Applied Materials Today
·
2026
·
IF 7
Huixing Li,Jiaxing Xiong,Fangwei Qi,Jun Zan,Xiuwen Gao,Wenjie Ma,Kunlong Li,Gao Pan,Pan He,Dongan Wang,Yang Shuai,Shuping Peng
Biomimetic hierarchical bone scaffold: outer Haversian canals and inner Gyroid pores for high memchanical strength. • Cascade antibacterial: thermal cleaves biofilms and Fe-NO bonds, releasing NO into bacteria to kill S. aureus and E. coli • Synergistic osteogenesis: thermal activates HSP70, synergizing with Ca 2+ and PO 4 3- to boost osteogenic differentiation. • pH regulation: amine groups from oxidative self-polymerization increase the pH value, enhancing scaffold stability. Poly- L -lactic acid (PLLA) is widely used in bone scaffold engineering due to its favorable biocompatibility, biodegradability, and processability. However, its mechanical properties are limited by insufficient crystallinity during fabrication. Moreover, bone repair is often accompanied by early bacterial infection and local pH reduction, which challenge the antibacterial effect, osteogenic capacity and structural stability of PLLA scaffolds. Herein, PLLA and hydroxyapatite (HA) are melt-blended into PLLA/HA (PHA). followed by self-polymerization of polydopamine (PDA) and electrostatic adsorption sodium nitroprusside of (SNP). The composite is then prepared into a PHA@PDA-SNP scaffold, with an outer Haversian canal layer and inner Gyroid-perforated. Ingeniously, the scaffold utilizes photothermal produced by near-infrared light to cleave biofilm and the Fe-NO bond in SNP, promoting NO release and entry into bacteria. Meanwhile, thermal can activate HSP70, synergizing with Ca 2+ and PO 4 3- released by PHA to boost osteogenic differentiation. Moreover, the amine groups retained during the oxidation process of PDA can weaken the acidic environment and enhance scaffold stability. Results show that the bone scaffold mimics the natural bone structure with high compressive strength (162.9 MPa) by biomimetic manufacturing. Scaffold exhibits cell osteogenic differentiation as evidenced by a 70% upregulation of HSP70 and Ca 2+ influx, and a 4.5-fold increase of ALP and ARS. Scaffold utilizes photothermal and NO to achieve antibacterial rates of 97.4% and 98.2% against S. aureus and E. coli , respectively. Download: Download high-res image (194KB) Download: Download full-size image
✓ 已验证
DOI
高影响因子
Small
·
2025
·
IF 12.1
Wei Ge,Beibei Gao,Shuxian Li,Guangbo Yu,Lu Gao,Zhemin Shen,Fu Wang,Junle Qu
Ratiometric fluorescence imaging in the second near-infrared (NIR-II) region holds great promise for the accurate identification of metastatic lymph nodes (MLNs), but faces challenges in biocompatible probe design with simplified composition and broad spectral tunability. Here, a minimalist, self-calibrating ratiometric probe based on homologous Ag 2 Se quantum dots (QDs) is developed. Through rational redesign of tributylphosphine-mediated coordination kinetics, continuous size-dependent emission tuning across 935–1710 nm, with the synthetic mechanism and structure–property relationships systematically elucidated, is achieved. The inherently low-toxicity Ag 2 Se core, combined with poly(amino acid) coating, ensures excellent biosafety, as validated by in vitro cytotoxicity and in vivo biochemical assays. Two spectrally distinct QDs (emitting at 1040 and 1305 nm, with full width at half maximum of 176 and 119 nm) enable multiplexed anatomical imaging, allowing both real-time intraoperative detection and postoperative assessment of MLNs, with a diagnostic threshold ratio of ≈0.9. This work presents a scalable strategy for full-NIR-II monochromatic QD synthesis and establishes a minimal-component biocompatible platform for precision ratiometric diagnostics.
