JOURNAL OF ALLOYS AND COMPOUNDS
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2025
·
IF 6.3
Ting Xiang,Xiunan Cai,Zhongqiu Luo,Xintao Zhou,Cuirong Yan,Jinying Yu,Jiayi Ge,Yueying Li
Fe-based composites exhibit favorable photo-Fenton catalytic performance for environmental remediation, but restricted by high electron hole recombination rate, low reactivity, and instability. Herein, a strategy of mechanical activation-strengthened Mn doping was innovatively proposed to construct Fe 2 O 3 porous microspheres derived from copper slag (CS) base polymers (MA-Mn/CS-Fe 2 O 3 ), and used for highly efficient photo-Fenton degradation of chloromycin hydrochloride (CTC). Benefiting from the collision and shearing of mechanical forces, improved mechanical strength and defect-rich structure were realized in the porous microspheres. Experiments and DFT calculation results reveal that mechanical activation (MA) strengthened Mn to replace the cation vacancy sites and iron ion sites in the octahedron of Fe 2 O 3 , resulting in the formation of rich oxygen vacancies (O V ) and new electronic transmission channels of O V Fe Mn, which act as trapping sites to enhance carrier separation, accelerate the Fe 3 + /Fe 2+ redox cycle, and boost the generation and transformation of reactive oxygen species (ROS). The O V Fe Mn facilitates H 2 O 2 adsorption for its barrierless dissociation into •OH by forming a bridging Mn Fe O O Fe Mn bond. Moreover, the hollow porous structure provides confined space for organic degradation, reduces ROS migration distance, and improves light utilization. These specialties contribute to the superior performance of the MA-Mn/CS-Fe 2 O 3 /Vis/Fenton system for CTC removal (97.3 % within 45 min) in a wide pH range (3 −11), remaining above 93.1 % efficiency after five consecutive cycles. This environmentally-friendly method offers new insights into the harmless treatment and valorization of CS and large-scale production of catalyst.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Guo Chen,Yanan Wu,Yichen Yao,Yumeng Zhu,Hongmei Shi,Minqian Zhao,Shuo Wang,Meijuan Zou,Gang Cheng
The intricate physiological microenvironment of the diabetic wound characterized by overexpressed reactive oxygen species (ROS), persistent inflammation, angiogenetic dysfunction, and bacterial infection impeded the healing process. Herein, a photo-crosslinking composite hydrogel was fabricated based on the methacrylate modification of sesbania gum (SG) and γ-polyglutamic acid (γ-PGA), which could trigger free radical polymerization to form interpenetrating polymer network under 365 nm UV. Meanwhile, the micronized traditional Chinese medicine Huoxue Tongluo extract (HXTL) was encapsulated into the hydrogel to prepare the wound dressing (H-SGPGA). The 1 H NMR and FT-IR successfully confirmed the synthesis of the methacrylate SG (SGMA) and γ-PGA (γ-PGAMA). Then, the enhanced mechanical properties, ROS scavenging (DPPH: 88.2 ± 0.9 %; ABTS+: 90.5 % ± 0.4 %) and the antibacterial capacity (97.04 % ± 0.58 % against S. aureus ) of H-SGPGA was investigated and confirmed in vitro . Finally, in the S. aureus infected diabetic wound model, the in vivo result demonstrated that the H-SGPGA significantly accelerated the diabetic wound repair process (8.31 % ± 5.54 % wound area on day 12) by promoting epidermis regeneration (79.13 % ± 5.99 %), collagen deposition (71.4 % ± 9.1 %), and angiogenesis (294.1 % ± 29.6 % of control group). Therefore, the composite H-SGPGA provided a potential treatment as the hydrogel dressing for the diabetic wound.
