DRUG DELIVERY
·
2019
·
IF 3.829
Jiu Wang,Yajing Wang,Ziqiang Wang,Fan Wang,Jie He,Xiaoyun Yang,Weidong Xie,Ying Liu,Yaou Zhang
The present study aims at designing a thermosensitive gel prepared from w1/o/w2 multiple microemulsions (MMEs) for the vaginal delivery of siRNA. The w1/o/w2 MMEs were prepared by two-step emulsifications: the first step was to prepare primary emulsions (w1/o) by low energy emulsification (LEE); the second step was to obtain stable w1/o/w2 MMEs by self-emulsifying. An extensive formulation optimization process was undertaken. The final w1/o/w2 MMEs could be formed in ddH2O, phosphate buffer solution (PBS, pH 7.4) and 1640 culture media with diameter size about 166.5 ± 13.1, 271.0 ± 11.1 and 278.7 ± 12.1 nm respectively. The release rates of siRNA from solutions, MMEs and MMEs-gels were completed within 2 h, 6 h and13 h respectively. The transfection efficiency of MMEs was confirmed both in vitro and in vivo. The relative target gene expressions of MMEs were 0.07 ± 0.05% vs. 0.37 ± 0.06% in Hela cells against Lipofectamine2000® and 1.88% ± 0.00% vs. 9.65% ± 0.02% in mouse vaginal mucosa against PEI. Good biocompatibility of MMEs was verified by cytotoxicity and pathological studies. Overall, our results indicated the potential of the MMEs-gel system for the vaginal delivery of siRNA.
✓ 已验证
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2019
·
IF 8.456
Wei Song,Hanqing Zhao,Jianqi Ye,Mengmeng Kang,Siyu Miao,Zhong Li
Ti–O–C channels for ultrafast sodium storage were constructed in N/S-co-doped TiO2–C nanofibers, which deliver a high rate performance of 181.9 mAh g–1 at 5 A g–1 after 3000 cycles. The existence of Ti–O–C bonds at the interface of TiO2–C phases was revealed by synchrotron radiation X-ray absorption spectra. Based on this, first-principles calculations further verified the low energy barrier for Na+ insertion/extraction in the Ti–O–C channels formed by the intimately integrated graphite layer with TiO2 near the surface. In addition, surface defects induced by heteroatoms accelerate the Na+ mass transfer through the pathway from the carbon surface to the Ti–O–C channel.
✓ 已验证
DOI
PubMed
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2020
·
IF 3.573
Yu Liu,Lu Han,Jinhao Zhang,Ruxue Yao,Haoqi Zhan,Huawei Yang,Liangjiu Bai,Lixia Yang,Donglei Wei,Wenxiang Wang,Hou Chen
O2 activation for the green conversion of chemicals has attracted a great deal of attentions in the field of chemistry. Developing catalysts for aerobic oxidation with both prominent instinct activity and desirable micro/nanostructure remains a tough challenge. In this work, hierarchical hollow Co–Ni–Mo–O mixed metallic-oxide nanotubes constructed by ultrathin CoMoO4/NiMoO4 nanosheets were fabricated using a sacrificial template method and employed as catalysts in aerobic oxidative desulfurization (AODS) of a model fuel. With air as the oxygen source, the catalyst demonstrated surprisingly high activity by achieving complete conversion of dibenzothiophene under mild reaction conditions. Besides, the catalyst demonstrated excellent stability on continuous repeated use. A further mechanism study reveals the electron coordination and transfer between different metal species as well as the activation route of O2. Based on the above-mentioned results, the catalyst which allows a good exposure of metal centers, a high concentration of oxygen vacancies, and the desired electronic structure is expected to serve as the high-performance AODS catalyst.