✓ 已验证
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 15.1
Yi Xing,Mengyun Zhou,Xiangmei Liu,Minghang Qiao,Liping Zhou,Tailin Xu,Xueji Zhang,Xin Du
Chemodynamic therapy (CDT), which catalyzes the production of highly toxic reactive oxygen species (ROS), has been widely used in tumor therapy in the past five years. However, most of the current nanomaterials for CDT are difficult to penetrate into the tumor effectively due to the lack of motility, resulting in an unsatisfactory CDT effect. Herein, bioinspired jellyfish-like carbon/manganese nanomotors (JCMNs) are designed to achieve hydrogen peroxide (H 2 O 2 ) and NIR light dual-propulsion for the enhanced CDT therapy. Based on the jellyfish-like asymmetric structure, the manganese component can catalyze H 2 O 2 to generate chemical concentration gradient, propelling JCMNs to dynamically generate ROS in cells by self-diffusiophoresis. In addition, the carbon component of JCMNs can absorb near-infrared (NIR) light to produce a temperature gradient, driving JCMNs to enhance tumor penetration by self-thermophoresis. The combination of chemical and NIR light propulsions significantly improves the efficiency of tumor CDT, revealing that it should be a reasonable strategy to promote the development of nanobiomedicine by endowing nanosystems with propulsion capacity.
✓ 已验证
产品关联
DOI
高影响因子
SCIENCE OF THE TOTAL ENVIRONMENT
·
2023
·
IF 9.8
Meiqing Zhu,Long Sun,Xina Liu,Xiaohui Pang,Fugang Fan,Xiaofan Yang,Rimao Hua,Yi Wang
Hg 2+ poses a great threat to human health and the environment due to its bioaccumulation and permanent damage. Herein, a reversible CHEF-based near-infrared fluorescent probe 2-(3-((E)-4-((E)-4-(diethylamino)-2- hydroxybenzylidene)amino)styryl)-5,5-dimethylcyclohex-2-en-1-ylidene)propanedinitrile ( DHEY ) capable of specifically recognizing Hg 2+ was constructed. DHEY exhibits advantages of large Stokes shift (157 nm), excellent selectivity , high sensitivity (LOD = 3.2 μg/L), and fast response efficiency (<3 min). Interestingly, DHEY can also realize rapid and effective detection of Hg 2+ after being recycled 7 times. The successful recovery of trace Hg 2+ in different environmental water samples fully demonstrates the potential of DHEY for actual applications. In particular, DHEY enables real-time observation of the distribution and translocation pattern of exogenous Hg 2+ in HeLa cells and zebrafish. This work provides important theoretical support for investigating the fate of heavy metal ions in the environment using fluorescence techniques.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ADVANCED MATERIALS
·
2023
·Vol. 35
·期 26
·2211432
·
IF 29.4
Xiaojun He,Yuna Qian,Chenglin Wu,Jiayao Feng,Xiaoshuai Sun,Qinxiang Zheng,Xiaokun Li,Jianliang Shen
Bacterial infections, such as bacterial keratitis (BK) and subcutaneous abscess, pose significant challenges to global healthcare. Innovative and new antibacterial agents and antibacterial strategies are in demand to control infections in this era of high drug resistance. Nanotechnology is gradually emerging as an economically feasible and effective anti-infection treatment. High-entropy MXenes (HE MXenes) are used to confer desirable properties with exposed active sites to high-entropy atomic layers, whose potential application in the field of biomedicine remains to be explored. Herein, monolayer HE MXenes are fabricated by implementing transition metals with high entropy and low Gibbs free energy to fill the gap in the biocatalytic performance of non-high-entropy MXenes. HE MXenes are endowed with extremely strong oxidase mimic activity ( K m = 0.227 m m ) and photothermal conversion efficiency (65.8%) in the second near-infrared (NIR-II) biowindow as entropy increases. Subsequently, HE MXenes realize NIR-II-enhanced intrinsic oxidase mimic activity for killing methicillin-resistant Staphylococcus aureus and rapidly removing the biofilm. Furthermore, HE MXenes can effectively treat BK and subcutaneous abscess infection induced by methicillin-resistant Staphylococcus aureus as nanotherapeutic agents with minuscule side effects. Overall, monolayer HE MXenes demonstrate promising clinical application potential in the treatment of drug-resistant bacterial infections and promote the healing of infected tissues.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Advanced Optical Materials
