CERAMICS INTERNATIONAL
·
2026
·
IF 6
Xinying Zhu,Mingchen Mei,Dingxin Wang,Song Liu,Rui Liu,Xi Kong,Letao Yang,Houbing Huang
Ceramic capacitors with stable dielectric responses at elevated temperatures are of great importance for advanced electronic applications. In this study, high-entropy-engineered (Ba 0.85 Sr 0.15 )TiO 3 –Bi(Mg 2/3 Ta 1/3 )O 3 solid solutions were developed to achieve broad-temperature dielectric stability. Among them, the composition with 25% and 30% Bi(Mg 2/3 Ta 1/3 )O 3 exhibit excellent dielectric properties, exhibiting room-temperature relative dielectric constants of 663 and 680, and dielectric losses of 0.6% and 1.1%, respectively. Particularly, they meet the X9R and X10R specification and dielectric loss of ∼0.6%, with capacitance variation less than ±15% from −74 °C to 265 °C, satisfying the X9R. The composition with 30% Bi(Mg 2/3 Ta 1/3 )O 3 shows the room-temperature dielectric constant of ∼680 and the dielectric loss of ∼1.1%, and showing TCC values within ±15% from −60 °C to 300 °C, which meets the X10R requirement. The improved dielectric temperature stability is associated with high-entropy-induced relaxor behavior together with enhanced high-temperature insulation characteristics, which jointly suppress dielectric loss and leakage current over a broad temperature range. These results demonstrate that high-entropy design is an effective route for developing high-performance temperature-stable dielectric materials for high-temperature capacitor applications.
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高影响因子
ACS Omega
·
2026
·Vol. 11
·期 28
·42728-42741
·
IF 5.2
Kong Wenbin,Su Baoqiang,Gu Han,Huang Weiqiang,Wang Jing,Zhu Yaqi,Xu Rongrong,Tong Dali,Xu Weiping
Cancer
remains a major global health challenge, and conventional
therapies are still limited by poor tumor specificity, therapeutic
resistance, and systemic side effects. Herein, we developed a glutathione
(GSH)-responsive FFSSFF coacervate system for the codelivery of chrysin
(CH) and the autophagy inhibitor 3-methyladenine (3-MA) to induce
tumor-selective autophagic stress. CH activated endoplasmic reticulum
stress and promoted autophagy through the GRP78/PERK and Akt/mTOR
signaling pathways, while 3-MA simultaneously disrupted autophagic
flux, leading to intracellular homeostasis imbalance, mitochondrial
dysfunction, excessive reactive oxygen species accumulation, and tumor
cell death. The resulting CH/3-MA@FFSSFF coacervates exhibited favorable
physicochemical properties, GSH-responsive behavior, efficient intracellular
uptake, and selective accumulation in tumor cells. Both in vitro and
in vivo experiments demonstrated potent antitumor activity of the
CH/3-MA@FFSSFF system. In particular, in an orthotopic lung cancer
model, CH/3-MA@FFSSFF effectively suppressed tumor growth, prolonged
median survival time, and inhibited tumor cell migration and invasion.
Collectively, this study presents a promising liquid–liquid
phase separation-derived coacervate platform for targeted combinational
cancer therapy through the induction of autophagic stress, with enhanced
therapeutic efficacy and reduced off-target toxicity.
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DOI
PubMed
高影响因子
CHEMICO-BIOLOGICAL INTERACTIONS
·
2026
·
IF 5.2
Zongzhong Liu,Yurong Song,Binbin Xie,Pengpeng Xia,Junlin Yang,Jiazuo Zhu,Hua Wang,Tian Wei
The ubiquitous food processing contaminant 3-monochloro-1,2-propanediol (3-MCPD) poses a potential threat to female reproductive health, yet the underlying mechanisms remain largely undefined. Here, we demonstrate that 3-MCPD exposure impairs ovarian function by disrupting germline stem cell (GSC) maintenance in Drosophila . 3-MCPD exposure dose-dependently induced ovarian atrophy, reduced fecundity, and GSC loss. Mechanistically, 3-MCPD triggered Golgi stress, leading to Mitf-dependent transcriptional upregulation of Atg9 . This, in turn, activated autophagy, which selectively degraded E-cadherin, a critical adhesion molecule for GSC maintenance. Notably, GSC-specific E-cadherin overexpression or Atg9 knockdown effectively rescued 3-MCPD-induced ovarian defects. We further identified a direct physical interaction between Atg9 and E-cadherin, corroborated by immunofluorescence co-localization and AlphaFold3 modeling, which revealed high-affinity binding interfaces that likely mediate this selective autophagic degradation. Both E-cadherin and Atg9 exhibit high evolutionary conservation, underscoring the translational relevance of our findings. This study delineates a novel Golgi stress-Mitf-Atg9 axis through which a prevalent food contaminant compromises female fertility, thereby identifying potential targets for intervention.
