APPLIED CATALYSIS B-ENVIRONMENTAL
·
2022
·
IF 24.319
Yingcong Wei,Wenying Zha,Lele Wang,Xiongfeng Ma,Shaohui Zhang,Rongjian Sa,Huaxiang Lin,Zhengxin Ding,Jinlin Long,Xianzhi Fu,Rusheng Yuan
Tailoring the surficial chemical environment of two-dimensional materials by organic modification is an effective way to optimize their catalytic behaviors. Herein, we present a dynamic coordination approach to improve the photocatalytic performance of ultrathin Co 2 CO 3 (OH) 2 nanosheets (u-CoCH) in NIR light (λ > 780 nm) driven carbonylation reaction by using the reacting substrates (diamines) as the ligands. The coordination of diamines with surface Co 2+ ions form a binuclear complex at the crystallographic planes of u-CoCH. The as-formed complexes can reduce the energy barrier of carbonylation reaction by weaking the N-H bond of the substrate on u-CoCH, and afford enhanced light response as well as the prolonged photogenerated electron lifetime. Together with the successful synthesis of a series of important structural motifs in pharmaceuticals and bioactive agents, the promoted photosynthesis reaction mode via in-situ formed surface complexes offers a model toward full-spectrum-solar-energy conversion in the field of chemical synthesis.
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INORGANIC CHEMISTRY
·
2022
·
IF 5.436
Chun-Han Lu,Yi-Ting Tsai,Tzong-Liang Tsai,Ting-Shan Chan,Xuejie Zhang,Chun Che Lin
The analysis of human body composition and food composition requires high-efficiency broadband near-infrared (NIR) lighting sources to achieve a portable, appropriately sized equipment. Herein, we develop a whitlockite-type NIR phosphor Sr9Sc(PO4)7:Cr3+ with an emission centered at 860 nm and full width at half-maximum of 147 nm. Due to the structural characteristics of the matrix, the 60 mol % Cr3+ substitution at the Sc3+ sites gives an internal quantum efficiency up to 56.5%. By replacing Sr with Ba and Ca, we observe a nontypical spectral shift phenomenon and discuss the influence of the second-sphere effect on octahedral Cr3+ ions. To evaluate the diagnostic application, we design a NIR ceramic device with a high optical power of 27.38 mW and high heat dissipation, which can decrease surface working temperature by nearly 50 °C for digital intraoral application. This study provides the research of the second-sphere coordination effect for selective octahedral sites such as Ca, Sr, and Ba coordinated by O atoms on a whitlockite-type crystal. Furthermore, the device promotes a nonionizing solution for detecting dental caries, tooth calcification, and diagnostic application.
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EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
·
2023
·
IF 6.7
Jianv Wang,Jing Jia,Qingqing He,Yang Xu,Hongye Liao,Xia Xiong,Li Liu,Changzhen Sun
Recent advancements in tumour-targeted therapies and immunotherapy offer hope to patients with various malignancies. However, the uncontrolled growth and metastatic infiltration of malignant tumours remain a huge therapeutic challenge. Therefore, this study aimed to develop an integrated multifunctional diagnostic and treatment reagent IR-251 that can not only be used for tumour imaging but also to inhibit tumour growth and metastasis. Besides, our results showed that IR-251 targeted and damaged the mitochondria in cancer cells via organic anion-transporting polypeptides . Mechanistically, IR-251 induced ROS overproduction by inhibiting PPARγ and then inhibiting the β-catenin signalling pathway and downstream protein molecules related to the cell cycle and metastasis. Moreover, the excellent anti-tumour proliferation and metastasis ability of IR-251 were verified in vitro/in vivo . And histochemistry staining revealed that IR-251 inhibited tumour proliferation and metastasis, which showed no significant side effect. In conclusion, this novel, multifunctional, mitochondria-targeting near-infrared fluorophore probe IR-251 has great potential in achieving accurate tumour imaging and inhibiting tumour proliferation and metastasis, and the underlying mechanism of action of IR-251 is mainly via the PPARγ/ROS/β-catenin pathway.
