COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
·
2024
·Vol. 27
·期 10
·1513-1522
·
IF 1.6
Zeng Yi,Zhou Li,Wan Ying,Fu Ting,Xu Paidi,Zhang Hongxing,Guan Ying
Objective: Functional dyspepsia (FD) is one of the most common gastrointestinal diseases, with a global prevalence of 10%-30%. However, the specific pathogenesis of FD has not yet been determined. As such, the aim of this study was to investigate the effects of saikosaponin D (SSD)
administration on the apoptosis, autophagy, and morphological structure of the intestinal cells of Cajal (ICCs) in FD. MethodsA rat model of FD was constructed by stimulating the rat tail with a sponge clamp at one-third of the distal tail length. An autophagy model was constructed for
ICCs using glutamate. The apoptosis rate in each group of cells was determined using flow cytometry. The expressions of ghrelin and substance P (SP) were detected using ELISA. Results: The body weight and food intake of male and female rats in the SSD group were consistently higher than
those in the model group. The SSD group showed substantial improvement compared with the model group, with no inflammatory cell infiltration and normal gastric mucosal structures. After intervention with SSD, the ultrastructure of the ICCs considerably improved and was clear. Compared with
the model group, the expressions of LC3 I/II, ghrelin, and SP proteins in the SSD group were significantly upregulated, and the apoptosis rate was significantly reduced. Conclusion: The administration of SSD improved ICC morphology and structure, inhibited excessive autophagy, and improved
FD, a gastrointestinal motility disorder, by regulating ghrelin and SP levels.
研究领域:
胃肠病学
·
药理学
·
细胞生物学
✓ 已验证
DOI
PubMed
高影响因子
Device
·
2024
·
IF 0
Cong Liu,Fang Wang,Xuemin Du
Manipulating objects using physical tweezers is crucial in physics, chemistry, and biology. Despite significant advancements, however, these tweezers are still limited by the need for complex electrode arrays, external power sources, and restricted charge-generation capability. Here, we report an innovative self-powered electrostatic tweezer (SET) that harnesses the unique capability of accumulation and tunability of triboelectric charges of the poly(vinylidene fluoride-trifluoroethylene) (P(VDF-TrFE))-based self-powered electrode during sliding triboelectrification, imparting unprecedented flexibility and adaptivity for object manipulation. The SET enables the precise manipulation of objects with diverse materials, including bubbles, solid balls, and liquid droplets, with a superior high velocity of 353 mm s −1 . Notably, the SET is adaptive to open-to-closed platforms, single-to-multiple objects, and two-dimensional (2D)-to-3D surfaces, thereby extending the SET to various applications including droplet robots, cell assembly, and pump-free microfluidics. By eliminating the need for complex electrode arrays, external power sources, and heat generation, the SET holds great potential for next-generation tweezers and microfluidics.
研究领域:
微流控
·
静电学
·
材料科学
·
纳米技术
·
生物物理学
✓ 已验证
DOI
RSC Advances
·
2017
·Vol. 7
·期 38
·23415-23421
·
IF 3.108
Sheng Yuan,Ming-Jian Zhang,Xiaoyang Yang,Zongwei Mei,Yongji Chen,Feng Pan
MoS2, a representative two-dimensional transition metal dichalcogenide, gains significant interest due to its unique layered structure and electronic structure. In this work, a novel MoS2-based hybrid thin film was constructed by disordered stacking of MoS2–NMP hybrid particles, which were mainly composed of MoS2(NMP)3 molecules stacking in a nearly-parallel manner through S⋯H–C hydrogen bonds. Interestingly, it presents a higher work function (5.42 eV) than Au (5.32 eV), and a unique thickness-dependent conductivity with p-type semiconductor characteristic. Using it as the back contact of CdTe solar cells, the efficiency was improved by 2.6% compared to the traditional cells, mainly from the great improvement in short-circuit current density (Jsc). This significant improvement in solar performance was ascribed to the matchable energy levels at the CdTe/MoS2-based thin film interface and its unique thickness-dependent conductivity. This work opens a new direction for the extensive applications of TMD-based materials.
