SCIENCE OF THE TOTAL ENVIRONMENT
·
2020
·
IF 6.551
Zhuxiu Zhang,Yue Xiao,Yifan Lei,Jihai Tang,Xu Qiao
The antibiotics abuse and the proliferation of antibiotic-resistant bacteria in the environment have a severe impact on both human health and ecosystem. In this study, a silica-nanocasting method was applied in Mg-MOF-74 template to generate a series of MgO/SiO 2 catalysts for the hydrolysis of β-lactam antibiotics. The Mg-based subunits in MOF-74 were converted to highly dispersed MgO nanoparticles with controllable particle size. MgO/SiO 2 -80 with the smallest MgO particle size exhibits the best catalytic performance in the hydrolysis of four β-lactam antibiotics. The kinetics study reveals the higher degradation rate and lower activation energy of MgO/SiO 2 -80 than other benchmark solid base catalysts. The proposed mechanism suggests that small MgO particle size provides more accessible oxygen anions with high proton affinity for the cleavage of the β-lactam ring, so that all hydrolytic products lose antimicrobial activity. The MgO/SiO 2 -80 serves as the potential high-performance solid base catalyst for the real-world antibiotic wastewater treatment .
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JOURNAL OF MOLECULAR LIQUIDS
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2019
·
IF 4.561
Subramanian Siva,Changzhu Li,Haiying Cui,Lin Lin
Isoeugenol is a natural dual antioxidant/prooxidant. In this research, the inclusion complex (IC) of isoeugenol with 2-hydroxypropyl- β -cyclodextrin (HP β CD) was prepared via the ultrasound (US) method. The US assisted isoeugenol/HP β CD-IC was investigated by various characterization techniques such as UV–Vis absorption, fluorescence, powder X-ray diffraction, Fourier transform infrared spectroscopy , thermal gravimetric analysis and differential scanning calorimetry . Absorption, fluorescence and infrared studies indicated that the alkyl chain of isoeugenol was deeply included in the HP β CD cavity. Through determinations of phase solubility and water solubility studies, significant enhancement of isoeugenol water solubility was confirmed after IC formation with the HP β CD. Thermal data proved that the IC formation significantly enhanced the thermal stability of isoeugenol. Antioxidant test results indicated that isoeugenol/HP β CD-IC exhibited better antioxidant activity than free isoeugenol due to its solubility enhancement. Furthermore, the isoeugenol/HP β CD-IC showed higher antibacterial activity of 96 ± 0.2% and 97 ± 0.5% against Staphylococcus aureus and Escherichia coli bacteria, respectively.
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CRYSTENGCOMM
·
2018
·Vol. 20
·期 19
·2705-2712
·
IF 3.304
Liangfei Ouyang,Tengfei Zheng,Liang Shen
The application of in situ powder X-ray diffraction (XRD) to monitor the polymorphic transformation and crystallization of glycine from an ionic liquid–water system is introduced. We compared the polymorphic crystallization processes of glycine in pure water, a hydrophilic ionic liquid 1-ethyl-3-methylimidazolium tetrafluoroborate ([Emim]BF4)- and a hydrophobic ionic liquid 1-butyl-3-methylimidazolium hexafluorophosphate ([Bmim]PF6)-water system. In these three cases, the mixture was predominantly composed of the metastable α-glycine, while the least stable β-glycine was only observed during the growth of crystals at room temperature and 32% humidity. The phase transformation from α- to β-glycine was clearly observed through the change in the intensity of characteristic peaks at 29.9° and 18.0° (2 theta) in the XRD patterns. In addition, the effect of the ionic liquid [Bmim]PF6 as an anti-solvent on the re-crystallization process of glycine from three commercially available brands was estimated. Also, the satisfactory reproducibility was obtained from glycine crystallization in the ionic liquid [Emim]BF4-water system in four independent experiments. Therefore, laboratory-based powder XRD analysis can not only provide dynamic information about phase transformation in situ, but can also discover the unstable or transition state in the polymorphic design and control crystallization processes by adding ionic liquids or other additives.
