INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2026
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IF 8.7
Guixi Wang,Sihang Shen,LiDong Wang,YiChenTian,Chao Li,Junnan He,Yuzhu Song
Chronic diabetic wounds have become a major global health challenge due to the vicious cycle driven by infection, oxidative stress, and inflammation. To address this issue, researchers developed a pH-responsive injectable hydrogel (SCP@QCNPs&DOX). The hydrogel is composed of oxidized sodium alginate, dihydrazide-modified γ-polyglutamic acid, and carboxymethyl chitosan, and is co-loaded with quercetin nanoparticles (QCNPs) and doxycycline. The quercetin nanoparticles are prepared via coordination between quercetin and cerium, which not only overcomes the inherent poor water solubility of quercetin but also endows them with antioxidant, anti-inflammatory, and enzyme-mimetic catalytic activities. The SCP@QCNPs&DOX hydrogel exhibits excellent biodegradability, biocompatibility, and stable rheological properties, enabling controlled release of quercetin nanoparticles and doxycycline. The hydrogel alleviates oxidative stress by scavenging reactive oxygen species (ROS) and maintaining mitochondrial membrane potential, inhibits inflammation by modulating the NF-κB pathway and inducing M2 macrophage polarization, and demonstrates potent antibacterial activity against Staphylococcus aureus and methicillin-resistant S. aureus (MRSA). In a diabetic rat model with MRSA infection, the hydrogel significantly suppresses inflammation, exerts antibacterial effects, promotes angiogenesis, and thereby accelerates wound healing. In summary, the SCP@QCNPs&DOX hydrogel represents a promising multifunctional platform for the treatment of infected diabetic wounds. Schematic illustration of the preparation of pH-responsive multifunctional SCP@QCNPs&DOX hydrogels and their role in promoting diabetic wound healing. (A) Preparation of QCNPs; (B) Preparation of hydrogels; (C) Antibacterial, antioxidant, immunomodulatory, and angiogenic functions of SCP@QCNPs&DOX hydrogels in promoting diabetic wound healing. Download: Download high-res image (119KB) Download: Download full-size image
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2023
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IF 8.2
Zhaowen Liu,Hongcai Wang,Yanan Bu,Ting Wu,Xiuqiong Chen,Huiqiong Yan,Qiang Lin
The application of hydrophobic β-carotene in the food industry are limited due to its susceptibility to light, high temperature, pH value, and other factors, leading to poor stability and low bioavailability. To address this problem, we adopt a more green and environmentally friendly reducing agent, 2-methylpyridine borane complex (pic-BH 3 ), instead of traditional sodium borohydride, to achieve the simple green and efficient synthesis of amphiphilic oxidized sodium alginate grafted oleoamine derivatives (OSAOLA) through the reduction amination reaction of Schiff base. The resultant OSAOLA with the degree of substitution (DS) of 7.2 %, 23.6 %, and 38.8 % were synthesized, and their CMC values ranged from 0.0095 to 0.062 mg/mL, indicating excellent self-assembly capability in aqueous solution. Meanwhile, OSAOLA showed no obvious cytotoxicity to RAW 264.7 cells, thus revealing good biocompatibility. Furthermore, β-carotene, as the hydrophobic active ingredients in foods was successfully encapsulated in the OSAOLA micelles by ultrasonic-dialysis method. The prepared drug-loaded OSAOLA micelles could maintain good stability when stored at room temperature for 7 d. Additionally, they were able to continuously release β-carotene and exert long-term effects in pH 7.4 PBS at 37 °C, effectively improving the bioavailability of β-carotene, which exhibited tremendous application potential in functional food and biomedical fields.
