APPLIED ORGANOMETALLIC CHEMISTRY
·
2026
·Vol. 40
·期 4
·e70543
·
IF 4.3
Xinhao Zhang,Qiang Wang,Haoyang Lin,Dingkai Hu,Biao Liu,Dezhi Cao,Guorong Zhao
The excessive consumption of fossil fuels has triggered a dramatic surge in CO 2 emissions, prompting the development of diverse mitigation strategies. Among these, the functionalization of metal–organic frameworks (MOFs) with polar amine moieties has emerged as a promising approach to substantially enhance their CO 2 capture capacity. In this study, HKUST-1 was synthesized via a solvothermal method and then modified with three different amines (DEA, TEPA, and PEI) by impregnation to prepare a series of solid amine adsorbents. The effects of the amine type, amine loading, and environmental parameters, including temperature, gas flow rate, CO 2 concentration, and humidity, on the CO 2 adsorption performance were systematically studied. Thermal stability, cycling performance, and adsorption kinetics were also evaluated. The results show that the PEI-modified adsorbent exhibits the best performance, with an optimal amine loading of 20%. Excessive amine loading leads to pore blockage and reduces adsorption capacity. Compared to unmodified HKUST-1, PEI20@HKUST-1 shows a 92% enhancement in CO 2 adsorption, attributed to PEI's bidentate adsorption mechanism and flexible polymeric chains, which contribute to a high amine utilization efficiency. Among the environmental factors studied, higher temperatures lower the CO 2 uptake due to thermodynamic constraints, whereas increasing flow rate and humidity first promotes and then suppresses adsorption. The optimal adsorption conditions are identified as 30°C, 20 mL min −1 flow rate, and 45% relative humidity. Moreover, PEI20@HKUST-1 displays good thermal stability and excellent cycling performance, retaining 88% of its initial adsorption capacity after 15 consecutive adsorption–desorption cycles. Kinetic analysis confirms that the adsorption process follows the Avrami model, which indicates a combined physisorption and chemisorption mechanism.
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Theranostics
·
2026
·Vol. 16
·期 13
·7571
·
IF 14.9
Linlin Song,Meixu Chen,Huiling Wang,Xin Wang,Tianyue Xu,Heqing Zhang,Shuwen Ran,Liwen Huang,Yingying Ma,Zhihui Liu,Zihan Xu,Yujie Zhao,Zichang Liu,Yong Luo,Xiujun Yu,Yulan Peng,Hubing Shi,Jing Jing,Xiujing He
Rationale Triple-negative breast cancer (TNBC) remains one of the most aggressive subtypes due to its poor immunogenicity and resistance to systemic therapies. Methods Here, we report a multifunctional NIR-II light-triggered theranostic nanoplatform, termed LQPO, that integrates liposome, Ti 3 C 2 quantum dots (QDs), perfluorohexane (PFH), and ozone to enable multimodal imaging-guided photo-gas synergistic therapy. The QDs, embedded within the liposomal bilayer, act as highly efficient NIR-II photothermal transducers, while the PFH core serves as a liquid-gas phase-change medium capable of dissolving and releasing ozone under localized heating. Results Upon NIR-II irradiation, LQPO produced strong photothermal and photoacoustic signals for real-time photoacoustic (PA) and contrast-enhanced ultrasound (CEUS) imaging, accompanied by vaporization of the PFH core and burst release of ozone. This spatiotemporally coordinated cascade induced potent oxidative stress and hyperthermia, synergistically driving GSDME-dependent pyroptosis and immunogenic cell death (ICD). The resulting “in situ vaccination” effect remodeled the tumor immune microenvironment and primed tumors for PD-1 blockade therapy. In vivo , NIR-II-activated LQPO achieved efficient tumor accumulation, strong PA/CEUS imaging contrast, and pronounced inhibition of both primary and abscopal tumors when combined with αPD-1 therapy. No significant systemic toxicity was observed, confirming its favorable biosafety. Conclusions Overall, this study establishes a single-laser-activated nanoplatform that unifies real-time multimodal imaging and photo-gas synergistic therapy, and converts localized treatment into a systemic antitumor immune response upon integration with checkpoint inhibition.