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CHEMICAL ENGINEERING SCIENCE
·
2024
·
IF 4.1
Xiaolin Bi,Nan Zhao,Meina Guo,Weihua Zhang,Fengping Zhou,Wuming Xie,Ruigang Wang
Roxarsone (ROX), a livestock growth enhancer, poses environmental and health hazards due to its remarkable stability, making traditional degradation methods ineffective. To tackle this issue, a novel Fenton-like composite, composed of nanoscale zero-valent iron supported on γ-aluminum oxide (nZVI/γ-Al 2 O 3 ), was synthesized to boost ROX degradation. Results demonstrated nearly complete mineralization of the ROX organic matrix within just 180 min, facilitated by the Lewis acidity sites of γ-Al 2 O 3 . Significantly, this composite exhibited selective adsorption of released AsO 4 3− ions on its surface, forming FeAsO 4 and Fe-As-Al complexes. It also established an internal redox cycle involving Fe(0), Fe(II), and Fe(III), ensuring a continuous and efficient generation of primary reactive oxygen species (·OH and O 2 ·− ). Thus, a simultaneous redox process occurred on the composite surface can be attributed to the synergy of the reducibility of nZVI and the oxidation catalyzed by ·OH and O 2 ·− . Initially, the nitro group of ROX was reduced by nZVI, forming more hydrophilic o-aminophenol, favoring subsequent oxidation and mineralization. Simultaneously, the As-C bonds in ROX were oxidized, yielding AsO 4 3− , which was subsequently adsorbed over extended reaction times. This innovative approach offers a potential solution for treating wastewater contaminated with metalloid-organic composite pollutants, addressing the environmental and health concerns associated with ROX residues.
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FUEL
·
2024
·
IF 6.7
Wei Xue,Mingwei Ma,Pan Hou,Peng Zhang,Wenzheng Liu,Yongchen Liu,Huijuan Yue,Xiaofeng Wang,Ge Tian,Shouhua Feng
The one-pot tandem conversion of furfural (FUR) to γ-valerolactone (GVL) is desirable due to the high value of GVL and the efficiency of the synthesis process. While MOF-808 presented a good catalytic potential among Zr-MOFs, it lacked the necessary Brønsted acidity for the tandem conversion. In this study, Zr-based metal–organic framework (MOF-808) was modified with acids of different strengths (triflic acid, sulfuric acid, sulfamic acid, and trifluoroacetic acid) using a two-step post-synthesis impregnation method. EPR results revealed the appearance of coordinatively unsaturated sites of Zr (Zr-CUS) in the first step of HCl-treated Zr-808-HCl and their disappearance in the subsequent acid-modified catalysts, clarifying the impregnation process. These modified frameworks (Zr-808-TF, Zr-808-S, Zr-808-SN, and Zr-808-CF) were employed as catalysts for the tandem conversion of FUR to GVL. Zr 3d XPS and solid-state 31 P MAS NMR spectra of TMPO adsorbed on the catalysts proved that Zr-808-TF outperformed other catalysts in terms of both Brønsted/Lewis acid strength and ratio. With such catalytic active sites, Zr-808-TF exhibited superior catalytic activity, achieving 83% GVL yield over an 8-hour reaction period. The four acid-modified catalysts not only differed in Lewis/Brønsted acid sites, but also exhibited different catalytic performances in the tandem conversion. The in-depth insight into the relationship between the modified functional groups and the acid-base sites provides a new avenue to optimize the acid-base sites and expands the application of MOFs in cascade catalysis.
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Biomaterials Science
·
2019
·Vol. 7
·期 6
·2582-2599
·
IF 5.251
He-Lin Xu,Meng-Qi Tong,Li-Fen Wang,Rui Chen,Xin-Ze Li,Yasin Sohawon,Qing Yao,Jian Xiao,Ying-Zheng Zhao
Keratinocyte growth factor (KGF) has a good therapeutic effect on injured corneas. However, due to the washout of tears and blinking, locally administrated KGF usually has a short residence time on the surface of an injured cornea, resulting in its poor bioavailability. Herein, a bioadhesive hydrogel is described produced using cysteine-modified γ-polyglutamic acid (PGA-Cys) as the hydrogel-forming material to locally deliver KGF. A series of PGA-Cys polymers with different graft ratios of cysteine were firstly synthesized and carefully characterized. Thereafter, the PGA-Cys hydrogel was screened by changing the graft ratio of cysteine and polymer concentration, and the apparent viscosities and bioadhesive force were also carefully investigated. It was found that PGA-Cys polymers with different graft ratios of cysteine exhibited tunable apparent viscosity and bioadhesive properties at the same polymer concentration. When PGA-Cys with a graft ratio of 1.5 mmol g−1 of cysteine (PGA-Cys-1.5) was used as hydrogel-forming material, the hydrogel exhibited a good gelation property with an apparent viscosity of 5.2 Pa s and strong bioadhesive force of 167 ± 0.5 mN. In vitro release study showed that KGF was slowly released from PGA-Cys-1.5 hydrogel over a longer time in comparison to PGA solution alone. Moreover, PGA-Cys-1.5 hydrogel enabled most of the encapsulated KGF to be retained on the cornea and conjunctiva after local administration. Meanwhile, the morphology of the corneal epithelium in the alkali-injured cornea of mice was well repaired after 7 days of treatment with KGF-PGA-Cys-1.5 hydrogel. The therapeutic mechanism was strongly associated with inhibiting corneal inflammation and neovascularization, promoting proliferation of the corneal epithelium and inhibiting apoptosis. Overall, the use of the bioadhesive PGA-Cys hydrogel with a suitable KGF release profile may be a more promising approach than using PGA solution alone and KGF to repair injured corneas.
