Drug Design Development and Therapy
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2023
·
IF 4.8
Yi-Jin Wu,Sa-Sa Zhang,Qin Yin,Ming Lei,Qi-Hai Wang,Wen-Gang Chen,Ting-Ting Luo,Peng Zhou,Cong-Lan Ji
Background α-Mangostin (MG) showed the potentials in alleviating experimental arthritis, inhibiting inflammatory polarization of macrophages/monocytes, and regulating peroxisome proliferators-activated receptor γ (PPAR-γ) and silent information regulator 1 (SIRT1) signals. The aim of this study was to analyze the correlations among the above-mentioned properties.Methods Antigen-induced arthritis (AIA) was established in mouse, which was treated with MG in combination with SIRT1/PPAR-γ inhibitors to clarify the role of the two signals in the anti-arthritic actions. Pathological changes were systematically investigated. Phenotypes of cells were investigated by flow cytometry. Expression and co-localization of SIRT1 and PPAR-γ proteins in joint tissues were observed by the immunofluorescence method. Finally, clinical implications from the synchronous up-regulation of SIRT1 and PPAR-γ were validated by experiments in vitro.Results SIRT1 and PPAR-γ inhibitors (nicotinamide and T0070097) reduced the therapeutic effects of MG on AIA mice, and abrogated MG-induced up-regulation of SIRT1/PPAR-γ and inhibition of M1 polarization in macrophages/monocytes. MG has a good binding affinity to PPAR-γ, and MG promoted the co-expression of SIRT1 and PPAR-γ in joints. Synchronously activating SIRT1 and PPAR-γ was revealed to be necessary by MG to repress inflammatory responses in THP-1 monocytes.Conclusion MG binds PPAR-γ and excites this signaling to initiate ligand-dependent anti-inflammatory activity. Due to certain unspecified signal transduction crosstalk mechanism, it then promoted SIRT1 expression and further limited inflammatory polarization of macrophages/monocytes in AIA mice.
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高影响因子
FOOD CHEMISTRY
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2022
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IF 9.231
Yanni Wu,Shudong He,Tiange Pan,Xinya Miao,Jie Xiang,Yongkang Ye,Xiaodong Cao,Hanju Sun
In order to fortify γ-aminobutyric acid (GABA) of brown glutinous rice (BGR), pre-germination strategy was employed, and effects of low-frequency (28 kHz) ultrasound treatment combined with CaCl 2 stress on the sprout length, germination rate, morphology, color, water, total polyphenol content (TPC), starch, protein, GABA contents and relevant metabolites were investigated. The germination rate would be inhibited under CaCl 2 concentration ≥ 2.0 % during 24 h soaking without ultrasound treatment, and no significant difference was also observed combined with 9 h ultrasound treatment. Ultrasound treatment was beneficial to water absorption, TPC enrichment, energy metabolism, lipid metabolism and protein hydrolysis. Higher contents of GABA (3.29 folds), pyruvic acid (7.63 folds), glycerol (4.88 folds), glutamate (2.02 folds) and glucose (1.32 folds) were obtained due to the antagonistic effect between the 30 w ultrasound treatment and 2.0 % CaCl 2 stress at the 9 h pre-germination, and energy, lipid and protein metabolomic pathways were all involved in the GABA accumulation.
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JOURNAL OF ANALYTICAL AND APPLIED PYROLYSIS
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2023
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IF 6
Jida Wang,Zhangshuai Ding,Feng Shi,Yifei Chen,Defa Hou,Fulin Yang,Can Liu,Yi Lu,Xu Lin,Zhifeng Zheng,Yunwu Zheng
An efficient and highly selective CaO-MgO-promoting γ-Al 2 O 3 decarboxylation catalyst was fabricated with different CaO to MgO ratios via a ball-milling method for regulating product distribution and production of gasoline-kerosene-diesel hydrocarbons via the catalytic copyrolysis of oleic acid (OA) and methanol under hydrogen-generating conditions. In addition, influencing factors, reaction mechanisms, possible reaction pathways and deactivation mechanisms were probed. The results showed that combining Ca, Mg and AlOx was vital for boosting oleic acid conversion, and synergy between metal and acid active sites via strong metal-support interactions enhanced deoxygenation-cracking activity. High-alkalinity CaO boosted C-C/C C bond cleavage, and MgO provided medium-strength Lewis acid sites; additionally, a large BET surface area and mesopore volume suppressed excessive hydrocracking reactions, improving biogasoline yield. Methanol addition provided active hydrogen atoms to enhance biogasoline selectivity at the expense of diesel and heavy oil production via olefinic cycles and aromatic cycle mechanisms and reduced coke deposition. The maximum hydrocarbon and biogasoline yields of 94.53% and 57.59% were achieved at OA/methanol= 5:1 and pyrolysis/catalytic temperature= 450/500 °C with1 g catalyst at a feedstock input rate of 0.1 ml/min.
