JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2025
·
IF 9.7
Chenglong Bao,Fengyu Wu,Fan Wang,Longyu Qiu,Menggang Li,Depeng Zhao,Yongsheng Yu,Weiwei Yang
The development of efficient heterogeneous catalysts for copper-catalyzed azide-alkyne cycloaddition (CuAAC) is crucial for overcoming the limitations of homogeneous systems, such as poor recyclability and catalyst leaching. In this study, we report the synthesis of nanosized hollow Cu(I)/Cu(II)-metal-organic frameworks (Nano-hollow Cu(I)/Cu(II)-MOF). The paddlewheel Cu(II) sites persist as robust structural nodes, while partial reduction engenders catalytically active planar tetranuclear Cu(I) sites strategically embedded within the framework. This unique architecture endowed Nano-hollow Cu(I)/Cu(II)-MOF with remarkable catalytic activity, achieving a turnover frequency (TOF) of 456.9 h −1 over 10 min for the CuAAC reaction between phenylacetylene and benzyl azide with a TOF 1.66-fold higher than the nanosphere control, underscoring the hollow structure's advantages. Moreover, the catalyst also demonstrated exceptional recyclability, maintaining a nearly constant catalytic conversion rate over 6 cycles. Theoretical calculations unveiled a dual‑copper synergistic mechanism, wherein coordinated charge redistribution mediated by both copper sites significantly lowered the activation barrier. The alkyne dehydrogenation is identified as the rate-determining step with a theoretical overpotential of 0.82 eV, which was pivotal for enhancing reaction efficiency. Beyond conventional catalysis, the Nano-hollow Cu(I)/Cu(II)-MOF exhibited versatile applicability, including rapid fluorescent molecule synthesis with a rate constant (k Flu ) of 0.1 min −1 and efficient DNA-templated ligation reactions with an apparent rate constant (k obs ) of 0.21 s −1 .
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Drug Testing and Analysis
·
2024
·
IF 2.6
Rui-Jia Chen,Zi-hua Zhang,Shenglan Yang,Shu-chen Yu,Jun-chang Wang,Ping-yong Liao,Ting-ting Qiu,Lu Xiao,Shang Xue,Hong Chen,Wen-bin Shao,Jian-wen Hu,Yun Lan,Xi-long Chen,Yue Xu,Tian-meng Zhou,Xue-jun Zhao,Wen-bin Liu
5F-MDMB-PICA, an indole-type synthetic cannabinoid (SC), was classified illicit globally in 2020. Although the extensive metabolism of 5F-MDMB-PICA in the human body warrants the development of robust analytical methods for metabolite detection and quantification, a current lack of reference standards for characteristic metabolites hinders such method creation. This work described the synthesis of 18 reference standards for 5F-MDMB-PICA and its possible Phase I metabolites, including three hydroxylated positional isomers R14 to R16 . All the compounds were systematic characterized via nuclear magnetic resonance, Fourier transform infrared spectroscopy, and high-resolution mass spectrometry. Furthermore, two methods were developed for the simultaneous detection of all standards using liquid chromatography–tandem mass spectrometry and ultra-performance liquid chromatography–quadrupole time-of-flight mass spectrometry. By comparison with authentic samples, R17 was identified as a suitable urine biomarker for 5F-MDMB-PICA uptake.
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ANALYTICAL BIOCHEMISTRY
·
2022
·
IF 3.191
Huikai Ma,Ping Wang,Yaoyao Xie,Jinghan Liu,Wei Feng,Sanqiang Li
A novel ratiometric electrochemical aptasensor was constructed for the detection of carcinoembryonic antigen (CEA) based on a hairpin DNA (hpDNA) probe and exonuclease Ⅰ (Exo Ⅰ)-assisted target recycling amplification strategy. A thiolated methylene blue (MB)-labeled hpDNA as the internal control element was fixed on the surface of the gold nanoparticles (AuNPs)-modified gold electrode (AuE) through Au–S bonds. A ferrocene (Fc)-modified aptamer DNA (Fc-Apt) was partially hybridized with hpDNA to form a Fc-Apt/hpDNA duplex. Due to the specific recognition of Fc-Apt to CEA, the presence of CEA caused dissociation of Fc-Apt from the duplex, and further triggered the degradation process of Exo Ⅰ and recycling of CEA. Hence, the Fc tags were released from the electrode surface and the oxidation peak current of Fc (I Fc ) decreased while that of MB (I MB ) remained stable owing to the distance between MB tags and the electrode unchanged. A linear relationship was observed between I Fc /I MB and the logarithm of CEA concentration from 10 pg mL −1 to 100 ng mL −1 with a detection limit of 1.9 pg mL −1 . Moreover, the developed aptasensor had been applied to detect CEA in diluted human serum with satisfactory results, indicating its great potential in practical applications.
