Materials Science & Engineering C-Materials for Biological Applications
·
2017
·
IF 4.164
Jianbing Wu,Xusheng Xie,Zhaozhu Zheng,Gang Li,Xiaoqin Wang,Yansong Wang
The effects of changing solution pH in the range of 3.6–10.0 during a one-step silk microsphere preparation process, by mixing silk and polyethylene glycol (PEG), was assessed. The microspheres prepared at low pH (3.6) showed a more homogeneous size (1–3 μm) and less porous texture than those prepared at neutral pH. High pH (10.0) inhibited microsphere formation, yielding small and inhomogeneous microspheres. Compared to neutral pH, low pH also increased the content of silk crystalline β-sheet structure from approx. 30% to above 40%. As a result, the microspheres produced at low pH were more thermally stable as well as resistant to chemical (8 M urea) and enzymatic (protease XIV) degradation when compared to microspheres prepared at neutral pH. Doxorubicin hydrochloride (DOX) and curcumin (CUR) were successfully loaded in silk microspheres via control of solution pH. The loading efficiency of DOX was approx. 95% at pH 7.0 and approx. 60% for CUR at pH 3.6, attributed to charge-charge interactions and hydrophobic interactions between the silk and drug molecules, respectively. When PBS, pH 7.4, was used as a medium for release studies, the pH 3.6 microspheres released both drugs more slowly than the pH 7.0 microspheres, likely due to the high content of crystalline β-sheet structure that enhanced drug-silk interactions as well as restricted drug molecule diffusion.
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Journal of Water Process Engineering
·
2024
·
IF 6.3
Jialin Wei,Zhiyuan Qiao,Dinghe Yan,Jingwen Chu,Xinyi Zheng,Dawei Ji,Changfa Xiao,Chun Wang
In this study, we deposited polyelectrolyte multilayers (PEMs) on Poly ( p -phenylene terephthamide) (PPTA) ultrafiltration (UF) substrates with strong polyelectrolytes (PEs): polystyrene sulfonic acid (PSS) and poly (diallyldimethylammonium chloride) (PDADMAC). The growth pattern of PEMs was shifted from linear to exponential by changing substrate potential, which was attributed to synergism and antagonism of dispersion of PEs on hydrophilic substrates and electrostatic interaction between PEs and substrates. Eventually, PEMs of layer-dominated and pore-dominated regimes were successfully obtained. We focused on the transition from the pore-dominated to the layer-dominated regime of PEMs. The PEMs nanofiltration (NF) membranes in this situation showed a better separation performance due to the together work of the interface and in-pore energy barriers. The retention rate of Na 2 SO 4 and MgSO 4 was 98 % and 91 %. The eosin Y retention rate was 99.9 % and only declined 2 % after 100 h. The hindered deposition of pore-dominated regimes led to denser and thinner layers, which achieved long-term acid resistance. It maintained a stable salt retention after 185 h cross-filtration of 0.1 M H 2 SO 4 feed solution. The performance of PEMs NF membrane was improved from a new perspective, and excellent acid-resistant nanofiltration membranes were obtained, which are expected to be used to treat industrial acidic wastewater.