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APPLIED SURFACE SCIENCE
·
2020
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IF 6.182
Pengcheng Wang,Jun Liu,Peiwen Xu,Xinzhen Feng,Weijie Ji
Three morphologically uniform γ-Al 2 O 3 crystallites [Al 2 O 3 hexagonal plates (Al 2 O 3 -HP), stacked hexagonal plates (Al 2 O 3 -SHP) and rods (Al 2 O 3 -R)] were controllably synthesized. The Co-Mo oxide precursor was loaded on these γ-Al 2 O 3 substrates via aqueous incipient wetness impregnation and transformed to the sulfides under 10% H 2 S/H 2 (v/v) atmosphere. The mainly exposed facet of Al 2 O 3 -HP and Al 2 O 3 -SHP was identified to be the (1 1 0) and (1 0 0)/(1 1 1), respectively; whereas a polycrystalline structure was observed over Al 2 O 3 -R. The original structural feature of oxide precursors, i.e., 2D polymeric/monomeric as well as 3D polymeric/MoO 3 species substantially varied over Al 2 O 3 -HP, Al 2 O 3 -SHP, and Al 2 O 3 -R, which in turn determines the effectiveness in sulfidation of surface oxide precursors. The richness of MoS 2 /Co 9 S 8 /Co-Mo-S species, and less fraction of partially sulphurated CoMoO x S 2 as well as CoO x /SO x 2− entities were recognized over Al 2 O 3 -HP. Based on the areal activity at 250 °C, the sulfides-Al 2 O 3 (1 1 0) interface is approximately 6–13.8 times more active than the poly-crystalline or commercial γ-Al 2 O 3 supported sulfides for water gas shift (WGS) in a hydrogen-rich stream. The sulfides-Al 2 O 3 (1 1 0) interface also notably outperformed the sulfides-Al 2 O 3 (1 0 0)/(1 1 1) interfaces for the reaction.
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APPLIED CATALYSIS B-ENVIRONMENTAL
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2018
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IF 11.698
Liping Ren,Wei Zhou,Bojing Sun,Haoze Li,Panzhe Qiao,Yachao Xu,Jiaxing Wu,Kuo Lin,Honggang Fu
Defect-engineered magnetic γ-Fe 2 O 3 ultrathin nanosheets/mesoporous black TiO 2 hollow sphere heterojunctions (γ-Fe 2 O 3 /b-TiO 2 ) are fabricated by a metal-ion intervened hydrothermal technique and high-temperature hydrogenation, which exhibit wide-spectrum response and magnetic separation. The specific surface area, pore size and pore volume of the resultant γ-Fe 2 O 3 /b-TiO 2 with hollow structure are ∼63 m 2 g −1 , 10.5 nm and 0.14 cm 3 g −1 , respectively. After surface hydrogenation, α-Fe 2 O 3 nanosheets are converted to γ-Fe 2 O 3 ultrathin nanosheets (∼6 nm) combined with the formation of surface defects. The ultrathin nanosheet structure facilitates the surface engineering and also favors the diffusion and transportation of photogenerated charge carriers. The apparent rate constant (k) of defect-engineered γ-Fe 2 O 3 /b-TiO 2 photocatalytic degradation biotoxic tetracycline is ∼3 times higher than that of α-Fe 2 O 3 /b-TiO 2 under AM 1.5 irradiation. The enhancement is attributed to the introduction of narrow bandgap unit-cell-thick γ-Fe 2 O 3 nanosheets, the hollow structure and the defect engineering, which are beneficial to solar-light-harvesting and rapid electron transport, and spatial separation of photogenerated charge carriers. The photocatalytic degradation mechanism is also proposed. The novel magnetic γ-Fe 2 O 3 /b-TiO 2 heterojunction is a promising photocatalyst for recovering the domestic sewage in environment.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2024
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IF 9.4
Xiuyun Li,Jie Cai,Ximeng Duan,Yamin Zhang,Min Cui,Shige Wang,Xiao An,Hefeng Wang
Establishing a physical barrier between the peritoneum and the cecum is an effective method to reduce the risk of postoperative abdominal adhesions. Meloxicam (MX), a nonsteroidal anti-inflammatory drug has also been applied to prevent postoperative adhesions. However, its poor water solubility has led to low bioavailability. Herein, we developed an injectable hydrogel as a barrier and drug carrier for simultaneous postoperative adhesion prevention and treatment. A third-generation polyamide-amine dendrimer (G3) was exploited to dynamically combine with MX to increase the solubility and the bioavailability. The formed G3@MX was further used to crosslink with poly-γ-glutamic acid (γ-PGA) to prepare