JOURNAL OF PHARMACEUTICAL SCIENCES
·
2016
·
IF 2.641
Juan Hu,He-Yu Li,Gareth R. Williams,Hui-Hui Yang,Lei Tao,Li-Min Zhu
Fibers of poly(N-isopropylacrylamide) (PNIPAAm), ethyl cellulose (EC), and a blend of both were successfully fabricated by electrospinning. Analogous drug-loaded fibers were prepared loaded with ketoprofen (KET). Scanning and transmission electron microscopy showed that the fibers were largely smooth and cylindrical, with no phase separation observed. The addition of KET to the spinning solutions did not affect the morphology of resultant fibers, and no drug particles could be observed to separate from the polymer matrix. X-ray diffraction demonstrated that the drug was present in the amorphous physical form in the fiber matrix. There are significant intermolecular interactions between KET and polymers, as evidenced by IR spectroscopy and molecular modeling . Water contact angle measurements proved that the PNIPAAm and PNIPAAm/EC fibers switched from being hydrophilic to hydrophobic when the temperature was increased through the lower critical solution temperature of 32°C. In vitro drug release studies found that the PNIPAAm/EC blend nanofibers were able to synergistically combine the properties of the 2 polymers, giving temperature-sensitive systems with sustained release properties. In addition, they were established to be nontoxic and suitable for cell growth. This study demonstrates that electrospun-blend PNIPAAm/EC fibers comprise effective and biocompatible materials for drug delivery systems and tissue engineering.
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COLLOIDS AND SURFACES B-BIOINTERFACES
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2022
·
IF 5.999
Ziyi Wang,Zhilong Xu,Xiangdong Xu,Juqun Xi,Jie Han,Lei Fan,Rong Guo
Noble metals act as nanozymes that can generate reactive oxygen species (ROS) by catalysis to induce apoptosis of tumor cells for cancer therapy. But they are easy to aggregate, which will affect their further application. Carbon materials are often used as the carrier of noble metals to improve their catalytic performance. However, designing a composite structure to build an efficient carbon/noble metal hybrid nanozyme with high catalytic performance for tumor therapy is still a significant challenge. In this work, a core-in-shell structure nanozyme composed of gold nanoparticles (AuNPs) embedded in nitrogen-doped hollow carbon nanoshells (AuNPs@N-HCNs) were fabricated, which exhibited peroxidase-like (POD-like) and oxidase-like (OXD-like) activity. Compared with core-out-of-shell structure composite, the AuNPs@N-HCNs showed a better ability to generate ROS to kill tumor cells. Furthermore, AuNPs@N-HCNs also exhibited satisfactory photothermal conversion properties, which helped build a platform for photothermal therapy. Meanwhile, the enzyme activity produced by AuNPs@N-HCNs increased significantly under light irradiation . Comparing the size of AuNPs in carbon shell, 15 nm AuNPs were better than 2 nm in both enzyme-like activities and in vivo therapeutic effect. In vitro and in vivo studies demonstrated that under the synergistic effect of light-enhancing nanozyme catalysis and photothermal therapy, AuNPs@N-HCNs could induce cancer cell apoptosis and destroy tumors effectively, which provided evidence for the feasibility of tumor catalytic-photothermal treatment.
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PubMed
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OPTICAL MATERIALS
·
2025
·
IF 4.2
Zihao Qiu,Gerile Naren,Rui Meng,Rui Liang
Rare-earth metal complexes have received wide attention for their excellent photo-physical properties and their light absorption capacity and energy transfer efficiency of organic ligands, which are the main factors affecting the photoluminescence of rare-earth metal co-mplexes. Therefore, in this study, four N -acyl amino acid praseodymium complexes, (Pr[CH 3 (CH 2 ) n CONHCH(CH 3 )COO] 3 , n = 4,6,8,10) with different carbon chain lengths were synthesized using H(hex-ala), H(oct-ala), H(dec-ala) and H(dod-ala) ligands and the Pr 3+ reaction method with the goal to obtain rare earth metal-organic complexes with good optical properties . The molecular structure of the praseodymium complexes was determined using CHN elemental analysis , 1 H NMR , and FT-IR spectroscopic analysis . Solubility tests in pure solvents have determined that Pr(oct-ala) 3 and Pr(dec-ala) 3 are highly soluble in polar solvents . However, Pr(dod-ala) 3 , which contains a long carbon chain and crystallizes easily, has a low solubility. The photophysical properties of the praseodymium complexes can be obtained by fluorescence spectroscopy in the visible region, which shows that the luminescence of the four praseodymium complexes occurs in the blue region, and the fluorescence lifetimes are about 0.32 μs. The effect of temperature change on the luminescence properties of the praseodymium complexes was analyzed by variable-temperature fluorescence spectroscopy . The fluorescence inte-nsity of Pr(dec-ala) 3 , which is more absorbent, is higher in the range of 25 °C–70 °C. The luminescence properties of praseodymium complexes in the near-infrared region were obtained by near-infrared emission spectroscopy , and three major emission intensities were found at 926 nm ( 1 D 2 → 3 F 2 ), 1001 nm ( 1 D 2 → 3 F 4 ), and 1376 nm ( 1 D 2 → 1 G 4 ), among which the intensity of the emission peaks of Pr(dod-ala) 3 was the strongest at 1001 nm, indicating a good match between the ligand-centered triplet state of Pr 3+ and the 1 D 2 emission state. In addition, in this study, the molecular structure of praseodymium complexes was geometrically optimized by density functional theory (DFT) method using Gaussian software, and the bond strengths and topological properties of the praseodymium complexes were obtained by Atoms in Molecules (AIM) theory analysis. The results show that there are closed-shell interactions between the ligand and Pr 3+ , in which Pr(oct-ala) 3 has the largest Pr–O bond strength among the complexes with different carbon chain lengths.