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JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY
·
2024
·
IF 1.9
Shu Wu,Chen Wang,Xia Chen,Lu Bai,Qiuhua Wu,Guolin Zhang
In this work, pH and temperature dual-responsive drug delivery vehicles (CDs/PNVCL@HMSNs) with 57.05% drug loading efficiency were prepared. Hollow mesoporous silicon nanoparticles (HMSNs) were synthesized by selective etching. The mixed shells on the surface of HMSNs were composed of carbon dots (CDs) and poly (N-vinylcaprolactam) (PNVCL), which were linked to HMSNs via Schiff base reaction. At room environment (pH = 7.4, T = 25 °C), PNVCL was stretched, so that the model drug Doxorubicin (DOX) could be transported freely through the mesopores. In the blood stream (pH = 7.4, T = 37 °C), PNVCL was collapsed, and DOX was encapsulated to form PNVCL@HMSNs-DOX. CDs were grafted to give CDs/PNVCL@HMSNs-DOX and could further inhibit the leakage of drugs. At the acidic environment of the tumor site, Schiff base bonds broke, leading to shell shedding and DOX release. The drug release could be real-time monitored by the change in fluorescence intensity, which was confirmed by the linear fitting of the fluorescence strength of CDs and the percentage of DOX released. CDs/PNVCL@HMSNs are intriguing drug delivery systems (DDSs), which can combine real-time monitoring and control of drug release.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2025
·
IF 5.4
Jing Wang,Cheng Yang,Jianzhong Jiang
Plant-based proteins have garnered increased attention in recent years due to their unique interfacial properties and biocompatibility. However, their low solubility under neutral pH conditions has always limited their applications. In this paper, oat globulin (OG) (0.01 wt% - 0.05 wt%) could solely stabilize Pickering emulsions with controllable rheological properties at different pH without any modifications. Low viscosity Pickering emulsions (V oil :V water = 1:1) with stability exceeding six months were formed at pH= 2 (221 Pa s) and 12 (109 Pa s), owing to the formation of small OG aggregates (100 nm) with high interfacial activity. Conversely, at pH= 5–10, Pickering emulsions with high viscosity were obtained, where larger-size OG particles aggregated at the oil-water interface. Therefore, the stability, droplet size, and viscosity of the Pickering emulsions stabilized by OG particles could be regulated by pH variation. The strategy harnesses the OG aggregation state at diverse pH levels to engineer emulsions with distinct properties, avoiding the need for chemical grafting modifications, heat, or high-intensity ultrasound treatments, which holds promise for potential applications in functional materials.
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LUMINESCENCE
·
2024
·Vol. 39
·期 12
·e70055
·
IF 3.2
Jiarui Si,Yikang Liu,Yuanfei Jiang,Yutong Chen,Anmin Chen,Mingxing Jin
The fluorescence quenching behavior of rhodamine 6G (R6G) by graphene oxide (GO) under varying pH conditions was investigated. Utilizing steady-state fluorescence spectroscopy, single-photon counting, and ultrafast time-resolved absorption spectroscopy, we explored the quenching efficiency at pH values of 3, 7, and 11. Our findings reveal that GO effectively quenches R6G fluorescence across all tested pH levels, with the most significant quenching observed at pH 7. This quenching efficiency is attributed to optimal electrostatic interactions and efficient charge transfer between GO and R6G at neutral pH. At pH 3, the quenching efficiency is moderately reduced due to partial protonation of GO, which weakens electrostatic interactions but maintains hydrogen bonding. At pH 11, the quenching efficiency is lowest, likely due to increased electrostatic repulsion and reduced charge transfer resulting from deprotonation of GO. Ultrafast time-resolved absorption spectroscopy further confirmed the dynamic nature of the quenching process, showing distinct differences in relaxation kinetics across the pH spectrum. This study highlights the critical role of pH in modulating the quenching mechanisms of GO and R6G, providing valuable insights for the design of pH-sensitive fluorescence sensing systems.
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SENSORS AND ACTUATORS B-CHEMICAL
·
2024
·
IF 8
Siyi Li,Kexin Li,Xianfeng Gong,Pengfei Yan,Shaoping Sun
Multifunctional polymeric micelles, which possess capabilities for tracking, bioimaging, stimuli-responsive drug release and tumor targeting, are essential in facilitating the effective delivery of anticancer drugs. Hence, a novel copolymer (CD-CS-Bio-TPAA, CCBT) was synthesized with biotin and hydroxypropyl-β-cyclodextrin conjugated chitosan as the hydrophilic segment and aggregation-induced emission (AIE) featured tetraphenylethene derivative (TPAA) as the hydrophobic segment. Interestingly, under acidic conditions, CCBT exhibited color-tunable AIE behavior as a result of the cleavage of benzoic imine bonds in TPAA molecules, transitioning from red to yellow. Furthermore, CCBT could also self-assemble into polymeric micelles and be used as drug carriers to encapsulate paclitaxel (PTX) (PTX/CCBT PMs) for self-indicating cancer therapy. In vitro release experiments demonstrated that PTX/CCBT PMs could release drugs specifically under acidic conditions. Fluorescence imaging experiments demonstrated that CCBT PMs exhibited excellent cell imaging capabilities and could be tracked due to their unique color-changing behavior. Moreover, PTX/CCBT PMs exhibited notable cytotoxic effects on MCF-7 cells and showed selective internalization by MCF-7 cells through biotin receptor-mediated active targeting. In vivo antitumor experiments confirmed that PTX/CCBT PMs possessed remarkable tumor-inhibiting effects and low systemic toxicity. This work suggested that PTX/CCBT PMs provided new ideas for self-indicating breast cancer treatment.
