Energy Storage Materials
·
2024
·
IF 18.9
Kaiqiang Zhang,Yang Ge,Qianchuan Yu,Pengbo Zhang,Yuge Feng,Zuoxiu Tie,Jing Ma,Zhong Jin
Self-stratified liquid electrode batteries are considered as a viable solution for large-scale energy storage applications due to their high safety and low cost. However, achieving long-term operation stability with high efficiency of selective ion migration/separation in multiple liquid phases remains a challenge. Here, we report an aqueous biphasic system based on imidazolium ionic liquids (ILs) for constructing membrane-free self-stratified aqueous biphasic Zn–I and Zn–Br batteries. The limited intersolubility and density difference between the IL-dominated catholyte and the aqueous anolyte create a self-stratified liquid-liquid phase separation structure, promising a reliable battery construction. Molecular dynamics simulations identify the internal association of IL, which forms a 3D H–bond network with the C–H···O interaction being the primary contributor, along with a thermodynamic electron transfer of ≤0.03 e. Additionally, a unique π + –bond effect is found between the positively charged imidazole ring of cation and the anion of IL. The as-constructed self-stratified aqueous biphasic Zn–halogen batteries work stably without the necessity of air isolation and exhibit long-term cycling stability (with a capacity mentation of 81.0 % for Zn–I batteries and 76.8 % for Zn–Br batteries over 1000 cycles), high energy efficiencies (93.5 % for Zn–I batteries and 86.7 % for Zn–Br batteries), inherent fire resistance and good scalability, demonstrating great potential for large-scale energy storage applications.
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高影响因子
FOOD CHEMISTRY
·
2022
·
IF 9.231
Pengfei Ma,Hua Ye,Hualin Guo,Xiaoyuan Ma,Lin Yue,Zhouping Wang
Herein, for the first time, a novel truncation strategy for aptamers’ sequences based on molecular docking was reported for the first time. T-2 toxin and AFB 1 aptamers were employed as models and fluorescence polarization was used to measure the affinity of aptamers. The T-2 toxin aptamer (T40) with 40 bases and the AFB 1 aptamer with 32 bases were successfully obtained with increased affinities compared with original aptamers. Meanwhile, circular dichroism, FAM-BHQ1 dual labeled T40, enzyme digestion, and molecular dynamics simulation were performed to investigate the binding mechanism between aptamer T40 and T-2 toxin. Finally, based on MnO 2 nanosheet and the fluorescence amplification effect of SYBR Green I, simplified and rapid fluorescence detection of T-2 toxin was achieved with a detection range of 0.03 nM to 30 nM, indicating the great potential of aptamer in practical detection applications.
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高影响因子
ANALYST
·
2013
·Vol. 138
·期 17
·4737-4740
·
IF 3.969
Chenchen Ge,Junhua Chen,Wei Wu,Zhiyuan Fang,Lingbo Chen,Qi Liu,Lin Wang,Xuerong Xing,Lingwen Zeng
An enzyme-free and label-free fluorescence turn on biosensor for amplified copper(II) ion (Cu2+) detection has been constructed based on self-assembled DNA concatamers and Sybr Green I. This assay is simple, inexpensive and sensitive, enabling quantitative detection of as low as 12.8 pM Cu2+.
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高影响因子
ANALYTICAL BIOCHEMISTRY
·
2022
·
IF 3.191
Huikai Ma,Ping Wang,Yaoyao Xie,Jinghan Liu,Wei Feng,Sanqiang Li
A novel ratiometric electrochemical aptasensor was constructed for the detection of carcinoembryonic antigen (CEA) based on a hairpin DNA (hpDNA) probe and exonuclease Ⅰ (Exo Ⅰ)-assisted target recycling amplification strategy. A thiolated methylene blue (MB)-labeled hpDNA as the internal control element was fixed on the surface of the gold nanoparticles (AuNPs)-modified gold electrode (AuE) through Au–S bonds. A ferrocene (Fc)-modified aptamer DNA (Fc-Apt) was partially hybridized with hpDNA to form a Fc-Apt/hpDNA duplex. Due to the specific recognition of Fc-Apt to CEA, the presence of CEA caused dissociation of Fc-Apt from the duplex, and further triggered the degradation process of Exo Ⅰ and recycling of CEA. Hence, the Fc tags were released from the electrode surface and the oxidation peak current of Fc (I Fc ) decreased while that of MB (I MB ) remained stable owing to the distance between MB tags and the electrode unchanged. A linear relationship was observed between I Fc /I MB and the logarithm of CEA concentration from 10 pg mL −1 to 100 ng mL −1 with a detection limit of 1.9 pg mL −1 . Moreover, the developed aptasensor had been applied to detect CEA in diluted human serum with satisfactory results, indicating its great potential in practical applications.