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高影响因子
ChemSusChem
·
2026
·Vol. 19
·期 12
·e70812
·
IF 5.9
Mengyao Guo,Jinxiong Wan,Jihuai Wu,Ying Wang,Weichun Pan,Shen Zhang,Guohua Chen,Yiming Xie,Xuping Liu,Zhang Lan
Power conversion efficiency (PCE) is limited by the high density of defects and poor energy level alignment of the SnO 2 /perovskite (PVK) buried interface in perovskite solar cells (PSCs). Herein, a synergistic molecular interface engineering strategy is designed by using an ionic liquid, 1-dodecyl-3-methylimidazolium bis(trifluoromethanesulfonyl) imide salt (DMIMTFSI) to modify this critical interface. The strong electron-withdrawing TFSI − anion induces a downward shift of the conduction band of SnO 2 , thereby optimizing energy level alignment and facilitating electron extraction. Meanwhile, the DMIM + cation passivates interfacial defects through robust chemical interactions with Pb 2+ and I − ions. Furthermore, the long alkyl chain of DMIMTFSI templates the formation of an ordered porous PbI 2 morphology, which improves the crystallinity of the overlying PVK film. The DMIMTFSI modification reduces the trap-state density by 31.86%, prolongs the carrier lifetime by 39.42%, and increases the built-in potential from 0.95 to 1.02 V. Therefore, the DMIMTFSI-modified device achieves a PCE of 24.14%, significantly outperforming the pristine device of 22.34%. The unencapsulated modified device retained 87% of its initial PCE after being stored for 1000 h under ambient conditions, demonstrating excellent environmental stability. This work provides a viable multifunctional interface engineering pathway toward high-performance and stable PSCs. Graphical The insertion of the ionic liquid of 1-dodecyl-3-methylimidazolium bis(trifluoromethanesulfonyl) imide (DMIMTFSI) into the interface of perovskite/tin oxide significantly improves the power conversion efficiency of perovskite solar cells from 22.34% to 24.14%. This is due to the synergistic effect of defect passivation, energy level modulation, and crystal growth promotion of DMIMTFSI.
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ChemCatChem
·
2026
·Vol. 18
·期 12
·e70879
·
IF 4.1
Minjie Hu,Chan Wu,Hui Yue,Sichun Yang,Xu Hou,Enxian Yuan,Jiancheng Zhou
Dry reforming of methane (DRM) offers a promising route to convert greenhouse gases into syngas, although fabricating Ni-based catalysts with long-term stability during reaction conditions remains challenging. Unlike the conventional H 2 pretreatment typically required for activating Ni-based catalysts prior to DRM, we herein reported a one-pot hydrothermal encapsulation strategy to directly synthesize Ni-Mo bimetallic catalysts confined within silicalite-1 (Ni x Mo@S-1) under CH 4 /CO 2 atmosphere for catalyst activation. In contrast to the conventional impregnation Ni 5 Mo/S-1 catalyst, this structural encapsulation approach effectively improved nickel dispersion and enhanced catalytic performance. XRD and TEM revealed that the encapsulated Ni 5 Mo@S-1 exhibited ultra-small nanoparticle size (∼2.3 nm) and Mo promoted high dispersion of Ni nanoparticles. Furthermore, XPS and XANES confirmed that Ni 5 Mo@S-1 facilitated the direct reduction of NiO to metallic Ni under CH 4 /CO 2 atmosphere, thereby inducing active Ni 0 sites and Ni-O-Si bond formation with reinforced metal-support interaction. Graphical The CH 4 /CO 2 atmosphere-induced strategy of encapsulation of Ni x Mo@S-1 enhances DRM performance. Pretreatment with different atmosphere revealed the distinct roles of CH 4 /CO 2 in fabricating the confinement structure of Ni 5 Mo@S-1 for DRM. The CH 4 /CO 2 pretreatment atmosphere directly drives the formation of both active Ni 0 and stabilizing Ni─O─Si bonds with the promotion of Mo, remarkably reinforcing metal-support interaction.