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KOREAN JOURNAL OF CHEMICAL ENGINEERING
·
2014
·Vol. 32
·期 6
·1158-1163
·
IF 1.241
Yang Wenge,Wu Keyi,Hu Yonghong,Zhang Tuan,Guo Qirun,Yang Shouhai,Shi Ying
The solubility of N-ethylcarbazole in (ethanol+petroleum ether) binary solvent mixtures was measured with the temperature changing from 280.15 K to 316.15 K. The experimental data matched the solvent/Redlich-Kister (CNIBS/R-K) equation and the Jouyban-Acree equation. Computational results showed the CNIBS/R-K equation was more suitable than the Jouyban-Acree equation. The solution process in the thermodynamic properties, including the Gibbs energy, enthalpy, and entropy, was calculated by the van’t Hoff analysis.
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REACTIVE & FUNCTIONAL POLYMERS
·
2013
·
IF 2.505
Zhiqiang Jie,Xiufang Yan,Lianhong Zhao,S.D. Worley,Jie Liang
A novel macroporous cross-linked antimicrobial resin containing quaternarized N-halamine groups, poly(1-chloro-5,5-dimethylhydantoinyl-3-ethyl-p-ethenylphenylmethyl dimethylammonium chloride) (Cl-PSQH), has been synthesized by a facile three-step reaction. The as-prepared resins were characterized by FT-IR, X-ray photoelectron spectroscopy, and zeta-potential measurement. Antimicrobial tests showed that Cl-PSQH was capable of about a 7-log inactivation of Staphylococcus aureus and Escherichia coli O157:H7 within 1 min of contact. Also, its regenerability and preliminary storage stability were investigated.
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ENERGY & FUELS
·
2020
·
IF 3.421
Wei Zhao,Shanshan Ruan,Siyu Qian,Beibei Feng,Chengcheng Ao,Lei Wang,Fuyi Liu,Lidong Zhang
Catalytic combustion has become a promising technology to address the accelerating volatile organic compounds (VOCs) emissions. In this work, cobalt modified ZSM-5 zeolite catalysts (3–18 wt % Co) were prepared to investigate the combustion of n-butane (one typical model component of VOCs). The performances of catalysts were evaluated by conducting experiments in a flow tube reactor. XRD, BET, FT-IR, and XPS were also utilized to characterize their physicochemical properties. A significant enhancement of the catalytic activity was demonstrated in terms of the cobalt supported over ZSM-5, with an optimal cobalt loading of 7 wt %. The excellent catalytic activity of 7 wt % Co-ZSM-5 is mainly attributed to a higher concentration of active surface Co3+ species. Furthermore, DFT calculations indicated that the role of Co can enhance the activity by decreasing the activation barriers for C–H bond cleavage. In addition, the primary reaction mechanism of n-butane combustion on Co-ZSM-5 was also revealed.