a hydrogel (GP@MX hydrogel) through the amide bonding. In vitro and in vivo experiments evidenced that the hydrogel had good biosafety and biodegradability. More importantly, the prepared hydrogel could control the release of MX, and the released MX is able to inhibit inflammatory responses and balance the fibrinolytic system in the injury tissues in vivo . The tunable rheological and mechanical properties (compressive moduli: from ∼ 57.31 kPa to ∼ 98.68 kPa;) and high anti-oxidant capacity (total free radical scavenging rate of ∼ 94.56 %), in conjunction with their syringeability and biocompatibility, indicate possible opportunities for the development of advanced hydrogels for postoperative tissue adhesions management.
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高影响因子
Journal of Materials Research and Technology-JMR&T
·
2025
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IF 6.6
Xiangjie Duan,Jie Zhao,Shuaida Song,Na Zhou,Jizhuang Fan,Bo Tian,Yunchen Du
The development of non-toxic and flexible polymer-based shielding composites has become a research hotspot due to the severe harm of γ ray to living organisms, mechanical equipment, and environment. However, the γ-ray shielding performance of polymer-based composites in high-energy range remains unsatisfactory. Herein, FLUKA Monte Carlo simulations capable of visualizing γ-photon transport behaviors are investigated in Bi 2 O 3 /PP and WO 3 /PP multi-layer composites with various layered configurations. The simulation results reveal significant anisotropic attenuation effects on shielding characteristics caused by layered configurations and incident path of γ-photons relative to the interface position. Subsequently, single-layer, AB, and sandwich-like ABA composites with a fixed thickness of 2.0 mm are experimentally fabricated via melt-mixing and hot press methods. At 1332 keV, sandwich-like WPPBPPWPP composite (WO 3 /PP outer layers + Bi 2 O 3 /PP core) achieves linear attenuation coefficients and radiation protection efficiency of 0.31 cm −1 and 6 %, respectively, which are 29 % higher than those of single-layer composite. These improvements originate from multiple scattering induced by interlayer interface. Additionally, layered configurations with externally placed high-density fillers (WO 3 ) and internally placed high atomic number fillers (Bi 2 O 3 ) further promote γ-photon attenuation in high-energy range. Experimental results validate the anisotropic shielding trends observed in MC simulations. Moreover, multi-layer composites demonstrate significantly improved energy storage capacity, thermal stability, and oxidation resistance while maintaining comparable to those of single-layer composites. This work provides a scalable strategy for developing non-toxic and flexible shielding materials applicable in nuclear protection, medical devices, and aerospace systems, where lightweight and efficient radiation attenuation are critical.
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高影响因子
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
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2020
·Vol. 413
·期 2
·577-584
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IF 3.637
Xie Qilong,Xia Ming,Sun Dekui,Cao Jiangping,Xiao Yong,Lin Mingui,Hou Bo,Jia Litao,Li Debao
For simultaneous analysis of four fat-soluble tocopherols (α-, β-, γ-, and δ-) in edible oils, an efficient and green method using deep eutectic solvent-based liquid-phase microextraction (DES-LPME) coupled with reversed-phase high-performance liquid chromatography (RP-HPLC) was developed. The DESs formed by different quaternary ammonium salts and ethanol were used as the extractants. Tetrabutylammonium chloride (TBAC)-ethanol DES at a molar ratio of 1:2 achieved the best extraction efficiency. Under the optimized conditions, the detection limits were in the range of 2.1–3.0 ng mL −1 . The intra-day and inter-day repeatability were in the ranges of 3.9–5.3% and 4.8–7.1%, respectively, and the recoveries for the real samples varied from 80.7% to 105.4%. The developed method was successfully employed for the determination of all four tocopherol homologues with an RP-HPLC system containing a COSMOSIL π-NAP column in five edible oils collected locally.
