4
Wenchao Ma,Na Du,Wanguo Hou
Prediction of surface tension and surface composition of multicomponent liquid mixtures remains challenging. A predictive model, called the “surface aggregation adsorption” (SAA) model, was proposed recently, but its applicability needs to be examined, especially for the monophasic solutions containing immiscible components. In this work, the surface tensions of binary and ternary solutions consisting of isopropanol ( i PrOH), water, and n -decane (DA) or n -tetradecane (TDA) were determined. Based on the SAA model, the model parameters of the binary ( i PrOH–water or DA or TDA) solutions were first estimated, and then used to predict the surface tension and composition of the ternary ( i PrOH–water–DA or TDA) solutions. The predicted surface tension values for the ternary solutions are well consistent with their experimental ones. Importantly, the so-obtained information on surface compositions can provide a better understanding of the surface adsorption behavior.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Changxin Xiang,Zehua Wang,Qing Zhang,Zijian Guo,Xiaona Li,Weiyi Chen,Xiaochun Wei,Pengcui Li
Poly(vinyl alcohol) (PVA) hydrogels exhibit great potential as ideal biomaterials for tissue engineering, owing to their non-toxicity, high water content, and strong biocompatibility. However, limited mechanical strength and low bioactivity have constrained their application in bone tissue engineering. In this study, we have developed a tough PVA-based hydrogel using a facile physical crosslinking method, comprising of PVA, tannic acid (TA), and hydroxyapatite (HA). Systematic experiments were conducted to examine the physicochemical properties of PVA/HA/TA hydrogels, including their compositions, microstructures, and mechanical and rheological properties. The results demonstrated that the PVA/HA/TA hydrogels possessed the porous microstructures and excellent mechanical properties. Furthermore, collagen type I (Col I) was used to further improve the biocompatibility and bioactivity of PVA/HA/TA hydrogels. In vitro experiments revealed that PVA/HA/TA/COL hydrogel could offer a suitable microenvironment for the growth of MC3T3-E1 cells and promote their osteogenic differentiation. Meanwhile, the PVA/HA/TA/COL hydrogel demonstrated the ability to promote bone regeneration and osteointegration in a rat femoral defect model. This study provides a potential strategy for the use of PVA-based hydrogels in bone tissue engineering.
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