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FOOD CHEMISTRY
·
2022
·
IF 9.231
Pengfei Ma,Hua Ye,Hualin Guo,Xiaoyuan Ma,Lin Yue,Zhouping Wang
Herein, for the first time, a novel truncation strategy for aptamers’ sequences based on molecular docking was reported for the first time. T-2 toxin and AFB 1 aptamers were employed as models and fluorescence polarization was used to measure the affinity of aptamers. The T-2 toxin aptamer (T40) with 40 bases and the AFB 1 aptamer with 32 bases were successfully obtained with increased affinities compared with original aptamers. Meanwhile, circular dichroism, FAM-BHQ1 dual labeled T40, enzyme digestion, and molecular dynamics simulation were performed to investigate the binding mechanism between aptamer T40 and T-2 toxin. Finally, based on MnO 2 nanosheet and the fluorescence amplification effect of SYBR Green I, simplified and rapid fluorescence detection of T-2 toxin was achieved with a detection range of 0.03 nM to 30 nM, indicating the great potential of aptamer in practical detection applications.
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高影响因子
Small
·
2025
·
IF 12.1
Qiqiong Ren,Pei Wang,Nan Zhang,Guojun Zhou,Xian-Ming Zhang
Organic–inorganic hybrid materials face significant barriers to large-scale commercialization, primarily stemming from their intrinsic vulnerability to moisture-triggered hydrolytic degradation. Herein, an ultra-stable 2D copper(I) iodide, Cu 6 I 6 (26dmpz) 3 , is engineered through a synergistic waterproofing strategy that integrates atomic-level passivation and surface-interface hydrophobicity. N-metal coordination in Cu 6 I 6 (26dmpz) 3 (26dmpz = 2,6-dimethylpyrazine) passivates H-bond donors at atomic-level, blocking hydrolytic degradation induced by N─H···O interactions. Its methyl-dominated non-polar surface and “hydrogen-bond-free” contribute to low surface energy (37.68 mJ m −2 ) and polarity (4.09 mJ m −2 ), minimizing water adsorption, as corroborated by a 130.8° contact angle. The 2D corrugated groove structure creates a physical barrier against water penetration at solid–liquid interfaces. This endows Cu 6 I 6 (26dmpz) 3 with exceptional water stability, preserving its structure and luminescence after 30 days in water. Moreover, it shows bright orange–red emission (616 nm) with strong blue-light response, attributed to halide/metal-to-ligand charge transfer. The fabricated white LED exhibits an ultra-high color rendering index (CRI = 89.9), showing tremendous potential for high-quality solid-state lighting.
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ANALYST
·
2013
·Vol. 138
·期 17
·4737-4740
·
IF 3.969
Chenchen Ge,Junhua Chen,Wei Wu,Zhiyuan Fang,Lingbo Chen,Qi Liu,Lin Wang,Xuerong Xing,Lingwen Zeng
An enzyme-free and label-free fluorescence turn on biosensor for amplified copper(II) ion (Cu2+) detection has been constructed based on self-assembled DNA concatamers and Sybr Green I. This assay is simple, inexpensive and sensitive, enabling quantitative detection of as low as 12.8 pM Cu2+.
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ACS Applied Energy Materials
·
2024
·
IF 5.4
Lei Zhou,Xin Wei,Junxiang Zhang,Xuecui Mei,Yun Li,Chaoyue Zheng,Furong Zhang,An Wen,Bin Wang
Sulfide solid electrolytes (SSEs) have some huge advantages in high room-temperature conductivity, good thermal stability, low interfacial resistance, etc. They are one of the ideal solid electrolytes for developing high energy density and high safety for all-solid-state lithium batteries (ASSLBs). However, the preparation of SSEs requires expensive Li2S as the raw material, whose high cost limits its practical application. Herein, a cost-effective SSE Li7.3P2.9S10.75X0.3 (X = F, Cl, Br, and I) was designed and prepared by using low-cost lithium and sulfur instead of expensive Li2S. Significantly, the cost of SSEs was reduced from $169.72 to $28.13 kg–1 based on replacing the Li2S strategy. Moreover, the prepared Li7.3P2.9S10.75X0.3 (X = F, Cl, Br, and I) solid electrolytes have a high ionic conductivity of 1.86–2.73 mS cm–1 at room temperature and a high voltage window of 5 V. On this basis, we assembled the all-solid-state lithium battery TiS2/Li7.3P2.9S10.75I0.3/Li–In, which presented a high initial discharge capacity of 219 mA h g–1 at room temperature and satisfactory cycle stability with a capacity retention of 86.7% after 100 cycles at 0.50 mA cm–2. This work provides an effective strategy for reducing the cost of SSEs, advancing the practical process of ASSLBs.