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高影响因子
Food Analytical Methods
·
2026
·Vol. 19
·期 12
·388
·
IF 3
Deng Guican,Bao Yonghua,Hong Yanping,Hong Jiaxin,Duan Luying,Du Huaying,Tan Zhimei,Wang Chunrong
As illegal synthetic colorants in food, Sudan dyes possess carcinogenic potential and can severely threaten human health following long-term intake. Rapid and sensitive detection of Sudan dyes in complex food matrices (e.g., chili powder and tomato sauce) remains a critical challenge for food safety supervision. Herein, a facile and sensitive detection strategy targeting Sudan I, II, III, and IV was established by combining magnetic substrates with surface-enhanced Raman spectroscopy (SERS). The influence of Au NPs loading on SERS analytical performance was systematically investigated, and FSA-3 was identified as the optimal substrate. Under optimized conditions, the limits of detection (LODs) for Sudan I–IV in chili powder and tomato sauce were determined to be 0.75–11.5 μg/kg, with satisfactory recoveries ranging from 84.5% to 110%. Compared with previously reported SERS methods and conventional analytical techniques, the proposed method exhibits excellent resistance to matrix interference capability and enables sensitive and efficient detection. This work provides a reliable and efficient alternative for the rapid screening of Sudan dye residues in complex food matrices, holding great promise for practical food safety applications.
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高影响因子
POLYHEDRON
·
2014
·
IF 2.047
Xue-Jie Tan,Hai-Zhen Liu,Chong-Zhao Ye,Jian-Fang Lou,Yun Liu,Dian-Xiang Xing,Sen-Peng Li,Shu-Lian Liu,Lai-Zhou Song
Two new ethylenediamine Schiff bases of 2-acetylthiazole and 2-acetylpyrazine (abbreviated as Th-Th and Py-Py respectively), as well as their silver(I) complexes [Ag(Th-Th)] 2 ·2(NO 3 ) and [Ag(Py-Py)] 2 ·2(NO 3 ) , have been prepared and characterized by a variety of physico-chemical techniques including elemental analyses, m.p., 1 H NMR, 13 C NMR, ESI-QTOF-MS, FT/IR, UV–Vis and theoretical calculations including density functional theory (DFT) and time dependent density functional theory (TD-DFT) methods. All structures were solved from single crystal X-ray diffraction (SXRD) data, except [Ag(Py-Py)] 2 ·2(NO 3 ) , whose crystal is not good enough for SXRD. Hence, conventional powder X-ray diffraction (PXRD) has to be used. As a first step, the stoichiometric formula of [Ag(Py-Py)] 2 ·2(NO 3 ) was ascertained by elemental analyses and ESI-QTOF-MS. IR and UV–Vis indicated the existence of coordinated Py-Py and charge-balancing NO 3 - . On the basis of symmetry character proved by NMR, three possible symmetrical Ag(I) coordination structures were designed and optimized by DFT method. Then, relative binding free energies were calculated to find the most appropriate molecule structure. DFT results suggest that four imine-N and four ortho-ring-N atoms from two Py-Py ligands are coordinated to two Ag(I) ions, resulting in a similar dimer structure as that of [Ag(Th-Th)] 2 ·2(NO 3 ) . The molecule structure was further confirmed by PXRD based crystal structure, which was solved following direct space method and refined by the Rietveld method. The antitumor activities of the Schiff bases and their silver(I) complexes have been evaluated against human lung cancer cell line A549. Both silver(I) complexes were found to display cytotoxicity (IC 50 = 3.15 ± 0.5 and 9.73 ± 1.1 μM) that is similar to or better than that of cisplatin, while metal-free Schiff bases show very low activity.