研究领域:
材料科学
·
光伏技术
·
纳米材料
·
半导体物理
·
表面科学
·
能源材料
✓ 已验证
DOI
高影响因子
INORGANIC CHEMISTRY
·
2022
·
IF 5.436
Yanyu Xie,Huanfeng Huang,Zhuodi Chen,Zhujie He,Zhixiang Huang,Shunlian Ning,Yanan Fan,Mihail Barboiu,Jian-Ying Shi,Dawei Wang,Cheng-Yong Su
The rational design and synthesis of highly efficient electrocatalysts for oxygen evolution reaction (OER) is of critical importance to the large-scale production of hydrogen by water electrolysis. Here, we develop a bimetallic, synergistic, and highly efficient Co–Fe–P electrocatalyst for OER, by selecting a two-dimensional metal–organic framework (MOF) of Co-ZIF-L as the precursor. The Co–Fe–P electrocatalyst features pronounced synergistic effects induced by notable electron transfer from Co to Fe, and a large electrochemical active surface area achieved by organizing the synergistic Co–Fe–P into hierarchical nanosheet arrays with disordered grain boundaries. Such features facilitate the generation of abundant and efficiently exposed Co3+ sites for electrocatalytic OER and thus enable Co–Fe–P to deliver excellent activity (overpotential and Tafel slope as low as 240 mV and 36 mV dec–1, respectively, at a current density of 10 mA cm–2 in 1.0 M KOH solution). The Co–Fe–P electrocatalyst also shows great durability by steadily working for up to 24 h. Our work thus provides new insight into the development of highly efficient electrocatalysts based on nanoscale and/or electronic structure engineering.
研究领域:
材料科学
·
电催化
✓ 已验证
DOI
高影响因子
Materials Today Communications
·
2023
·
IF 3.8
Mihong Cao,Luyi Wang,Qian Zhang,He Zhang,Shengwen Zhong,Jun Chen
In this work, a conductive slurry containing CNTs is used as a modification reagent for the Super-P (SP) conductive agent. After CNTs is recombined with SP, spherical SP particles with a diameter of about 60 nm are evenly dispersed on the surface of CNTs nanotubes with a diameter of 20 nm, which effectively improves the specific surface area of the conductive agent. As a result, the battery using 1.5 % CNTs/SP composite conductive agent shows a smaller EIS impedance value, which makes the comprehensive behaviors of the LiNi 0.5 Co 0.2 Mn 0.3 O 2 battery significantly improved. The CNTs/SP battery shows larger CV curve area and smaller potential difference between oxidation and reduction peaks. In addition, the initial charge and discharge capacity of CNTs/SP battery are 181.7 and 184.7 mAh/g respectively with initial Coulombic efficiency of 98.4%, which are much higher than the pristine SP battery (173.7 and 182.0 mAh/g respectively with initial Coulombic efficiency of 95.4 %). After 70 cycles, the discharge capacity of CNTs/SP battery can still remain at 175.3 mAh/g with capacity retention ratio of 97.2 %, which are also much higher than the pristine SP battery (142.5 mAh/g with capacity retention ratio of 82.8 %). Moreover, compared with the pristine SP batteries, the CNTs/SP batteries show larger discharge capacities at different rates of 0.2 C, 0.5 C, 1.0 C, 2.0 C, 3.0 C and 5.0 C. After combining SP with CNTs nanowires, the discharge capacity, initial coulombic efficiency, cycle stability and rate capability of LiNi 0.5 Co 0.2 Mn 0.3 O 2 electrode are effectively improved, which provides a new idea for the development of novel conductive agent for high-performance cathode materials of lithium ion batteries .