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ACS Nano
·
2023
·
IF 17.1
Min Wei,Jingwen Bai,Xiao Shen,Kangliang Lou,Yiyang Gao,Ruichan Lv,Peiyuan Wang,Xiaolong Liu,Guojun Zhang
Breast-conserving surgery (BCS) is the standard of care for early breast cancer patients, while the high ratio of reoperation is still a challenge due to inaccurate margin assessments. In patients with locally advanced or advanced breast cancer, radiotherapy is an important treatment for local control or improvement of quality of life. However, enhancing sensitization to radiotherapy is an unmet medical need. To solve the above clinical predicaments, a glutathione (GSH) exhausting virus-like silicon dioxide nanoprobe with Gd coating and folic acid (FA) modification is designed. After loading ICG in the mesopores, the VGd@ICG-FA probe efficiently targets tumor cells with high resolution, due to its virus-like morphology and folate acid anchoring. Especially, the fabricated nanoprobe enables the identification of tiny cancers and navigates precise surgery under NIR-II fluorescence imaging. Moreover, after the nanoprobes enter into the cytoplasm of cancer cells, tetrasulfide linkages in the silica framework are broken under the triggering of high GSH concentrations. In turn, the broken framework exhausts GSH to disrupt intracellular reactive oxygen species (ROS) homeostasis, and Gd produces more ROS under radiotherapy, further activating ferroptosis, and resulting in the enhancement of radiotherapy in breast cancer. Therefore, our nanoprobe exhibits tremendous potential as a NIR-II fluorescence imaging agent with no systematic side effects for precise cancer surgery and nanotherapeutics for boosting radiation sensitivity in future clinical translation of breast cancer.
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Journal of Materials Chemistry B
·
2023
·Vol. 11
·期 25
·5898-5909
·
IF 7
Mei Yang,Jun Yao,Borui Su,Nini Xin,Ting Zhou,Mingze Zeng,Chengheng Wu,Dan Wei,Jing Sun,Hongsong Fan
As nanozymes, carbon dots (CDs) have attracted increasing attention due to their remarkable properties. Besides general enzyme activity, their photoluminescence and photothermal properties have been explored rarely, whereas their synergistic effects might produce CDs-based nanozymes of high performance. Here, iron-doped CDs (Fe-CDs) with tunable fluorescence and enhanced peroxidase-like activity were designed to develop a novel “three-in-one” multifunctional platform to provide dual-mode/dual-target detection and near infrared (NIR)-assisted antibacterial ability. This proposed strategy for a H2O2 test exhibited a wide linear relationship with a low limit of detection (LOD) of 0.16 μM (colorimetric) and 0.14 μM (ratiometric fluorescent). Furthermore, due to the nature of cholesterol being oxidized to H2O2 by cholesterol oxidase, sensitive and selective detection of cholesterol was realized, and the LOD was 0.42 μM (colorimetric) and 0.27 μM (ratiometric fluorescent), surpassing that reported previously. This result suggested that Fe-CDs could be used for dual-mode quantification of large family of H2O2-producing metabolites, thereby paving the way for developing multi-mode sensing strategies based on nanozymes. Moreover, this platform showed synergistic effects for antibacterial application, indicating great prospects for bacterial killing as well as wound disinfection and healing. Hence, this platform could contribute to the construction of multifunctional CDs with high performance.
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SENSORS AND ACTUATORS B-CHEMICAL
·
2023
·
IF 8.4
Jie Zhang,Jia Liu,An Liu,Shu He,Wei Shao
In recent years, smart hydrogels have been widely applied to various types of hydrogel actuators due to their unique stimulus responsibility, such as temperature responsiveness, near-infrared (NIR) light responsiveness, pH responsiveness, etc. Herein, segmented poly (N-isopropyl acrylamide) (PNIPAM) based hydrogel actuators with both temperature and NIR light actuation behaviors were constructed. Polydopamine (PDA) was firstly used to modify MXene nanosheets to fabricate an efficient photothermal conversion material. Then they were added into PNIPAM matrix to prepare PDA@MXene/PNIPAM hydrogels. The prepared PDA@MXene/PNIPAM hydrogels exhibited three-dimensional network structure with the tensile strength of 26.84 kPa, and they were successfully assembled into segmented hydrogel actuators. The assembled segmented hydrogel actuator exhibited high bending angle of 470° in 1.75 s in 55 °C hot water and bending angle of 203° in 15 s when irradiated by 6 W/cm 2 NIR light. The segmented hydrogel actuators displayed good programmable actuation performance. Finally, they were applied as smart devices, such as hydrogel hook for grasping object, switch for controlling circuit and valve for governing fluid flow. This work provides a novel strategy for fabricating programmable hydrogel actuators and will inspire new ideas and constructions for smart soft hydrogel actuators.
