CHEMICAL ENGINEERING JOURNAL
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2026
·
IF 12.5
Hongyu Yang,Yuelin Zhao,Sen Mu,Siqi Wang,Aiyang Tong,Dongkai Wang,Jiajia Jia,Ji Li
HA@CZ enables acid-responsive local Ca 2+ /Zn 2+ ion therapy. • Zn 2+ impairs Ca 2+ extrusion and drives sustained Ca 2+ overload. • Dual-ion stress induces caspase-1/GSDMD and caspase-3/GSDME pyroptosis. • HA@CZ cascade-induces pyroptosis and activates the STING pathway. • Local HA@CZ treatment sensitizes 4 T1 tumors to PD-1 blockade. Triple-negative breast cancer responds poorly to immune checkpoint blockade, partly because of insufficient tumor-local immune priming. Controlled delivery of bioactive ions offers an opportunity to induce inflammatory tumor cell death while limiting nonspecific systemic exposure. Here, we developed hyaluronic acid-modified, zinc containing calcium carbonate nanoparticles (HA@CZ) for acid-responsive synchronized Ca 2+ /Zn 2+ delivery. HA@CZ remained colloidally stable under physiological conditions but released Ca 2+ and Zn 2+ more rapidly under tumor relevant acidic conditions. HA@CZ markedly promoted intracellular Ca 2+ /Zn 2+ accumulation, induced mitochondrial dysfunction, and triggered gasdermin dependent pyroptosis through the caspase-1/GSDMD and caspase-3/GSDME axes. Mechanistically, the key distinction of HA@CZ does not lie in Ca 2+ overload alone, but in converting Ca 2+ overload from a direct ion burden process into a Zn 2+ initiated Ca 2+ homeostasis collapse mechanism. Zn 2+ impaired mitochondrial energy metabolism and ATP dependent Ca 2+ extrusion, thereby lowering the threshold for sustained Ca 2+ overload after synchronized ion release. The resulting dual ion stress promoted mitochondrial deoxyribonucleic acid leakage and activated cyclic GMP–AMP synthase stimulator of interferon genes signaling, thereby coupling tumor cell pyroptosis with endogenous deoxyribonucleic acid sensing activation. In syngeneic 4 T1 tumor models, HA@CZ suppressed tumor growth after both systemic and local administration, promoted dendritic cell maturation and CD8 + T-cell infiltration, and remodeled the tumor immune microenvironment toward a pro-inflammatory phenotype. Intratumoral studies confirmed its intrinsic therapeutic superiority over free CaCO₃, Zn 2+ , and their physical mixture, while combination with anti-PD-1 therapy enhanced control of both primary and distant tumors. Furthermore, tumor re-challenge experiments demonstrated that HA@CZ induced durable antitumor immune memory. These findings establish HA@CZ as a controlled-release ion nanotherapeutic that couples synchronized Ca 2+ and Zn 2+ delivery to pyroptosis associated immune activation and checkpoint blockade sensitization. Download: Download high-res image (150KB) Download: Download full-size image
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高影响因子
Materials
·
2025
·Vol. 18
·期 12
·2770
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IF 3.2
Qianqian Zheng,Yanwen Ren,Cuicui He,Jingjing Nie,Binyang Du
The transition to renewable energy makes energy storage crucial. Aqueous organic redox flow batteries (AORFBs) show great potential in large-scale energy storage due to their outstanding safety compared to conventional systems. Derivatives of 2,2,6,6-tetramethylpiperidin-1-oxyl (TEMPO) show significant promise as catholyte materials in AORFBs. In this work, a bipyridine-ester dual-modified TEMPO derivative, (2,2,6,6-tetramethyl-1-piperidinyloxy)carbonyl-ethyl-(4-(pyridin-4-yl)benzyl) ammonium bromide (TEMP-BPy) was successfully synthesized via a two-step functionalization. The synthesized compound was experimentally confirmed to possess excellent electrochemical stability. The electron-withdrawing effect of the 4,4′-bipyridine moiety elevates the redox potential by 60 mV. When implemented as a catholyte paired with methyl viologen (MV) as the anolyte in AORFB, the TEMP-BPy/MV system demonstrates excellent performance: achieving a cell voltage of 1.28 V and an energy density of 14.5 Wh L−1at a 0.6 M (16.08 Ah L−1) concentration with 71.3% material utilization. Notably, it demonstrates exceptional cycling stability with an average capacity retention of 99.86% per cycle over 200 cycles, and it exhibits particularly impressive initial stability, with an average capacity retention of 99.997% per cycle during the first 100 cycles.
