iScience
·
2026
·
IF 4.5
Hanlin Yang,Weiwei Li,Hailong Zhang,Yameng Liu,Miaomiao Cui,Yurong Zhu,Li Hou,Shaoju Min,Jie Ren,Yujie Tan
Conventional cervical cancer therapies often cause severe side effects and face recurrence challenges. Although the natural flavonoid fisetin (FIS) exhibits strong anticancer properties, its clinical utility is restricted by poor aqueous solubility. To overcome this, we engineered a tumor-targeting nanotherapeutic, PEG-FA@ZIF-8@FIS, by encapsulating FIS within a zeolitic imidazolate framework-8 (ZIF-8) core surface-functionalized with polyethylene glycol-folic acid(PEG-FA). Both in vitro and in vivo models demonstrate that this system effectively suppresses cancer cell proliferation, migration, and tumor growth with excellent biocompatibility. Mechanistically, transcriptomic and lipidomic analyses reveal that PEG-FA@ZIF-8@FIS exerts its anticancer effects by downregulating aquaporin-3 (AQP3) expression, which subsequently disrupts tumor lipid metabolism. By linking AQP3 inhibition to metabolic impairment via a targeted delivery platform, this work establishes a highly biocompatible and effective translational strategy for cervical cancer intervention.
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PubMed
高影响因子
JOURNAL OF SOLID STATE CHEMISTRY
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2026
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IF 3.2
Zubair Maroof,Jingrui Li,Zhihang Zhang,Haomiao Li,Zhongshi Hu,Zhaoxin Wu,Bo Jiao
Novel 1D lead bromide perovskitoid with [PbBr 5 ] 3− square pyramids. • Cyclic amine cation enables stable 1D corner-sharing inorganic chains. • Five-coordinated geometry separates electron and hole transport pathways. • Electrostatic-sprayed detector exhibits high sensitivity and low detection limit. Low-dimensional hybrid organic-inorganic perovskitoids have demonstrated substantial potential for direct X-ray detection owing to exceptional X-ray attenuation, high activation energy for ion migration and good environmental stability. However, the influence of organic cations, especially the nitrogen heterocycle-based organic cations, on lead bromide perovskitoid properties remains insufficiently explored. Herein, we synthesized a one-dimensional lead bromide perovskitoid, (1,2-Pmpz)PbBr 4 , employing 2-(1-piperazinyl) pyrimidine as the organic cation. (1,2-Pmpz)PbBr 4 exhibits a novel perovskitoid structure in the triclinic
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高影响因子
APPLIED SURFACE SCIENCE
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2026
·
IF 6.6
Qi Zhang,Dongsheng He,Wei Xu,Yanhong Fu,Yuan Tang,Zhili Li,Wanqing Li,Jiayu Ma,El-Sayed R.E. Hassan
[C 8 mim]Br selectively floats quartz (88.13%) over fluorapatite (4.43%) at pH 7.01. • Binary mixture flotation with [C 8 mim]Br achieves a P 2 O 5 grade of 31.49% with 91.59% recovery, confirming superior selectivity over conventional DDA. • [C 8 mim] + selectively adsorbs on quartz via electrostatic attraction with Si-O − sites and C–H···O hydrogen bonding with silanol groups, while fluorapatite lacks these active sites. • Short-chain imidazolium ionic liquids serve as promising collectors for reverse flotation desilication of phosphate ores, offering a new reagent strategy for phosphate mineral processing. The reverse flotation separation of quartz from fluorapatite using 1-octyl-3-methylimidazolium bromide ([C 8 mim]Br) ionic liquid as a novel collector was investigated, with dodecylamine (DDA) employed as a benchmark. Micro-flotation tests showed that [C 8 mim]Br selectively collected quartz (88.13%) with negligible flotation of fluorapatite (4.43%) at pH 7.01 and 50 mg/L, demonstrating superior selectivity over DDA. Binary mixture flotation (fluorapatite: quartz = 1:1) achieved a P 2 O 5 grade of 31.49% with a recovery of 91.59%. Zeta potential and contact angle measurements revealed that [C 8 mim]Br increased the zeta potential of quartz by 14.05 mV and enhanced its contact angle from 19.41° to 79.75°, while exerting minimal influence on fluorapatite. Microcalorimetry demonstrated that the adsorption heat of [C 8 mim]Br on quartz (0.237 J/g) was significantly higher than that on fluorapatite (1.6 × 10 −3 J/g). FTIR and XPS analyses indicate that [C 8 mim]Br is adsorbed on the quartz surface mainly through electrostatic attraction between the imidazolium cation and deprotonated Si-O − sites. The optimized configuration obtained from DFT calculations shows that C-H···O hydrogen bonds exist between the protons at the C4/C5 positions of the imidazole ring and surface oxygen atoms (H···O = 1.971 Å, C-H···O = 141°), whereas no stable adsorption configuration is obtained on the fluorapatite surface. These findings demonstrate that [C 8 mim]Br is a promising selective collector for the reverse flotation desilication of siliceous-calcareous phosphate ores. [C8mim] + adsorbed on the quartz surface through electrostatic attraction with deprotonated Si-O − sites, supplemented by hydrogen bonding between the C–H proton and surface silanol groups. In contrast, the fluorapatite surface lacks such active sites for anchoring of [C8mim]+, which accounts for the selective separation. Download: Download high-res image (120KB) Download: Download full-size image