·
2022
·Vol. 11
·期 5
·2202291
·
IF 10.05
Shuai Huang,Yu Yan,Mengmeng Shang,Yining Wang,Yixin Sun,Peipei Dang,Jun Lin
Cr 3+ -activated near-infrared (NIR) phosphors have attracted wide attention owing to applications in phosphor-converted light-emitting diodes (pc-LED) for spectroscopy. Because a broader spectrum covers more information to detect, the width of the spectrum is an important parameter to consider. Here, the blue LED excitable ultra-broadband Cr 3+ -activated LiInGeO 4 phosphors, which exhibit unprecedented long-wavelength NIR emission with a wide full-width at half maximum (FWHM) of 305 nm, are developed. The overall emission tuning from 1165 to 875 nm with broadened FWHM from 305 to 508 nm is realized through designing continuous solid solution hosts of LiIn 1− z Sc z GeO 4 /(LiIn) 1− y Mg 2 y GeO 4 and finite solid solution hosts of (LiIn) 1− y Zn 2 y GeO 4 :Cr 3+ . The observation of such long-wavelength NIR from Cr 3+ not Cr 4+ is studied and confirmed by electron paramagnetic resonance, X-ray absorption near-edge structure, and steady-/transient-state photoluminescence. The formation of finite solid solutions induces the change in the local structure of Cr 3+ that ultimately leads to the observation of super broadband (FWHM = 508 nm) luminescence. The luminescence mechanism is discussed in this study. Finally, this study demonstrates that the as-synthesized phosphors with tunable NIR luminescence can be well used in NIR pc-LEDs for spectroscopy detection.
✓ 已验证
产品关联
DOI
高影响因子
Nano Today
·
2023
·
IF 17.4
Jiahuan Xu,Liang Chen,Sujun Ding,Xinyue Dai,Yanfei Dai,Yu Chen,Xuejun Ni
Two-dimensional (2D) transition metal carbides/nitrides (MXenes) have been extensively applied in biomedicine . However, the potential of MXene-based nanomedicine in sonodynamic therapy (SDT) has been rarely explored. Here, under the guidance of theoretical calculation, Nb 2 C MXenes are engineered as a high-performance sonocatalyst/sonosensitizer through mild in-situ self-oxidation. The work function values of Nb 2 C MXenes with different oxidation degrees are calculated to determine the optimized conditions to construct efficient Schottky heterojunction in the self-oxidized Nb 2 C MXenes. Experimentally, the niobium oxide clusters are homogeneously self-generated in-situ in Nb 2 C MXenes to form efficient Schottky barriers after the mild hydrothermal oxidation. The results reveal that the Schottky heterojunction can accelerate the separation of sono-triggered electron-hole pairs and inhibit their recombination, which profoundly augments the reactive oxygen species (ROS) generation efficiency of the in-situ self-oxidized Nb 2 C MXenes (denoted as Nb 2 C-Ox) under ultrasound (US) irradiation. The mild oxidation also allows the Nb 2 C-Ox to inherit the high photothermal performance of Nb 2 C MXenes in the second near-infrared (NIR-II) window. Accordingly, the developed Nb 2 C MXene-originated sonocatalyst/sonosensitizer can achieve high therapeutic efficacy based on the sonodynamic effect and NIR-II photonic hyperthermia. Therefore, this work proposes a theoretical calculation-oriented strategy to design and fabricate new MXene-based sonocatalysts/sonosensitizers for biomedical applications .