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DOI
PubMed
高影响因子
Chinese Journal of Natural Medicines
·
2026
·Vol. 24
·期 2
·227-236
·
IF 7.5
Rakotomalala Manda Heriniaina,Xia Chen,Yulian Wu,Wenfeng Liao,He Fei,Peipei Wang,Kan Ding
Pancreatic cancer, specifically pancreatic ductal adenocarcinoma (PDAC), ranks among the most prevalent malignancies and is a leading cause of cancer-related mortality worldwide. Therefore, there is an urgent need to identify novel anti-pancreatic cancer agents. This study reports a newly identified homogeneous polysaccharide, designated ESPPW, isolated from Arthrospira platensis ( A. platensis ). The molecular weight of ESPPW is estimated at 356 kDa, and it consists predominantly of glucose and rhamnose, with minor amounts of mannose, glucuronic acid, galacturonic acid, galactose, xylose, arabinose, and fucose. ESPPW inhibits the proliferation and migration of PDAC cells both in vitro and in vivo . Mechanistic investigations reveal that ESPPW induces apoptosis through activation of caspase-3 and is associated with upregulation of the tumor-suppressor protein p53. Notably, treatment with 2.8 nmol·L −1 of ESPPW leads to significant time-dependent downregulation of galectin-3 (Gal-3) and glypican-6 (GPC-6). These findings are corroborated by immunohistochemical analysis of tumor xenograft tissues. Furthermore, overexpression of Gal-3 and GPC-6 reverses the pro-apoptotic effect of ESPPW, as indicated by restored cycle regulatory proteins (CDK2) expression. In conclusion, these data demonstrate that ESPPW suppresses PDAC cell growth by promoting apoptosis and disrupting the functional activity of Gal-3 and GPC-6.
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DOI
PubMed
高影响因子
JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN
·
2026
·Vol. 40
·期 1
·52
·
IF 3.1
Lu JiaHao,Zhao ChenHao,Qiu YingQI,Shen Li-Qun,Zhu Hua,Zhang Miao
Survivin, a multifunctional regulator of mitosis and apoptosis, plays a central role in cancer progression and therapy resistance, making it an attractive target for anticancer drug development. In this study, a series of 4,6-diphenyl-3-cyanopyridine derivatives were designed and synthesized as potential survivin inhibitors through an integrated strategy combining 3D-QSAR modeling, molecular docking, molecular dynamics simulations, and biological evaluation. The CoMFA and CoMSIA models established reliable structure–activity relationships and provided contour-map-based guidance for rational molecular optimization. Newly designed derivatives displayed enhanced antiproliferative effects against melanoma cells, and computational analyses revealed that the most promising compound showed stable and preferential binding within the BIR domain of survivin, particularly in its dimeric form. These findings demonstrate the effectiveness of contour-guided optimization in discovering novel survivin-targeting scaffolds and highlight 4,6-diphenyl-3-cyanopyridine derivatives as promising leads for further anticancer drug development. Future studies will focus on improving selectivity, clarifying the inhibition mechanism at the molecular level, and evaluating in vivo efficacy.
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PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2013
·
IF 3.172
Jingjing Jiao,Bing Han,Meijia Lin,Ni Cheng,Li Yu,Min Liu
A series of salt-free catanionic surface active ionic liquids (SAILs), 1-alkyl-3-methylimidazolim alkyl sulfates (denoted as [C n mim][C m SO 4 ], n = 6, 8, 10; m = 12 and n = 4; m = 10, 14) were synthesized by an ion exchange reaction and their surface properties in aqueous solution were examined systematically by surface tension, fluorescence and electrical conductivity measurements. As catanionic surfactants, these SAILs exhibit notably higher surface activity, compared to the cationic or anionic analogues. Increment in both cationic and anionic alkyl chain lengths for [C n mim][C m SO 4 ] can both improve the amphiphilic character remarkably. This can be ascribed to cooperative interactions as formation of catanionic pairs between alkyl-substituted imidazolium cations and alkyl sulfate anions. The negative micellization Gibbs free energy values prove that the micellization of all the 1-alkyl-3-methylimidazolim alkyl sulfates investigated is a spontaneous process. Any additional CH 2 group makes the micellization process easier regardless if it is on a cation or an anion. When keeping the total carbon atom number constant, we find that the [C n mim][C m SO 4 ] molecules with greater asymmetric alkyl chains display superior surface activity. This work indicates that the self-assembly of these imidazolium-based salt-free catanionic SAILs can be tailored by adjusting the mismatch of alkyl chains. These SAILs are expected to have potential applications in the fields of colloidal and interface and nanomaterial synthesis.