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高影响因子
VETERINARY RESEARCH
·
2026
·Vol. 57
·期 1
·175
·
IF 3.8
Jiang Luyao,Yang Fan,Wu Jiayan,Li Zhengliang,Zhu Xiemin,Pan Hao,Zhang Shaotong,Pan Haochun,Wang Hang,Yao Jingting,Yan Ping,Gao Qingqing,Huan Changchao,Gao Song,Jiao Xinan,Liu Xiufan
Host defense peptides (HDPs) possess both direct bacteriocidal and immunomodulatory activities. In this study, chicken cathelicidin-1 (cCATH-1) and chicken cathelicidin-3 (cCATH-3) were selected based on their markedly different minimum inhibitory concentrations (MICs) against avian pathogenic Escherichia coli (APEC) strains, with MICs of cCATH-1 being 4- to 16-fold lower than those of cCATH-3. However, following intraperitoneal challenge with APEC strain E058 (4 × 10⁶ CFU/mouse), 80% of cCATH-3 treated mice survived while 20% of cCATH-1 treated mice survived. Flow cytometry (FC) revealed significantly lower peripheral blood Ly6C high monocytes but higher peritoneal Ly6C high macrophages in cCATH-3-treated mice at 4 and 8 h post-treatment. Peritoneal CCL3 secretion was significantly upregulated in cCATH-3 treated mice at 8 h post-treatment. Upon knockout of macrophages, the protection of cCATH-3 in mice against APEC E058 challenge was markedly abolished. In vitro, peritoneal macrophages treated with cCATH-3 showed stronger bacteriocidal activity than those treated with cCATH-1. Mouse CCL-3 (mCCL3)-specific antibody neutralize the effect of mCCL3 on macrophages chemotaxis in vitro. mCCL3-specific antibody administration resulted in 0% survival in cCATH-3-treated mice versus 60% survival in cCATH-3-treated mice administered with mock antibody, while cCATH-1-treated mice showed 0% survival administered with either mCCL3-specific antibody or mock antibody after APEC E058 strain challenge. In summary, cCATH-3 provides robust protection against APEC infection compared with cCATH-1 in mice, partially through CCL3-mediated macrophage chemotaxis and enhanced bacteriocidal activity in activated macrophages, revealing a novel mechanism of avian cathelicidins and supporting HDPs as alternatives to antibiotics for controlling avian colibacillosis.
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高影响因子
ACTA PHYSICO-CHIMICA SINICA
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2026
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IF 13.5
Saijia Dong,Renyuan Yang,Xiaonan Liu,Yue Wang,Yupeng Hu,Daohai Zhang,Teng Zhou
Lightweight, ultrathin, and absorption-dominated electromagnetic interference (EMI) shielding materials are highly desired to alleviate secondary electromagnetic pollution caused by conventional reflection-dominated shielding materials. Herein, Fe(acac) 3 -assisted PAN-derived porous carbon membranes were fabricated through nonsolvent-induced phase separation (NIPS), freeze-drying, and high-temperature carbonization to achieve efficient absorption-dominated EMI shielding performance. The interconnected porous conductive carbon framework facilitated the dissipation of incident electromagnetic waves by providing continuous conductive channels and abundant internal scattering interfaces. Different Fe(acac) 3 contents were introduced to evaluate their influence on graphitization degree, electrical conductivity, and EMI shielding performance. Notably, with only 1 wt% Fe(acac) 3 loading, the obtained C-P-P/AcFe-2 membrane with a thickness of only 0.42 mm exhibited the best overall shielding performance, including an electrical conductivity of 7.12 S mm −1 , exhibiting an average EMI shielding effectiveness of 94.9 dB and a corresponding SE A value of 80.2 dB in the X-band. The SE A /SE R ratio reached 5.5, indicating obvious absorption-dominated shielding behavior. Meanwhile, the SSE t value reached 4013.4 dB cm 2 g −1 , demonstrating its lightweight shielding capability. This work provides a feasible approach for developing lightweight, ultrathin, low-filler-loading, and absorption-dominated EMI shielding materials. Download: Download high-res image (272KB) Download: Download full-size image A lightweight and ultrathin porous carbon membrane was developed by introducing Fe(acac) 3 as a molecular-level precursor to construct an interconnected conductive network and magnetic components. The optimized membrane achieves absorption-dominated EMI shielding with a shielding effectiveness of 94.9 dB and an absorption contribution of 80.2 dB at a thickness of only 0.42 mm.
