SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2023
·
IF 4.4
Bin Yang,Jia Liu,Fengming Zhang,Yuting Wang,Xin Liu,Shiyue Niu,Yue Yuan,Shuyun Bi
A highly sensitive surface-enhanced Raman spectroscopy approach was established for the detection of dextromethorphan hydrobromide (DXM) utilizing nano CuO modified silver nanoparticles (CuO@AgNPs) as substrate. Ultraviolet visible spectra (UV-vis), X-ray diffraction (XRD) and transmission electron microscopy (TEM) characterized the synthesized CuO@AgNPs. UV-vis and fourier transform infrared (FT-IR) were adopted to investigate the interaction between DXM and CuO@AgNPs. The optimal experimental conditions (the dosages of CuO@AgNPs and NaCl as well as mixing time) were explored. The enhancement factor (EF) was 1.71 × 10 6 . The linear relationship between SERS intensity and the concentration of DXM in the range of 67 – 1000 nmol L −1 was obtained as I SERS = 25.81 c + 40398.77, and the limit of detection (LOD) was 2.12 nmol L −1 (S/N = 3). The interference of K + , Mg 2+ , Zn 2+ , Ca 2+ , Cu 2+ , Fe 3+ , glucose, HSA, L-tryptophan, soluble starch and ibuprofen were investigated. The method was successfully applied to test DXM in serum samples. The recovery was 99.06% – 101.51% with the relative standard deviation (RSD) of 0.74% – 3.87%.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2018
·
IF 5.667
Shuai Yue,Xiao-Ting Sun,Yue Wang,Wen-Shu Zhang,Zhang-Run Xu
Surface-enhanced Raman scattering (SERS) spectroscopy is an ultrasensitive analytical technique with high specificity, making it an ideal candidate for therapeutic drug monitoring. However, SERS measurement of drugs in biological samples is inevitably affected by the proteins adsorbed nonspecifically on metal nanoparticles, so the drugs usually require separation before SERS detection. In this work, semipermeable alginate microparticles containing gold nanoparticles were fabricated via a centrifugal microfluidic chip, and served as a reliable substrate for SERS detection of 6-thioguanine in serum without protein removal. In comparison with the conventional microfluidic methods using oil for droplet generation, this oil-free method can fabricate more clean and versatile microparticles. The microparticles were characterized by size/charge selectivity and pH response, which effectively improved anti-interference ability and SERS sensitivity for 6-thioguanine detection in serum. The microparticles were further endowed with magnetic property and SERS activity simultaneously by forming Janus structures embedded with magnetic nanoparticles and gold nanoparticles separately in independent hemispheres, which was convenient for manipulation in SERS detection. More broadly, the microparticles are potentially applicable for SERS detection of other small molecules in complex real samples.
✓ 已验证
产品关联
DOI
高影响因子
FOOD CHEMISTRY
·
2026
·
IF 10.4
Xinru Yu,Hongbin Pu,Da-Wen Sun
A reliable IMIPCs–AMoO 2 /C SERS analytical method was established. • Validated results were acceptable for IMI in fresh fruit and vegetable juices. • The method displayed good linear correlation, low LOD, trueness and precision. • The mechanisms of a modularly integrated synergistic strategy were explored. • Rapid detection of trace levels of IMI in the sample was achieved (10 min). Imidacloprid (IMI), a first-generation neonicotinoid insecticide, is taken up by plants and distributed to edible parts owing to its systemic transport properties. This leads to its residues in fruit and vegetable juices, posing a potential food safety risk. Herein, we report a modular integrated synergistic SERS strategy for reliable, efficient and selective detection of IMI. An IMI-imprinted polymer-pesticide carb (IMIPCs) cartridge was designed for recognition, purification, and enrichment. The AMoO 2 /C SERS substrate, optimised through annealing, aligns its bandgap with the excitation wavelength, while IMI adsorption induces band bending and triggers charge-transfer resonance, enabling signal amplification. Under optimised conditions, the method exhibits excellent linearity from 0.500 ng/mL to 50.0 ng/mL, a low detection limit of 0.0904 μg/kg, and high accuracy in spiked typical juice matrices (tomato, celery, apple, and mixed juices), with recoveries of 92.7%–98.1% (RSD%, 0.332%–2.50%) and no significant difference compared with the HPLC method at the 95% confidence level. Application to twenty real samples collected from the market, including