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JOURNAL OF NANOBIOTECHNOLOGY
·
2023
·Vol. 21
·期 1
·1-14
·
IF 10.2
Chen Ming,Chen Xiao-Tong,Zhang Lian-Ying,Meng Wei,Chen Yong-Jian,Zhang Ying-Shan,Chen Zhi-Cong,Wang Hui-Min,Luo Chun-Mei,Shi Xiu-Dong,Zhang Wen-Hua,Wang Mao-Sheng,Chen Jin-Xiang
Since the successful clinical trial of AuroShell for photothermal therapy, there is currently intense interest in developing gold-based core-shell structures with near-infrared (NIR) absorption ranging from NIR-I (650–900 nm) to NIR-II (900–1700 nm). Here, we propose a seed-mediated successive growth approach to produce gold nanoshells on the surface of the nanoscale metal–organic framework (NMOF) of UiO-66-NH2 (UiO = the University of Oslo) in one pot. The key to this strategy is to modulate the proportion of the formaldehyde (reductant) and its regulator / oxidative product of formic acid to harness the particle nucleation and growth rate within the same system. The gold nanoshells propagate through a well-oriented and controllable diffusion growth pattern (points → facets → octahedron), which has not been identified. Most strikingly, the gold nanoshells prepared hereby exhibit an exceedingly broad and strong absorption in NIR-II with a peak beyond 1300 nm and outstanding photothermal conversion efficiency of 74.0%. Owing to such superior performance, these gold nanoshells show promising outcomes in photoacoustic (PA), computed tomography (CT), and photothermal imaging-guided photothermal therapy (PTT) for breast cancer, as demonstrated both in vitro and in vivo.
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Biomaterials Science
·
2021
·Vol. 10
·期 4
·960-969
·
IF 6.843
Zhongpeng Yu,Jie Sun,Hongling Deng,Hong Kan,Chen Xu,Kai Dong
With the long-term widespread overuse of antibiotics, a large number of antibiotic-resistant bacteria have emerged and become a serious threat to healthcare systems. As an alternative strategy, near-infrared light (NIR)-actuated photothermal treatment has been developed for killing antibiotic-resistant bacteria. Although promising, the widespread applications of photothermal antibacterial platforms face great challenges due to the skin-harmful high laser irradiation. In this work, a novel NIR-responsive hydrogel membrane for effective photothermal sterilization upon light irradiation at skin-permissible intensity has been successfully prepared using a sodium alginate-based hydrogel membrane containing tannic acid–Fe(III) compounds (STF). The as-prepared STF displayed excellent mechanical capacity and fabricability. More importantly, the as-prepared STF revealed superior photothermal efficiency under a low-intensity NIR irradiation (0.3 W cm−2), which was below the maximum permissible exposure of skin (0.33 W cm−2). In addition, the STF showed the excellent performance of photothermal sterilization for MRSA both in vitro and in vivo. Furthermore, the STF showed good biocompatibility. Based on the simple synthesis method, outstanding mechanical properties, excellent photothermal sterilization performance and good biocompatibility, the STF could be a promising wound dressing for antibiotic-resistant bacterial infections.
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ADVANCED FUNCTIONAL MATERIALS
·
2023
·
IF 19
Fangli Gao,Liang Zhu,Liting Jiang,Jie Zhang,Shenglu Ji,Weihua Gao,Guanglei Ma,Yi Chang,Xiaoming Ma,Yuming Guo
The efficient way to increase the therapeutic efficacy of nanomedicines is by encouraging the penetration and enhancing the retention of nanoparticles at the tumor site. However, it is a serious dilemma that small nanoparticles can penetrate deep into the tumor tissue but easily be cleared into the surrounding tissues. In order to solve this dilemma, a smart nanosystem is created to address this problem, ensuring both the effective penetration of tiny nanoparticles (NPs) and their appropriate retention at the tumor site. CuS NPs that is modified with peptides are prepared facilely, and can aggregate in situ through the intermolecular crosslinking reaction catalyzed by the transglutaminase (TGase) abundantly expressed at the tumor site, resulting in an outstanding photothermal effect for tumor therapy. Upon NIR irradiation, the photothermal effect of CuS-K and CuS-Q induced the disintegration of liposomes and prompted the release of CuS-K, CuS-Q, and indocyanine green (ICG). Simultaneously, CuS-K and CuS-Q aggregated under the catalysis of TGase after being internalized by tumor cells to enhance photothermal therapy. The current study provides valuable inspiration to design nanomedicines with prolonged circulation time in the blood system, better penetration, and retention at the tumor site, and multimodal tumor therapy to achieve the desired therapeutic efficacy.
