Materials Today Communications
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2024
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IF 3.7
Ning Li,Qing Ma,Linyi Xu,Yue Wang,Li Zhang,Yiguo Jiang,Hongzhuo Liu
Diabetic foot ulcer (DFU) is a serious complication of diabetes, often leading to high risks of amputation and imposing considerable economic burdens on patients. Hyperglycemia induced impaired angiogenesis and increased susceptibility to bacterial infection are common obstacles in DFU wound healing, which impede the recovery process. In this work, a novel multifunctional polydopamine reduced graphene oxide chelating copper ions chitosan (PDA-rGO@Cu/CS) hydrogel was developed. Specifically, PDA-rGO@Cu/CS hydrogel dressing was facilitated efficient sterilization and angiogenesis, which attributed to the remarkable photothermal performance and the catalyzing NO release function of hydrogel. Experimental results indicated that the hydrogel accelerated the wound healing process in diabetic rats after topical application and the wound closure rate reached up to 91.57% (vs. 60% of the control) on day 14. Furthermore, in vitro/vivo antibacterial assays demonstrated that the hydrogel possessed antibacterial activity against E.coli and S.aureus , and improved infected wound healing as well as wound closure, which reached up to 90.42% on day 10. Mechanistically, H&E staining, Masson staining, immunofluorescent staining for CD31&α-SMA and IL-6 exhibited that the hydrogel accelerated full-thickness skin wound reconstruction by inhibiting inflammation, promoting collagen deposition and accelerating angiogenesis. Collectively, PDA-rGO@Cu/CS hydrogel provided a promising and efficient treatment strategy for DFU.
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REACTIVE & FUNCTIONAL POLYMERS
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2025
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IF 5.1
Jianhui Chen,Feng Ma,Yan Qin,Junying Li,Pengfei Yang
With the rapid development of industry, dye wastewater increasingly damaged the ecological environment and human health. Therefore, the treatment of wastewater became an urgent environmental issue. In this paper, sodium lignosulfonate was modified with the Reimer-Tiemann reaction and then cross-linked with chitosan hydrochloride to prepare modified sodium lignosulfonate-chitosan hydrochloride (MSL-CHC) composite materials, which were characterized by infrared spectra (FT-IR), scanning electron microscope (SEM), Brunauer-Emmett-Teller (BET) surface area, and X-ray photoelectron spectroscopy (XPS). Then, the adsorption performance of MSL-CHC for Congo red (CR) was investigated under different conditions, including adsorbent dosage, adsorption time, inorganic salt ion species, ionic strength and adsorption temperature. The results showed that the adsorption was consistent with the pseudo-second-order kinetic model, indicating that chemical adsorption was dominant. The adsorption isotherm could be fitted as the Langmuir model, indicating monolayer chemical adsorption. Thermodynamics studies showed that the adsorption of CR was a spontaneous endothermic process. The maximum adsorption capacity for CR was 804.32 mg·g −1 . Furthermore, the adsorption capacity of different dyes, as well as the adsorption process in various inorganic salt solution, indicated that MSL-CHC composites had good universality, anti-interference ability and recyclability. The composite materials were environmentally friendly, pollution-free, and easy to obtain, which were ideal bio-based adsorption materials for removing dyes from water.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
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IF 7.7
Enjuan Shi,Xiaoqin Wang,Huili Jing,Yayuan Xu,Lei Feng,Fatao He,Dajing Li,Zhuqing Dai
In this study, N -Methyl-N-nitrosourea (MNU) was intraperitoneally injected to construct a mouse retinitis pigmentosa (RP) model to evaluate the protective effect of chitosan and β-carotene on RP. The results demonstrated that chitosan synergized with β-carotene significantly reduced retinal histopathological structural damage in RP mice. The co-treatment group of β-carotene and chitosan restored the retinal thickness and outer nuclear layer thickness better than the group treated with the two alone, and the thickness reached the normal level. The content of β-carotene and retinoids in the liver of chitosan and β-carotene co-treated group increased by 46.75 % and 20.69 %, respectively, compared to the β-carotene group. Chitosan and β-carotene supplement suppressed the expressions of Bax, Calpain2, Caspase3, NF-κB, TNF-α, IL-6, and IL-1β, and promoted the up-regulation of Bcl2. Chitosan and β-carotene interventions remarkably contributed to the content of SCFAs and enhanced the abundance of Ruminococcaceae , Rikenellaceae , Odoribacteraceae and Helicobacteraceae . Correlation analysis demonstrated a strong association between gut microbiota and improvement in retinitis pigmentosa. This study will provide a reference for the study of the gut-eye axis.