fruit and vegetable juice samples such as kiwi, kale, banana, and orange juices and their mixtures, demonstrated good selectivity, reliability, and reproducibility, with residue levels detected in the ppb range. Overall, this LEGO-inspired SERS method provides a simple, efficient and highly selective analytical strategy for monitoring IMI residues in fruit and vegetable juices, and can serve as a supplementary screening tool for routine food safety monitoring of such juice products. Its applicability to complex high-fat or protein-rich matrices, such as milk-based or nut-based beverages, remains to be further validated through subsequent research. Download: Download high-res image (199KB) Download: Download full-size image
✓ 已验证
产品关联
DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2023
·Vol. 47
·期 46
·21225-21231
·
IF 3.3
Ziyu Zhou,Atian Xie,Yuanhang Tan,Junfeng Zhang,Changguo Xue
Herein, a 3D SERS substrate based on nickel foam (NF) and silver nanoparticles (AgNPs/NF 3D SERS) was synthesized using vacuum-assisted thermal evaporation deposition. The performance of the AgNPs/NF 3D SERS substrate was investigated using rhodamine 6G (R6G) as a probe molecule at different AgNP deposition levels. The highest sensitivity of the substrate with a limit of detection (LOD) of 10−9 M and an enhancement factor (EF) of 1.56 × 106 was achieved when the optimal amount of AgNPs was reached. Moreover, the use of R6G at 10−6 M concentration as the probe molecule ensured the relative standard deviation (RSD) of 9.2% for the AgNPs/NF 3D SERS substrate, and its SERS performance hardly decreased after 30 days of placement at room temperature, which evidenced that the prepared SERS substrate had favorable stability and repeatability. Finally, the substrate was used to analyze carbendazim in deionized and river water in two different environments. The results revealed that the LOD of CBZ was as low as 10−7 M under both conditions, and there was a good linear relationship between the CBZ concentration and the SERS signal intensity (R2 = 0.955 and 0.927, respectively), which demonstrated the great potential of AgNPs/NF 3D SERS substrates for pesticide residue identification in practical analysis.
✓ 已验证
产品关联
DOI
高影响因子
Analytical Methods
·
2023
·Vol. 15
·期 44
·6088-6096
·
IF 3.1
Pei Zeng,Huan Zhang,Qi Guan,Qianqian Zhang,Xianzai Yan,Lili Yu,Luying Duan,Chunrong Wang
The design and preparation of various effective three-dimensional (3D) silver nanostructures is a frontier area of research in the field of surface-enhanced Raman scattering (SERS). This paper demonstrates a simple and novel method for the preparation of a substrate, whose surface was covered by a 3D interconnected network of Ag nanostructures, and the resulting network structure surface is free of organic contaminants. The EDS measurements confirm the metallic nature of the formed 3D Ag nanonetwork substrate. Additionally, the influence of experimental parameters on the morphology of the 3D Ag nanonetwork was also investigated, such as reaction time, hydrofluoric acid concentration, silver nitrate concentration and sodium citrate concentration. The 3D Ag nanonetwork has good uniformity. Importantly, the 3D Ag nanonetwork substrate was used to accurately and reliably detect amaranth (AR) and sunset yellow (SY) in beverages, with the lowest detection limit of 3 and 0.1 μg L−1, respectively. Therefore, this substrate is expected to be a promising candidate for SERS detection and offers attractive potential for a wider range of applications.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2023
·
IF 4.4
Xu Tao,Zinuo Zhang,Zijian Liu,Xinyu Fan,Qian Yu,Lingzi Xu,Hui Wang,Jiaqi Guo,Xianming Kong
We proposed a triple functional SERS substrate by immobilized Ag nanoparticles on the surface of filter paper. The high dense Ag nanoparticles were distributed on the SERS substrate via in-situ growth process. By optimizing the parameter in preparation process, the optimal filter paper SERS substrate was fabricated by using 30 mM of AgNO 3 with 20 S growth time. Due to capillary-effect wicking of cellulose fiber, the paper SERS substrate provide simple, fast and pump-free function for transferring analyte onto sharp tip through development of fluid. The fluid flow also brings target concentrate effect within the tip area. Furthermore, the separation feasibility was obtained during the development process of fluid. The preconcentrated effects not only enhanced the SERS signal of analyte, but also improve the fluorescence visible effect. The filter paper SERS substrate was successfully used for separating, concentrating and detecting Sudan dye from chili product, the detection limit could achieve 10 −6 M. This study developed a portable, cost-effective and eco-friendly SERS substrate for separating and detecting trace chemical in food.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MICROCHEMICAL JOURNAL