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高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
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2026
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IF 6.7
Weijie Yan,Tao Li,Peihong Shi,Zhaoqi Hu,Jinliang Huang,Wenfa Fang,Libin Xia
NIR pc-LEDs develop rapidly due to its spectral tunability and compact design. However, NIR phosphors with both high efficiency and superior thermal quenching resistance are scarce. In this study, a novel NASICON-type structure phosphate NaAlNb(PO 4 ) 3 :Cr 3+ phosphor was synthesized successfully. The crystal structures and the luminescence behaviors were systematically investigated. The phosphor exhibits a broadband NIR emission from 700 to 1100 nm, centered at 808 nm and with a full-width at half maximum (FWHM) of 131 nm. Owing to the high structural rigidity (Θ D = 624.9 K) and wide optical bandgap (E g = 4.1 eV), NaAlNb(PO 4 ) 3 :Cr 3+ shows a high internal quantum efficiency (IQE) of 87% and excellent thermal quenching resistance (retaining 84.19% of its room-temperature intensity at 373 K). A NIR pc-LED was fabricated by combining the as-prepared phosphor with a 460 nm blue LED chip, achieving a high photoelectric conversion efficiency of 18.37% and a strong NIR output power of 50.19 mW at a driving current of 100 mA. All results indicate the NaAlNb(PO 4 ) 3 :Cr 3+ is a promising phosphor for NIR light practical applications.
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高影响因子
Journal of Environmental Chemical Engineering
·
2026
·Vol. 14
·期 3
·122940
·
IF 7.5
Ze Fu,Hong Lu,Shaoting Zhuo,Jichao Wang,Qiansheng Li,Xiaona Li,Haikun Zhang
To harness the potential of low-concentration, microbially secreted flavins as redox mediators, a novel biocarrier was designed via molecular simulation and synthesized via covalently grafting 2-chloro-4,6-diamino-1,3,5-triazine (CDAT) onto reduced graphene oxide (rGO)-modified polyurethane foam (CDAT-rGO-PUF). CDAT-rGO-PUF exhibited higher adsorption capacity for flavins and more efficiently resisted the interference of inorganic salt and cell lysate compared with rGO-PUF and CDAT-PUF, which was primarily attributed to the formed hydrogen bonding between CDAT and flavins. In Shewanella sp. RQs-106 -mediated reduction system of 3-nitrobenzenesulfonate (3-NBS), the adsorption behavior of CDAT-rGO-PUF accelerated extracellular electron transfer from flavin to rGO and cellular synthesis of flavins, resulting in over 37% increase in the bioreduction rate of 3-NBS compared with those in the presence of rGO-PUF and CDAT-PUF. Repeated usage experiments showed that CDAT-rGO-PUF had good catalytic stability. These findings indicate that the novel biocarrier is of potential application for adsorbing extracellular flavins to enhance the treatment of wastewaters containing nitroaromatic compounds.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Haijie Cai,Xingyu Wang,Jingting Han,Yayao Song,Jingwen Wang,Zhaomin Gao,Tianjun Ni,Yongheng Zhu
Gas sensors for detecting foodborne pathogen biomarkers offer a promising approach to enhance food safety monitoring. However, sensors based on conventional sensing materials often lack the requisite sensitivity for trace-level pathogen metabolites. Herein, PdPt/ZnO hollow concave nanocages are rationally designed through a surface-tailored strategy to achieve rapid and ultrasensitive detection of the Listeria monocytogenes biomarker 3-hydroxy-2-butanone at ultralow concentrations. The representative 1%PdPt/ZnO-based sensor exhibits superior sensing properties: high response (R a /R g = 92.8@5 ppm), rapid response/recovery kinetics (14/15 s), ultralow detection limit (20 ppb), excellent selectivity, and over 30-day stability at an operating temperature of 150 °C. The combination of ex-situ / in-situ characterization and DFT calculations reveals that the hollow concave nanocage morphology synergistically activated by PdPt bimetallic sites dramatically increases active site density, accelerates oxygen diffusion, and lowers the reaction energy barrier, thereby enabling the efficient adsorption and conversion of oxygen species and 3-hydroxy-2-butanone. Crucially, the sensor enables rapid response of Listeria monocytogenes in actual food samples and distinguishes it from other foodborne pathogens, demonstrating its significant potential for accurate, real-time, and non-invasive monitoring of Listeria monocytogenes contamination.