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Materials Express
·
2018
·Vol. 8
·期 3
·199-210
·
IF 1.597
Yang Ling,Wang Zhengxiang,Zhao Tian,Zhong Yunfei,Liu Yuejun
Due to unique optical properties and high information concealment, upconversion materials, with excellent luminescent properties and good water dispersibility, have received significant attention in many fields recently, particularly for packaging anti-counterfeiting. In a vast majority
of parameters, chelating ligands played an essential role in controlling the phase structure, morphology and surface characteristics of the upconversion materials, thus produced an effect on photoluminescent properties. Herein, we demonstrated a facile hydrothermal synthetic strategy of β-NaYF4
upconversion microcrystals using waterborne polyurethane (WPU) prepolymer as the ligand. In order to achieve high intensity, the WPU polymer was prepared through molecular design and optimized preparation process, and the influence of WPU prepolymer with different ammonia contents on the luminescence
property of the crystals was investigated thoroughly. The results of powder X-ray diffraction (XRD), field emission scanning electron microscopy (FE-SEM), high-resolution transmission electron microscopy (HRTEM) and selected area electron diffraction (SAED) indicated that the as-prepared NaYF4
crystal possessed hexagonal phase structure, a forked rod shape, high crystallinity and excellent crystal quality. Interestingly, the crystal capped with WPU prepolymer possessed good water dispersibility and its fluorescence intensity at 540 nm was 10∼15 times as higher as that of the
crystal chelated with trisodium citrate (TSC) or ligand-free. The possible reasons have been proposed. It was demonstrated that the β-NaYF4 (Er3+/Tm3+, Yb3+/Er3+ or Yb3+/Tm3+ co-doped) crystals capped
with WPU prepolymer would be promising candidates to prepare waterborne RGB anti-counterfeit inks which were eco-friendly and suitable for stamping designable patterns and handwriting on flexible packaging substrates. The patterns and handwritings were invisible under ambient conditions, while
displayed bright multicolor fluorescence upon 980 nm irradiation, which confirmed that the as-prepared crystals exhibited high potential in packaging anti-counterfeiting.
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JOURNAL OF MOLECULAR STRUCTURE
·
2023
·
IF 3.8
Yongmei Zhao,Jianwu Lv,Hongli Yu,Kang Huang,Zhihan Du,Wen Luo
A novel series of dictamnine derivatives were synthesized and evaluated as dual inhibitors for cholinesterase and β-amyloid aggregation. These molecules exhibited potent acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activities at the micromolar to sub-micromolar levels. Compound 7k exhibited the strongest inhibitory activity for both AChE and BChE, with IC 50 values of 0.40 μM and 0.63 μM, respectively, improving results from its precursor dictamnine and the commercial inhibitor galanthamine. Kinetic analyses and molecular modeling results indicated a mixed-type inhibition of AChE by compound 7k . In addition, some of the derivatives revealed potent inhibitory activity of AChE induced β-amyloid (Aβ) aggregation. Moreover, 7k did not show toxicity against SH-SY5Y and HL-7702 cells at the tested concentration. Therefore, these dictamnine derivatives, and especially 7k , are suitable candidates for the treatment of Alzheimer's disease and should be further studied.
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Analytical Methods
·
2015
·Vol. 7
·期 11
·4602-4607
·
IF 1.821
MingHui Li,WenShen He,LiJun Zhang,ChengLi Duan
A capillary zone electrophoresis method was established for simultaneous analysis of penicillin G and penicillin acid in milk. Milk samples were deproteinized and the analytes were extracted with acetonitrile. Separation of target compounds was performed through electrophoresis. Under optimum conditions, the proposed method demonstrated good correlation coefficients (R > 0.9953), precision (<6.2%), accuracy (89.2–96.8%), and limits of detection and quantification of penicillin G and penicillin acid (LOD, 0.01 and 0.5 μg mL−1, LOQ, 0.04 to 1.7 μg mL−1, respectively). The proposed method for the determination of penicillin and penicillin acid in milk is rapid, convenient and low-cost, and can measure β-lactamase activity in milk. The thermal stabilities of penicillin G, penicillin acid, and β-lactamases in milk were satisfactory when the temperature was lower than 303 K. When the temperature was higher than 353 K for 5 h, β-lactamase tended to be inactivated completely. When the temperature was 373 K, penicillin G and penicillin acid were easily degraded.
