JOURNAL OF POWER SOURCES
·
2018
·
IF 6.945
Na Wang,Gaoyi Han,Hua Song,Yaoming Xiao,Yanping Li,Ying Zhang,Hongfei Wang
Thin layers of continuous gold have been deposited on the both sides of porous polypropylene films (PPF) via electroless plating method to form a sandwich structure with two conductive surfaces and an intermediate insulating layer (Au/PPF/Au). Then poly (3, 4-ethylenedioxy thiophene) (PEDOT) layers are electrodeposited on the two conductive sides via cyclic voltammetry method to form the sandwich-structured PEDOT-Au/PPF/Au-PEDOT. Gel electrolyte of H 3 PO 4 /polyvinyl alcohol (H 3 PO 4 /PVA) is then added to the sandwich-structured PEDOT-Au/PPF/Au-PEDOT to form the integrated flexible supercapacitor of Au-PEDOT|H 3 PO 4 /PVA|PEDOT-Au. The PEDOT-Au/PPF/Au-PEDOT sandwiched structures are characterized and the capacitive performances of the integrated flexible cells are investigated in detail. The results show that the optimum integrated flexible cell exhibits excellent cycling stability (91.8% capacitance retention after 20000 cycles) and relatively high areal specific capacitance. Furthermore, the cells of Au-PEDOT|H 3 PO 4 /PVA|PEDOT-Au not only exhibit excellent bending endurance (99.1% capacitance retention after 5000 repeated bending cycles), but also can be conveniently connected in series without additional wires. This integrated flexible cell may exhibit potential application in portable electronics.
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CURRENT PHARMACEUTICAL BIOTECHNOLOGY
·
2024
·Vol. 25
·期 4
·477-487
·
IF 2.2
Chen Jianmin,Yu Sijin,He Zemin,Zhu Danhong,Cai Xiaozhen,Ruan Zhipeng,Jin Nan
Background: Cinnamic acid and its derivatives have gained significant attention in recent medicinal research due to their broad spectrum of pharmacological properties. However, the effects of these compounds on xanthine oxidase (XO) have not been systematically investigated, and the
inhibitory mechanism remains unclear. Objectives: The objective of this study was to screen 18 compounds and identify the XO inhibitor with the strongest inhibitory effect. Furthermore, we aimed to study the inhibitory mechanism of the identified compound. Methods: The effects of
the inhibitors on XO were evaluated using kinetic analysis, docking simulations, and in vivo study. Among the compounds tested, 4-NA was discovered as the first XO inhibitor and exhibited the most potent inhibitory effects, with an IC50 value of 23.02 ± 0.12 μmol/L.
The presence of the nitro group in 4-NA was found to be essential for enhancing XO inhibition. The kinetic study revealed that 4-NA inhibited XO in a reversible and noncompetitive manner. Moreover, fluorescence spectra analysis demonstrated that 4-NA could spontaneously form complexes with
XO, referred to as 4-NA–XO complexes, with the negative values of ΔH and ΔS. Results: This suggests that hydrogen bonds and van der Waals forces play crucial roles in the binding process. Molecular docking studies further supported the kinetic analysis and provided insight
into the optimal binding conformation, indicating that 4-NA is located at the bottom outside the catalytic center through the formation of three hydrogen bonds. Furthermore, animal studies confirmed that the inhibitory effects of 4-NA on XO resulted in a significant reduction of serum uric
acid level in hyperuricemia mice. Conclusion: This work elucidates the mechanism of 4-NA inhibiting XO, paving the way for the development of new XO inhibitors.