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高影响因子
Cell Metabolism
·
2026
·
IF 37
Defu Li,Bo Xia,Ruoci Hu,Zhao Zhang,Cong Xu,Hanjian Zhou,Xiao Li,Yonglin Hua,Shusong Wu,Ke Zhang,Yuwei Jiang,Jiangwei Wu,Yexian Yuan
Cold exposure induces beige adipogenesis in white adipose tissue, enhancing thermogenesis and energy expenditure. While gut microbiota-derived metabolites influence host metabolism, their role in thermogenic adaptation remains poorly defined. Here, we identify P. copri as a key microbial mediator of cold-induced adipose remodeling. Cold exposure expands P. copri in the colon, which produces 3-phenylpropionic acid (3-PPA), a metabolite that promotes beige adipocyte formation and increases energy expenditure. Mechanistically, 3-PPA signals through free fatty acid receptor 1 in M2-like macrophages, inducing chemokine C-X-C motif chemokine 13 (CXCL13) secretion, which recruits T follicular helper cells to facilitate beige adipogenesis. Lineage-tracing analyses show that adipocyte progenitor cells generate new beige adipocytes in response to 3-PPA. Moreover, 3-PPA supplementation counteracts high-fat diet-induced obesity in mice and promotes thermogenesis in mouse, pig, and human adipose progenitor cells. These findings define a microbiota-immune-adipose progenitor axis regulating cold adaptation and highlight microbial metabolites as potential metabolic therapies.
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PubMed
高影响因子
EUROPEAN JOURNAL OF PHARMACOLOGY
·
2026
·
IF 5.7
Xu-Jiao Song,Lu Bai,Xin-Ran Dong,Han Zhang,Yi-Bing Chen,Yuan-Lu Cui
3-Methylindole (3-MI) administered intranasally establishes a non-invasive, ethically sound depression model. • Targets the olfactory pathway to replicate core pathological features of depression. • Novel depression model based on the “olfactory dysfunction-neuroinflammation-hippocampal injury” cascade. Olfactory dysfunction has been closely linked to depression. However, the olfactory bulbectomy (OBX) model, a commonly employed animal model of depression, presents significant limitations, including poor alignment with clinical etiology and an elevated risk of mortality. In this study, we introduced an innovative, non-invasive model of depression by inducing olfactory dysfunction via the intranasal administration of a thermosensitive poloxamer gel containing 3-methylindole (3-MI) loaded in hydroxypropyl-β-cyclodextrin (HP-β-CD). This method specifically targets the olfactory pathway, thereby enhancing the model's safety and reliability. Through behavioral assessments, histopathological examination, transmission electron microscopy (TEM), immunohistochemistry, and neurotransmitter analyses, we found that the intranasal administration of the 3-MI gel significantly impaired olfactory sensitivity, damaged the olfactory epithelium, and induced inflammation and oxidative stress within the olfactory bulb. These alterations resulted in depressive-like behaviors, mitochondrial dysfunction, and apoptosis in the hippocampus, as well as reduced neurotransmitter release and metabolism in brain tissues. Treatment with mecobalamin or fluoxetine effectively alleviated olfactory dysfunction and depressive symptoms, respectively. Mecobalamin restored olfactory function and ameliorated depressive pathologies. Importantly, fluoxetine substantiated the model's predictive validity by reversing depressive and neurochemical deficits, although its efficacy in improving olfactory function was limited. Compared with the OBX and chronic unpredictable mild stress (CUMS) models, the intranasal 3-MI gel administration approach avoids both invasive surgery and prolonged stress exposure, aligning with animal welfare principles through minimized distress. These findings affirm the dual utility of this approach as both an effective and ethically optimized method for modeling depression. Schematic illustration of 3-MI/HP-β-CD-ATG for nose-to-brain delivery, inducing depression via olfactory dysfunction. Download: Download high-res image (331KB) Download: Download full-size image