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高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
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IF 7.7
Bingbing Xu,Yue Zhang,Jia Li,Boxiang Wang,Ruoxin Li,Dehong Cheng,Guangtao Chang
Conductive hydrogels have attracted intensive attention for their promising applications in flexible electronics, sensors, and electronic skins. However, extremely poor adaptability under cold or dry environmental conditions along with inferior repairability seriously hinders the development of hydrogels in wearable electronics. Here, a triple network conductive hydrogel (PBCP A -MXene) was prepared by proportionally mixing polyvinyl alcohol (PVA), borax, chitosan (CS), phytic acid (PA), and MXene. The prepared triple network hydrogels composed of robust chitosan polysaccharide as the first network, tough PVA biopolymer gel as the second network, and MXene nanosheets as the third network. Facilitated by triple networks, multiple hydrogen bonds, and electrostatic interactions of CS and PA, the obtained hydrogels not only exhibited outstanding mechanical properties (tensile strain of ∼1580 %, stress of ∼280 kPa) and electrical properties (∼ 2.72 S/m), but also possessed excellent self-healing, self-adhesion, anti-freezing and anti-drying properties. This work presents a strategy for the development of biopolysaccharide hydrogels for applications in the field of sensors.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
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IF 7.7
Shuhan Liu,Jianing Wang,Xin Wang,Lintongqing Tan,Tao Liu,Yudie Wang,Yihan Shi,Zhuoran Zhang,Sheng Ding,Kexin Hou,Wen Zhang,Fan Li,Xin Meng
Timely healing of acute wounds and stopping wound chronicity are current and future priorities in wound therapy. It is urgent and relevant to develop a wound dressing that has antimicrobial and monitors the wound microenvironment in real time. In this study, quaternary ammonium chitosan (HTCC) was selected as the antimicrobial agent and CS/PEO/HTCC nanofiber membranes (CPHs) were prepared by electrostatic spinning technique. The nanofiber membrane (CPH91) with the best antimicrobial performance was screened by the disk diffusion method and drug susceptibility testing by dilution method, and its antimicrobial effect on S. aureus was better than that of E. coli . Subsequently, functional carbon dots (CDs) were synthesized by solvothermal method and doped into CPH91 nanofibers by electrospinning. A good linear relationship between pH value (5.0–8.0) and the fluorescence intensity of CDs was observed. In addition, the nanofibers (CPH91@CDs) had good morphology, hydrophilicity, and biocompatibility. Changes in fluorescence intensity of CPH91@CDs at different pH (5.0–8.0) were monitored and converted into RGB values that were linearly fitted to pH value. Finally, the potential of CPH91@CDs of improving wound healing and instantaneously controlling wound healing process was confirmed by an infected wound model ( S. aureus ) on the back of SD rats.
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Materials Chemistry Frontiers
·
2025
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IF 6.4
QiHang Bu,ZeiFeng Yue,ZiHan Wang,Ning Jiang,Haibo Luo,RongXue Sun,QianYuan Liu,JianHua Xu,Cheng Wang,JiaJun Fu
Given the environmental problems caused by petroleum-based packaging materials, there is an urgent requirement for the development of sustainable bio-based green active packaging materials. Despite this need, the practical application of bio-based polymers, such as chitosan and cellulose, is limited due to their poor mechanical properties and barrier properties. Here, we prepared a novel chitosan-based green active composite film, employing chitosan nanoparticles encapsulating gallic acid as nanofillers. The interfacial interactions between the nanoparticles and chitosan matrix were found to significantly enhance the mechanical properties and barrier properties of the composite film. Moreover, the integration of gallic acid-loaded nanoparticles substantially improved the antimicrobial and antioxidant activities of the composite film. These improvements are crucial for inhibiting the proliferation of food-borne microorganisms and the oxidation of lipids, thereby preserving the quality and safety of foods. Freshness preservation experiments have demonstrated that this composite film could effectively mitigate the quality degradation of crayfish meat during storage, thereby verifying its potential application in the field of food packaging. Consequently, this sustainable bio-based green active packaging film has the potential to replace the traditional petroleum-based packaging film and inspires the development of new sustainable bio-based active packaging films.