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MICROCHIMICA ACTA
·
2020
·Vol. 187
·期 3
·1-9
·
IF 6.232
Tong Xia,Li Te,Long Ruiqing,Guo Ying,Wu Lihui,Shi Shuyun
A fluorescence (FL) probe for determination of γ -glutamyl transpeptidase (GGT) activity and evaluation of inhibitors was developed based on the inner filter effect (IFE) of nitrogen-doped carbon dots (N-CDs). Bright green emissive N-CDs were synthesized by one-step hydrothermal technique with catechol and ethylenediamine. The excitation and emission wavelengths for N-CDs were 408 and 510 nm, respectively. γ - l -Glutamyl-4-nitroanilide ( γ -G4NA) was employed as the substrate of GGT. The absorption spectrum of GGT catalytic product (4-nitroaniline, 4-NA) overlapped greatly with the excitation spectrum of N-CDs. 4-NA acted as the absorber in IFE to quench the FL of N-CDs. Thus, the FL quenching of N-CDs was closely related to GGT activity. The established FL method offered good linear relationship within 2.0–10.0 U L −1 ( R 2 , 0.982) and 10.0–110.0 U L −1 ( R 2 , 0.998) with a low detection limit of 0.6 U L −1 . The method was successfully applied to investigate GGT activity in human serum samples with acceptable recoveries (99.1–105.0%). The approach was also employed for screening GGT inhibitors from different polar extracts of Schisandra chinensis . Results indicated that this strategy presents superior characteristics for GGT sensing. This method has great potential as a candidate for diagnosis of GGT-related diseases and high-throughput drug discovery.
Graphical abstract
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CHEMOSPHERE
·
2019
·
IF 5.108
Wuming Xie,Fengping Zhou,Xiaolin Bi,Dongdong Chen,Zijun Huang,Yuhui Li,Shuiyu Sun,Jingyong Liu
Nickel (Ⅱ)−ethylenediaminetetraacetic acid (Ni−EDTA) complexes are widely present in electroplating effluents. Owing to its chemical stability, Ni−EDTA is hardly removed in traditional Fenton/Fenton-like processes with conventional iron (Fe)−based catalyst. In this study, oxygen vacancies were introduced into our highly efficient and novel Fe 3 O 4 @γ−Al 2 O 3 catalysts using Cu doping for Ni−EDTA decomposition in Fenton−like system. Without noble−metal cocatalyst, the introduction of oxygen vacancies in Cu−doped Fe 3 O 4 @γ−Al 2 O 3 catalysts exhibit excellent Fenton−like activity even in neutral or alkaline conditions. Experimental results revealed that, without the aid of extra energy, Ni−EDTA complexes could be effectively decomposed over oxygen vacancies−based catalyst. Electron paramagnetic resonance (EPR), X−ray photoelectron spectroscopy (XPS), oxygen temperature−programmed desorption (O 2 −TPD), and hydrogen temperature−programmed reduction (H 2 −TPR) were used to get a deep insight into the decomposition mechanism. Additionally, by employing the Al−containing support, stable layered double−hydroxide phases of Ni Al could be formed, indicating that a synergy of oxidation and adsorption could simultaneously take place, which led to the recovery of released Ni 2+ ions and also reduction in secondary pollution. To investigate the decomposition process of Ni−EDTA over oxygen vacancies−based catalyst, liquid chromatography−quadrupole/electrostatic field orbitrap high resolution mass spectrometry (LC−MS/MS) was employed to identify the generated intermediates, and thus, a plausible decomposition pathway was successfully conceived.