✓ 已验证
DOI
高影响因子
AAPS PHARMSCITECH
·
2021
·Vol. 22
·期 7
·1-7
·
IF 3.246
Wang Beilei,Shan Xiaoxiao,Lv Shujie,Zha Liqiong,Zhang Caiyun,Dong Qiannian,Chen Weidong
3-O-β-D-galactosylated resveratrol (Gal-Res) was synthesized from resveratrol (Res) and 3-O-β-D-galactose (Gal) in our previous study. In order to improve the pH sensitivity and bioavailability of Gal-Res, Gal-Res nanoparticles (Gal-Res NPs) were prepared using polydopamine (PDA) as a drug carrier. The drug loading (DL %) and entrapment efficiency (EE %) of Gal-Res NPs were 46.80% and 88.06%. The average particle size, polydispersity index (PDI), and Zeta potential of Gal-Res NPs were 179.38 ± 2.83 nm, 0.129 ± 0.013, and − 28.05 ± 0.36 mV, respectively. The transmission electron microscope (TEM) showed that Gal-Res NPs had uniform spherical morphology. Compared with the fast release of raw Gal-Res, the in vitro release of Gal-Res NPs was slow and pH-sensitive. The results of the blood vessel irritation and hemolysis test demonstrated that Gal-Res NPs had good hemocompatibility. The pharmacokinetics study in rats showed that area under the curve of plasma drug concentration time (AUC 0→600 ) and half-life (t 1/2 ) of Gal-Res NPs were enhanced 1.82-fold and 2.19-fold higher than those of raw Gal-Res. The in vivo biodistribution results showed that Gal-Res NPs were more distributed in liver tissue than Gal-Res. Gal-Res NPs with high bioavailability and liver accumulation were hopeful drug delivery systems (DDS) to treat liver diseases. Graphical abstract
✓ 已验证
DOI
PubMed
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2020
·Vol. 44
·期 45
·19868-19879
·
IF 3.288
Sleshi Fentie Tadesse,Dong-Hau Kuo,Worku Lakew Kebede,Lalisa Wakjira Duresa
Discharging of organic pollutants from industrial activities into the water bodies is a common worldwide problem, which can adversely affect human life and the environment. Recently, many efficient, eco-friendly, and cost-effective photocatalytic methods have been investigated for environmental remediation. In this study, a simple and facile precipitation method at low temperature was proposed for the synthesis of V-doped Mo(O,S)2 oxysulfide. The crystallinity, morphology, elemental composition, and optical and electrical properties of the as-synthesized materials were characterized by XRD, Raman spectroscopy, FT-IR spectroscopy, FE-SEM, TEM, XPS, PL, and EIS. The photocatalytic performance of both bare and V-doped Mo(O,S)2 was evaluated in the degradation of methylene blue (MB) dye. The holes (h+) and hydroxyl radicals (OH˙) were identified as the main oxidative species for MB degradation. V-Mo(O,S)2-10 synthesized with 10% vanadium precursor showed the highest photocatalytic efficiency for MB degradation under visible light irradiation with an apparent rate constant of 0.028 min−1, which was much greater than that of bare Mo(O,S)2 at 0.0098 min−1. Besides, V-Mo(O,S)2-10 had the lowest recombination rate of electron–hole pairs and charge transfer resistance to enhance the photocatalytic activity, as evidenced by PL and EIS analyses. Therefore, V-doped Mo(O,S)2 can be a potential candidate for photocatalytic degradation of organic dyes for environmental remediation.
✓ 已验证
DOI
高影响因子
KINETICS AND CATALYSIS
·
2023
·Vol. 64
·期 6
·909-921
·
IF 1.1
Li Linbo,Du Yijun,Li Yao,Shao Linjun,Qi Chenze,Zhou Shujing,Li Jinjing
Abstract Developing a facile and accurate method for assessing catalytic activities of supported metals can significantly promote the preparation and application of supported metal catalysts. Herein, we synthesized five MCM-41 materials functionalized with Schiff-base groups, which were employed as the supports for copper cations. The chemical structures and coordination of copper cations on the supports were characterized by Fourier-transform infrared spectroscopy (FT-IR) and X-ray photoelectron spectroscopy (XPS). The grafting densities were calculated by analyzing the results of thermal gravimetric analysis (TGA) and elemental analysis (EA). The microstructures of these supported copper catalysts were analyzed by transmission electron microscopy (TEM) and X-ray diffraction (XRD). The oxidation of thioanisole to methylphenyl sulfoxide was employed to determine the catalytic activities of these supported copper catalysts while their o -Ps annihilation properties were evaluated by the positron annihilation lifetime spectroscopy. It is found that the o -Ps annihilation properties were linearly correlated with their catalytic activities. Therefore, the catalytic activities of supported copper species surrounded by different functional groups can be easily determined through o -Ps annihilation.