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JOURNAL OF MEMBRANE SCIENCE
·
2025
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IF 9
Hao Zhu,Ping Zhang,Zhuoheng Tu,Xingbang Hu,Youting Wu
Chitosan (CS) is a potential membrane material for acid gas separation owing to its advantages of low cost, high biocompatibility, good film-forming property, and abundant amine groups. However, due to the strong hydrogen bonding network inside bulky CS, it has poor solvent processability and high membrane crystallinity leading to slow gas permeation. Herein, via alkylating primary amine on chitosan using 1-bromohexyl-3-methylimidazolium bromide ([Brhmim]Br), water-processable ionic liquid-grafted chitosan (ICS) membrane was fabricated for H 2 S separation. Furthermore, polyethylene glycol (PEG) was introduced into ICS to improve H 2 S separation performance owing to its good plasticizing ability and highly reversible hydrogen bonding interaction with H 2 S. The successful fabrication of ICS and ICS/PEG membranes was validated using various characterizations. Notably, H 2 S/CO 2 /CH 4 (20/20/60 vol%) mixed gas permeation test shows H 2 S permeability up to ∼1100 Barrer, with desired H 2 S/CH 4 (∼24) and H 2 S/CO 2 (∼11) selectivity obtained. Quantum chemical calculations revealed that both the ionic liquid and PEG have highly reversible hydrogen bonding interaction with H 2 S, which facilitates H 2 S permeation. Overall, this work proposes a novel and green method for preparing modified chitosan membranes targeting H 2 S separation, which may provide a new insight into the design of sustainable membrane materials for natural gas desulfurization.
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LANGMUIR
·
2025
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IF 3.9
Yuan Bai,Xinyu Gan,Zongxian Jing,Pengfei Fan
The development of efficient and environmentally sustainable adsorbents for dye removal from wastewater remains a significant environmental challenge. Azo dyes, such as methyl orange (MO), persist in aquatic environments due to their high chemical stability and resistance to biodegradation. Although chitosan-based materials have been extensively studied for dye adsorption, their low solubility, poor mechanical stability, and limited adsorption capacity restrict large-scale applications. In this study, sulfonated chitosan/graphene oxide (SCSGO) and N,O-carboxymethyl chitosan/graphene oxide (N,O-CMCSGO) were synthesized and evaluated for MO adsorption. SCSGO and N,O-CMCSGO exhibit high MO adsorption capacities (265.67 and 239.60 mg/g, respectively), with Freundlich isotherm modeling confirming multilayer adsorption on heterogeneous surfaces via combined electrostatic, hydrogen bonding, and π–π interactions. Kinetic analysis indicates nonspontaneous adsorption controlled by external and intraparticle diffusion. FTIR and XPS analyses confirm that functionalization alters the surface chemistry, enhancing the MO affinity. Notably, after five consecutive adsorption–desorption cycles, SCSGO maintains over 90% of its original adsorption efficiency.
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ENERGY & FUELS
·
2025
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IF 5.3
Jiaqi Peng,Shanshan Li,Fubin Chen,Jie Ling,Mingtao Zheng,Chaofan Hu,Jianle Zhuang,Huashou Li,Hanwu Dong
Utilization of abundant renewable resources for preparing green materials for energy storage, such as supercapacitors, is important and challenging. The organic-acid-assisted hydrothermal process has recently emerged to be an effective way to regulate the porous structure of the final activated carbon. In this work, citric/acetic acids are employed as hydrothermal assisting reagents for the carbonization of chitosan prior to KOH activation of the hydrochar, for conducting a comparative study to better understand the effects of these organic acids. The study systematically investigated the impact of the acetic acid/citric acid addition ratio on the products of hydrochar and KOH-activated porous carbon. The results demonstrated that the addition of acetic acid (AC) was more conducive to the development of mesopores, while the addition of citric acid (CA) was more favorable for the development of micropores. The hierarchical distribution of the pore structure resulted from AC hydrothermal exhibiting the optimal electrochemical and cycle life performance at the same concentration. The highest specific surface area (3336 m2/g) was achieved when 0.8 mol/L AC (08ACK3) was added, which was significantly higher compared to those of nonassisted conventional as well as CA hydrothermal. In the three-electrode system, the specific capacitance of 08ACK3 reached 431.5 F/g at 0.5 A/g, which was higher than those of most of the previously reported chitosan-based porous carbon materials. Furthermore, the specific capacity retention was even higher at 10 A/g, which was 96% of the original specific capacitance after 30,000 charge/discharge cycles. Compared to citric acid, which predominantly enhances the total specific surface area by increasing micropores (<2 nm), acetic acid shows a stronger tendency to augment the micro-mesopore (1.1–3 nm) specific surface area, consequently contributing to the overall surface area improvement.