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PHYTOMEDICINE
·
2026
·
IF 11.3
Hansheng Wang,Keyi Li,Haomou Pu,Yaoyao Xiong,Dan Luo,Jinjie Song,Hongjie Jiang,Xiaoping Yu,Tao Deng
Background The molecular basis of retinal photochemical damage remains incompletely understood, limiting the development of targeted therapeutic strategies. Delphinidin, an anthocyanidin with reported protective effects, represents a promising candidate, but its direct molecular target and mechanism of action are unclear. Methods The molecular target of delphinidin was identified using Activity-Based Protein Profiling (ABPP), DARTS-MS, SPR, and CETSA. Its functional effects were investigated in 661W photoreceptor cells and in a light-induced retinal damage model in Sprague-Dawley rats. Protein carbonylation was assessed via an alkynylaniline probe, and Voltage-Dependent Anion Channel 1 (VDAC1) oligomerization was examined by chemical crosslinking. Mitochondrial function, cGAS-STING pathway activation, and ferroptosis markers were evaluated to delineate the underlying mechanism. Results VDAC1 was identified as a direct target of delphinidin. Light exposure induced VDAC1 carbonylation and oligomerization, leading to mitochondrial dysfunction characterized by cytochrome c release and mitochondrial DNA (mtDNA) leakage into the cytosol. Cytosolic mtDNA activated cGAS-STING pathway, which in turn promoted loss of the ferroptosis suppressor GPX4 and triggered ferroptosis. Delphinidin interrupted this cascade by binding to VDAC1 and inhibiting its carbonylation and oligomerization, thus limiting mtDNA leakage, attenuating cGAS-STING activation, preserving GPX4 abundance, and inhibiting ferroptosis. In vivo , delphinidin intervention conferred significant protective effects, as evidenced by preservation of retinal histoarchitecture and reduced oxidative damage and ferroptosis, Conclusion This study identifies a novel mechanistic axis in RPD linking VDAC1 dysregulation to mtDNA-driven innate immune activation and ferroptosis. It further establishes delphinidin as a direct VDAC1 targeting compound and highlights its therapeutic potential for the prevention of RPD. Download: Download high-res image (219KB) Download: Download full-size image
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高影响因子
PHYTOMEDICINE
·
2026
·
IF 11.3
Li Song,Yue Li,Wenjing Li,Bingfeng Lin,Wenlong Xiao,Yuzhen Xia,Feida Wang,Mingli Ye,Wei Wang,Nani Wang
Background Sarcopenia is a prevalent disorder among postmenopausal women, representing a debilitating condition with limited treatment options. Icariin (ICA), a prenylated flavonol glycoside, is commonly used in conditions associated with estrogen deficiency; however, its efficacy and mechanism in postmenopausal sarcopenia remain undefined. Purpose This study aimed to evaluate the therapeutic effect of ICA on postmenopausal sarcopenia and to elucidate its underlying mechanism, with a focus on the estrogen receptor α/fatty acid transport protein 1 (ERα/FATP1) pathway. Study design An integrated approach was employed, combining in vivo pharmacological evaluation, multi-omics analyses, and in vitro mechanistic validation. Methods The in vivo therapeutic effect of oral ICA was assessed by evaluating muscle function, histology, and senescence markers. Human muscle transcriptome datasets and mouse single-cell RNA sequencing data were analyzed. In vitro validation was performed in D-galactose-induced senescent C2C12 myoblasts. Target engagement was confirmed by molecular docking, cellular thermal shift assay, and surface plasmon resonance, and mechanistic validation was performed via FATP1 knockdown. Results Oral administration of ICA significantly improved muscle mass, function, and fiber cross-sectional area, while attenuating lipid deposition and cellular senescence. Single-cell RNA sequencing revealed a diminished myoblast pool with downregulated ERα in aged muscle. This finding aligns with human transcriptome data, linking reduced ERα/FATP1 signaling and dysregulated fatty acid metabolism to sarcopenia. Metabolomic analysis identified FATP1 as a critical transporter of eicosapentaenoic acid and docosapentaenoic acid, which activated the protein kinase B/ mammalian target of rapamycin pathway to promote myogenesis. Importantly, ICA functioned as a dual-target agonist, directly binding to and upregulating both ERα and FATP1, thereby elevating eicosapentaenoic/ docosapentaenoic acid levels and reactivating the protein kinase B/ mammalian target of rapamycin/ myogenic differentiation 1 axis. The specificity of this pathway was confirmed, as FATP1 knockdown completely abrogated the protective effects of ICA. Conclusion This study identifies the ERα/FATP1 axis as a pivotal therapeutic target for sarcopenia. ICA, acting as a first-in-class dual agonist of this pathway, represents a promising candidate for sarcopenia treatment by synchronously modulating estrogen signaling and fatty acid metabolism. Download: Download high-res image (181KB) Download: Download full-size image