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RENEWABLE ENERGY
·
2025
·
IF 9.1
Shuaixia Hou,Wenlei Xie
Hierarchical porous materials have been considered as promising catalyst carriers due to their large specific surface area and multi-sized pore structure, which can efficiently reduce the mass-transfer resistance of macromolecular reactants as well as improve the exposure of the active sites. In this research, a series of hierarchical porous solid acid catalysts with dual metal oxide active centers, namely Mo/V@H-Al 2 O 3, was prepared by introducing Mo and V into hierarchical porous H-Al 2 O 3 carriers via a successive incipient wetness impregnation approach. The functional species, crystal structures, morphological features, and acidic properties of the synthesized Mo/V@H-Al 2 O 3 catalysts were explored using various characterization techniques. Results showed that this catalyst not only possessed the structural advantages of relatively large surface area and ordered hierarchical porous structure, but also contained dual Brønsted-Lewis acid sites. With the low-cost acidic oils as feedstocks, this catalyst can concurrently catalyze the oil transesterification and free fatty acid (FFA) esterification reaction with the oil conversion rate of 94.3 % and full conversion of FFA under the optimized conditions, achieving one-pot transformation of the acidic oil to biodiesel and thereby simplifying the laborious separation procedure. The synergistic effect between the hierarchical porous structure and the strong acidity was shown to boost the catalytic performance of this Mo/V@H-Al 2 O 3 catalyst for the efficient biodiesel production. The high moisture and FFA-tolerant capacity emerged for this catalyst, and it had good reusability during the biodiesel production process, still with above 80 % of oil conversion even after five cycles of reuse, endowing it to have the great potential for cost-effective and sustainable production of biodiesel in particular with low-cost acidic oils as feedstocks.
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CATALYSIS LETTERS
·
2019
·Vol. 149
·期 6
·1690-1700
·
IF 2.372
Xiong Xingquan,Yi Chao,Liao Xu,Lai Shilin
A simple, highly efficient and green route for the synthesis of 2-amino-4 H -benzo[ b ]pyrans and 1,4-dihydropyridines has been developed by using γ-cyclodextrin (γ-CD) as catalyst in deep eutectic solvent (DES) of urea-choline chloride (urea-ChCl), for the first time, accomplished via a one-pot, three-component strategy. All the reactions were successfully carried out under mild conditions and gave good to excellent yields (86–98%) in 8–28 min in the presence of 5 mol% of the γ-CD catalyst. The short reaction time, green reaction medium, moderate reaction conditions, simple work-up procedure and use of easily available reagents are the attractive features of this novel synthetic method. More importantly, the urea-ChCl-γ-CD catalytic system was regenerated and reused up to 6 times with a slight drop in the product yields. Graphical
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2026
·
IF 8.7
Guixi Wang,Sihang Shen,LiDong Wang,YiChenTian,Chao Li,Junnan He,Yuzhu Song
Chronic diabetic wounds have become a major global health challenge due to the vicious cycle driven by infection, oxidative stress, and inflammation. To address this issue, researchers developed a pH-responsive injectable hydrogel (SCP@QCNPs&DOX). The hydrogel is composed of oxidized sodium alginate, dihydrazide-modified γ-polyglutamic acid, and carboxymethyl chitosan, and is co-loaded with quercetin nanoparticles (QCNPs) and doxycycline. The quercetin nanoparticles are prepared via coordination between quercetin and cerium, which not only overcomes the inherent poor water solubility of quercetin but also endows them with antioxidant, anti-inflammatory, and enzyme-mimetic catalytic activities. The SCP@QCNPs&DOX hydrogel exhibits excellent biodegradability, biocompatibility, and stable rheological properties, enabling controlled release of quercetin nanoparticles and doxycycline. The hydrogel alleviates oxidative stress by scavenging reactive oxygen species (ROS) and maintaining mitochondrial membrane potential, inhibits inflammation by modulating the NF-κB pathway and inducing M2 macrophage polarization, and demonstrates potent antibacterial activity against Staphylococcus aureus and methicillin-resistant S. aureus (MRSA). In a diabetic rat model with MRSA infection, the hydrogel significantly suppresses inflammation, exerts antibacterial effects, promotes angiogenesis, and thereby accelerates wound healing. In summary, the SCP@QCNPs&DOX hydrogel represents a promising multifunctional platform for the treatment of infected diabetic wounds. Schematic illustration of the preparation of pH-responsive multifunctional SCP@QCNPs&DOX hydrogels and their role in promoting diabetic wound healing. (A) Preparation of QCNPs; (B) Preparation of hydrogels; (C) Antibacterial, antioxidant, immunomodulatory, and angiogenic functions of SCP@QCNPs&DOX hydrogels in promoting diabetic wound healing. Download: Download high-res image (119KB) Download: Download full-size image