研究领域:
材料科学
·
电化学
·
能源存储技术
✓ 已验证
DOI
高影响因子
POLYMER
·
2017
·
IF 3.684
Jia-Min Li,Chuan-Shan Hu,Jian-Ming Shao,Hui-Juan Li,Peng-Yun Li,Xi-Chuan Li,Wei-Dong He
Ternary hydrogels composed of poly[acrylamide- co -2-(dimethylamino)ethyl methacrylate] [P(AM- co -DMAEMA)], poly(vinyl alcohol) (PVA) and β -cyclodextrin ( β -CD) were fabricated based on the multiple physical interactions such as inclusion complexation, hydrogen bonding and polymer crystallinity , and exhibited high storage modulus . To illustrate the individual role of each physical interaction, symmetrical investigation has been performed. P(AM- co -DMAEMA)s with two compositions , prepared by radical polymerization at −20 °C below the freezing point of reaction medium of water, were served as the inclusion guest for the inclusion host of β -CD. The inclusion complex between dimethylaminoethyl group of DMAEMA and β -CD was identified through 2D NOESY NMR spectroscopy . Hydrogen bonding between each pairs of hydrogel components was confirmed with FTIR analysis and contributed the second form of crosslinkage. Under freezing polymerization and further freezing-thawing treatment, PVA component tended to crystallize to serve as the third type of physical crosslinkage, which was recognized with X-ray diffraction. Rheological and thermo-gravimetrical analysis was used to inspect the modulus and thermal stability of the hydrogels, respectively. Three hydrogels of P(AM- co -DMAEMA)/PVA-g- β -CD, P(AM- co -DMAEMA)/PVA/ β -CD and P(AM- co -DMAEMA)/PVA were synthesized under the same condition to make the comparison. The whole results disclosed the strong dependence of hydrogel properties on the hydrogel components, reflecting the synergistic effects of different physical crosslinkages for the formation of those physical hydrogels.
研究领域:
材料科学
·
高分子化学
✓ 已验证
DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2018
·
IF 5.667
Weiwei Mao,Bin Cai,Zhizhen Ye,Jingyun Huang
A glucose oxidase (GOx) based p-NiO/n-Bi 4 Ti 3 O 12 sandwich heterojunction was fabricated and explored as a glucose electrochemical sensor. The constructed GOx/p-NiO/n-Bi 4 Ti 3 O 12 sandwich structure effectively prevents the leakage of GOx. Dandelion-like Bi 4 Ti 3 O 12 nanowires were directly grown on the titanium foil substrates, and dense NiO nanoparticles were deposited by employing pulsed laser deposition at room temperature. Amperometric measurements towards glucose were carried out, and efficient direct electron transfer was successfully achieved. The enzyme biosensor showed a linear range from 20 μM to 3.55 mM (R = 0.999) with an ultrahigh sensitivity of 215 μA mM −1 cm −2 , response time within 2 s, low detection limit of 1.26 μM (S/N = 3) and high specificity. The apparent Michaelis-Menten constant (Km app) was estimated to be 0.22 mM. Intercrossed nanowires and interconnected pores favor the electrons transfer and the massive GOx loading. Binder-free feature leads to a seamless connection between Bi 4 Ti 3 O 12 nanowires and the substrate. Co-catalysis of GOx and p-NiO/n-Bi 4 Ti 3 O 12 heterojunction plays a synergetic role in gaining performance boosts. The GOx based p-NiO/n-Bi 4 Ti 3 O 12 heterojunction biosensor remedies the limitation of enzyme-based glucose sensor and be potentially applied in practice.
