AICHE JOURNAL
·
2017
·Vol. 63
·期 8
·3395-3403
·
IF 2.836
Min Xiao,Ding Cui,Helei Liu,Paitoon Tontiwachwuthikul,Zhiwu Liang
In this work, the equilibrium CO 2 solubility in the aqueous tertiary amine, N-methyl-4-piperidinol (MPDL) was measured over a range of temperatures, CO 2 partial pressures and amine concentrations. The dissociation constant of the MPDL solution was determined as well. A new thermodynamic model was developed to predict the equilibrium CO 2 solubility in the MPDL-H 2 O-CO 2 system. This model, equipped with the correction factor (C f ), can give reasonable prediction with an average absolute deviation of 2.0%, and performs better than other models (i.e., KE model, Li-Shen model, and Hu-Chakma). The second-order reaction rate constant (k 2 ) of MPDL and the heat of CO 2 absorption (–ΔH abs ) into aqueous MPDL solutions were evaluated as well. Based on the comparison with some conventional amines, MPDL revealed a high-equilibrium CO 2 loading, reasonably fast absorption rate when compared with other tertiary amines, and a low energy requirement for regeneration. It may, therefore, be considered to be an alternative solvent for CO 2 capture. © 2017 American Institute of Chemical Engineers AIChE J , 63: 3395–3403, 2017
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高影响因子
CURRENT DRUG METABOLISM
·
2024
·Vol. 25
·期 10
·754-768
·
IF 2.1
Xiaoyun Liu,Dafang Zhong,Chongzhuang Tang,Xiaofeng Xu,Hong Lan,Xingxing Diao
Background BPI-460372 is an orally available, covalent, irreversible small molecule inhibitor of the transcriptional enhanced associate domain (TEAD) 1/3/4, which is currently in clinical development for the treatment of cancers with Hippo pathway alterations. Objectives This study aimed to determine the cytochrome P450 (CYP) phenotyping, metabolic stability, and in vitro and in vivo metabolic profile of BPI-460372. Methods The CYP phenotyping and metabolic stability were assessed by measuring the depletion of substrate. The metabolic profile in hepatocytes and rat and dog plasma was analyzed using ultra-high-performance liquid chromatography combined with Orbitrap tandem mass spectrometry (UHPLC-Orbitrap-HRMS). Results BPI-460372 was mainly metabolized by CYP2D6, CYP3A4, and CYP1A2. BPI-460372 exhibited low clearance in human, monkey, and rat hepatocytes, while moderate clearance in dog and mouse hepatocytes. A total of 10 metabolites were identified in five species of hepatocytes, and no human-unique metabolite was detected. In rat plasma and dog plasma, the primary metabolites were M407 (BPI-460430) and M423 (BPI-460456), respectively. The two metabolites were quantitatively determined in rat and dog plasma in pharmacokinetic and toxicological studies. The major metabolic site was 2-fluoro-acrylamide, and major metabolic pathways in hepatocytes, and rat and dog plasma involved oxidative defluorination, hydration, glutathione (GSH) conjugation, hydrolysis, cysteine conjugation, and N-acetyl cysteine conjugation. β-lyase pathway contributed to the metabolism of BPI-460372 in rats to a certain degree. Conclusion This study elucidated the metabolism of BPI-460372 and provided a basis for pharmacokinetic and toxicological species selection, human pharmacokinetics prediction, and assessment of clinical co-administration limitations and possible metabolic pathways in humans.
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高影响因子
CHIRALITY
·
2022
·Vol. 34
·期 5
·701-710
·
IF 2.183
Fan Wang,Yuqing Wang,Yixuan Min,Junqing Li,Lili Zhang,Ting Zheng,Jun Shen,Yoshio Okamoto
A novel cellulose derivative bearing bulky 4-(2-benzothienyl)phenylcarbamate substituents ( Cel-1 ) was readily synthesized by carbamoylation followed by Suzuki–Miyaura coupling reaction. The corresponding coated-type chiral stationary phase (CSP) was prepared on basis of the derivative, and its chiral recognition ability was then evaluated by high-performance liquid chromatography (HPLC). The chiral recognition ability of the cellulose derivative was greatly influenced by introduction of the bulky benzothienyl pendants on the aromatic moieties of phenylcarbamates, compared with its analog with smaller groups. Many racemates, including the metal tris(acetylacetonate) complexes, chiral drug, and the analyte with axial chirality, were sufficiently separated with good enantioselectivities on Cel-1 . Some of them were even higher than those on the commercially powerful Chiralcel OD, which is also a coated-type CSP derived from cellulose phenylcarbamate derivative containing smaller 3,5-dimethyl pendants. The 1 H NMR and circular dichroism (CD) spectra of Cel-1 indicated that the obtained derivative possessed a regular higher order structure, and a strong cotton effect was observed within the absorption range of π-conjugated pendant at 350–500 nm. Impressively, the cellulose derivative bearing the bulky 4-(2-benzothienyl)phenylcarbamates exhibited good enantioselective fluorescence quenching behavior to the enantiomer pair of 1-phenylethylamine, probably suggesting its potential for the application as a chiral fluorescent sensor with high efficiency. The combination of the arrangement of bulky π-conjugated benzothienyl pendants on the phenylcarbamate moieties surrounding the helical backbone and the regular higher order structure of the polymer itself probably played a key role for this high chiral fluorescent recognition ability of Cel - 1 . The interaction sites of bulky 4-(2-benzothienyl)phenylcarbamate pendants in its excited state can exhibit higher enantioselective discrimination via fluorescent response to the chiral compound Q1 , whereas the chiral recognition ability of Cel-1 to the same compound in the ground state had no clear improvement.