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高影响因子
ANALYTICA CHIMICA ACTA
·
2021
·
IF 6.558
Linjie Wang,Xuechao Xu,Peng Liu,Mengzhu Wang,Xiangheng Niu,Jianming Pan
Abnormal levels of halide ions in drinking water have enormous threats to human health, and thus designing reliable and sensitive methods to quantify and distinguish these ions becomes extremely crucial. Herein, we develop a single-nanozyme colorimetric array based on target-induced differential surface passivation for the quantification and discrimination of Cl − , Br − and I − ions. Silver citrate (Ag 3 Cit) is designed as an oxidase mimic to efficiently catalyze the 3,3′,5,5′-tetramethylbenzidine (TMB) chromogenic reaction. When halide ions (Cl − , Br − and I − ) are present, due to their different precipitation interactions with the Ag(Ⅰ) entity in Ag 3 Cit, they can passivate the active surface of the nanozyme to various degrees, resulting in the inhibited TMB chromogenic reaction differentially. According to this principle, simple and efficient quantitative detection of Cl − , Br − and I − ions was achieved, with all the detection limits down to the nM level. By employing Ag 3 Cit as a single sensing element, a nanozyme catalysis-based colorimetric array was further established, and both individual and mixed ions were successfully distinguished by integrating the array with principal component analysis . Accurate identification of unknown samples was also verified via a double-blind protocol, indicating potential applications of the array in practice.
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高影响因子
INORGANICA CHIMICA ACTA
·
2022
·
IF 3.118
Jing-Wen Zhang,Ling-Xiao Wang,Xun Cheng,Lin-Lin Hou,Jing-Zhe Li,Chun-Feng Wang,Xiao-Wei Yan,Kuan-Guan Liu
To prepare new series of mixed-valence polynuclear Cu(I/II) clusters, chloride ions are introduced to construct two mixed-valence polynuclear Cu(I/II) clusters for evaluating their photothermal conversion performance. X-ray single-crystal structural analysis reveals their molecular formula are {Cu II [Cu I (Cy 3 P)] 4 (BTA) 4 Cl 2 }·5DMF (I·5DMF, Cy 3 P = triscyclohexylphosphine, BTA = benzotriazole, DMF = N, N -Dimethylformamide) and {(Cu II ) 3 [Cu I (PPh 2 Py)] 6 (BTA) 8 Cl 4 }·6DMF (II· 6 DMF, Ph 2 PyP = diphenyl-2-pyridylphosphine), respectively. X-ray Photoelectron Spectroscopy (XPS) and Electrospray Ionization Mass Spectrometry (ESI-MS) confirm their chemical composition and charge state. The reported two mixed-valence Cu I /Cu II clusters have different nucleus (penta-nucleus for I and nano-nucleus for II) and different proportion of valence state (1/4 for I vs 1/2 for II). The thermogravimetric analysis (TGA) reveals the thermal stability of both clusters is less than our previously reported penta-nucleus mixed-valence Cu I /Cu II clusters. Contrastively studies of their optical absorption properties by the solid-state ultraviolet diffuse reflection spectra indicate high-nucleus mixed-valence Cu I /Cu II cluster with higher proportion of Cu II is superior to those penta-nucleus mixed-valent Cu(I/II) clusters. With the introduction of chloride ions to the structures of mixed-valence Cu I /Cu II clusters have not remarkably changed their photothermal conversion performance. This study provides a practicable way to construct new mixed-valence Cu I /Cu II clusters with different photothermal conversion performance.
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高影响因子
MOLECULES
·
2018
·Vol. 23
·期 3
·543
·
IF 3.098
Zhi-Feng Li,Meng-Ying Zhou,Ting Tan,Chen-Cong Zhong,Qi Wang,Shi-Lin Yang,Yu-Lin Feng,Hui Ouyang
Ziyuglycoside I (ZGS1) is a promising drug candidate for the treatment of leucopenia. Currently, information on ZGS1 and its in vivo metabolite ziyuglycoside II (ZGS2) is limited. The objective of this study was to investigate the pharmacokinetics, tissue distribution, and excretion of ziyuglycoside I (ZGS1) and its metabolite ziyuglycoside II (ZGS2) in rats. In our study, a simple and sensitive high-performance liquid chromatography-mass spectrometry (HPLC-MS/MS) method was established for simultaneous determination of ZGS1 and its metabolite for Sprague-Dawley rat pharmacokinetics studies. The method was validated following internationally-approved guidelines. The results presented in this study indicated that subcutaneous administration of ZGS1 prolonged its extension time and increased the area under the curve (AUC0–t) of ZGS2 during 0 to t minutes. In summary, in this study, the pharmacokinetic characteristics of ZGS1 and its metabolite ZGS2 were defined and its tissue distribution, and excretion in rats were described. Our finding may be beneficial for leucopenia drug that focus on ZGS1.Keywords:ziyuglycoside I (ZGS1);ziyuglycoside II (ZGS2);LC-MS/MS;pharmacokinetics;tissue distribution;excretion
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高影响因子