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JOURNAL OF MOLECULAR LIQUIDS
·
2021
·
IF 6.165
Fengxin Guo,Qiong Liu,Jiao Sha,Zidan Cao,Yuanhui Chong,Yu Li,Tao Li,Baozeng Ren
The solubility of amitriptyline hydrochloride (AMT) (Form I) in fourteen mono-solvents, including {methanol, 2-methoxyethanol, ethanol, 2-ethoxyethanol, n-propanol, 2-propoxyethanol, n-butanol, 2-butoxyethanol, n-octanol, n-hexanol, n-heptanol, n-pentanol, N-Methyl pyrrolidone (NMP), N,N-Dimethylformamide (DMF)} was determined under 0.1 MPa from 278.15 K to 323.15 K by laser detection method. The experimental results showed that as the temperature increasing, the solubility of AMT (Form I) gradually increased. The order of solubility of AMT (Form I) in fourteen mono-solvents at 298.15 K was: methanol (0.1753) > 2-methoxyethanol (0.1488) > 2-ethoxyethanol (0.1082) > 2-propoxyethanol (0.08140) > ethanol (0.07940) > 2-butoxyethanol (0.06600) > n-propanol (0.05720) > NMP (0.04480) > DMF (0.04230) > n-butanol (0.04050) > n-pentanol (0.03210) > n-hexanol (0.02700) > n-heptanol (0.02250) > n-octanol (0.004700). In addition, the Hansen solubility parameter (HSP) was applied to further discuss the miscibility of AMT (Form I) in the studied solvents. Molecular dynamics simulation explored the intermolecular interaction between solute and solvents. And the solvent effect of AMT (Form I) in the tested pure solvents was explained by the KAT-LSER model. The basic data of experimental solubility of AMT (Form I) were correlated with five thermodynamic models, including NRTL, λh, modified Apelblat, NRTL-SAC and two-Suffix Margules. Furthermore, the van't Hoff equation was applied to calculate the dissolution thermodynamic properties of AMT (Form I) in all tested solvents, including Δ dis H o , Δ dis S o and Δ dis G o .
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APPLIED SURFACE SCIENCE
·
2022
·
IF 7.392
Qian Lei,Zhenting Zhao,Wenda Wang,Yong Chen,Jie Hu,Lin Chen
Ultrasensitive determination of Sudan I is critically important for food products due to its potential carcinogenicity. Herein, an electrochemical sensor was developed for Sudan I detection by using nanocomposites-based glassy carbon electrodes (GCE). Cobalt trioxides (Co 3 O 4 ) dodecahedron were initially derived from zeolitic imidazolate frameworks (ZIF) and interconnected by carbon nanotubes (CNTs). After that, the Co 3 O 4 -CNTs complexes were functionalized with platinum nanoparticles (PtNPs), giving rise to a hierarchic system (PtNPs@Co 3 O 4 -CNTs/GCE) ultrasensitive to the cooperative binding activity of Sudan I. The electrochemical responses of as-proposed PtNPs@Co 3 O 4 -CNTs/GCE sensors have been evaluated toward Sudan I detection under different optimum conditions. Especially, the obtained results demonstrated that the Pt 4.5 NPs@(Co 3 O 4 ) 1 -(CNTs) 1 /GCE sensor exhibits the superior electrochemical responses with high sensitivity (27870 μA·mM −1 ·cm −2 ), wide linear range (0.03 μM-100 μM) and low limit of detection (0.005 μM, S/N = 3). These results are promising for the development of high performance sensors of Sudan I which can be used for various food applications.