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EMBO Molecular Medicine
·
2026
·Vol. 18
·期 5
·1990
·
IF 7.9
Yini Huang,Yan Ye,Xinmei Zhu,Dengpan Liang,Ruiqin Cui,Xiaopeng Yuan,Xitao Li,Quanming Zou,Haibo Li,Wei Huang
The limitations of existing drugs and the development of drug resistance make it urgent to develop new drugs against methicillin-resistant Staphylococcus aureus (MRSA). The re-development of the antibacterial activity of drugs that have already been proven safe for human use is an effective way. In this study, we discovered that the Src homology region 2 domain-containing phosphatase-1 (SHP-1) agonist SC-43, exhibits potent activity against Gram-positive bacteria, including MRSA. The mode of action studies revealed that SC-43 inhibits the key enzyme coproporphyrin ferrochelatase (CpfC) of the coproporphyrin-dependent (CPD) heme synthesis pathway and interferes with the bacterial porphyrin metabolism. The determination of the structure of CpfC derived from S. aureus (SA CpfC ) in this study allowed us to reveal the inhibitory effect of SC-43 at the molecular level. Animal experiments showed that SC-43 has the potential to become a new anti-MRSA drug. In conclusion, this study discovered a new anti-MRSA activity of a drug currently undergoing clinical trials and simultaneously verified the feasibility of developing new anti-Gram-positive bacteria drugs by inhibiting the CPD pathway. The limitations of existing drugs and the emergence of drug resistance make the development of new therapies against methicillin-resistant Staphylococcus aureus (MRSA) increasingly urgent. Here, we demonstrate that the Src homology region 2 domain-containing phosphatase-1 (SHP-1) agonist SC-43 exhibits antibacterial activity against MRSA. The limitations of existing drugs and the emergence of drug resistance make the development of new therapies against methicillin-resistant Staphylococcus aureus (MRSA) increasingly urgent. Here, we demonstrate that the Src homology region 2 domain-containing phosphatase-1 (SHP-1) agonist SC-43 exhibits antibacterial activity against MRSA.
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高影响因子
Small
·
2026
·
IF 11.8
Mo Chen,Die Jia,Yinlong Wu,Ke Wang,Xing Zhao,Xing Guo,Shaobing Zhou
Rheumatoid arthritis (RA) is a chronic autoimmune disorder driven by systemic inflammation and progressive joint damage. While antigen-specific immune tolerance holds promise as a therapeutic strategy, its clinical translation is hampered by the rapid clearance and unintended immunogenicity associated with conventional antigen delivery. To address these limitations, we developed a tolerogenic nanovaccine (CMLT) that co delivers a multi epitope citrullinated peptide (CitC) and an immunosuppressive thrombospondin-1 (TSP-1) plasmid via a lipid nanoparticle (LNP) platform. By rationally tuning LNP components, we achieved efficient plasmid encapsulation and stable conjugation of CitC, resulting in homogeneous nanoparticles with favorable stability. In a collagen induced arthritis (CIA) mouse model, prophylactic administration of CMLT potently suppressed disease development, significantly mitigating clinical symptoms, reducing histopathological joint damage, and preserving bone architecture. Mechanistically, CMLT fostered an immunosuppressive microenvironment marked by elevated expression of TGF-β1 and TSP-1, expansion of antigen specific regulatory T cells (Tregs), and suppression of autoreactive antibodies and pro inflammatory cytokines. Therapeutic intervention during active arthritis similarly alleviated inflammation and attenuated joint pathology. This synergistic nanovaccine platform provides a targeted and effective approach for re establishing immune homeostasis in RA.