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POLYMER JOURNAL
·
2019
·Vol. 52
·期 1
·145-152
·
IF 2.639
Bai Hongyuan,Han Li,Ma Hongwei,Yang Lincan,Li Chao,Liu Pibo,Shen Heyu,Lei Lan,Zhang Songbo
A sulfur-containing styrene derivative, 4-methylenethiochromane (META), was subjected to anionic copolymerization with isoprene (Ip) modified with different additives. The reactivity of META can be effectively regulated with additives; thus, gradient and alternating copolymers were prepared in a facile manner. When THF and TMEDA were utilized in the copolymerization, the reactivity was better than that observed without additives, and thus, gradient copolymers with different gradient extents can be synthesized. In addition, metal alkoxides (such as sodium 2,3-dimethylpentan-3-olate (NaODP) and potassium tert -butoxide ( t -BuOK)) were better able to regulate the reactivity, and the copolymers exhibited alternating and nearly alternating sequences. Therefore, the regulation of the alternating or gradient copolymerization of META and Ip was facilely realized through the use of additives.
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Journal of Physical Chemistry C
·
2022
·
IF 4.177
Tongxin Xiao,Ying Chen,Yuning Liang
The photocatalytic conversion of CO2 into hydrocarbon fuels by utilizing abundant solar energy is a promising and eco-friendly approach to address the energy crisis and global warming. In this work, the sensitizer Ni(II) tetra(4-carboxylphenyl)porphyrin (NiTCPP) was successfully combined with TiO2 nanotube arrays (TiO2NTs) by three methods, and their performances in the photocatalytic reduction of CO2 under simulated solar irradiation were studied. The results showed that NiTCPP/TiO2NTs exhibit a greatly ameliorated photocatalytic activity, and the photocatalytic reduction activities of NiTCPP/TiO2NTs prepared by different methods were different. The catalyst prepared by the impregnation method displayed the highest photoreduction efficiency. The reduction rate of CO2 into CH4 was up to 33.89 μmol/cm2/h with a quantum efficiency of 0.65% (at 420 nm), about 5 times that of the bare TiO2NTs. The introduction of NiTCPP not only efficiently expands the light absorption range but also enhances the charge separation efficiency. Furthermore, a possible mechanism of its CO2 photoreduction performances was systematically presented.
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Cell Reports
·
2023
·Vol. 42
·期 11
·113349-113349
·
IF 8.8
Shao Q,Wijaya CS,Wang S,Meng X,Yuan C,Ma C,Xu S
Maintaining cellular viability relies on the integrity of the plasma membrane, which must be repaired upon damage. Soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE)-mediated membrane fusion is a crucial mechanism involved in membrane repair. In C. elegans epidermal cell hyp 7, syntaxin-2 (SYX-2) facilitates large membrane wound repair; however, the underlying molecular mechanism remains unclear. Here, we found that SNAP-25 protein RIC-4 and synaptobrevin protein SEC-22 are required for SYX-2 recruitment at the wound site. They interact to form a SNARE complex to promote membrane repair in vivo and fusion in vitro. Moreover, we found that SEC-22 localized in multiple intracellular compartments, including endosomes and the trans-Golgi network, which recruited to the wounds. Furthermore, inhibition of RAB-5 disrupted SEC-22 localization and prevented its interaction with SYX-2. Our findings suggest that RAB-5 facilitates the formation of the RIC-4/SEC-22/SYX-2 SNARE complex and provides valuable insights into the molecular mechanism of how cells repair large membrane wounds.
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JOURNAL OF ORGANIC CHEMISTRY
·
2023
·
IF 3.6
Wen Li,Hexiang Wang,Yuan Zhang,Limin Zhao,Pengfeng Guo,Hua Cao,Xiang Liu
Pyridinium 1,4-zwitterionic thiolates were regarded as powerful and versatile building blocks to prepare nitrogen- and sulfur-containing heterocycles. Herein, we reported a copper-catalyzed formal [4 + 1] annulation of pyridinium 1,4-zwitterionic thiolates and diazo compounds without any additives to access a library of trifunctionalized indolizines in good yields. Besides, isoquinolinium 1,4-zwitterionic thiolates and imidazolium 1,4-zwitterionic thiolates were also applied to this formal [4 + 1] annulation reaction. Of particular note is that various functional groups such as −CO2R, −CO2NR2, −CF3, −CN, and −(O)P(OR)2 could be easily introduced into cycloaddition products indolizines by this strategy.