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Molecular Biomedicine
·
2025
·Vol. 6
·期 1
·1-18
·
IF 10.1
Zhang Shuqin,Cheng Yajia,Gao Yujia,Xu Feifei,Wang Yuna,Zhang Junling,Shang Yue,Li Deguan,Fan Saijun
With advancements in radiotherapy technologies, the detrimental effects of ionizing radiation on biological systems, particularly the hematopoietic system, have caused significant concern. N 6 -methyladenosine (m 6 A), the most pervasive representative of post-transcriptional modifications, plays critical roles in diverse biological events. Non-coding RNA comprises the vast majority of the human genome. This study aimed to explore the role of long non-coding RNA (lncRNA) m 6 A modification in γ-ray irradiation-induced hematopoietic injury. By using mouse models, it was found that γ-radiation rapidly damaged hematopoietic bone marrow cells (BMCs), triggering apoptosis, oxidative stress and DNA damage, along with up-regulation of m 6 A Reader proteins. We revealed the time-conditioned landscape of lncRNA m 6 A methylome of BMCs in the short term after radiation and found that a dynamic “change-then-recover” trend involved. LncRNA Snhg15 was identified as a key regulator through integration analysis of the methylome and transcriptome data. Its m 6 A modification was closely related to progression of radiation injury in BMCs. Further research demonstrated that the novel m 6 A Reader LRPPRC could interact with the modification site of Snhg15 , stabilize Snhg15 and promote its expression, thereby exacerbating radiation-induced injury to BMCs both in vitro and in vivo. Knockdown of Lrpprc or Snhg15 could alleviate the radiation injury to the hematopoietic system. Additionally, the LRPPRC- Snhg15 axis was involved in the radio-protective efficacy of gut microbiota-derived valeric acid. These findings uncover a novel mechanism by which m 6 A-modified lncRNA Snhg15 is stabilized by LRPPRC modulates γ-irradiation-induced hematopoietic injury, providing potential therapeutic targets for the prevention and treatment of radiation injuries.
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ULTRASONICS SONOCHEMISTRY
·
2026
·
IF 10.2
Rong Zhu,Guifang Zhang,Nuo Li,Jiling Li,Dongjie Zhang
Ultrasound and slightly acidic electrolyzed water (SAEW) treatments have been widely applied to enrich γ-Aminobutyric Acid (GABA) during the germination of grains and legumes; however, the effects and underlying mechanisms of their combined treatment on GABA enrichment remain unclear. After 72 h of germination, this study investigated the impacts of different treatment methods—distilled water treatment (GM), ultrasound treatment (UGM), SAEW treatment (SGM), and combined treatment (USGM)—on key enzyme activities, protein structural characteristics, and the GABA metabolic pathway in germinated mung beans. The results indicated that the combined treatment of ultrasound and SAEW promoted GABA enrichment in germinated mung beans, with the GABA content reaching 6.25 ± 0.025 mg/g. Additionally, it significantly enhanced the activities of glutamate decarboxylase (GAD), diamine oxidase (DAO), and polyamine oxidase (PAO) to 0.359 ± 0.008 U/g, 0.554 ± 0.021 U/g, and 1.265 ± 0.036 U/g, respectively ( p < 0.05). Fourier-transform infrared spectroscopy and intrinsic fluorescence spectroscopy analyses revealed that the combined treatment significantly increased the content of α-helix and β-turn structures in the protein secondary structure ( p < 0.05), while reducing the proportions of β-sheet and random coil structures, and enhanced protein surface hydrophobicity. Untargeted metabolomics analysis further demonstrated that the combined treatment significantly upregulated the levels of amino acid-related compounds, with a strong positive correlation observed between Glu and GABA content. Moreover, it primarily facilitated GABA synthesis by modulating pathways such as arginine-proline metabolism, arginine biosynthesis, alanine, aspartate, and glutamic acid metabolism, and butanoate metabolism. The findings of this study provide theoretical support for elucidating the molecular mechanisms by which ultrasound and SAEW promote GABA enrichment in mung beans and offer new insights for developing functional mung bean foods rich in GABA..
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