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高影响因子
Antioxidants
·
2025
·Vol. 14
·期 10
·1222
·
IF 6.6
Hanziyi Zhou,Shibo Sun,Haowen Liu,Tong Li,Yiran Xu,Rui Yang,Haiyan Liu,Leiyu He,Weiping Xu,Shui Guan,Jianqiang Xu
Selenoprotein thioredoxin reductase 1 (TXNRD1) is frequently upregulated in various cancer cells to sustain cellular redox homeostasis, and its inhibition has emerged as a promising anti-cancer strategy. In this study, we identified PK11007, a thiol-modifying compound previously characterized as a p53 reactivator, as a potent inhibitor of TXNRD1. PK11007 irreversibly inhibited recombinant TXNRD1 in a time- and dose-dependent manner. Using differential scanning fluorimetry (DSF) and LC–MS/MS analysis, we confirmed that PK11007 covalently modifies the C-terminal redox motif (Cys497-Sec498) of TXNRD1. In non-small cell lung cancer (NSCLC) H1299 cells, PK11007-induced TXNRD1 inhibition disrupted cellular redox balance, leading to impaired autophagy flux and cell death. Similar autophagy suppression was observed in TXNRD1-knockdown cells, as well as pharmacological inhibition of TXNRD1 by Auranofin (AF) and TXNRD1 inhibitor 1 (TRi-1). Taken together, these findings highlight that oxidative stress contributes to the cytotoxic effects of PK11007 and uncover autophagy disorder as a downstream consequence of TXNRD1 inhibition.
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高影响因子
Cell Death & Disease
·
2025
·Vol. 16
·期 1
·1-14
·
IF 9.6
Zhang Pengchao,Cheng Jian,Liu Zhao,Adeshakin Funmilayo O.,Dai Liujiang,Niu Xiangyun,Zhang Ziyang,Peng Xixia,Li Long,Liu Maoxuan,Yan Dehong,Yang Xiaolu,Wan Xiaochun,Zhang Guizhong
Anoikis resistance, an essential prerequisite for tumor metastasis, is now recognized as a promising target in the fight against tumor progression. However, the detailed mechanisms of anoikis resistance are not fully understood, and drugs targeting anoikis resistance are not currently available. Here we report that NY-ESO-1, a well-known cancer-testis antigen, is linked to a poor prognosis in tumor patients and that it is crucial for anoikis resistance and tumor metastasis. Overexpression of NY-ESO-1 in cancer cells enhanced ERK1/2 activation, which in turn promoted resistance to anoikis, increased colony formation in soft agar, and facilitated lung metastasis in mice. Conversely, NY-ESO-1 knockdown significantly reduced ERK1/2 activity, leading to enhanced anoikis, diminished colony formation, and impaired metastatic potential. Mechanistically, NY-ESO-1 acts as a scaffold protein to recruit the deubiquitinase OTUB1 to PP1α, forming a ternary complex that prevents PP1α from being ubiquitinated. The OTUB1’s deubiquitinase activity, not its ability to suppress E2 enzymes, is necessary for reducing polyubiquitination and improving PP1α stability. Finally, accumulated PP1α proteins significantly activate downstream ERK1/2. Blockade of ERK1/2 or knocking down PP1α antagonized NY-ESO-1-mediated anoikis resistance. These results not only reveal a previously unrecognized mode for deubiquitinase substrate expansion but also highlight the function of NY-ESO-1 in anoikis resistance and suggest NY-ESO-1 as a novel attractive target for preventing tumor metastasis.