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高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2018
·Vol. 53
·期 11
·8385-8397
·
IF 2.993
Zhang Hui,Zhao Yanming,Wen Mingming,Dong Youzhong,Fan Qinghua,Kuang Quan,Liu Huatao,Lian Xin
A new sodium ferrous orthophosphate Na
x
Fe 4 (PO 4 ) 3 (1.1 ≤ x ≤ 1.2) with P 2 1 / n symmetry has been successfully synthesized via a solid-state reaction for the first time. The structure consists of FeO 5 pyramids, FeO 6 octahedron, and PO 4 tetrahedra which form large six-sided tunnels along \( \vec{b} \) direction and three- or four-sided tunnels running along \( \vec{a} \) direction. When evaluated as the anode materials for sodium-ion batteries, the first discharge and charge capacities of 553 and 264 mAh g −1 for Na 1.1 Fe 4 (PO 4 ) 3 /C and 583 and 315 mAh g −1 for Na 1.2 Fe 4 (PO 4 ) 3 /C, respectively, can be obtained at 10 mA g −1 current density. Compared to the Na 1.1 Fe 4 (PO 4 ) 3 /C, Na 1.2 Fe 4 (PO 4 ) 3 /C exhibits a better cycling performance, where the charge capacity of about 100 mAh g −1 can still be maintained after 15 cycles. The electrode kinetics are investigated further by the electrochemical impedance spectroscopy.
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高影响因子
DALTON TRANSACTIONS
·
2019
·Vol. 48
·期 27
·10320-10326
·
IF 4.052
Ying-Jie Jia,Yi-Gang Chen,Ting Wang,Yao Guo,Xiao-Fang Guan,Xian-Ming Zhang
Two new alkali–metal bismuth iodates KBi(IO3)3(OH) (1) and NaBi(IO3)4 (2) have been synthesized by a hydrothermal method via tuning of alkali–metal ions. Compound 1 crystallizes in the space group P and features a [Bi(IO3)3(OH)]n chain with eight-membered Bi–O–I–O–Bi–O–I–O rings. The [Bi(IO3)3(OH)]n chain consists of paddlewheel-like dimeric Bi2(OH)2(IO3)4 units linked by IO3 pairs. Compound 2 in the polar space group Cc features a [Bi(IO3)4]− double layer with Bi4I4 eight-membered rings (8-MRs). NaBi(IO3)4 exhibits a strong second harmonic generation (SHG) response of ∼5.0 × KDP (KH2PO4) and a wide transmittance window (0.4–12 μm), and structure analyses and theoretical calculations reveal that polarization results mainly from the proper alignment of the IO3 groups. The calculated electronic structure based on the DFT method indicates that the BiOn and IO3 groups dominate their optical properties.
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高影响因子
POLYMER SCIENCE SERIES B
·
2015
·Vol. 57
·期 5
·522-529
·
IF 0.577
Zhang Qi,Hao Ning,Zhang Qi,Liu Zhiyong
A novel clay-silane coupling agent-polymer hybrid material based on polyvinyl acetate (PVAc)–organophilic montmorillonite (OMMT) and 3-methacryloxypropyltrimethoxysilane (KH570) has been prepared via in situ emulsion polymerization and studied the influence of KH570 on thermostability, tensile behavior and water resistance of nanocomposite. The structure of the nanocomposite was characterized by Fourier transform infrared (FTIR), X-ray diffraction (XRD) and transmission electron microscopy (TEM). The Morphological studies showed that the OMMT was satisfactorily dispersed in the PVAc/OMMT/KH570 nanocomposite and most of them were exfoliated. Thermal properties of the samples were investigated by thermogravimetric analysis (TGA). Thermogravimetry results indicated that the initial weight-loss temperature of PVAc/OMMT/KH570 nanocomposite was enhanced from 241.0 to 298.5°C. The tensile strength was 11.4 ± 0.3 MPa for PVAc/OMMT/KH570 nanocomposite while the value of PVAc was 7.6 ± 0.3 MPa. And the water-resistance obtained by means of water-solution content and water absorption analysis was improved remarkably as well. Generally speaking, we synthesized PVAc/OMMT/KH570 nanocomposite with excellent thermostability, good mechanical property and superior water-resistance.