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高影响因子
Journal of Environmental Chemical Engineering
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2021
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IF 5.909
Siyi Zhang,Kamile Arkin,Yuxin Zheng,Jicheng Ma,Yuyang Bei,Di Liu,Qingkun Shang
In this paper, an environmentally friendly, visible and easy-to-recycle spherical adsorbent (SA@PEI-CDs, SA : sodium alginate, PEI: polyethyleneimine, CDs : carbon dots) has been prepared from functionalized positively charged biomass carbons dots (PEI-CDs) and anionic polyelectrolyte sodium alginate (SA) through electrostatic self-assembly. SA@PEI-CDs can efficiently and preferentially adsorb Pb 2+ . Compared to bare SA, the adsorption capacity of SA@PEI-CDs increased from 206.93 mg/g to 380.39 mg/g (at pH=4), which enhanced 83.82%. It can still maintain 85.67% of the original adsorption capacity after five cycles. The quenching of the blue fluorescence of the adsorbent derived from carbon dots indicates that the adsorption process has reached saturation. The investigation about the adsorption isotherm models, kinetics and thermodynamic parameters reveals that the adsorption process follows Freundlich isotherm model based on chemical adsorption , which is an endothermic spontaneous reaction with an increase in entropy. The possible adsorption mechanism is electrostatic attraction, ion exchange, and together with the coordination of -NH 2 , -OH, -COOH with Pb 2+ . In addition, the extremely easy-to-recycle spherical adsorbent is also used in the multi-layer adsorption and separation of simulated sewage samples in the water purifier model. For simulated water samples whose concentration of five/three types of heavy metal ions exceeds 100 times the standard, after using adsorbent SA@PEI-CDs for two or three consecutive adsorptions, the content of heavy metals decreases rapidly, which is far below the limit value of high-quality water. The Pb 2+ ion concentration decreased from 1.0 mg/L to 0.002540 mg/L and 0.003611 mg/L, respectively.
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高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
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2021
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IF 7.312
Haoyu Yue,Zhijie Shang,Pan Xu,Dongyue Feng,Xinxue Li
A novel EDTA functionalized chitooligosaccharide/sodium alginate/Ca 2+ physical double network hydrogel (ECSDNH) was prepared by using of high-salinity oilfield produced water. The formation and structure of ECSDNH were characterized by FT-IR and SEM. Various factors, including EDTA functionalized chitooligosaccharide content, pH of solution, initial concentration of heavy metal ions, temperature and contact time, were thoroughly investigated to explore their effect on adsorption capacity of ECSDNH. The obtained results showed that ECSDNH had higher adsorption capacity for Zn 2+ , Ni 2+ and Mn 2+ . The maximum adsorption capacities of Zn 2+ , Ni 2+ and Mn 2+ were 160.19 mg/g, 72.67 mg/g and 52.43 mg/g at 298 K, respectively. The pseudo-second-order kinetic model and Langmuir isotherm model fit the experimental data fairly well. The thermodynamic parameters of the adsorption, Δ H ° , Δ S ° , and Δ G ° , were also calculated. In addition, the ECSDNH still had higher removal efficiency for three metal ions after three adsorption-regeneration cycles, indicating its potential application for removing heavy metal ions from wastewater.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2019
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IF 3.131
Qifang Zheng,Liyan Zhao,Jing Wang,Shuo Wang,Yuxing Liu,Xiaofei Liu
Double-network hydrogels have become a research hotspot in the field of hydrogels because of their high strength and toughness. Here, we prepared PAM/SA-Fe dual physically crosslinked hydrogels formed by hydrophobic association and ionic coordination. The fracture stress, elastic modulus and toughness of the PAM/SA-Fe hydrogel are 1.39 MPa, 122.12 kPa and 7320.83 kJ/m 3 respectively. The hydrogel also has excellent self-recovery, puncture resistance, fatigue resistance and self-healing performance. In addition, swelling and thermogravimetric analysis tests confirmed that the hydrogel has pH sensitivity and good thermal stability. Finally, we observed the chemical composition and internal microstructure of the hydrogel by SEM and FITR. The PAM/SA-Fe hydrogel provides a new design method for double-network hydrogels and has broad application prospects in electronic skin, sensors and medicine.
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DESALINATION
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2024
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IF 8.3
Xiaole Gong,Xiaohua Zhao,Zhihan Yang,Zihan Guo,Jiangtao Xu,Honglei Liu,Jingquan Liu
Solar-driven interfacial evaporation (SIE) represents a promising desalination technology leveraging solar energy and seawater. Nevertheless, the majority of SIE systems face constraints such as high costs, intricate fabrication processes, and limited tolerance to salt. Therein, we designed and developed an eco-friendly, simple, and low-cost way to construct independent and elastic three-dimensional networks using tannic acid (TA), polypyrrole (PPy), and sodium alginate (SA) via the triple action mechanism of Fe 3+ for efficient water evaporation (TPS-x). When the mass ratios of PPy and TA are designed as 1:2, 1:1, 2:1, and 3:1, and crosslinked with sodium alginate and FeCl 3 , four composites (TPS-1, TPS-2, TPS-3, and TPS-4) are obtained, in which the light absorption and evaporation properties of TPS-3 are the optimal, with an evaporation rate up to 2.451 kg m −2 h −1 and a photothermal conversion efficiency up to 84.74 %. Additionally, the TPS-3 evaporator has excellent stability and salt tolerance, maintaining more than 95.5 % of its original evaporation rate after 20 days of cycling tests. Due to its exceptional photothermal evaporation performance, TPS-3 shows potential for practical commercial applications, particularly in the fields of wastewater treatment and desalination.