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MATERIALS RESEARCH INNOVATIONS
·
2025
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IF 0
Mengyuan Zhao,Tingting Wu,Jiale Han,Fang Li,Hongyuan Zhao
This work designed a low-cost and sensitive electrochemical sensor based on chitosan (CTS)-modified peanut shell-derived porous carbon (PSPC) for the detection of carbendazim (CBZ). PSPC exhibited a unique three-dimensional interconnected porous structure. The hierarchical porous carbon architecture with high specific surface area not only enhanced the adsorption capacity of CBZ but also significantly increased the interface contact area of electrode/electrolyte. CTS was uniformly deposited on the surface of PSPC via ultrasound-assisted liquid-phase dispersion method for the preparation of the PSPC@CTS nanocomposite. Benefiting from the good biocompatibility, adsorption ability and film-forming property of CTS, the PSPC@CTS modified electrode demonstrated good CBZ enrichment ability and improved structural stability. The PSPC@CTS/GCE sensor exhibited a low detection limit of 17.41 nM (S/N = 3) within the linear CBZ concentration range of 0.01–10.0 µM. Satisfactory recoveries of 96.78 –100.42% could validate its practical application potential of the PSPC@CTS modified sensor for the CBZ detection in food samples.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
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IF 8.5
Jiayao Yang,Jie Fei,Xiaohuan Liu,Hongpeng Wang,Jun Huang
The advancement of biomedicine and molecular diagnostics depends on effective nucleic acid separation methods. Nevertheless, creating high-performing and environmentally friendly nucleic acid adsorbent materials is still challenging. In order to achieve high-quality DNA capture, this work creatively created a rare earth metal hybridized magnetic chitosan nanoparticle (Fe 3 O₄@CS@La(OH)₃) by combining the biocompatibility of chitosan with the effective coordination ability of La 3+ . The results showed that Fe₃O₄@CS@La(OH)₃ had a high specific surface area and superparamagnetism, with a high adsorption capacity of DNA up to 370.37 mg/g, and 80 % of DNA could be captured within 5 min, and the capture rate was up to 96.7 % within 2 h. This was primarily ascribed to the strong coordination and electrostatic interaction between La 3+ and nucleic acids. Furthermore, the adsorption efficiency continued to exceed 90 % after five cycles, indicating exceptional reproducibility. This study involved the novel combination of the rare earth metal lanthanum with magnetic chitosan. The utilization of its unique coordination chemistry significantly enhanced the capture efficiency of nucleic acids, presenting potential applications in precision medicine and disease detection.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
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IF 8.5
Jing Peng,Qiyue Xiao,Jieyu Xue,Yijia Cao,Jiayi Chen,Jingwen Zhao,Yuanrong Ding,Xuhong Yang,Yong Yang
As modern industry continues to advance, noise pollution is becoming increasingly severe, posing a significant threat to the global economy and human health. Given their porous structure and lightweight properties, aerogels exhibit substantial potential in the field of acoustics. Concurrently, the use of environmentally-friendly, biodegradable materials such as chitosan (CS) and polyvinyl alcohol (PVA) not only helps address environmental challenges but also contributes to reducing pollution. This study investigates the microstructural evolution of CS/PVA aerogels through compositional tuning, aiming to significantly enhance their acoustic properties. Through meticulous adjustment of the CS and PVA concentrations during the sol-gel process, we successfully fabricated aerogels with a remarkable low density of 0.0240 g·cm −3 and a high porosity of 98 %. The resulting aerogels demonstrate exceptional acoustic performance, with a sound transmission loss (STL) exceeding 20 dB in the frequency ranges of 450 to 1000 Hz and greater than 3000 Hz, and a noise reduction coefficient (NRC) of 0.428 at a thickness of only 18 mm. In addition, CS/PVA aerogel also exhibits certain thermal insulation properties, with a minimum thermal conductivity of 0.0387 W·m −1 ·K −1 . These findings underscore the potential of CS/PVA aerogels as low-density and environment friendly acoustic materials.
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