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高影响因子
ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Yang Tang,Qun Jiang,Rongli Chen,Siqi Wu,Yichang Luo,Xi Huang,Guofang Yu,Cui Shao
Recent advances in immune checkpoint inhibitors (ICIs), particularly those targeting PD-1/PD-L1, have transformed cancer treatment. However, their efficacy is often hampered by the immunosuppressive tumor microenvironment (TME). Here, we developed a cantharidin-loaded nanomedicine (CA@TPGS-AmP), composed of D-α-tocopheryl polyethylene glycol succinate (TPGS) and naturally derived amphiphilic peptides (AmP), designed to enhance PD-1 blockade via induction of immunogenic cell death (ICD). In vitro, CA@TPGS-AmP markedly improved the solubility of cantharidin and exhibited superior penetration in 3D tumor spheroids. It effectively triggered key ICD events, including calreticulin (CRT) surface exposure, ATP release, and HMGB1 translocation, thereby promoting dendritic cell (DC) maturation. In vivo, CA@TPGS-AmP significantly augmented the antitumor efficacy of PD-1 therapy in 4T1 orthotopic breast cancer and LLC lung cancer models. Mechanistically, the combination therapy remodeled the TME into an immunostimulatory state by increasing CD8+ T cell infiltration and activation, leading to enhanced tumor suppression compared to monotherapies. These findings support CA@TPGS-AmP as a promising adjunct to PD-1 blockade and highlight the potential of natural product-based nanomedicine in advancing cancer immunotherapy.
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高影响因子
FOOD RESEARCH INTERNATIONAL
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2026
·
IF 8.8
Fedrick C. Mgomi,Chunlei Lu,Anqi Tang,Shu Xu,Fei Chen,Lei Yuan,Zhen-quan Yang
The survival of probiotics during transit through the gastrointestinal tract (GIT) remains a significant challenge, limiting their in vivo functional efficacy. Microorganisms often resist adverse conditions by forming biofilms. Leveraging this property, the current study introduces a novel biofilm-inspired encapsulation approach using single- and multilayer-coated sodium alginate gel beads (SAGBs) to promote in situ biofilm formation by Lacticaseibacillus paracasei NN4–1. Comparative analyses were conducted to assess bacterial viability in SAGBs, planktonic cells, and biofilm cells under simulated GIT conditions. In vitro studies showed enhanced resistance in SAGBs, with a survival rate of 81.48% compared to unencapsulated cells. Additionally, biofilm encapsulation increased biochemical production, yielding average protein and polysaccharide concentrations of 0.633 mg/mL and 1.056 mg/mL, respectively. The scanning electron microscope revealed clusters of bacterial colonization inside the SAGBs. Whole-genome sequencing revealed multiple genes associated with biofilm formation, stress tolerance, adhesion, acid, and bile salt resistance. Multilayer of SAGBs reduced bacterial leakage by 52.52%, slowed small-molecule diffusion, and slightly improved textural properties without compromising bacterial metabolic activity or growth. Furthermore, SAGBs exhibited markedly higher survival (99.43%) than planktonic (76.3%) and biofilm cells (77.5%) after 21 days of refrigerated storage in milk. This approach offers promising applications in designing next-generation functional foods and targeted probiotic delivery systems, warranting higher viability of probiotics under adverse conditions of the GIT.