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PubMed
高影响因子
Laser & Photonics Reviews
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2026
·
IF 9.7
Yi Zhang,Weibin Chen,Yuhang Kuang,Tao Hu,Ming Zhao,Zhiguo Xia,Xinping Zhang
Laser phosphor display is promising for next-generation high-quality display technology due to its high brightness, wide color gamut, and low speckle. However, the lack of high performance narrow-band green emitters with robust laser resistance remains a critical bottleneck. Herein, we develop RbSr 4 (BO 3 ) 3 :Eu 2+ (RSBO:Eu 2+ ) as a narrow-band green emitter, which exhibits an emission peak at 526 nm with a narrow full width at half maximum of only 50 nm under blue light excitation. The highly dense and rigid host framework effectively suppresses lattice relaxation and electron–phonon coupling despite Eu 2+ occupying multiple cation sites in RSBO. Highly stable RSBO:Eu 2+ was further embedded into a low-melting P 2 O 5 -Al 2 O 3 -B 2 O 3 -Na 2 O glass matrix to fabricate a phosphor-glass composite (RSBO:Eu-PGC), demonstrating good thermal stability and a high saturation threshold exceeding 40 W/mm 2 . The corresponding rotating phosphor wheel maintained a low surface temperature of 79.9°C under 40 W/mm 2 blue-laser irradiation, effectively mitigating thermal degradation. A prototype laser display system using a rotating wheel integrating RSBO:Eu-PGC and K 2 SiF 6 :Mn 4+ -PGC achieved a wide color gamut of 107% National Television System Committee (NTSC) standard, which highlights the great potential of narrow-band green-emitting RSBO:Eu-PGC for laser phosphor display applications.
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高影响因子
EUROPEAN JOURNAL OF PHARMACOLOGY
·
2026
·
IF 5.7
Ying Huang,Jiale Li,Yingzhou Qin,Bo Qie,Qianqian Wang,Cuijuan Liu,Yimin Zhu
A cyclic peptide binding with TIM-3, TBP1, was screened by a novel CX 12 C cyclic peptide display library base on bacterial surface display. • TBP1 effectively disrupted TIM-3 interactions with CEACAM-1 and PtdSer. • TBP1 restored the function of exhausted T cells in vitro . • TBP1 synergized with anti-PD-1 antibody, improving anti-tumor immunity in vivo . Immune checkpoint blockade (ICB) therapies, particularly antibodies blocking, the programmed cell death protein 1 (PD-1)/programmed cell death-ligand 1 (PD-L1), have shown clinical success but remain limited by suboptimal response rates, often due to insufficient immune activation. T-cell immunoglobulin and mucin domain-containing protein-3 (TIM-3), a non-redundant immune checkpoint frequently co-expressed with PD-1, drives severe T-cell exhaustion in solid tumors and contributes to resistance against anti-PD-1/PD-L1 therapy. Thus, dual blockade of TIM-3 and PD-1 may restore more effective anti-tumor immunity. Compared to antibodies, low-molecular-weight peptides offer advantages in combination therapy, including better tissue penetration, lower immunogenicity, improved tolerability and low production costs. Cyclic peptides, in particular, provide enhanced biological activity and proteolytic stability. Here, we present TBP1, a cyclic peptide identified via a bacterial surface display library, which binds TIM-3 with high affinity and specificity. Competitive blocking assays and molecular docking confirmed that TBP1 effectively disrupts TIM-3 interactions with Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM-1) and Phosphatidylserine (PtdSer). In vitro , TBP1 restored exhausted T-cell function by disrupting the TIM-3/CEACAM-1 interaction. In CT26 tumor-bearing mice, TBP1 synergized with an anti-PD-1 antibody, enhancing anti-tumor immunity by promoting CD4 + T cell infiltration and IL-2 secretion. These findings identify TBP1 as a novel TIM-3-targeting cyclic peptide and support its potential application in combination immune checkpoint blockade. Download: Download high-res image (372KB) Download: Download full-size image
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高影响因子
危险品化学品经营许可证（带存储）