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JOURNAL OF MATERIALS SCIENCE
·
2021
·Vol. 56
·期 23
·13043-13055
·
IF 4.22
Zhu Yao,Rong Jian,Mao Kaili,Yang Dongya,Zhang Tao,Qiu Fengxian,Pan Jianming,Pu Zhilong
Polymer of cyclodextrin (CD) is still of great sustainable interest in the scientific research attributing to its excellent physicochemical properties. Owing to its water solubility and superior binding capacity, CD is usually modified through various strategies to exploit its application area. Herein, for the first time, magnetic β-cyclodextrin (β-CD) polymer is endowed with boronate affinity property via mild chemical modifications to specifically separate natural drug raw material shikimic acid (SA). The uniform morphology, magnetic response ability and composition analysis of the porous adsorbent were highly supported by the characterizations. The capture process towards SA depending on the pH value is explored in detail by adsorption kinetics, equilibrium, selectivity and reusability. It is found that specific recognition sites decorated on the surface of magnetic β-CD provides strength support for selective adsorption and separation of shikimic acid. The prepared adsorbent shows high adsorption quantity ( Q , mg g −1 ) of 31.60 mg g −1 at 25 °C, high specific recognition and good adsorption capacity (above 83.7%) and stability after five cycles. This study gives a new sight on the utilization of porous β-CD-based material by grafting functional boric acid group for specific capture of natural cis-diol-containing compounds.
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JOURNAL OF CELLULAR PHYSIOLOGY
·
2024
·
IF 4.5
Zhiguang Chen,Qi Zhao,Lianghong Chen,Songlan Gao,Lingshuai Meng,Yingjie Liu,Yu Wang,Tiegang Li,Jinqi Xue
Osteogenic differentiation is important for fracture healing. Microfibrial-associated glycoprotein 2 (MAGP2) is found to function as a proangiogenic regulator in bone formation; however, its role in osteogenic differentiation during bone repair is not clear. Here, a mouse model of critical-sized femur fracture was constructed, and the adenovirus expressing MAGP2 was delivered into the fracture site. Mice with MAGP2 overexpression exhibited increased bone mineral density and bone volume fraction (BV/TV) at Day 14 postfracture. Within 7 days postfracture, overexpression of MAGP2 increased collagen I and II expression at the fracture callus, with increasing chondrogenesis. MAGP2 inhibited collagen II level but elevated collagen I by 14 days following fracture, accompanied by increased endochondral bone formation. In mouse osteoblast precursor MC3T3-E1 cells, MAGP2 treatment elevated the expression of osteoblastic factors (osterix, BGLAP and collagen I) and enhanced ALP activity and mineralization through activating β-catenin signaling after osteogenic induction. Besides, MAGP2 could interact with lipoprotein receptor-related protein 5 (LRP5) and upregulated its expression. Promotion of osteogenic differentiation and β-catenin activation mediated by MAGP2 was partially reversed by LRP5 knockdown. Interestingly, β-catenin/transcription factor 4 (TCF4) increased MAGP2 expression probably by binding to MAGP2 promoter. These findings suggest that MAGP2 may interact with β-catenin/TCF4 to enhance β-catenin/TCF4's function and activate LRP5-activated β-catenin signaling pathway, thus promoting osteogenic differentiation for fracture repair. mRNA sequencing identified the potential targets of MAGP2, providing novel insights into MAGP2 function and the directions for future research.
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FOOD CHEMISTRY
·
2025
·
IF 9.8
Shupeng Su,Junhua Lu,Xinyi Yin,Mengjiao Wang,Fumin Wang,Yuejiu Pang
β-carotene, a vital carotenoid, is limited by poor solubility and stability. Though Pickering nanoemulsions offer superior protection for β-carotene than conventional nanoemulsions, developing food-grade Pickering nanoemulsions remains challenging due to particle size and amphiphilicity issues. This study developed a food-grade Pickering nanoemulsion stabilized by chitosan nanoparticles via high-power ultrasonication. Under optimized conditions (pH 6.5, 2 % oil phase, 1.0 wt% chitosan, 455 W ultrasonication for 180 min), a stable nanoemulsion of 388 nm was obtained with minimized β-carotene loss. These nanoemulsions exhibited exceptional environmental stability, maintaining robust stability under varying pH (3.0–7.0), ionic strength (100–500 mM NaCl), and thermal stress. Thermal stability and extended storage tests demonstrated superior β-carotene protection compared to conventional Tween 20-stabilized emulsions. This work provides a novel strategy for food-grade Pickering nanoemulsions, enabling β-carotene application in functional foods and pharmaceuticals.