Graphical abstract
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JOURNAL OF MICROENCAPSULATION
·
2019
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IF 2.04
Yingting Wang,Along Zuo,Xiaoyan Huang,Ying Ying,Xinsheng Shu,Xianxiong Chen,Yatao Yang,Junxian Ma,Guimiao Lin,Xiaomei Wang,Lin Mei,Gan Liu,Yingying Zhao
Taxane-based chemotherapy-loaded drug delivery systems have great potential for cancer treatment. The docetaxel (DTX)-loaded PAMAM-based poly (γ-benzyl-l-glutamate)-b-d-α-tocopheryl polyethylene glycol 1000 succinate (PAM-PBLG-b-TPGS) nanoparticles and the docetaxel (DTX)-loaded PAMAM-based poly (γ-benzyl-l-glutamate) (PAM-PBLG) nanoparticles were designed using a modified nanoprecipitation method. The particle size, encapsulation efficiency (EE), and in vitro release characteristics of the nanoparticles were tested. The effects of the two nanoparticles on the cellular uptake and cell viability on human cervical cancer cell line Hela and the human breast cancer cell line MCF-7 were compared. Furthermore, their antitumor efficiency was evaluated through in vivo tumour growth experiment in comparison with free DTX. PAM-PBLG-b-TPGS nanoparticles displayed high EE, smaller diameter, and a nice releasing profile. Besides, based on the high EE and ‘self-controlled’ drug release of the DTX-loaded PAM-PBLG-b-TPGS nanoparticles, they exhibited stronger cytotoxicity (lower survival rate) and higher uptake rate than DTX-loaded PAM-PBLG nanoparticles in Hela cells and MCF-7 cells. Furthermore, compared with DTX-loaded PAM-PBLG nanoparticles and free DTX, DTX-loaded PAM-PBLG-b-TPGS nanoparticles produced a potent anti-tumour effect. Thus, the DTX-loaded PAM-PBLG-b-TPGS nanoparticles provide a novel attractive nanocarrier for the DTX delivery of chemotherapy to human breast cancer cells and human cervical cancer cells.
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高影响因子
Current Pharmaceutical Analysis
·
2024
·Vol. 20
·期 8
·907-919
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IF 0.7
Wenhao Wang,Qinggui Lei,Chuanxi Wang,Qi Huang,Zhengming Qian
IntroductionCordyceps sinensis, a renowned traditional Chinese medicinal substance, contains pharmacologically beneficial compounds, including γ-aminobutyric acid (GABA), necessitating efficient analytical methods for quality assessment. This study aims to develop a rapid, cost-effective, and eco-friendly liquid chromatography-tandem mass spectrometry (LC–MS/MS) method for GABA quantification in Cordyceps sinensis and its related species. The objective is to enhance the quality control standards within the Cordyceps sinensis industry and for those of its related species.MethodsThe study innovated a swift analytical procedure. Optimal conditions were determined through systematic evaluations of extraction solvents, durations, and chromatographic settings, prioritizing speed and solvent minimization.ResultsThe proposed LC–MS/MS method achieved precise quantification of GABA in a reduced time frame and significantly lowered solvent consumption, enhancing method efficiency by 22-fold compared to reported LC methods. The method exhibited robustness and scored the highest blue applicability grade index score, underscoring its suitability for academic and industrial applicaition.ConclusionThe validated LC–MS/MS approach offers a sustainable avenue for the rapid and accurate measurement of GABA in Cordyceps sinensis and its related species, improving the quality control process and ensuring product authenticity. This method stands out as a model for green analytical chemistry, propelling forward the eco-friendly analytical evaluation of health-related compounds.