·
2023
·
IF 4.8
Yifei Li,Yucui Zhang,Huan Jiang,Mengyao Qi,Xia Zhang,Baowang Zhu,Lei Han
Although the fact that H 2 O 2 is employed in the medical, food, and chemical industries, trace detection of H 2 O 2 remains a difficult and significant problem. For the detection of H 2 O 2 residues, SERS assays based on enzyme inhibition techniques show promise. As a result, we csynthesized CeO 2 @nanogel/Au nanoparticles with dual enzyme-like capabilities to detect hydrogen peroxide in this study. CeO 2 nanozymes possess both peroxidase-like and oxidase-like activities which could oxidize colorless 3,3′,5,5′-tetramethylbenzidine to blue TMB oxide. Surprisingly, after the addition of nanogel, CeO 2 @nanogel were prepared and both of its dual enzymatic activities decreased, especially the oxidase-like enzymes almost disappeared. To better investigate the enzyme catalytic activity, Au NPs were introduced and CeO 2 @nanogel/Au nanozymes were self-assembly prepared. Based on the significantly enhancement of CeO 2 @nanogel/Au nanozymes peroxidase activity, we developed a Raman detection method for H 2 O 2 with TMB ox as the probe molecule. The Raman intensity showed good linearity for the concentration of H 2 O 2 in the range of 10 -9 M−10 −1 M with a correlation coefficient of R 2 = 0.9922 and a detection limit of 2.68 × 10 -12 M. Thus, the proposed SERS mode sensor exhibited good selectivity and interference resistance, providing a new avenue for environmental monitoring.
✓ 已验证
产品关联
DOI
高影响因子
Journal of Physical Chemistry C
·
2023
·
IF 3.7
Huan-Yu Chen,Xing-Biao Liu,Qi-Xin Guan,Can-Jun Zou,Ping-Ping Fang
The detection of antibiotics has attracted great attention among scientists and health researchers in the past decades. However, it is still difficult to realize the sensitive and selective detection of antibiotics with similar structures. Herein, the antibiotic molecules of oxytetracycline (OTC) can be sensitively and selectively detected by surface-enhanced Raman spectroscopy (SERS) on NH2–UiO-66(Zr)@Au nanoparticles (NPs). The SERS substrate of NH2–UiO-66(Zr)@Au NPs realizes a detection sensitivity of 1 × 10–12 g·L–1 for 4-mercaptobenzoic acid, indicating its high SERS activity. A high detection sensitivity of 10–11 g·L–1 is obtained for OTC on such a SERS substrate. Besides the high sensitivity, NH2–UiO-66(Zr)@Au NPs can also selectively detect OTC from streptomycin sulfate, salicylic acid, and ofloxacin by SERS on NH2–UiO-66(Zr)@Au NPs, with a selective detection limit of 10–10 g·L–1. Furthermore, OTC can be selectively detected in a real sample of river water with a detection limit of 1.0 × 10–10 g·L–1. Therefore, this study provides an effective way to enrich and detect antibiotics in real samples in the environment.
✓ 已验证
产品关联
DOI
高影响因子
Food Science and Human Wellness
·
2023
·
IF 7
Linglin Fu,Yanzhuo Du,Jinru Zhou,Huan Li,Minzi Wang,Yanbo Wang
Gluten, known as the major allergen in wheat, has gained increasing concerns in industrialized countries, resulting in an urgent need for accurate, high-sensitive, and on-site detection of wheat gluten in complex food systems. Herein, we proposed a silver nanoparticles (AgNPs)/metal-organic framework (MOF) substrate-based surface-enhanced Raman scattering (SERS) sensor for the high-sensitive on-site detection of wheat gluten. The detection occurred on the newly in-situ synthesized AgNPs/MOF-modified SERS substrate, providing an enhancement factor (EF) of 1.89 × 10 5 . Benefitting from the signal amplification function of AgNPs/MOF and the superiority of SERS, this sensor represented high sensitivity performance and a wide detection range from 1 × 10 -15 mol/L to 2 × 10 -6 mol/L with a detection limit of 1.16 × 10 -16 mol/L, which allowed monitoring the trace of wheat gluten in complex food system without matrix interference. This reliable sandwich SERS sensor may provide a promising platform for high-sensitive, accurate, and on-site detection of allergens in the field of food safety.