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高影响因子
APPLIED SURFACE SCIENCE
·
2017
·
IF 3.387
Yan Zhao,Yang Gao
The microstructure of plasma-sprayed nanostructured yttria-stabilized zirconia (YSZ) coatings may change during high-temperature exposure, which would influence the coating performance and service lifetime. In this study, the phase structure and the microstructural evolution of 3YSZ (zirconia-3 mol% yttria) and 5YSZ (zirconia-5 mol% yttria) nanostructured coatings were investigated by means of sintering at 1400 °C for 50–100 h. The microhardness, elastic moduli, and thermal shock cycles of the 3YSZ and 5YSZ nanostructured coatings were also investigated. The results showed that the redistribution of yttrium ions at 1400 °C caused the continuous increase of monoclinic-phase zirconia, but no obvious inter-splat cracking formed at the cross-sections, even after 100 h. Large voids appeared around the nanoporous zone because of the sintering of nanoscale granules upon high-temperature exposure. The microhardness and elastic moduli of the nanostructured coatings first increased and then decreased with increasing sintering times. The growth rate of the nanograins in the 3YSZ coating was lower than that in 5YSZ, which slowed the changes in 3YSZ coating porosity during sintering. Although the 3YSZ coating was prone to monoclinic phase transition, the experimental results showed that the thermal shock resistance of the 3YSZ coating was better than that of the 5YSZ coating.
研究领域:
材料科学
·
表面工程
·
陶瓷涂层
·
热障涂层
·
高温材料
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高影响因子
JOURNAL OF MOLECULAR LIQUIDS
·
2019
·
IF 4.561
Qi Liu,Xiaoxiao Chen,Yan Guo,Chuanhong Han,Jing Li,Lihan Jia,Jie Liu,Xilian Wei
A ternary phase diagram of the system of 1-butyl-3-methylimidazolium tetrafluoroborate ([ Bmim ]BF4), sodium dodecylbenzenesulfonate (SDBS) and water using ocular estimate and turbidity method was drawn based on experimental data at 298.2 K. We got a narrow aqueous two-phase region near the side of water-ionic liquid (IL). A series of samples with different compositions around the phase diagram were chosen. The enthalpy change of these systems after injecting triply distilled water into these samples has been studied by using isothermal titration microcalorimetry (ITC). It is found that with increasing the water content there are weak endothermic and exothermic processes appearing, separately, which matches perfectly with the location of the formation and disappearance of the aqueous two-phase in the ternary phase diagram. This suggests the ITC is a feasible and effective method for the thermodynamic study of aqueous two-phase systems (ATPS) and was first reported. The experimental results show that the formation of the ATPS is endothermic (Δ H > 0), but the process of disappearing is exothermic (Δ H < 0). Due to the formation of aqueous two-phase is a thermodynamic spontaneous process under the isothermal constant pressure, we can judge that the formation of this ATPS is an entropy driven course and the vanishing is a synergy driven process by entropy and enthalpy.
研究领域:
物理化学
·
热力学
·
胶体与界面化学
·
分离科学
·
分析化学
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高影响因子
Advanced Optical Materials
·
2022
·Vol. 11
·期 3
·2202195
·
IF 10.05
Xiaojing Li,Zilong Chen,Fuming Li,Fangfang Zhang,Zhihua Yang,Shilie Pan
A long-lasting challenge in ultraviolet (UV) nonlinear optical (NLO) materials design is to combine conflicting and harsh properties into one structure, including wide UV transparency, strong NLO efficiency, and moderate birefringence to realize phase-matching at short wavelength. A fluorine-directed material design strategy is adopted to accelerate the process of finding NLO materials with optimal performances. In this work, taking LiB 3 O 5 (LBO) as a maternal structure, one O atom with two F atoms is substituted and LiNaB 6 O 9 F 2 which possesses novel double interpenetrating 3 [B 6 O 9 F 2 ] ∞ networks and fluorine-directed optimal performances including enhanced birefringence and phase-matching capacity is successfully obtained. The perfect balance among deep-UV cutoff edge, large second-harmonic generation (SHG) response (1.1 × KDP), and moderate birefringence (0.067 at 1064 nm) of LiNaB 6 O 9 F 2 makes it a promising UV NLO crystal.
研究领域:
材料科学
·
晶体化学
·
非线性光学
·
功能材料
·
固体化学
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高影响因子
危险品化学品经营许可证（带存储）