✓ 已验证
产品关联
DOI
高影响因子
CERAMICS INTERNATIONAL
·
2023
·
IF 5.2
Guang Yang,Yongwei Liu,Chuanfan Yang,Fang Xia,Yupeng Wu,Yaroslav Shpotyuk,Viktor Takats,Huidan Zeng,Yinsheng Xu,Hongfei Chen,Yanfeng Gao
This work presents the influence of glass matrix SiO 2 –B 2 O 3 –NaF on the formation of near-infrared (NIR)-shielding functional units in energy-saving glass windows. The structural analyses by XRD , XPS , and Raman confirmed that the NIR-shielding performance is insensitive to SiO 2 or B 2 O 3 glass network formers but is significantly impacted by the concentration of NaF. This is because the presence of a reasonable amount of NaF provides the much-needed sodium for the formation of NIR-shielding functional units Na 5 W 14 O 44 but too much NaF (>22 mol.%) can inhibit the formation of Na 5 W 14 O 44 by transforming the W– O –W chain in the interconnected [WO 6 ] and [WO 4 ] polyhedrons into W–O - bonds. By adjusting NaF to the optimal level (16 mol.%) and adding only a small amount of H 2 WO 4 (1.9 mol.%) as the tungsten source in the raw materials, excellent optical properties and thermal insulation performance have been achieved in the produced bulk glass, with a high transmission of 65.8% at 550 nm in the visible light region and a low transmission of 6.6% at 1550 nm in the NIR region. This performance is much better than soda lime glass and ITO glass and is comparable to cesium tungsten bronze-based membrane coated glass. This study paves a way for glass composition design to achieve high NIR-shielding performance with the minimum amount of tungsten source, leading to cost-effective glass fabrication and enhanced mechanical strength of energy-saving glass windows.
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
·
IF 8.2
Wenqi Song,Tiantian Xu,Liwei Qian,Sufeng Zhang,Chaoli Wang,Yuzhen Zhao,Zemin He,Valentin Nica,Zongcheng Miao
With the trend of sustainable development and the complex medical environment, there is a strong demand for multimodal antibacterial cellulose wound dressing (MACD) with photothermal therapy (PTT). Herein, a novel MACD fabrication strategy with PTT was proposed and implemented through graft polymerization of an imidazolium ionic liquid monomer containing iron complex anion structure. The fabricated hydrogels exhibited excellent antibacterial properties because of the efficient photothermal conversion ability (68.67 %) of ionic liquids and the intrinsic structural characteristic of quaternary ammonium salts. The antibacterial ratio of cellulosic hydrogel dressings to S. aureus and E. coli could reach 99.57 % and 99.16 %, respectively. Additionally, the fabricated hydrogels demonstrated extremely low hemolysis rates (<5 %) and excellent cell viability (~>85 %). Furthermore, in vivo antibacterial experimental results proved that the fabricated antibacterial dressings could significantly accelerate wound healing. Therefore, the proposed strategy would provide a new method of designing and preparing high-performance cellulose wound dressings.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry B
·
2022
·Vol. 10
·期 48
·10083-10096
·
IF 7.571
Hai Zhu,Xuequan Zhang,Qiusheng Wang,Jin Deng,Zhuangzhuang Zhang,Xiaoxian Zhang,Jun Cao,Bin He
The combined use of photothermal therapy (PTT) and photodynamic therapy (PDT) could circumvent the drawbacks of each individual therapeutic strategy, resulting in an enhanced antitumor effect. However, the lack of highly effective photo-agents that are irradiation-safe in the biologically transparent window hinder the advancement of phototherapy clinically. Hence, in this study, a charge separation engineering strategy was adopted to fabricate a nanoplatform with heterojunctions, namely, in situ TiO2-loaded MXene (Ti3C2/TiO2 heterojunctions). This nanoplatform exhibited reduced bandgap (1.68 eV), enhanced NIR-II photothermal conversion efficiency (44.98%), and