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CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Han Zhang,Lu Wang,Hao Zhang,Zhenjie Gu,Zhihua Qiao,Chongli Zhong
A novel Pebax-based ternary MMM was rationally designed with PEG serving as a dual-functional additive. • Interfacial regulation via PEG modification effectively boosts membrane gas diffusion performance and improves filler dispersion. • The optimized membrane exhibits enhanced C 2 H 6 /C 2 H 4 separation performance with balanced permeability and selectivity. Ethylene (C 2 H 4 ) purification from ethylene-ethane (C 2 H 6 ) mixtures is a crucial process in the petrochemical industry, and membrane separation technology offers a promising solution to overcome the limitations of traditional separation technologies. In this work, a Pebax/PEG/CAU-1-OH ternary mixed matrix membranes (MMMs) was rationally designed and fabricated by incorporating poly(ethylene glycol) (PEG) as a functional additive and CAU-1-OH (a hydroxyl-functionalized ultra-microporous aluminum-based MOF) into the Pebax matrix. The structural properties of CAU-1-OH and the resultant membranes were systematically characterized via X-ray diffraction (XRD), scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FT-IR), X-ray Photoelectron Spectroscopy (XPS) and gas adsorption measurements. CAU-1-OH exhibited preferential adsorption for C 2 H 6 over C 2 H 4 with an ideal adsorption solution theory (IAST) selectivity of 3.15, along with a C 2 H 6 adsorption capacity of 91.76 cm 3 g −1 . PEG played a dual role: it disrupted the crystalline structure of Pebax to increase free volume, and acted as a molecular bridge between Pebax and CAU-1-OH via hydrogen bonding interactions, thereby improving the dispersion of CAU-1-OH and enhancing interfacial compatibility. The gas separation performance of the ternary MMMs was evaluated using a C 2 H 6 /C 2 H 4 (50:50, v /v) mixture at 25 °C and 2 bar. Gas permeation tests showed that the Pebax/PEG/CAU-1-OH (20) ternary MMM exhibited a C 2 H 6 permeability of 1533.6 barrer and C 2 H 6 /C 2 H 4 selectivity of 4.76. The hydroxyl groups in CAU-1-OH can form strong hydrogen bonds with C 2 H 6 , leading to a stronger adsorption preference for C 2 H 6 , as supported by DFT calculations. Additionally, the ternary MMM exhibited outstanding long-term stability and pressure resistance, with stable separation performance maintained over 10 days and under various pressures. These results indicate that the Pebax/PEG/CAU-1-OH ternary MMM offers a viable strategy for developing an efficient C 2 H 6 /C 2 H 4 separation materials.
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高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2026
·
IF 3.1
Wei Du,Jing Xie,Jianlei Qi,Dan Zhou,Jianzhong Yin
The recycling of polyethylene terephthalate (PET), a widely used polyester plastic, has become an increasingly significant issue. This study aims to develop an efficient and environmentally friendly catalytic system for the degradation of waste PET and realize the resource utilization of polyester. The methanolysis of PET was investigated using 1-ethyl-3-methylimidazolium tetrafluoroborate ([Emim]BF 4 ) as a catalyst. The effects of temperature, time, [Emim]BF 4 dosage, and methanol dosage on the reaction were systematically examined. The conversion of PET reached 100% with a dimethyl terephthalate (DMT) yield of 74.06% under optimal conditions: 200°C, 2 h, a PET-to-[Emim]BF 4 mass ratio of 5:1, and a PET-to-methanol mass ratio of 6:1. Kinetic analysis revealed that the reaction followed first-order kinetics, with an apparent activation energy of 51.16 kJ/mol. A possible mechanism for the [Emim]BF 4 -catalyzed methanolysis of PET was proposed. Furthermore, density functional theory (DFT) calculations demonstrated that [Emim]BF 4 could effectively reduce both the reaction energy barriers and the final-state energy, thereby enhancing the reaction rate and favoring the forward progression of the reaction.