研究领域:
生物医学工程
·
材料科学
·
分析化学
✓ 已验证
DOI
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2022
·Vol. 139
·期 38
·e52905
·
IF 3.057
Jin Wang,Jingjing Bian,Bin Pu,Yuanlu Wang,Mengde Deng
Polyelectrolyte hydrogel used for supercapacitors have the roles of both electrolyte and separator, the morphology and the strength of gel polyelectrolyte (GPE) are the keys for ionic transport properties therein. Here, the P(NVP- co -SPE)/polyvinyl alcohol (PVA) IPN hydrogel was prepared by photopolymerization and thermal polymerization, respectively. The influences of preparation method on morphology, mechanical strength and electrochemical performances were studied. Photopolymerized IPN GPE (UV-GPE) exhibits a special regular microphase separation structure, and therefore has outstanding strength-toughness and better electrochemical performance. The tensile strength and the toughness increased intensively from the 6.2 MPa and 3.4 MJ m −3 of thermal polymerized IPN GPE (TH-GPE) to 28.5 MPa and 24.9 MJ m −3 , respectively. The maximum swelling ratio of UV-GPE is increased from 327% of TH-GPE to 630%. The ionic conductivity of UV-GPE increased from 4.29 × 10 −2 S/cm of TH-GPE to 5.82 × 10 −2 S/cm. UV-GPE has higher response current and specific capacitance. It also has the obviously better charge–discharge symmetry and cycling stability, and the capacity retention rate is still 92.3% after 1000 cycles. Thus, it brings out the fast, eco-economic photopolymerization method is an effective way to prepare high-performance polyelectrolyte hydrogel.
研究领域:
材料科学
·
电化学
✓ 已验证
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2015
·
IF 2.752
Sha Jin,Dian Li,Peng Yang,Jia Guo,Jennifer Q. Lu,Changchun Wang
Stimuli responsive drug delivery systems have attracted considerable attention due to their ability to deliver drugs on demand to special tissues and cells (e.g. cancer cells). In this paper, we fabricated a new kind of redox/pH dual stimuli-responsive biodegradable poly(methacrylic acid) (MAA) nanohydrogels crosslinked by N , N -bis(acryloyl)cystamine (BACy) through a facile reflux-precipitation polymerization. Subsequently polyethylene glycol (PEG) was grafted onto the surface of nanohydrogels to improve their long circulation time. This kind of PEGylated nanohydrogels could be degraded into short linear polymer chains in the solution of 10 mM glutathione (GSH) due to the sensitive disulfide bonds in the cross-linked networks. Interestingly, we found that the hydrophilic PEGylated nanohydrogels could be simultaneously loaded with hydrophilic drug doxorubicin (DOX) and hydrophobic drug paclitaxel (PTX) with high drug loading efficiency because of its regional hydrophobic nature in the nanohydrogels. The cumulative release profile showed that either lower pH (5.0) or reducing environment (GSH) or a combination could significantly accelerate the drug release from the drug-loaded nanohydrogels. In addition, the experimental results on living cells indicated that the multi-drug-loaded system had synergistic effect on cancer therapy.
研究领域:
药剂学
·
生物材料
·
肿瘤学
✓ 已验证
DOI
高影响因子
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
·
2021
·Vol. 168
·期 6
·066514
·
IF 4.316
Xiaopeng Liu,Yan Liu,Yun Wang,Dingzhong Yuan,Jinbiao Liu,zuqing Zhu
Polyphosphazene, as a precursor, was synthesized by ultrasonication using 4,4-diaminodiphenyl ether and hexachlorocyclotriphosphazene (HCCP). It was carbonized and functionalized at high temperature to obtain carboxylic acid functionalized N, P co-doped carbon materials (denoted as NPCs-COOH). The structure of NPCs-COOH was characterized by Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM), X-ray photoelectron spectroscopy (XPS), X-ray diffractometry (XRD), Raman spectrometry (Raman), Thermogravimetric analysis (TG) and N2 adsorption-desorption isotherm (BET). The electrosorption properties were explored under different pH values, applied potentials, initial concentrations and contact time. The optimal pH for electrosorption was 5.0 while the equilibrium time was 30 min. The maximum electrosorption capacity from the experiments towards U(VI) was about 551.46 mg g−1 under the most suitable applied potential of 0.9 V, which was much higher than other carbon materials. Meanwhile, it also showed excellent recyclability with a 23.3% reduction of electrosorption capacity after six cycles. A plausible mechanism of electrosorption was presented using XPS analysis. The results showed the N, P co-doped NPCs-COOH can be used in the electrosorption field to remove U(VI) effectively in solution.