✓ 已验证
产品关联
DOI
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2023
·
IF 4.4
Qingyi Wei,Chaoying Pan,Tengfei Wang,Hongbin Pu,Da-Wen Sun
High-performance plasmonic substrates have recently attracted much research attention. Herein, a three-dimensional gold nanoparticles (AuNPs) spherical liquid array (SLA) with high “hot spots” and tunable nanometer gap by optimizing the proportion of AuNPs colloids over chloroform was synthesized based on a water–oil interfacial self-assembly strategy. The substrate demonstrated excellent surface-enhanced Raman scattering (SERS) performance using tetrathiafulvalene and rhodamine 6G (R6G) as probe molecules. With a simple extraction and soaking pretreatment process, the SLA exhibited high sensitivity for analysing triazophos on apple peels, with a limit of detection (LOD) of 0.005 µg/mL and recovery ranging from 96 to 110 %. Particularly, the chloroform produced an inherent characteristic peak at 665 cm −1 , which was used as the internal standard to correct SERS signal fluctuation, leading to an improvement of the corresponding coefficient R 2 from 0.97 to 0.99, thus improving the reproducibility. Therefore the SLA substrate possesses the potential for quantitative analysis of food contaminants.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2023
·
IF 8.4
Jihua Xu,Junkun Wang,Chengrui Zhang,Xiaofei Zhao,Jing Yu,Baoyuan Man,Haipeng Si,Zhen Li,Chao Zhang
Nanoplastics are widespread and pose a potential threat to human health. In this work, we designed a flexible multiscale cavity structured (MCS) surface-enhanced Raman scattering (SERS) substrate decorating Ni 3 S 2 nanocavity on a modified polyvinylidene fluoride (PVDF) microcavity. The dense two-dimensional Ni 3 S 2 nanosheets can provide a large surface area for the deposition of plasmonic silver nanoparticles (Ag NPs), increasing the density and strength of the “hotspots”. Additionally, the nanocavity (width ∼500 nm), formed by the nanosheet surroundings, offers not only electromagnetic enhancement of the cavity mode for SERS but also a crucial detection site for nanoplastics attachment. This effectively addresses the challenge of SERS detection due to the scale mismatch between nanoplastics (>50 nm) and conventional “hotspots” (<10 nm). Moreover, the flexible imprinted PVDF microcavity endows the proposed substrate with omnidirectional “hotspots” enhancement, ensuring the signal stability and the feasibility of in-site detection of the actual sample. As a result, we achieved the successful in-site detection of polystyrene (PS) spheres of different sizes on the surface of oysters, with a detection limit of 10 -3 mg/mL for 50 nm diameter. The flexible multiscale cavity SERS substrate is expected to show great potential in food safety and environmental monitoring.
✓ 已验证
产品关联
DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2021
·
IF 7.46
Zhi-Qin Geng,Di Xu,Yuhang Song,Wei-Peng Wang,Yun-Peng Li,Cai-Qin Han,Guo-Hai Yang,Lu-Lu Qu,Pulickel M. Ajayan
Hyperbilirubinemia refers to an increase in bilirubin (BR) levels and is a serious health concern; in severe cases, hyperbilirubinemia can lead to the death of newborns infants within the first month. Traditional analytical technologies normally involve complex sample pretreatment procedures yet present unsatisfactory detection limits for BR levels. In this study, we developed a recyclable surface-enhanced Raman scattering (SERS) substrate by modifying functional boron nitride (M-BN) monolayer nanosheets on silver nanoarrays (Ag NRs/M-BN) for label-free detection of BR in complex biological samples. Modification of M-BN to silver nanoarrays (Ag NRs) significantly improved the detection sensitivity and long-term stability of the substrate due to the strong surface adsorption ability and thermal stability of M-BN. The limit of detection (LOD) of BR in blood obtained from the Ag NRs/M-BN was as low as 2.5 × 10 −8 M, which was attributed to its superior affinity for hydrophobic BR molecules. The spiked blood samples were practically tested with recovery values of around 80 %, and relative standard deviations (RSD) were less than 15 %. The results, combined with the excellent reusability of the as-developed substrates, indicated that the Ag NRs/M-BN substrate provides a simple yet promising platform for nondestructive detection of BR.
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）