✓ 已验证
DOI
高影响因子
FUEL
·
2020
·
IF 5.578
Jing-Pei Cao,Tao Xie,Xiao-Yan Zhao,Chen Zhu,Wei Jiang,Ming Zhao,Yun-Peng Zhao,Xian-Yong Wei
Selective hydrogenolysis, the aromatic ether C-O bonds under mild conditions, is crucial for the valorization of lignin. In this context, the effects of H 2 and solvent on the hydrogenolysis of lignin model compounds over Ru catalysts were explored. With H 2 as hydrogen donor, the Ru/AC exhibited the highest activity for converting lignin model compounds into monomeric compounds, whereas H 2 led to low selectivity of aromatics. However, isopropanol was the good H-donor solvent, which could provide a large amount of active hydrogen to promote the cleavage of C-O bonds. Additionally, the yield of aromatics in isopropanol was higher than that under H 2 atmosphere. It could be ascribed to the fact that isopropanol is the protic solvent which displays Lewis basicity, and is a good H-bond donor and a good H-bond acceptor. The higher electron-releasing inductive effect of isopropanol made it easier to provide active hydrogen. Based on the experiments, the mechanism of benzyl phenyl ether hydrogenolysis in H 2 and isopropanol system was presented.
✓ 已验证
DOI
高影响因子
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
·
2022
·Vol. 194
·期 11
·5274-5291
·
IF 3.094
Lei Jiping,Tang Kexin,Zhang Ting,Li Yan,Gao Zhen,Jia Honghua
2-O-α-D-Glucosyl glycerol (2-αGG) can be used as a multipurpose anti-aging, cell-stimulating, and skin moisturizing agent in the cosmetic industry. Sucrose phosphorylase (SPase) has been widely used in the production of 2-αGG. In this paper, the gene encoding sucrose phosphorylase from Bifidobacterium longum (BlSP) was inserted into pRSF-Duet-1 to construct the recombinant plasmid pRSF-BlSP and was functionally expressed in E. coli BL21(DE3) to be used as a biocatalyst for the synthesis of 2-αGG firstly. The mutations of BlSP were carried out based on alanine scanning, and a positive mutant G293A with a 50% increase in activity for 2-αGG production was identified. Mutant G293A has less K m and bigger k cat / K m towards glycerol than the parental BlSP. Subsequently, the production of 177.6 g/L 2-αGG was attained from 1 M sucrose and 1.2 M glycerol catalyzed by 17 mg/mL G293A mutant. This study indicated that BlSP has good potential in the production of 2-αGG.
✓ 已验证
DOI
PubMed
高影响因子
MACROMOLECULAR BIOSCIENCE
·
2013
·Vol. 14
·期 2
·280-288
·
IF 3.742
Feifei Li,Bin Chen,Zhaohua Ping,Xiangxiang Jia,Xin Guo,Longqiang Xiao,Lijian Liu
Lipophilic 6- O -poly ( ϵ -caprolactone)- L -ascorbic acid (AA-6-PCL) is synthesized through ROP of ϵ -caprolactone (CL). The number of repeating CL units in the polymer chain varies from 6 to 19. AA-6-PCL loaded supramolecular polymer micelles (SMPMs) are constructed with β-cyclodextrin (β-CD) and PCL as blocks. Transmission electron microscopy images show a nanospheric morphology of the micelles with a size range of 43.3 ± 5.0 nm. The drug loading contents are 22.53–39.23% for AA-6-PCL. AA-6-PCL exhibits high radical scavenging capacity (93.96–96.73%) and efficient scavenging potency, and a cytotoxicity study proves the excellent cytocompatibility of AA-6-PCL loaded β-CD/PCL SMPMs, which altogether herald their potential application in the study of the induced pluripotent stem cells.