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高影响因子
PHYTOMEDICINE
·
2025
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IF 8.3
Wei Zhou,Long Zhu,Xiaoran Zu,Yaolei Ma,Pan Shen,Yangyi Hu,Pengfei Zhang,Zhexin Ni,Ningning Wang,Dezhi Sun,Zhijie Bai,Xiang Gao,Chaoji Huangfu,Yue Gao
Background Combined radiation and wound skin injury (RW) are frequently observed in patients undergoing tumor surgery plus radiotherapy, and but specific treatment is lacking. Chitosan (CS) and carboxymethyl cellulose (CMC) are commonly used to prepare hydrogel with good biocompatibility and low toxicity. Cannabidiol (CBD) has presented anti-inflammatory, antioxidant, and neuroprotective properties. Methods CMC, CS, and CBD were used and designed for three types of hydrogels (CMC/CS2/CBD, CMC/CS3/CBD, CMC/CS4/CBD) with different ratios of CMC and CS based on previous report and our preliminary experiments. The CMC/CS/CBD hydrogel was synthesized using electrostatic interaction without chemical crosslinking, characterized via fourier transform infrared (FT-IR), and tested for mechanical properties, swelling behavior, biocompatibility, antioxidant activity, cytotoxicity, and hemocompatibility. 60 Co γ irradiation (5 Gy, 0.62 Gy/min) combined with 1 cm circular trauma was applied to establish RW mice model. Topical applications of CMC/CS3, CMC/CS2/CBD, CMC/CS3/CBD were used to treat RW injury once a day for 10 consecutive days. The mice were euthanized 7, 14, 21 days after radiation, and samples were collected. Results FT-IR confirmed the successful formation of a polyelectrolyte network. The CMC/CS3/CBD hydrogel exhibited optimal mechanical strength, rapid gelation, high swelling capacity, and excellent biocompatibility. Both CMC/CS2/CBD and CMC/CS3/CBD hydrogels effectively improved RW injury 7, 14, 21 days after radiation. Reduced inflammation and increased collagen production were observed the two groups. The significant increased expression of interleukin (IL) - 1β, IL-22, IL-17A, IL-6 , tumor necrosis factor-α, granulocyte-macrophage colony-stimulating factor, C-C motif chemokine ligand (CCL)2, CCL3, CCL4, CCL5, CCL11 in the RW group was greatly inhibited after treatment with CMC/CS3/CBD hydrogel. Transcriptome analysis revealed the hydrogel’s impact on lipid metabolism and epithelial differentiation pathways. Conclusions By integrating CBD into a CMC/CS-based hydrogel without using toxic crosslinkers, this study provides a novel, biomaterial-based, biocompatible approach for RW injury. These findings pave the way for future clinical application of CMC/CS3/CBD hydrogel in RW injury.
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高影响因子
JOURNAL OF HAZARDOUS MATERIALS
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2011
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IF 3.723
Hui Wang,Yuming Huang
Prussian-blue (PB)-modified γ-Fe 2 O 3 magnetic nanoparticles (PBMNPs) were successfully synthesized based on electric interactions between negatively charged [Fe(CN) 6 ] 4− and positively charged γ-Fe 2 O 3 nanoparticles. The in situ PB coating was generated by the coordinating reaction between the adsorbed [Fe(CN) 6 ] 4− and the ferric ions on the surface of γ-Fe 2 O 3 NPs. The as-prepared PBMNPs were characterized by FT-IR, XRD, TEM, and used to remove organic pollutants from aqueous solution, namely, using methylene blue (MB) as model compound. The experimental results showed that the target compound could be removed efficiently from solution over a wide pH range from 3 to 10 in the presence of PBMNPs as peroxidase-like catalyst and H 2 O 2 as oxidant. Under optimal conditions, MB could be removed completely after 120 min of reaction at 298 K; the chemical oxygen demand (COD) removal efficiency and the total organic carbon (TOC) abatement efficiency were 53.6% and 35%, respectively. Furthermore, the PBMNPs catalysts showed high magnetization, temperature tolerance, long-term storage and operational stability, and they could be readily separated from solution by applying an external magnetic field. Finally, a possible reaction mechanism for MB degradation was also discussed.
研究领域:
环境科学
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纳米材料学
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催化化学
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水处理技术
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环境功能材料
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危险品化学品经营许可证（带存储）