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高影响因子
JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
·
2026
·Vol. 46
·期 9
·118223
·
IF 6.3
Lan Gao,Yun Zhang,Xi Jiang,Shihua Ding
Ga 3+ heterovalent substitution for Zn 2+ was beneficial for modifying ZnZrTa 2 O 8 ceramic. The enlarged Q × f was caused by a combination of grain size and total lattice energy U Total increase. The improvement of τ f was attributed to the increase in Ta-O bond energy. Zn 0.99 Ga 0.01 ZrTa 2 O 8.005 ceramics exhibited optimal Q × f of 103,236 ± 2155 GHz (@7.38 GHz) and τ f = -17.65 ± 1.61 ppm/℃. The improved τ f provided great convenience for gaining temperature stable dielectric ceramics. Afterward, ZnTa 2 O 6 as a temperature compensator was added to adjust the τ f to zero. The Zn 0.99 Ga 0.01 ZrTa 2 O 8.005 dissolved into ZnTa 2 O 6 lattice. As a result, 0.4Zn 0.99 Ga 0.01 ZrTa 2 O 8.005 -0.6ZnTa 2 O 6 ceramic sintered at 1350 ℃ obtained the desirable dielectric properties: ε r = 28.18 ± 0.01, Q × f = 81,919 ± 394 GHz (@6.70 GHz), τ ƒ = -0.51 ± 0.06 ppm/℃.
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ORGANIC PROCESS RESEARCH & DEVELOPMENT
·
2026
·
IF 3.5
Jinnai Liu,Jiawei Tang,Hao Chen,Li Zhang,Ganlan Li,Fuli Zhang,Shaoxin Chen,Jun Yu
(S)-3-Bromo-2-(1-methoxyethyl)pyridine 1 is a key intermediate of RMC-6236. In this report, we detail the development and optimization of a highly enantioselective chemoenzymatic and kilogram-scale process for 1. The developed process for intermediate (S)-1-(3-Bromopyridin-2-yl)ethanol 3 was performed on 1 kg scale with a substrate concentration of 70.0 g/L, achieving a yield of 93.0% and an ee value of >99.9%. Subsequently, a simple and effective NaHMDS/CH3I methylation system afforded the title compound 1, in 95.0% yield and with >99.9% ee, achieving 88.4% overall yield from intermediate 1-(3-bromopyridin-2-yl)ethanone 2. This represents a notable increase compared to the early stage process (overall yield 55.5%). This optimized highly efficient and sustainable process was demonstrated during kilogram-scale production of 1.
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高影响因子
JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2026
·
IF 2.4
Zhen Chang,Yaxuan Zhen,Chunying Zhu,Taotao Fu,Youguang Ma
The densities and dynamic viscosities of pure components, binary solutions and ternary solutions of 2-amino-2-methyl-1-propanol (AMP), 2-ethylaminoethanol (EAE) and water were systematically measured at (293.15–323.15) K. Based on experimental findings, calculations were made for the excess molar volume, thermal expansion coefficient, dynamic viscosity deviation, and solution viscous activation energy to assess intermolecular interactions. The negative excess molar volumes of binary and ternary aqueous solutions indicate significant hydrogen bonding interaction and a filling effect within the solutions. The negative excess molar volumes of binary and ternary aqueous solutions indicate significant hydrogen bonding interactions and a filling effect within the solutions. For the AMP–EAE system, the hydrogen bonding interaction and filling effect are weakened due to the similar volume and steric hindrance effect.
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高影响因子
RENAL FAILURE
·
2026
·
IF 3.8
Jia Wang,Jin-Wei E.,Jiong Zhang
Roxadustat (ROX) has a protective action against contrast-induced acute kidney injury (CI-AKI). Excessive production of reactive oxygen species (ROS) plays a significant role in exacerbating the deterioration of renal function. Notably, activation of Nrf2/HO-1 signaling can reduce ROS production. We constructed a mouse model of CI-AKI by iohexol injection. The effect of ROX on CI-AKI was assessed by measuring serum blood urea nitrogen (BUN) and creatinine (Cr), evaluating renal histopathology, and analyzing the expression level of Nrf2 and HO-1. Additionally, levels of ROS, malondialdehyde (MDA), proinflammatory cytokines (IL-6, TNF-α, and IL-1β), as well as the activities of antioxidant kinases superoxide dismutase (SOD) and glutathione (GSH), were examined. The results showed that ROX significantly suppresses the iohexol-induced decline in the activity of antioxidant enzymes, increases the levels of ROS, MDA, Cr, IL-6, IL-1β, BUN and TNF-α, and attenuates renal pathological injury. Furthermore, ROX enhanced the iohexol–induced increase in Nrf2 and HO-1 expression. However, these effects of ROX on CI-AKI were abolished by ML-385, a Nrf2 inhibitor. Our findings indicate ROX attenuates CI-AKI by down-regulating inflammation and restoring the balance between oxidative stress and anti-oxidant defenses. This may involve the activation of the Nrf2/HO-1 signaling pathway to clear excessive ROS.