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International Journal of Minerals Metallurgy and Materials
·
2020
·Vol. 27
·期 12
·1687-1694
·
IF 1.713
Tian Dong-hua,Han Zhen-chao,Wang Ming-yong,Jiao Shu-qiang
Graphite materials are widely used as electrode materials for electrochemical energy storage. N-doping is an effective method for enhancing the electrochemical properties of graphite. A novel one-step N-doping method for complete and compact carbon paper was proposed for molten salt electrolysis in the LiCl-KCl-Li 3 N system. The results show that the degree of graphitization of carbon paper can be improved by the electrolysis of molten salts, especially at 2.0 V. Nitrogen gas was produced at the anode and nitrogen atoms can substitute carbon atoms of carbon paper at different sites to create nitrogen doping during the electrolysis process. The doping content of N in carbon paper is up to 13.0wt%. There were three groups of nitrogen atoms, i.e. quaternary N (N-Q), pyrrolic N (N-5), and pyridinic N (N-6) in N-doping carbon paper. N-doping carbon paper as an Al-ion battery cathode shows strong charge-recharge properties.
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INTERNATIONAL BIODETERIORATION & BIODEGRADATION
·
2020
·
IF 4.074
Chengcheng Feng,Ying Zhang,Lei Wang,Xiaoqian Li,Yiyang Chen,Jianhua Qu,Kai Zhen
Phthalate esters (PAEs) in the environment are mainly reported to be removed through the biochemical degradation by microorganisms . However, the adsorption of DBP is the initial process of using it as a carbon source. In this process, little is known about changes in cell surface properties at the subcellular level of degrading bacteria. In our work, Novosphingobium species DNB-S3 was found to be an efficient DBP-degrading bacterium with 95% DBP removal in 72 h at an initial concentration of 500 mg L −1 . In soil simulation experiment, the initial concentration of DBP decreased from 25 mg kg −1 to 1.9 mg kg −1 after the inoculation of DNB-S3. In addition, DNB-S3 also showed degradation capability on other PAEs. DNB-S3 was cultured under four treatment conditions with different carbon sources, namely MSM-DBP, MSM-GLU, MSM-DBP + GLU, and LB. The cell surface hydrophobicity , functional groups on cell surface and morphological changes of DNB-S3 were further investigated. Morphological studies showed that the presence of DBP induced the disappearance of microcapsule on DNB-S3. Infrared spectroscopy and Raman spectra of DNB-S3 surface showed that the lipid-containing groups on the outer membrane were externally exposed from cellular structure, resulting in an increase of cell surface hydrophobicity (CSH). Eventually, the high CSH indicates that DNB-S3 has an efficient ability of DBP uptake. Our research adds an interesting dimension to the degradation study of bacterially mediated organic pollutants and the uptake mechanisms of hydrocarbons.
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Journal of Energy Storage
·
2025
·
IF 9.8
Jingfang Zhang,Jiangping Ran,Weishang Jia,Xinxiu Yan,Lanxiang Feng,Wei Zou,Yaoyue Yang,Liping Wang
Lithium metal batteries (LMBs) are recognized as one of the most promising next-generation energy storage systems due to their exceptionally high energy density and relatively low cost. However, the inevitable growth of lithium dendrites remains a critical challenge. Electrolyte additives have emerged as a straightforward and effective strategy for anode modification. Among these, nitrate salts (particularly LiNO 3 ) have been widely employed to suppress the polysulfide “shuttle effect” in lithium‑sulfur (Li S) batteries while enhancing Coulombic efficiency (CE). Nevertheless, the underlying reaction mechanisms remain insufficiently understood. To guide the rational design of high-performance electrolyte additives, this study systematically investigates the synergistic effects of different cationic nitrate additives (K + , Na + ) and N O bond anions (NO 3 − , NO 2 − ) on Li deposition behavior. The results demonstrate that NO 3 − can effectively participate in the Li + solvation process, facilitating the formation of an inorganic-rich, high-quality solid electrolyte interphase (SEI). In contrast, although NO 2 − exhibits stronger adsorption energy with both Li + and the Li (110) surface, which enables more uniform lithium deposition, it fails to construct a stable SEI structure. Furthermore, cations demonstrate distinct synergistic interactions with N O anions during electrochemical processes, significantly influencing Li + deposition kinetics. This work provides fundamental insights into the mechanistic roles of K + /Na + -based nitrate and nitrite additives in LMBs. Additionally, a novel characterization approach utilizing conventional transmission electron microscopy (TEM) is proposed to evaluate SEI quality, providing a practical tool for interfacial analysis. These findings present valuable guidelines for designing advanced electrolyte additives and controlling Li deposition behavior in high-energy-density battery systems.