研究领域:
材料科学
·
环境科学
✓ 已验证
DOI
高影响因子
mLife
·
2023
·Vol. 2
·期 2
·190-200
·
IF 0
Hongzhe Li,Jiazhi Ding,Longji Zhu,Fei Xu,Wenjing Li,Yanpo Yao,Li Cui
Application of agricultural waste such as rapeseed meal (RM) is regarded as a sustainable way to improve soil phosphorus (P) availability by direct nutrient supply and stimulation of native phosphate-solubilizing microorganisms (PSMs) in soils. However, exploration of the in situ microbial P solubilizing function in soils remains a challenge. Here, by applying both phenotype-based single-cell Raman with D 2 O labeling (Raman-D 2 O) and genotype-based high-throughput chips targeting carbon, nitrogen and P (CNP) functional genes, the effect of RM application on microbial P solubilization in three typical farmland soils was investigated. The abundances of PSMs increased in two alkaline soils after RM application identified by single-cell Raman D 2 O. RM application reduced the diversity of bacterial communities and increased the abundance of a few bacteria with reported P solubilization function. Genotypic analysis indicated that RM addition generally increased the relative abundance of CNP functional genes. A correlation analysis of the abundance of active PSMs with the abundance of soil microbes or functional genes was carried out to decipher the linkage between the phenotype and genotype of PSMs. Myxococcota and C degradation genes were found to potentially contribute to the enhanced microbial P release following RM application. This work provides important new insights into the in situ function of soil PSMs. It will lead to better harnessing of agricultural waste to mobilize soil legacy P and mitigate the P crisis. Impact statement Stimulation of native soil microorganisms to release soil P stocks is a sustainable means of agricultural production, but faces a major challenge in terms of the deciphering of in situ microbial phosphorus (P) solubilization functions. In this study, single-cell Raman spectroscopy and carbon, nitrogen and P (CNP) functional gene chips were used to reveal the phenotypes and genotypes of microbial P solubilization function in three farmland soils amended with agricultural waste of rapeseed meal (RM). Effects of RM on soil properties, active phosphate-solubilizing bacteria, and CNP functional genes that may contribute to P solubilization were revealed, providing important insights into the use of agricultural waste to improve P utilization efficiency.
研究领域:
微生物学
·
环境科学
·
农学
✓ 已验证
DOI
Nanomaterials
·
2021
·Vol. 12
·期 1
·117
·
IF 5.076
Pratima Pandey,Rajashree Sahoo,Khusbu Singh,Sanghamitra Pati,Jose Mathew,Avinash Chandra Pandey,Rajni Kant,Ihn Han,Eun-Ha Choi,Gaurav Raj Dwivedi,Dharmendra K. Yadav
Bacteria employ numerous resistance mechanisms against structurally distinct drugs by the process of multidrug resistance. A study was planned to discover the antibacterial potential of a graphene oxide nanosheet (GO), a graphene oxide–zinc oxide nanocomposite (GO/ZnO), a graphene oxide-chitosan nanocomposite (GO–CS), a zinc oxide decorated graphene oxide–chitosan nanocomposite (GO–CS/ZnO), and zinc oxide nanoparticles (ZnO) alone and in a blend with antibiotics against a PS-2 isolate ofPseudomonas aeruginosa. These nanocomposites reduced the MIC of tetracycline (TET) from 16 folds to 64 folds against a multidrug-resistant clinical isolate. Efflux pumps were interfered, as evident by an ethidium bromide synergy study with nanocomposites, as well as inhibiting biofilm synthesis. These nanoparticles/nanocomposites also decreased the mutant prevention concentration (MPC) of TET. To the best of our knowledge, this is the first report on nanomaterials as a synergistic agent via inhibition of efflux and biofilm synthesis.
研究领域:
微生物学
·
纳米医学
·
药理学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）