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高影响因子
ChemCatChem
·
2021
·Vol. 14
·期 6
·e202101539
·
IF 5.686
Siwei Zhao,Shaohua Jin,Huanmin Liu,Youxin Su,Wei Liu,Shengfu Li,Chongchong She,Haonan Li,Kun Chen
Graphical A series of all-inorganic lead-free halide perovskite inverse opals were prepared and furtherly used as the photocatalysts to promote the polymerization of EDOT under the irradiation of visible light. All the samples exhibited the nice replica of the artificial template and high crystallinity. The bandgap of the catalysts was adjusted by screening the ratios of bromide to iodide and antinomy to bismuth. Cs 3 Bi 0.5 Sb 1.5 Br 9 showed the highest performance of the photocatalytic polymerization for EDOT, indicating the dual halide perovskites are more flexible than single halide perovskite in terms of bandgap engineering. A series of all-inorganic lead-free halide perovskite inverse opals were prepared and furtherly used as the photocatalysts to promote the polymerization of 3, 4-ethylenedioxythiophene (EDOT) under the irradiation of visible light. All the samples exhibited the nice replica of the artificial template and high crystallinity. The bandgap of the catalysts was adjusted by screening the ratios of bromide to iodide and antinomy to bismuth, respectively. Among all the samples, Cs 3 Bi 0.5 Sb 1.5 Br 9 inverse opal showed the best catalytic performance and the excellent stability in terms of the morphology and the crystalline phase after four cycles of photocatalytic polymerization. Since EDOT is commercially available, the present observation suggested a convenient protocol of preparing the composited materials or optoelectronic devices based on the lead-free halide perovskites and the conductive poly(3, 4-ethylenedioxythiophene).
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高影响因子
DYES AND PIGMENTS
·
2018
·
IF 3.767
Xiao-Lei Zhao,Jiao Geng,Bin Hu,Dan Xu,Wei Huang
New monomethine dyes have been prepared by a simple and highly efficient method in acetic anhydride, in which the common pyridine-2,6-dione moiety and thiophene derivatives occupy each side of the methine unit. Among them, the ternary monomethine-azo dyes were first obtained by the particularly useful post-modification synthetic strategy, in order to further adjust the π -conjugated system and electronic spectra of 2-amino-3-cyano-4-chloro-5-formylthiophene based heterocyclic hydrazone/azo dyes. UV−Vis spectral analyses reveal that the synthesized heterocyclic dyes exhibit a large color gamut because of the extension of the conjugation length of the chromophore , where the maximum absorption wavelength ( λ max ) is significantly red-shifted up to 181 nm from binary monomethine to ternary monomethine-azo dyes.
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高影响因子
JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL
·
2015
·
IF 3.615
Shuang Fan,Yi Luan,Jingjing Wang,Hongyi Gao,Xiaowei Zhang,Ge Wang
A novel ferric chloride immobilized poly(4-vinylpyridine) (P4VP) catalyst was developed via a coordination chemistry-based approach. The pyridine moiety of poly(4-vinylpyridine) spheres functioned as the nitrogen donor to bind iron ions, as well as to decrease the amount of pyridine used in the catalytic reaction system. The monodispersed catalyst was well dispersed in the organic solvent during the catalytic procedure, taking advantage of its nanomorphology and uniform size. The catalytic activity of various monodispersed catalysts based different mass fractions of the divinylbenzene (DVB) was investigated, meanwhile the capacities of supported Fe(III) in the various catalysts were also discussed. The P4VPDVB 10% -Fe(III) catalyst exhibited high catalytic activity in the benzylic oxidation of benzylic methylenes and secondary benzylic alcohols. It was easily separated from the reaction system and reused several times without obvious degradation of catalytic activity. Moreover, leaching tests suggested that the as-synthesized P4VPDVB 10% -Fe(III) catalyst was a true heterogeneous catalyst without significant metal leaching.