✓ 已验证
DOI
PubMed
高影响因子
Journal of Energy Storage
·
2025
·
IF 9.8
Dongke Cai,Mingxia Tang,Shuai Jiang,Debin Yan,Yinchuan Zhu,Yan Meng,Dan Xiao,Qian Zhao,Wei Feng,Xicui Zhang
This study presents a sustainable F/O co-doped hard carbon (PD-F800) derived from panda excrement via NH 4 F-assisted hydrothermal doping for sodium-ion battery anodes. PD-F800 delivers a reversible capacity of 472.87 ± 5.1 mAh g −1 at 100 mA g −1 with an initial Coulombic efficiency of 66.2 ± 2.1 %, maintains 317.72 ± 4.0 mAh g −1 at 1000 mA g −1 , and retains 72.7 ± 3.3 % capacity after 1000 cycles. In situ XRD/Raman, EIS/DRT and GITT jointly indicate that F/O co-doping introduces non-bonded F states and regulates defect/interfacial chemistry, which lowers Na + adsorption/desorption barriers, increases Na + diffusion kinetics, and stabilizes an inorganic-rich SEI, thereby coupling fast surface-controlled storage with reversible interlayer/pore processes. This work establishes a safe, scalable route from waste biomass to high-performance anodes and clarifies the structure-interface-kinetics linkage enabling advanced Na-ion storage.
✓ 已验证
DOI
高影响因子
ACS Sustainable Chemistry & Engineering
·
2025
·
IF 7.3
Zidan Zou,Zhuoya Chai,Jia Zhang,Chun Chen,Yunxia Zhang,Haimin Zhang,Huijun Zhao,Guozhong Wang
Developing efficient catalysts for selective C═O hydrogenation remains challenging due to the thermodynamic preference for C═C bond activation in α,β-unsaturated aldehydes. To address this limitation, we engineered Pt1Co10 nanoalloys within ethylenediamine-functionalized mesoporous silica (MS) by marrying vacuum-assisted impregnation with spatially constrained self-assembly. This dual spatial–temporal control strategy can achieve precise charge redistribution at metal interfaces, geometric confinement suppressing Ostwald ripening, and optimal hydrogenation pathways via hierarchical porosity. Under industry-feasible conditions (25 °C, 0.5 MPa H2), the Pt1Co10/MS system delivers 96.8% cinnamaldehyde conversion with 72.1% cinnamyl alcohol yield, outperforming conventional Pt or Co catalysts. More importantly, the MS framework’s strain accommodation capability enables activity retention over the cycle test, and the electronic synergy between Pt and Co can optimize adsorption energetics to suppress competitive C═C hydrogenation pathways. This work establishes an approach of bimetal synergy for steering adsorbed intermediate configurations, offering universal strategies for selective hydrogenation catalysis.
✓ 已验证
产品关联
DOI
高影响因子
ENVIRONMENTAL TECHNOLOGY
·
2018
·
IF 1.666
Chao Wu,Peilun Xu,Bailong Xu,Wei Li,Sujing Li,Xiangqian Wang
In this study, one- and two-phase partitioning biotrickling filters (1P-BTF and 2P-BTF, respectively) inoculated with a pre-acclimated mixed culture were examined for the removal of hydrophobic and refractory o-xylene. A small fraction of silicone oil (5% v/v) was added as a non-aqueous phase. Due to the presence of silicone oil, the 2P-BTF exhibited superior performance and stability for o-xylene biodegradation at steady and transient operations. Higher macro-kinetic constants for o-xylene removal by the Michaelis–Menten model were obtained for the 2P-BTF with a saturation constant of 0.396 g m−3 and a maximum elimination capacity of 105.7 g m−3 h−1. The enhancement of removal performance for the 2P-BTF was supported by dominant specialized microorganisms with o-xylene biodegradability. The diversity of microbial community was influenced by the presence of silicone oil. This study demonstrated that a BTF with 5% of silicone oil could be applied for the treatment of hydrophobic and refractory volatile organic compounds. It also provided valuable information for better understanding the relationship between microbial community and removal performance using two-phase partitioning bioreactors.
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）