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Catalysts
·
2021
·Vol. 11
·期 11
·1336
·
IF 4.146
Xiaolong Zhang,Lei Chen,Yang Liu,Qian Duan
Composite nanostructure materials are widely used in catalysis. They exhibit several characteristics, such as the unique structural advantage and the synergism among their components, which significantly enhances their catalytic performance. In this work, CoPt nanoparticles and reduced-graphene-oxide-based nanocomposite catalysts (rGO/CoPt, rGO/CoPt/Ag) were prepared by using a facile co-reduction strategy. The crystalline structure, morphology, composition, and optical characteristics of the CoPt nanoparticles, rGO/CoPt nanocomposite, and rGO/CoPt/Ag nanocomposite catalysts were investigated by a set of techniques. TheID/IGvalue of the rGO/CoPt/Ag nanocomposite is 1.158, higher than that of rGO/CoPt (1.042). The kinetic apparent rate constant, k, of the rGO/CoPt/Ag nanocomposite against 4-nitrophenol (4-NP) reduction is 5.306 min−1, which is higher than that of CoPt (0.495 min−1) and rGO/CoPt (1.283 min−1). The normalized rate constant, knor, of the rGO/CoPt/Ag nanocomposite is 56.76 min−1mg−1, which is higher than some other catalytic materials. The rGO/CoPt/Ag nanocomposite shows a significantly enhanced catalytic performance when compared to CoPt nanoparticles and the rGO/CoPt nanocomposite, which may confirm that the novel rGO/CoPt/Ag nanocomposite is a promising catalyst for the application of catalytic fields.
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PLoS One
·
2021
·Vol. 16
·期 9
·e0255504
·
IF 3.24
Jing Zhang,Zhou-Tao Pei,Ya-Ni Zhao,Meng Zhang,Li-Ling Zhang,Wen-Qiang Wang,Jing-Ya Wu,Ran Yu,Li-Wei Sun
Benzophenone (BPs) and 4-Methylbenzylidene Camphor are used as ultraviolet (UV) filters to protect the skin and hair in personal care products. The discharging of the three chemicals may endanger the receiving water ecosystem. In the present study, the mutagenicity of BP-6, BP-8, and 4-Methylbenzylidene Camphor was tested using the Salmonella typhimurium reverse mutation test (Ames test) in the system with and without rat liver microsomal preparations (S9). Four S . typhimurium strains, TA97, TA98, TA100, and TA102 were employed in the Ames tests. The mutagenicity was detected from all three chemicals. The addition of S9 increased the mutation ratios of three chemicals to four strains, except BP-6 to TA100 strain and 4-MBC to TA97 and TA98 strain. In the mixed experiment, all positive effects were detected in the absence of S9. However, the results all became negative in the presence of S9. For the mixture of BP-6 and 4-MBC, positive results were detected on four tester strains except for the TA100 strain. For the mixture of BP-6, BP-8, and 4-MBC, positive results were detected on four strains. The mixture test results showed antagonism in mutagenicity for the mixture of BP-6 and 4-MBC to TA98 and TA100 strains and the mixture of BP-6, BP-8, and 4-MBC to TA100 and TA102 strains.
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Journal of Physical Chemistry C
·
2019
·
IF 4.309
Bo Yu,Bo Han,Xinrui Jiang,Chenggang Zhou,Kaisheng Xia,Qiang Gao,Jinping Wu
Catalytic hydrogenation of 4-nitrophenol (4-NP) to 4-aminophenol (4-AP) is widely recognized as one of the most effective solutions to deal with the water-related environmental issues, where catalysts with high activity and long cycle life are always pursued. In this paper, oxygen-rich boron nitride (BNO)-supported Au nanoparticles (Au/BNO) were proposed to serve as catalysts for 4-NP hydrogenation. Our results show that the Au nanoparticles are well dispersed on the highly porous BNO substrate with a small particle size of 2.2 nm. Under the optimal reaction conditions, the 4-NP molecules could be completely reduced to 4-AP in 2.5 min over Au/BNO with a relatively high conversion rate constant of 2.25 min–1. Moreover, the as-synthesized Au/BNO is also highly stable with no visible efficiency decay after been reused for several times. The excellent durability of the catalyst could be ascribed to the strong anchoring strength between the Au nanoparticles and BNO substrate, leading to a negligible metal loss or particle agglomeration upon cycling. The role of O heteroatoms in promoting the activity and durability of the Au/BNO catalyst was further confirmed by first-principles calculations. Our simulation results indicate that the high activity of Au/BNO could be attributed to the strong π–π attraction between BNO and 4-NP, which facilitates the fast diffusion of 4-NP molecules to the surface of Au/BNO. The long cycle life of Au/BNO is correlated to the partially destroyed electronic conjugation of the substrate, leading to a relatively strong coordination interaction between BNO and the Au atom to stabilize the metal nanoparticles.