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ACS Applied Nano Materials
·
2024
·
IF 5.3
Sifang Zhao,Fengjiao Chen,Xianwu Chen,Hongze Liang,Hui Tan,Lingling Zhao
The tumor microenvironment is characterized by several hallmarks such as an acidic pH and high glucose levels in tumor tissues and increased expression of specific proteins and/or sugars on the surface of tumor cells. These unique hallmarks of tumors can be considered in the design of multifunctional drug delivery nanosystems to improve the efficiency of tumor therapy through targeted drug delivery and specific drug release in the tumor tissue. In this study, phenylboronic acid-modified pH- and glucose-responsive polymer micelles were designed for the targeted delivery of anticancer drugs. The polymeric micelles demonstrated prolonged and pH/glucose-triggered drug release and enhanced cellular internalization by B16F10 cells through a receptor-mediated endocytosis pathway. The polymeric micellar system could inhibit the proliferation of B16F10 cells with IC50 values lower than those of unmodified micelles. In addition, the polymeric micellar system could markedly suppress cell migration, colony formation, and invasion and promote the apoptosis of B16F10 cells, indicating good anticancer efficiency in vitro. Therefore, this polymeric nanocarrier provides a potential platform for targeted anticancer therapy.
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CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Ning Gao,Yunbo Wang,Huixin Luo,Yingtong Xu,Jining Liu,Yingwen Chen
The accumulation of oily waste increases annually with the growth in crude oil demand. Its toxicity and high heating value present both opportunities and challenges for treatment technologies. In recent years, the emergence of hydrophobic deep eutectic solvents (HDES) has promoted advancements in low-toxicity extraction processes. Leveraging the advantages of HDES and addressing the challenges posed by real oily sawdust (with a 67.9 % oil content), this study presents a novel green HDES solvent composed of ethyl maltol and fatty acids, accompanied by a corresponding extraction process. At a low temperature of 60 °C, the process achieved impressive results: an oil extraction efficiency close to 86.3 %, a dehydration rate exceeding 92.2 %, and a heavy metal removal rate ranging from 15 % to 75 %. In the exploration of solvents recycling, pH-switching facilitated the deprotonation and protonation of phenol-fatty acid HDES, promoting effective recovery of the oil phase. Even after 5 cycles, the oil extraction rate could still be maintained above 75 %. It is worth noting that the regenerated HDES exhibited greater selectivity for extracting light oil after multiple uses. The total ratio of saturated and aromatic hydrocarbons reached approximately 81.7 %, significantly enhancing the value of the recovered oil. Integrating systematic characterization with the extraction performance, as well as the variation in recovered oil phase components, highlighted the multifaceted effects of introducing ethyl maltol. Specifically, this effect is demonstrated in its ability to enhance the oil phase’s solubility by regulating the intermolecular spacing of HDES, and to impede the dissolution of heavy oil into its gaps by optimizing the local zone through the formation of complexes with HDES and heavy metals.
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JOURNAL OF ALLOYS AND COMPOUNDS
·
2024
·
IF 5.8
Pei Yu,Fengting Luo,Shijian Chen
Rational designing Mo-based heterojunction catalysts as hydrogen evolution catalysts is seriously significant for the widespread utilization of hydrogen energy. Here, the ingenious hierarchical construction of MoP 2 /MoS 2 nanowires was delivered with high conductivity of porous MoP 2 and abundant active sites of defect-rich MoS 2 . Under synergistic effect of two materials, this catalyst achieves a dramatically optimized electronic structure to boost hydrogen evolution in all-pH range. The optimal MoP 2 /MoS 2 /CC nanoreactor showed overpotentials of 47.11, 60.16, and 89.83 mV to drive −10 mA cm −2 and Tafel slopes of 51.69, 52.04, and 73.79 mV dec −1 in acidic, alkaline, and neutral media, respectively. This finding may provide an effective approach for elevating the pH-universal electrocatalytic performance in order to achieve industrial hydrogen evolution.