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高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
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2024
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IF 8
Zaihua Duan,Boyu Zhang,Mingxiang Zhang,Zhen Yuan,Yadong Jiang,Huiling Tai
Electrochemical power generation humidity sensors have received great attention recently, but it is challenging for achieving good humidity sensing and power generation performances simultaneously. Herein, we construct a high-performance power generation humidity sensor based on NaCl/sodium alginate (SA) humidity sensing electrolyte and Cu/Zn electrodes. Benefiting from the reasonable selection of humidity sensing electrolyte and electrode materials and the design of sensor structure, the optimized NaCl/SA humidity sensor exhibits wide humidity sensing detection range (10.9−91.5% relative humidity (RH)), short response time (5.6 s), and good repeatability (20 cycles) at 25°C. Importantly, the humidity sensor has high response voltage (∼0.7 V), large short circuit current (∼24 μA) and loading power (∼2.63 μW) at 91.5% RH. The NaCl/SA humidity sensor can be used for passive visual humidity indication by connecting it to a pointer microammeter. In addition, we designed signal processing circuit and software program to recognize respiratory patterns using NaCl/SA humidity sensor. This work not only achieves a high-performance electrochemical humidity sensor, but also provides a useful reference for its applications in passive visual humidity and respiratory patterns detections.
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FOOD CHEMISTRY
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2025
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IF 9.8
Kaiwen Xie,Xiang Xu,Chengcheng Gao,Zhenjiong Wang,Linghan Meng,Xiao Feng,Xiaozhi Tang
The regulatory effects of different mannuronate/guluronate ratios in sodium alginate (SA) and calcium ion (Ca 2+ ) concentrations on the structure and properties of starch-SA interpenetrating polymer network (IPN)-enhanced extruded buckwheat noodles were investigated. The thermal stability of buckwheat noodles was improved by increasing the G block proportion, and 1% Ca 2+ concentration led to the highest thermal stability. With increasing G proportion and Ca 2+ concentration, cooking loss and elongation at break of extruded noodles gradually decreased. The cooking time initially decreased and then increased. Noodle hardness, chewiness, and breaking strength significantly increased. In vitro starch digestion showed that when the SA M/G ratio was 1:2 and the Ca 2+ concentration was 1%, the predicted glycemic index of noodles was the lowest and the resistant starch content was the highest. According to curve fitting based on the sensory evaluation results, the overall noodle acceptability was higher when hardness was between 3800 and 5200 g.
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PubMed
高影响因子
POLYMER ENGINEERING AND SCIENCE
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2025
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IF 3.2
Ge Yan,Qifeng Chen,Lixin Zhang,Yunjia Wang
This study presents a reusable adsorbent material for industrial wastewater treatment. Double-network interpenetrating gel beads were prepared via condensation reaction and hydrogen bonding between sodium alginate and collagen, combined with PVA and ion crosslinking. The addition of collagen enhanced the equilibrium swelling ratio, strengthened the double-network structure, and increased adsorption sites. Optimal adsorption of tannic acid occurred at a collagen/PVA mass ratio of 1:2, achieving a maximum capacity of 261.53 mg/g and a removal rate of 78.46%. Influenced by multiple factors, the adsorption process followed pseudo-second-order kinetics, indicating chemisorption dominance. The beads maintained good adsorption capacity and structural stability over four adsorption–desorption cycles, demonstrating excellent reusability.