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EUROPEAN POLYMER JOURNAL
·
2023
·
IF 6
Jie Xie,Xiaobing Wang,Yonghui Wang,Jiawei Li,Chun Cao,Ming Jin
Developing high-performance photoinitiation systems with high sensitivity is of great significance in one/two-photon polymerization. Especially, photoinitiators with rapid photobleaching effects, deep curing abilities and potential for two-photon lithography have great commercial prospects. However, such photoinitiators often require complex organic synthesis, thus having relatively limited varieties. Double benzylidene ketone is widely used as a high-performance dye and can be constructed through a one-step classical aldol condensation reaction. The optimization of its structure often involves introducing extended conjugated structures or different terminal substituents. However, the synergistic impacts of side substituents with different electron effects are rarely studied. Here, six novel carbazolyl double benzylidene ketones with tert -butyl on the terminal position and F atom or N , N -dimethylamino groups substituted at the side position on conjugated structures are designed and prepared to explore the structure–activity relationships. Notably, results show that introducing electron-donating groups at both positions can effectively induce a redshift in the absorption spectra of molecules, and the introduction of an electron-withdrawing F atom on the side position induces impressive photobleaching during photopolymerization under visible LED irradiation. Moreover, CZs/MDEA with PETA exhibit fast writing speed and excellent nano-patterning capability under 780 nm laser in two-photon polymerization (TPP) and have potential applications in 3D microfabrication technologies.
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JOURNAL OF RARE EARTHS
·
2021
·
IF 3.712
Jingzhi Dou,Bei Chen,Guixia Liu,Xiangting Dong,Wensheng Yu,Jinxian Wang,Yunxiao Zhang,Zhanguo Li,Jiang Zhu
Photothermal therapy (PTT) has presented its inherent application value in cancer treatment. Nevertheless, single-functional photothermal materials cannot meet the precise diagnosis and treatment of cancer. Therefore, it is important to design a nanocomposite that has both high therapeutic efficiency and multimodal imaging capabilities. In our work, a new nanostructure of gold nanorods (AuNRs) with silver shells decorated by BaGdF 5 :Yb 3+ ,Er 3+ nanoparticle was synthesized by a simple way. The biostability of AuNRs is increased by coating with silver shells, and the AuNR@Ag nanoparticles can be used as excellent surface enhanced Raman scattering (SERS) probe. Moreover, the modification of BaGdF 5 :Yb 3+ ,Er 3+ nanoparticles provides the possibility of real-time optical imaging of the tumor area. Under the irradiation of NIR laser, the AuNR@Ag/BaGdF 5 :Yb 3+ ,Er 3+ nanocomposites (NCs) have strong upconversion emission and excellent photothermal conversion efficiency. Meanwhile, the NCs show low cytotoxicity and good biocompatibility in MTT cytotoxicity test. Moreover, the NCs are also exceptional contrast agents for CT imaging. For in vitro photothermal therapy test, NCs show excellent killing efficiency on tumor cells. Therefore, the multifaceted research of AuNR@Ag/BaGdF 5 :Yb 3+ ,Er 3+ multifunctional nanomaterials provides a break for high-efficiency tumor photothermal therapy and multimodal imaging.
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Bioactive Materials
·
2021
·
IF 14.593
Jie Yu,Sha Liu,Yupeng Wang,Xidong He,Qingfei Zhang,Yanxin Qi,Dongfang Zhou,Zhigang Xie,Xiaoyuan Li,Yubin Huang
The combination of tumor ablation and immunotherapy is a promising strategy against tumor relapse and metastasis. Photothermal therapy (PTT) triggers the release of tumor-specific antigens and damage associated molecular patterns (DAMPs) in-situ. However, the immunosuppressive tumor microenvironment restrains the activity of the effector immune cells. Therefore, systematic immunomodulation is critical to stimulate the tumor microenvironment and augment the anti-tumor therapeutic effect. To this end, polyethylene glycol (PEG)-stabilized platinum (Pt) nanoparticles (Pt NPs) conjugated with a PD-L1 inhibitor (BMS-1) through a thermo-sensitive linkage were constructed. Upon near-infrared (NIR) exposure, BMS-1 was released and maleimide (Mal) was exposed on the surface of Pt NPs, which captured the antigens released from the ablated tumor cells, resulting in the enhanced antigen internalization and presentation. In addition, the Pt NPs acted as immune adjuvants by stimulating dendritic cells (DCs) maturation. Furthermore, BMS-1 relieved T cell exhaustion and induced the infiltration of effector T cells into the tumor tissues. Thus, Pt NPs can ablate tumors through PTT, and augment the anti-tumor immune response through enhanced antigen presentation and T cells infiltration, thereby preventing tumor relapse and metastasis.
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