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高影响因子
ACS Applied Polymer Materials
·
2026
·
IF 5.2
Eun Kyu Sun,Kyungwhan Min,Ook Choi,Senthil Kannan,Tae-Hyun Kim
Polymer of intrinsic microporosity-1 (PIM-1) is recognized for its exceptional gas permeability, attributed to its high free volume and microporosity. However, it presents several disadvantages, including low selectivity, plasticization, and poor aging properties. To address these challenges, PIM-nPI-Tz, a series of composite membranes containing triazine cross-links, was developed herein by spin-coating nitrile-functionalized polyimidazolium (PI-CN) onto a PIM-1 membrane, followed by heat treatment. The resulting coating layer increased the selectivity of the PIM-1 membrane, given its CO2 affinity, while the formation of triazine increased the backbone-to-backbone spacing, enhancing the diffusivity and permeability of the membrane. Notably, PIM-5PI-Tz (involving PIM-1 coated with a 5% PI-CN solution) exhibited a 73% increase in CO2 permeability (7539 barrer) and a 34% rise in CO2/N2 selectivity (24.4), nearly equivalent to the 2019 Robeson upper bound in terms of overall gas separation. Moreover, the plasticization of the membrane was effectively suppressed, even at a feed gas pressure of 20 bar. Further, its gas separation performance was retained over 300 days under CO2/N2 mixed-gas conditions, demonstrating its superior antiplasticization and antiaging characteristics. The coating material used herein, PI-CN, exhibits a significantly higher CO2-philicity than conventional coating materials, such as Pebax, PEG, and PDMS. Moreover, during the spin-coating and subsequent heat treatment processes, molecular rearrangement within PI-CN facilitates CO2 diffusion, further enhancing the gas transport performance of the PIM membrane.
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高影响因子
ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Jiayi Xin,Jiawen Hu,Ziyang Song,Changwen Zhao,Dong Chen,Wantai Yang
The persistent accumulation of polymers in terrestrial ecosystems poses significant environmental challenges. Herein, the biodegradation of poly(1-hexene-maleic anhydride) (HMA) in soil and Pseudomonas aeruginosa was investigated to mitigate its environmental impact. The experimental results revealed that the mineralization rate of HMA reached 17.6% after 90 days of incubation in soil. Bacterial degradation led to a 79.0% weight loss after cultivation with Pseudomonas aeruginosa for 30 days. In addition, HMA exposure induced distinct shifts in soil microbial communities, with Proteobacteria abundance increasing from 40.3 to 48.9% after the initial 5 days but subsequently declining to 34.6% due to the inhibitory effects of biodegradation intermediates. Furthermore, phytotoxicity assays demonstrated that soybean seedlings exhibited pronounced root elongation, reduced lateral root formation, and elevated oxidative stress biomarkers after HMA exposure. Earthworm (Eisenia fetida) tests revealed that the biotoxicity of HMA depended on both concentration and exposure time. The median lethal concentration after 24 h was 3.63 mg/cm2, and the mortality rate reached 46.7% after 14 days in soil. Progressive degradation of HMA mitigated both oxidative stress and biotoxic effects over time, indicating a self-attenuating ecological risk profile. These findings provide a comprehensive understanding of the environmental behavior, biodegradation mechanisms, and biotoxic effects of HMA, offering valuable insights for the design and assessment of sustainable petroleum-based polymers.
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