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IBRO Neuroscience Reports
·
2025
·
IF 2.9
Penghui Cao,Shichuan Shen,Ziyan Fang,Junjie Tan,Jinwei Wang,Nannan Pan
Objective This study aims to investigate the role of the TGF-β/Smad Signaling in depression comorbidity in epileptic individuals and to evaluate the effect of losartan on depressive symptoms. Methods Li-Popilocarpine was used to induce status epilepticus (SE) in rats. The rats in which SE was successfully induced were randomly divided into the SE saline group and the SE losartan group. Then, the rats in the different groups were given the corresponding interventions for 20 days. After the intervention, the depression levels of the rats in each group were evaluated. Upon completion of the intervention, brain tissue was collected for comprehensive assessment of TGF-β mRNA levels, TGF-β/Smad Signaling-related protein expression, and GFAP⁺ astrocyte density in the rat hippocampus. Results The depression-like behavior of SE rats was more obvious than that of control rats. TGF-β mRNA, p-Smad2, p-Smad3 and GFAP⁺ astrocyte expression levels were significantly greater in SE rats than in control rats. Compared with the SE-saline group, the depression-like behavior of the SE-losartan group improved. The expression levels of TGF-β mRNA p-Smad2, p-Smad3 and GFAP⁺ astrocyte expression in the SE-losartan group rats were lower than those in the SE-saline group. Conclusion The TGF-β/Smad Signaling is an important Signaling leading to depression-like behavior in epileptic rats. Losartan is a drug that can significantly improve the depression-like behavior of epileptic rats by regulating the TGF-β/Smad Signaling. Findings in this study support losartan as a repurposable central nervous system drug for comorbid depression in epilepsy, warranting further clinical investigation.
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JOURNAL OF MATERIALS SCIENCE
·
2025
·
IF 3.9
Chen Boyang,Liu Xinyu,Liu Yiyuan,Gao Zeliang,Zhang Kun,Mu Wenxiang
Semiconductor X-ray detectors have attracted considerable attention recently owing to their high sensitivity and excellent stability. Among them, semi-insulating β-Ga 2 O 3 stands out due to its superior thermal stability, high breakdown electric field, and high crystal quality, enabling the fabrication of high-performance detectors suitable for various working environments. In this study, Ni 2+ was introduced into β-Ga 2 O 3 as a deep-level acceptor via doping engineering. A high-resistivity Ni-doped β-Ga 2 O 3 crystal was grown using the edge-defined film-fed growth (EFG) method. X-ray fluorescence spectrometer (XRF) confirmed a Ni doping concentration of 0.544 at%. The crystal exhibited a rocking curve with a full width at half maximum (FWHM) of 65.13 arcsec and clear, symmetric Laue patterns. The ultraviolet–visible (UV–Vis) transmission spectrum showed a cutoff edge at 265.5 nm, yielding a bandgap of 4.67 eV. Moreover, the semi-insulating behavior of Ni: β-Ga 2 O 3 was indicated by the infrared absorption edge extended beyond 10 μm. Raman spectroscopy revealed lattice distortion due to Ni 2+ incorporation, causing shifts in peak positions and intensities without phase change. A metal–semiconductor–metal (MSM)-structured X-ray detector based on Ni: β-Ga 2 O 3 was fabricated and characterized under various biases and dose rates. The device exhibited excellent stability at 1000 V with a high sensitivity of 663.36 μC/Gy·cm 2 , outperforming detectors from other semi-insulating β-Ga 2 O 3 crystals due to its superior crystal quality and high breakdown strength. Furthermore, low oxygen vacancy concentration contributed to fast response times of 0.20 s (rise) and 0.23 s (fall). The detection limit was estimated to be 12.04 nGy/s, highlighting its potential for low-dose X-ray detection.
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FOOD CHEMISTRY
·
2025
·
IF 9.8
Feifan Li,Li Huang,Chunrui Yuan,Mingzhu Dai,Xiaoxi Yang,Yumiao Lang
The emulsifying properties and stability of high internal phase Pickering emulsion (HIPPEs) stabilized by octenyl succinic anhydride (1 %–26 % by weight of MP) modified myofibrillar protein (OSA-modified MP) were investigated. Using 3 % OSA modified MP to stabilize β-carotene-loaded HIPPEs, and systematically exploring the effect of β-carotene concentration (0.005–0.100 wt%) on internal structural and functional properties of HIPPEs. Results show that as the amount of OSA increases, the emulsion droplets become smaller and more uniform. The HIPPEs stabilized by OSA-modified MP have good thermal stability, storage stability and centrifugation stability, but poor freeze-thaw stability. HIPPEs achieved a 93 % encapsulation efficiency for 0.25 % β-carotene. HIPPEs enriched with carotene demonstrate superior antioxidant performance compared to carotene alone. In addition, the stable emulsion of OSA-modified MP encapsulating β-carotene exhibits a sustained release effect. This study contributes to the advancement of bioactive delivery systems.
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