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高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
·
2026
·
IF 15
Hanjing Lu,Min Li,Wenxuan Fan,Zhao Li,Ji Cheng,Rui Liu,Pan Xu,Ding Luo,Jinghua Li,Xiaoran Liu
Sepsis-associated acute lung injury (ALI) is a critical clinical problem owing to the complex interactions between inflammation and oxidative stress. It is often associated with high mortality rates and a lack of therapeutic options. To simultaneously combat the interconnected inflammatory and oxidative stress pathways in sepsis-associated ALI, we designed near-infrared (NIR)-responsive nanomedicine by co-loading ferroptosis inhibitor Ferrostatin-1 (Fer-1) with Prussian blue nanozymes (denoted as Fer-1@PB) to achieve synergistic therapy and enhanced efficacy. Fer-1@PB combines the multi-enzyme mimetic properties of PB nanoparticle-based nanozyme (PBzyme) for reactive oxygen species (ROS) scavenging and the ferroptosis-inhibitory function of Fer-1 with spatiotemporally controlled burst release under NIR irradiation. The 0.05), and the conclusion of colloidal stability remains completely unchanged. All the above revisions are limited to typographical adjustments, wording accuracy, and minor typo corrections. No experimental data, results, figures, or cistance. Sincerely, Xiaoran Liu (on behalf of all authors) Corresponding author"?> Fer-1@PB nanozymes exhibited strong therapeutic efficacy in cellular and animal sepsis-related ALI models, with an increased survival rate, reduced pulmonary edema and histopathological damage, and recovery of lung function. Mechanistic investigations using transcriptomic analysis (RNA-seq) and experimental validation revealed that the therapeutic effects were mediated by the modulation of the CXCL2/ARF6/NCF1 signaling axis. This study introduces Fer-1@PB as a highly efficient and biosafe nanotherapeutic approach for ALI via synergistic anti-oxidative and anti-inflammatory effects. It also outlines a new molecular mechanism of action, yielding new insights into the precise nanomedicine for inflammatory lung disease.
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高影响因子
JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY
·
2016
·
IF 1.112
Jianbin Qin,Guangcheng Zhang,Xuetao Shi
The viscoelasticity of shear thickening fluid (STF), a crucial property in the protective composite applications, with different silica nanoparticle concentrations in ionic liquid, 1-butyl-3-methylimidizolium tetrafluoroborate ([C4min]BF4), was studied at different temperatures and with shear frequencies through oscillatory shear, respectively. All STFs present strain thickening behavior. With increasing silica nanoparticle concentration, the critical shear strain for the onset of strain thickening decreased, while the complex viscosity, storage modulus, and loss modulus increased significantly. The critical shear strain increased with an increase of temperature, while the complex viscosity, storage modulus, and loss modulus decreased notably. The critical shear strain was constant with increasing the frequency of strain, while the complex viscosity decreases slightly. The storage modulus and loss modulus were independent with frequency in the strain thickening region. Nanoparticle clusters leading to strain thickening were demonstrated. The viscoelastic response of STFs to varying silica nanoparticle content, temperature, and frequency investigated here will help to design the specific application of STFs in soft protective composites and damping devices.
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