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APPLIED SURFACE SCIENCE
·
2024
·
IF 6.3
Menglu Wang,Bolong Liang,Shumin Lin,Zhe Zhao,Hongbin He,Xiliang Li,Shu-xuan Liang
The magnetic Fe 3 O 4 @ZIF-8 with high adsorption properties and easy separation were embedded in BiOX (X = Cl, Br, I) to synthesize Fe 3 O 4 @ZIF-8@BiOX using a simple one-pot solvothermal strategy. The crystal structure, surface morphology, photoelectric properties, thermal stability and magnetic response of the three materials were compared and analyzed, and the effect on the removal of OTC and Cr(VI) from single and coexisting systems by adsorption-photocatalysis is discussed. The results show Fe 3 O 4 @ZIF-8@BiOI has the highest separation efficiency of photogenerated carriers upon photoexcitation and stronger light absorption capacity, and exhibits better adsorption-photocatalytic activity than the other two materials in the photocatalytic reduction of Cr(VI) (68 % and 65 % removal for single and coexisting systems) and degradation of OTC (86 % and 59 % removal for single and coexisting systems). It is noteworthy that in the coexistence of Cr(VI) and OTC, a slight decrease of removal occurred, which could be due to a competitive effect between two pollutants being greater than the synergistic effect. ∙O 2 - is the main active substances in the adsorption-photocatalysis process. Finally, this work demonstrates the excellent adsorption and photocatalytic ability of Fe 3 O 4 @ZIF-8@BiOI for the simultaneous removal of Cr(VI) and OTC, which has great potential for practical wastewater treatment.
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DALTON TRANSACTIONS
·
2020
·Vol. 50
·期 1
·197-207
·
IF 4.174
Yan Zhao,Lei Li,Bo Ding,Xiu-Guang Wang,Zheng-Yu Liu,En-Cui Yang,Xiao-Jun Zhao
Decontamination of industrial wastewater containing toxic organic dye molecules and oxoanions is urgently desirable for environmental sustainability and human health. Water-stable porous metal–organic frameworks (MOFs) have emerged as highly efficient photocatalysts and/or adsorbents for water purification through controllable integration of the constitutive requirements. To reveal the inclusion anion effect of microporous MOFs on wastewater treatment, two isostructural MOFs incorporating positive charge and semiconductive characteristics, {[Cu(tpt)]·3H2O·0.5SO4}n (1) and {[Cu(tpt)]·2H2O·ClO4}n (2, tpt = 2,4,6-tris(4-pyridyl)-1,3,5-triazine), have been synthesized and employed as dual-functional materials for both dye photodegradation and oxoanion removal. The two MOFs possess the same 3-fold interpenetrating cationic backbones but are encapsulated by highly disordered sulfate or perchlorate in the open channels. These included anions have significantly tuned the hydrophilicity of the channels, extended the visible-light absorption, optimized the bandgap and decreased the conduction band potential. Under the low-energy irradiation of a 30 W LED lamp, MOF 1 has selectively and efficiently degraded rhodamine B compared to 2 with accelerated kinetics, resulting from the stronger reduction ability and less migration resistance of the photogenerated electrons. Instead, MOF 2 can quickly capture harmful MnO4− and Cr2O72− by exchanging with the entrapped ClO4−, with maximum adsorption amounts of 557 and 168 mg g−1, respectively, under ambient conditions. The improved decolorization of the aqueous solution over 2 benefits essentially from the shape and charge memory effect and the smaller hydration energy of ClO4− than SO42−. These interesting observations highlight the importance of the included anions inside the porous MOF semiconductors on wastewater treatment.
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Advanced Science
·
2021
·Vol. 8
·期 14
·2100524
·
IF 16.806
Miaomiao Kang,Zhijun Zhang,Wenhan Xu,Haifei Wen,Wei Zhu,Qian Wu,Hongzhuo Wu,Junyi Gong,Zhijia Wang,Dong Wang,Ben Zhong Tang
Photodynamic therapy (PDT) has long been recognized to be a promising approach for cancer treatment. However, the high oxygen dependency of conventional PDT dramatically impairs its overall therapeutic efficacy, especially in hypoxic solid tumors. Exploration of distinctive PDT strategy involving both high-performance less-oxygen-dependent photosensitizers (PSs) and prominent drug delivery system is an appealing yet significantly challenging task. Herein, a precise nuclear targeting PDT protocol based on type-I PSs with aggregation-induced emission (AIE) characteristics is fabricated for the first time. Of the two synthesized AIE PSs, TTFMN is demonstrated to exhibit superior AIE property and stronger type-I reactive oxygen species (ROS) generation efficiency owing to the introduction of tetraphenylethylene and smaller singlet–triplet energy gap, respectively. With the aid of a lysosomal acid-activated TAT-peptide-modified amphiphilic polymer poly(lactic acid)12k–poly(ethylene glycol)5k–succinic anhydride-modified TAT, the corresponding TTFMN-loaded nanoparticles accompanied with acid-triggered nuclear targeting peculiarity can quickly accumulate in the tumor site, effectively generate type-I ROS in the nuclear region and significantly suppress the tumor growth under white light irradiation with minimized systematic toxicity. This delicate “Good Steel Used in the Blade” tactic significantly maximizes the PDT efficacy and offers a conceptual while practical paradigm for optimized cancer treatment in further translational medicine.
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