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高影响因子
Chemical Engineering Journal Advances
·
2021
·
IF 0
Xiaomiao He,Saishuai Bai,Jizhou Jiang,Wee-Jun Ong,Jiahe Peng,Zhiguo Xiong,Guodong Liao,Jing Zou,Neng Li
Excitonic effects induced via Coulomb interactions and an appropriate interfacial contact of electrode modified materials play crucial roles in transfer/separation of interfacial charge carriers during the electrochemical sensing process. Herein, an oxygen vacancy (V o ) mediated step-scheme (S-scheme) heterojunction of WO 2.9 /g-C 3 N 4 was fabricated by electrostatic self-assembly of high-purity commercial WO 2.9 nanoparticles and ultrathin g-C 3 N 4 nanosheets, where g-C 3 N 4 nanosheets were prepared via polymerization followed ultrasonic-assisted exfoliation. The fabricated V o -S-scheme WO 2.9 /g-C 3 N 4 heterojunction-based sensor exhibited superior electrochemical performance for detecting environmental hormone 4-nitrophenol (4-NP). Due to the introduction of V o , an increased free-charge-carriers, a built-in electric field and a high adsorption energy are generated at the heterojunction interface, which all can significantly improve the sensitivity of this proposed sensor. It also showed good reproducibility, high accuracy, good recovery, and strong feasibility for 4-NP detection in real samples. This work not only conduces significantly to understanding the defective structures and S-scheme heterojunctions, but also provides new insights into designing and constructing novel efficient electrochemical sensors.
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JOURNAL OF POWER SOURCES
·
2018
·
IF 6.945
Na Wang,Gaoyi Han,Hua Song,Yaoming Xiao,Yanping Li,Ying Zhang,Hongfei Wang
Thin layers of continuous gold have been deposited on the both sides of porous polypropylene films (PPF) via electroless plating method to form a sandwich structure with two conductive surfaces and an intermediate insulating layer (Au/PPF/Au). Then poly (3, 4-ethylenedioxy thiophene) (PEDOT) layers are electrodeposited on the two conductive sides via cyclic voltammetry method to form the sandwich-structured PEDOT-Au/PPF/Au-PEDOT. Gel electrolyte of H 3 PO 4 /polyvinyl alcohol (H 3 PO 4 /PVA) is then added to the sandwich-structured PEDOT-Au/PPF/Au-PEDOT to form the integrated flexible supercapacitor of Au-PEDOT|H 3 PO 4 /PVA|PEDOT-Au. The PEDOT-Au/PPF/Au-PEDOT sandwiched structures are characterized and the capacitive performances of the integrated flexible cells are investigated in detail. The results show that the optimum integrated flexible cell exhibits excellent cycling stability (91.8% capacitance retention after 20000 cycles) and relatively high areal specific capacitance. Furthermore, the cells of Au-PEDOT|H 3 PO 4 /PVA|PEDOT-Au not only exhibit excellent bending endurance (99.1% capacitance retention after 5000 repeated bending cycles), but also can be conveniently connected in series without additional wires. This integrated flexible cell may exhibit potential application in portable electronics.
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高影响因子
JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY
·
2020
·Vol. 96
·期 3
·697-703
·
IF 2.75
Aslam Khan,Dandi Wei,Zhuan Wang,Xintai Su,Jide Wang,Sultan Alam,Lu Wang,Ronglan Wu,Anatoly S Maloletnev,Chao Yang
BACKGROUND 4-Nitrophenol, as a representative hazardous contaminant, may pose potential risks to the environment in the process of production, storage, and use. Catalytic hydrogenation reduction offers a promising route to the removal of 4-nitrophenol by its transformation into the less toxic and biodegradable 4-aminophenol. In this work, nickel−cobalt bimetal oxide nanostructures were fabricated by the thermal decomposition of metal organic frameworks and cooperatively utilized for the catalytic reduction of 4-nitrophenol. RESULTS The as-fabricated oxide catalysts were characterized and analyzed with several physicochemical measurements, including X-ray diffraction, scanning electron microscopy, transmission electron microscopy, X-ray photoelectron spectroscopy, thermogravimetry, Fourier-transform infrared spectroscopy, Raman spectroscopy, nitrogen adsorption, and electrochemical impedance spectroscopy. The catalytic reduction of 4-nitrophenol was conducted in the presence of the as-prepared oxide nanostructures with varying Ni/Co ratios to evaluate their catalytic activity. The optimal catalyst (Ni–Co–O) delivered the activity parameter of k’ app = 12.0 min −1 mg −1 , which was higher than either NiO (2.4 min −1 mg −1 ) or Co 3 O 4 (3.6 min −1 mg −1 ). Moreover, the induction time of the 4-nitrophenol reduction was significantly reduced by using the bimetal oxide catalyst. Based on the surface and electrochemistry analyses, the enhancement of catalytic activity for the Ni–Co bimetal oxide nanostructures was discussed. CONCLUSION The above results indicated that the cooperation of nickel with cobalt into bimetal oxide nanostructures exhibited an enhanced catalytic activity, which not only promoted the conversion rate of 4-nitrophenol, but also shortened the reduction induction period.