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MOLECULES
·
2021
·Vol. 26
·期 23
·7140
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IF 4.412
Jingwen Chen,Yinxuan Li,Wenzheng Shi,Hui Zheng,Li Wang,Li Li
This study aimed to develop an active biodegradable bilayer film and to investigate the release behaviors of active compounds into different food matrices. Cinnamaldehyde (CI) or thymol (Ty) was encapsulated inβ-cyclodextrin (β-CD) to prepare the activeβ-CD inclusion complex (β-CD-CI/β-CD-Ty). The tilapia fish gelatin-sodium alginate composite (FGSA) containingβ-CD-CI orβ-CD-Ty was coated on the surface of PLA film to obtain the active bilayer film. Different food simulants including liquid food simulants (water, 3% acetic acid, 10% ethanol, and 95% ethanol), solid dry food simulant (modified polyphenylene oxide (Tenax TA)), and the real food (Japanese sea bass) were selected to investigate the release behaviors of bilayer films into different food matrixes. The results showed that the preparedβ-CD inclusion complexes distributed evenly in the cross-linking structure of FGSA and improved the thickness and water contact angle of the bilayer films. Active compounds possessed the lowest release rates in Tenax TA, compared to the release to liquid simulants and sea bass. CI and Ty sustained the release to the sea bass matrix with a similar behavior to the release to 95% ethanol. The bilayer film containingβ-CD-Ty exhibited stronger active antibacterial and antioxidant activities, probably due to the higher release efficiency of Ty in test mediums.Keywords:biodegradable bilayer film;tilapia fish gelatin;β-cyclodextrin inclusion complex;release kinetics;food simulants;active activities
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Jianing Zhang,Junjun Zhang,Lei Zhou,Nurmymeti Yasen,Abudulekemu Abudinaibi,Xiaowei Huang,Xiaodong Zhai,Zhihua Li,Jiyong Shi,Remah Sobhy,Ibrahim Khalifa,Xiaobo Zou
Intelligent films are essential for real-time monitoring of food spoilage. However, the application is often limited by challenges such as hydrophilicity and color instability. In this study, two high hydrophobic bilayer indicators based on sodium alginate-polyvinyl alcohol/chitosan-zein with alizarin grafted onto ZIF-8 carrier (AL@ZIF-8) were fabricated using the casting method and electrospinning, respectively. Molecular docking simulations confirmed the successful grafting of AL@ZIF-8 onto the film substrates. The performance of films was compared and the effectiveness in monitoring freshness indicators was evaluated. The cast film had a precisely controlled thickness due to self-assembly performance, resulting in superior mechanical properties (TS = 10.64 MPa, EB = 43.764 %). In comparison, the nanofiber films demonstrated higher UV-blocking ability (ΔE < 4), faster spoilage response, and greater safety (Cell viability >80 %). Importantly, the nanofiber films exhibited higher sensitivity in monitoring beef freshness, with a color change pattern strongly correlating with spoilage (R 2 = 0.8976).
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Journal of Environmental Chemical Engineering
·
2026
·Vol. 14
·期 6
·125225
·
IF 7.5
Xianhong Zhao,Pengfei Zong,Yifan Wang,Yuhao Wu,Chengxuan Song,Shoufang Wang,Hangzhou Zhang
Recyclable LZPS hydrogel microspheres were successfully synthesized. • LZPS microspheres revealed remarkable adsorption capacity towards Eu(III) and Pb(II). • LZPS microspheres displayed excellent stability in removal of Eu(III) and Pb(II). • Long-term field studies on Eu(III) and Pb(II) behaviors in medium were required. • Multicomponent synergy enhanced adsorption capacity and ion selectivity. With the fast growth of the nuclear industry and application of radioisotopes, the pollution of aquatic environments with radionuclides and heavy metals has become increasingly severe. Thus, there is a pressing demand to develop novel adsorbent materials with high efficiency, high selectivity, and good recyclability. Herein, a novel zinc-aluminum layered double hydroxide/zeolitic imidazolate framework-67 integrated with polydopamine functionalized sodium alginate hydrogel microsphere (Zn Al-LDH/ZIF-67/PDA/SA, denoted as LZPS), was successfully synthesized to achieve the efficient enrichment of Eu(Ⅲ) and Pb(Ⅱ). As revealed by characterization measurements, the hydrogel microsphere was successfully constructed with abundant surface functional groups contributing to the prominent adsorption behavior of the adsorbent. The impact of diverse environmental factors on the adsorption behavior of LZPS for Eu(Ⅲ) and Pb(Ⅱ) in wastewater was systematically examined through macroscopic experiments. The experimental conclusions demonstrated that LZPS exhibited excellent adsorption capability toward Eu(Ⅲ) and Pb(Ⅱ). Adsorption equilibrium for Eu(Ⅲ) and Pb(Ⅱ) was attained within 150 min, and the pseudo-second-order model offered a satisfactory description of the adsorption kinetic data. At 303 K, the maximum adsorption capacity of Eu(Ⅲ) and Pb(Ⅱ) using Langmuir model was 2.10 × 10 −3 mol/g and 9.28 × 10 −4 mol/g, respectively. It was confirmed by XPS analysis that Eu(Ⅲ) and Pb(Ⅱ) adsorption on LZPS was predominantly driven by electrostatic interaction, ion exchange, surface complexation, and reduction reaction. Overall, the LZPS hydrogel microsphere was possessed significant application prospects and potential practical value for the efficient treatment of Eu(Ⅲ) and Pb(Ⅱ) in nuclear wastewater. Download: Download high-res image (236KB) Download: Download full-size image
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