JOURNAL OF ORGANOMETALLIC CHEMISTRY
·
2014
·
IF 2.302
Xuezhu Wang,Yongyong Wang,Jing Zhang,Xiaoli Zhao,Ye Liu
A series of ionic Au(I)-complexes ligated by the phosphine-functionalized ionic liquids were synthesized and characterized, which are composed of the Au(I)-complex cation and the counteranion of OTf − , AuCl 4 − , or PF 6 − , respectively. The single crystal X-ray diffraction analyses show that the Au(I)-centered vector in 1A , 1B , 2A , 3A , and 4A all possess the slightly twisted linear geometry, and in each individual the Au(I)-center is coordinated by one chlorine and one imidazolium-based phosphine. The aggregation of 1B in acetone can lead to the formation of the trinuclear Au(I)-complex of 1C due to the aurophilic Au(I)–Au(I) interaction, the electrostatic attraction, and the steric preference. When these ionic Au-complexes were employed as precatalysts for hydration of phenylacetylene in aqueous-methanol media, the reaction proceeded selectively according to Markovnikov's rule with moderate to high yields of acetophenone . The highest activities were achieved over 2A with hydrophobic PF 6 − as the counteranion and the trinuclear 1C under mild conditions (75 °C, 2 h), in conjunction with the additive of proton acid H 2 SO 4 . The ion-pair effect on the catalytic performance of the corresponding Au(I)-complexes, coming from the phosphine-ligated cations and the counteranions, were investigated.
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高影响因子
JOURNAL OF SEPARATION SCIENCE
·
2025
·Vol. 48
·期 10
·e70271
·
IF 2.8
Man Yang,Tianyu Liu,Wentao Ma,Alimjan Esmayil,Zihang Yu,Kunze Du,Yanxu Chang
An innovative approach combining electrochemistry with online quadrupole time-of-flight-mass spectrometry (EC-MS/MS) was employed to study the oxidative products and metabolic pathways of three bioactive compounds found in Phellodendri Chinensis Cortex , including phellodendrine, obaculactone, and obacunone. This advanced analytical technique provided detailed insights into their transformation processes. The simulation of phase I metabolism reactions was conducted within an electrochemical microreactor system. The heart of this apparatus was a reliably performing boron-doped diamond electrode. Meanwhile, a defined concentration of glutathione (GSH) was injected into the reaction system to obtain phase II metabolites. The metabolites were collected and concentrated for offline electrochemistry-ultra-high-performance liquid chromatography-quadrupole-time of flight-mass spectrometry analysis (EC-UHPLC-MS/MS). The main converted products and metabolic pathways were further verified through in vitro liver microsome incubation experiments. It was revealed that the simulated metabolic process based on the electrochemical system effectively produced a variety of metabolites from the compounds, which were subsequently compared with those obtained from rat liver microsomal incubations. Without matrix interference, the drug metabolic process could be effectively simulated and analyzed using the electrochemical system. The findings underscore the utility of electrochemistry as a robust tool for preliminary investigations into the metabolism of natural products, offering a reliable and efficient alternative to traditional methods.
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高影响因子
CHEMICO-BIOLOGICAL INTERACTIONS
·
2025
·
IF 5.4
Tingting Zheng,Hang Yin,Hongna Shan,Lihuan Sun,Lili Jiang,Yong Liu
Enzalutamide (formerly called MDV3100), a second-generation androgen receptor inhibitor primarily used for treating castration-resistant prostate cancer (CRPC), has been shown to regulating UDP-glucuronosyltransferases (UGTs) expression, while its effects on the activity of UGT isoforms remain unclear. This study aimed to systemically investigate the effects of enzalutamide and its phase I metabolite on the UGT activities, and to assess the risk of drug-drug interactions (DDIs) resulting from UGT inhibition. Using high-performance liquid chromatography (HPLC) and enzyme kinetic studies, we evaluated the inhibitory effects of enzalutamide and its main phase I metabolite, N-desmethyl enzalutamide on 12 UGT isoforms and inhibition patterns. Our findings demonstrated that both enzalutamide and its metabolite exhibited potent inhibition against UGT1A1, with evidence of synergistic effects. Enzyme kinetic analysis revealed that both enzalutamide and its metabolite acted as competitive inhibitors of UGT1A1. In vitro-in vivo extrapolation (IVIVE) prediction indicated that concomitant use of enzalutamide with UGT1A1 substrates could induce clinically significant DDIs. Therefore, special caution should be warranted when administering enzalutamide alongside other drugs metabolized by UGT to mitigate potential DDIs.
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高影响因子
危险品化学品经营许可证（带存储）