extended absorption edge compared to pristine TiO2 for enhanced photodynamic effect. More importantly, the proliferation of tumor cells could be efficiently inhibited at a 5 mm chicken breast depth after 1064 nm laser irradiation, and the intracellular ROS production significantly increased under 660 nm or even 1064 nm laser irradiation with heterojunctions (HJs) compared with that of TiO2. Moreover, the in vivo data further confirmed that the as-prepared heterojunctions could efficiently eradicate tumors efficiently via improved photothermal effect with NIR-II laser irradiation and upregulated ROS production. Collectively, the reported HJs strategy provides an opportunity for the success of combinational PTT and PDT therapy in tumor treatment.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nanophotonics
·
2022
·Vol. 11
·期 12
·2875-2889
·
IF 7.923
Mengya Zhang,Yue Tian,Anxin Jiao,Hui Ma,Chang Wang,Linqi Zheng,Shuang Li,Ming Chen
Ultrasensitive trace-detection of toxic and carcinogenic polycyclic aromatic hydrocarbons (PAHs) can ceaselessly propel the environmental surveillance in aqueous ecosystems. Due to the intrinsic nonadsorptive feature of PAHs, the promising technique of surface-enhanced Raman scattering (SERS) spectroscopy has been restricted to diverse functional ligands-based surface modifications of nano-substrates. However, it is not suitable for practical ultralow liquid analysis. Herein, we propose an extraordinary strategy to boost liquid-near infrared (NIR)-SERS activity of plasmonic Au/Ag nano-urchins (NUs) by introducing extra 808 nm laser-triggered an additional strong electromagnetic enhancement into routine 785 nm laser-Raman system. The synergistic double laser-excited NIR-SERS of colloidal Au/Ag NUs enables the Raman signals of crystal violet to be significantly enhanced, approaching a maximum of ∼34-fold increase than that of traditional bare 785 nm laser-excitation. More importantly, the improved liquid-NIR-SERS enables the in-situ detection limit of pyrene molecules in lake water to be achieved at ∼10 −9 M, which is already better than many previous SERS results based on the complicated functionalized nano-substrates. The established double laser-boosted NIR-SERS can also be easily extended to the simultaneous trace-detection of three PAHs-contaminated mixtures, supporting well distinguishable capability. Undoubtedly, the present work opens a new versatile and innovative avenue for ultrasensitive NIR-SERS monitoring of nonadsorptive toxic pollutants in wastewater.
✓ 已验证
产品关联
DOI
高影响因子
CERAMICS INTERNATIONAL
·
2022
·
IF 5.532
Guang Yang,Chuanfan Yang,Fang Xia,Daming Hu,Joël Brugger,Barbara E. Etschmann,Jessica Hamilton,Hongfei Chen,Yanfeng Gao
Near-infrared (NIR)-shielding glasses for energy-saving window applications were prepared by forming sodium tungsten bronze-like (Na 5 W 14 O 44 ) functional units in the 29SiO 2 –43B 2 O 3 –28NaF glass matrix. The glasses were synthesized by a facile melt-quenching process where 4–8 mol.% H 2 WO 4 was added as the W source. The optimal glass was produced using 6 mol.% H 2 WO 4 , which had a low NIR transmission of 15.4% and a high visible light transmission of 59.8%. The possible mechanism for the formation of Na 5 W 14 O 44 in glasses were discussed based on XRD , Raman, XPS , XANES and EXAFS characterization of the glass samples, the glass samples after further crystallization, and the samples produced by staged heating of the starting materials. Crystalline or amorphous Na 5 W 14 O 44 formed during heating partially due to the protection by molten B 2 O 3 . Subsequently, amorphous Na 5 W 14 O 44 clusters are present in the glass acting as NIR-shielding functional units. This study sheds a light on further development of non-film-based and highly efficiency energy-saving windows.
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）