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CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Jihui Yao,Zhikang Xu,Shuo Cheng,Yuanyuan Yue,Haibo Zhu
The use of dodecahydro- N -ethylcarbazole in hydrogen storage for liquid organic hydrogen carrier systems holds potential for achieving large-scale application. In order to investigate the relationship between dodecahydro- N -ethylcarbazole dehydrogenation performance and Pt particles size, a series of monometallic Pt/Al 2 O 3 catalysts with different Pt particles size from 0.70 nm to 5.12 nm were controlled synthesized by a simple impregnation method. The obtained catalysts are systematically characterized via XRD, 27 Al MAS NMR, SEM-EDS, TEM, N 2 -adsorption, CO-IR, H 2 -TPR and NH 3 -TPD analyses, which provide essential micro-structure of these catalysts. The dehydrogenation of dodecahydro- N -ethylcarbazole over Pt/Al 2 O 3 is a typical consecutive reaction, which follows a reaction sequence of dodecahydro- N -ethylcarbazole → octahydro- N -ethylcarbazole → tetrahydro- N -ethylcarbazole → N -ethylcarbazole. These dehydrogenation steps are quite sensitive to the Pt particle size. Large Pt particle can greatly enhance the reaction rates in octahydro- N -ethylcarbazole → tetrahydro- N -ethylcarbazole and tetrahydro- N -ethylcarbazole → N -ethylcarbazole steps. However, these two steps are difficult to take place in small Pt particles. The high performance of large Pt particle in dehydrogenation can be ascribed to its highly exposed (1 1 1) crystal face. The optimized catalyst Pt 5.0 /γ-Al 2 O 3 with Pt average size of 4.63 nm demonstrated exceptional performance in dodecahydro- N -ethylcarbazole dehydrogenation at 180 °C and 101 kPa, and the dodecahydro- N -ethylcarbazole conversion of 100 %, N -ethylcarbazole selectivity of 96.44 % and dehydrogenation efficiency of 98.73 % can be achieved. These results provide valuable insights for the development of efficient metal-based catalysts for liquid organic hydrogen carriers hydrogen storage system.
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高影响因子
Cell Reports Physical Science
·
2024
·
IF 7.9
Ruihao Ma,Xiangjun Xu,Bowen Jin,Siwen Liu,Jinguo Cao,Shimin Wang,Erjing Wang,Liang Chu,Congcong Wu
Developing sufficient dynamics for charge separation and transfer is critical to improve photovoltaic performance. Normally, dynamics can be modulated by band bending via surface engineering, but this has typically been negligible in the p-n homojunction for boosted perovskite solar cells. Herein, we adopt carbon dots as an addition to induce a bilayer p-n perovskite homojunction to improve interfacial charge transfer within perovskite solar cells. Notably, the inclusion of carbon dots induces the spontaneous assembly of a bilayer structure, where the upper layer is enriched with dots and the underlying layer remains pristine perovskite. This unique arrangement creates a p-n homojunction, accompanied by an internal electric field, which allows for modulating energy levels and facilitating charge-carrier separation and transfer. Benefiting from the p-n homojunction, the power conversion efficiency of the perovskite solar cells increases from 18.57% to 21.09%. Additionally, the hydrophobic nature of the carbon dots considerably enhances the humidity stability of the solar cells.
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APPLIED CATALYSIS B-ENVIRONMENTAL
·
2023
·
IF 22.1
Zheyang Liu,Jianli Liang,Qianqian Song,Yang Li,Zhiquan Zhang,Min Zhou,Wei Wei,Hui Xu,Chun-Sing Lee,Huaming Li,Zhifeng Jiang
Efficient conversion of CO 2 to high value-added chemical products is a promising strategy for achieving carbon neutrality . Although the photocatalyst technique has been made widespread researched, highly efficient photoreduction CO 2 with metal-free photocatalysts remains a challenge. Herein, we report a zero-dimensional black phosphorus quantum dots (BPQDs)-decorated one-dimensional carbon nitride nanotubes (CNNT) photocatalyst that reduces CO 2 to CO with a rate of 44.6 μmol g –1 h –1 , which is better than the similar photocatalysts and pristine carbon nitride nanotubes . Synchrotron radiation XAFS measurements substantiate the construction of N-P electron transfer channels within BPQDs and CNNT. Time-resolved PL spectrum demonstrates the faster separated electron hole pairs . In situ irradiated X-ray photoelectron spectroscopy confirms the photogenerated-electron flow trend and the active site of photocatalytic reaction. Moreover, the main intermediate *COOH is verified by in situ FT-IR characterization which is corresponding to the previous research. The construction of atomic-level N-P charge transfer channel efficiently facilitates the charge transfer and accelerates the catalytic rate. This work provides a novel insight into the design of BPQDs-anchoring heterostructures for photocatalytic CO 2 reduction.
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