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高影响因子
PROCESS BIOCHEMISTRY
·
2020
·
IF 2.952
Yuan Lu,Hongqian Dai,Hanbing Shi,Lan Tang,Xingyuan Sun,Zhimin Ou
Fe 3 O 4 -Arg was selected as the optimal carrier due to its high activity recovery of immobilized cells in the preparation of Fe 3 O 4 -Arg-Cells. The optimal immobilization conditions for the preparation of Fe 3 O 4 -Arg-Cells were 30 °C, 4 h, pH 7, and 3 g dry yeast. The activity recovery of immobilized cells reached 76.8 %. For a batch reduction in a shaker in an alternating magnetic field, Fe 3 O 4 -Arg-Cells were used as a catalyst to gain ethyl ( R )-4-chloro-3-hydroxybutyrate (( R )-CHBE). For further improvement in reduction productivity, a continuous reduction in the magnetic fluidized bed reactor system (MFBRS) was completed. Under their optimal transformation conditions, it took 24 h for Fe 3 O 4 -Arg-Cells to complete the conversion of ethyl 4-chloro-3-oxobutanoate (COBE) (0.8553 mol/L) in the shaker and only 8 h for the batch reduction in an alternating magnetic field. Continuous reduction in MFBRS provided new ideas for the efficient production of ( R )-CHBE; 1.5882 mol/L (10 mL) of COBE can be completely converted in 6 h. The conversion and enantiomeric excess (e.e.) of ( R )-CHBE were 100 % and above 99.9 % respectively, in the three reaction systems mentioned above.
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高影响因子
Optical Materials Express
·
2021
·Vol. 11
·期 9
·3015-3022
·
IF 3.442
Xiangfa Kong,Chaohui Cheng,Qifan Wang,Mianwu Meng,Mianwu Meng,Chaoshu Chen,Xiujian Wang,Siyu Huang,Siyu Huang,Siyu Huang,Weixin Gan,Weixin Gan
A Au-Ga alloy layer is synthesized on a Au sheet substrate at low temperature and a new nanoporous Au material is then prepared based on Ga removal from the Au-Ga alloy by a electrochemical method. X-ray diffraction analysis confirms that the grains of the newly formed Au layer are refined and scanning electron microscopy suggests that the newly formed Au layer has a nanoporous structure with a pore size of∼16 nm. The cyclic voltammetry curve of the prepared nanoporous Au in a 1 M KCl solution presents a square structure of a supercapacitor with a specific capacitance of mF·cm-2, which is 86 times that of the smooth Au electrode. The 4-mercaptobenzoic acid (4-MBA) modified nanoporous Au material is used as a Raman substrate to detect Hg2+ with surface-enhanced Raman scattering. from 1.0×10−10 mol·L-1 to 1.0×10−5 mol·L-1), and the limit of detection is 1.0×10−10 mol·L-1.
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高影响因子
RSC Advances
·
2020
·Vol. 10
·期 19
·11210-11218
·
IF 3.119
Yan Zhang,Fengsong Qi,Yujian Liu
The high B-doped ordered mesoporous carbon (HPB-OMC) was prepared by using 4-hydroxyphenylboronic acid-modified phenolic resin (HPBPF) as a boron and carbon precursor via the evaporation-induced self-assembly (EISA) approach. The chemical composite, mesoporous structure, and electrochemical properties of the as-prepared HPB-OMC are investigated. The results show that both highly boron-doped and well-ordered mesoporous structure are achieved for HPB-OMCs, owing to the improvement of solubility of the resins in ethanol, and the enhancement of thermal stability of pore channels during carbonization. Moreover, the HPB-OMCs exhibit an ideal electric double-layer capacitor performance. With the increase of the B-doped content, the specific capacitance of the HPB-OMC electrode rises gradually, then drops off a little. The HPB-OMC with a high B content (3.96 wt%) shows a much high specific capacitance of 183 F g−1 at a current density of 1 A g−1, suggesting its promising application in the field of supercapacitors.
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高影响因子
危险品化学品经营许可证（带存储）