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JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
·
2024
·
IF 5.9
Jun Gao,Miaomiao Li,Haiying Chen,Ze Xu,Junyao Li,Yong Kong,Xiaoming Zuo
Stimuli-responsive copolymeric hydrogels (CH) are synthesized for controlled drug delivery. Oxidized glycyrrhizic acid is connected to acrylamide through Schiff base reaction, which is then copolymerized with N,N-bis (acryloyl) cystamine and N-isopropylacrylamide by free-radical polymerization for the loading of 5-fluorouracil with a loading efficiency of 96.7 %. The lower critical solution temperature of the CH is 39.14 °C. The N-isopropylacrylamide unit in the CH is sensitive to temperature, endowing the CH with temperature sensitivity. The carboxyl groups of oxidized glycyrrhizic acid can be deprotonated in alkaline solutions, and the electrostatic repulsions between the resultant carboxylate can cause swelling of the CH. The disulfide bond (S–S) of the N,N-bis (acryloyl) cystamine unit can be reduced to sulfhydryl (–SH) by glutathione, and thus the CH is also reduction-sensitive. Therefore, temperature, reduction and pH-controlled delivery of 5-fluorouracil from the CH is achieved. Cytotoxicity assay reveals that the drug-free hydrogels have good biocompatibility while the CH shows high cytotoxicity against human hepatoma SMMC-7721 cells, and the cell viability is only 25 % at the CH concentration of 1 mg mL −1 .
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JOURNAL OF CHEMICAL PHYSICS
·
2024
·Vol. 161
·期 5
·
IF 3.1
Li Xiaoping,Ma Lijing,Zhou Yu,Lu Xinlong,Jing Li,Jing Dengwei
Regarding the rheological properties of fluids, certain nanoparticles can markedly modify the rheological behavior of low surface tension solutions by interacting with surfactant molecules. In this work, a low surface tension fluid with cetyltrimethylammonium chloride was prepared, and the silica nanoparticles were uniformly dispersed into it by ultrasonic dispersion. By adjusting the size, shape, and concentration of nanoparticles, the fluid behavior can be changed from Newtonian to non-Newtonian with finely tuned viscosity and characterized by a shear-thinning rheological behavior. In addition, this work explored how variations in environmental temperature and solution pH affect the rheological responses of the low surface tension suspension system. The experimental findings revealed that increasing the temperature substantially decreases the system’s viscosity and induces a shear-thickening behavior. It is particularly significant that, under extreme pH conditions (either strongly acidic or alkaline), the viscosity of the nanoparticle suspensions was markedly enhanced at a particle concentration of 10 000 ppm. This interesting result coincided with a notable reduction in the zeta potential and an increase in the average particle size, suggesting an intensified aggregation of particles within the suspension system. A mechanism detailing the interaction between silica nanoparticles and surfactant micelles was proposed. This work indicates that the incorporation of nanoparticles into surfactant solutions offers a powerful approach to modulating fluid rheology across various conditions.
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Nanoscale
·
2024
·Vol. 16
·期 21
·10448-10457
·
IF 5.8
Feng Yang,Shiwen Gong,Die Hu,Lihua Chen,Wenyuan Wang,Bo Cheng,Jing Yang,Binbin Li,Xinyu Wang
With continuous advances in medical technology, non-invasive embolization has emerged as a minimally invasive treatment, offering new possibilities in cancer therapy. Fluorescent labeling can achieve visualization of therapeutic agents in vivo, providing technical support for precise treatment. This paper introduces a novel in situ non-invasive embolization composite material, Au NPs@(mPEG-PLGTs), created through the electrostatic combination of L-cysteine-modified gold nanoparticles (Au NPs) and methoxy polyethylene glycol amine-poly[(L-glutamic acid)-(L-tyrosine)] (mPEG-PLGTs). Experiments were undertaken to confirm the biocompatibility, degradability, stability and performance of this tumor therapy. The research results demonstrated a reduction in tumor size as early as the fifth day after the initial injection, with a significant 90% shrinkage in tumor volume observed after a 20-day treatment cycle, successfully inhibiting tumor growth and exhibiting excellent anti-tumor effects. Utilizing near-infrared in vivo imaging, Au NPs@(mPEG-PLGTs) displayed effective fluorescence tracking within the bodies of nude BALB-c mice. This study provides a novel direction for the further development and innovation of in situ non-invasive embolization in the field, highlighting its potential for rapid, significant therapeutic effects with minimal invasiveness and enhanced safety.
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