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LANGMUIR
·
2025
·
IF 3.9
Zixu Ren,Yu Yu,Dingyang Chen,Minsi Shi,Rui Zhao
Polyamidoxime fibers have been widely studied for uranium extraction from seawater, but improving the amidoxime (AO) group utilization and increasing the selectivity toward uranium remain challenging. Herein, a hyperbranched macromolecular cross-linking strategy was employed to construct hyperbranched polyethylenimine (PEI) among the molecular chains of polyamidoxime nanofibers (PAN/PEI-AO nanofibers). This approach simultaneously suppressed chain entanglement and effectively reduced hydrogen bond formation between amidoxime groups, thereby significantly enhancing the utilization efficiency of AO groups. Moreover, the PEI structure also facilitated the dissociation of CO32– from uranyl tricarbonate ([UO2(CO3)3]4–) and comprised amino groups as assistant groups for enhanced uranium uptake. The above cross-linking effect by PEI was confirmed by experimental data and theoretical calculation, resulting in high uranium uptake (474.8 mg g–1) alongside good deep removal capability (kd = 7.7 × 105 mL g–1) from [UO2(CO3)3]4– solution. Moreover, PAN/PEI-AO nanofibers also exhibited good selectivity and reusability toward uranium and showed a uranium extraction capacity of 8.24 mg g–1 after 20 days’ testing from natural seawater. The obtained adsorption performance of PAN/PEI-AO nanofibers exceeded traditional polyamidoxime nanofibers and many reported uranium adsorbents. Overall, this work offers a strategy to improve the performance of polyamidoxime fibers, which possess the potential to extract real uranium species from natural seawater.
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CHIRALITY
·
2025
·Vol. 37
·期 11
·e70060
·
IF 3
Shuling Dong,Jiayi Sun,Fan Ding,Ji Wu,Ronghua Fan,Li Zhou
In this work, a new strategy was proposed for the preparation of a chiral stationary phase based on β-cyclodextrin and calix[4]arene polymer. The chiral stationary phase was characterized by scanning electron microscopy, energy dispersive x-ray spectroscopy, Fourier transform infrared spectroscopy, and thermogravimetric analysis. The introduction of calix[4]arene polymer increased chirality recognition by increasing recognition sites and interactions, including hydrogen bonding, π–π interaction and synergistic inclusion effect. Compared with the home-made β-cyclodextrin–based chiral column, the prepared β-cyclodextrin–calix[4]arene polymer-based chiral column showed superior enantioseparation performance toward 1-phenylethanol, prothioconazole, promethazine, propranolol, and bisoprolol. These chiral compounds can be separated within 10 min under reversed-phase mode with resolutions ranging from 1.62 to 1.80. These findings will provide an important reference for developing novel supramolecule-based chiral stationary phases.
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Nature Communications
·
2025
·Vol. 16
·期 1
·10551
·
IF 15.7
Meng Qingcai,Li Chengxi,Cai Yuping,Chen Ying,Chen Xiaoqing,Wang Xin,Zhang Biling,Zhang Yue,Liu Feng,Chen Meixin
Itaconate accumulates in macrophages upon bacterial infection, and manifests antibacterial activity. Convincing evidence substantiates that itaconate is transported across the plasma membrane and vacuolar membrane, but the molecular bases underlying bidirectional transport of itaconate across membranes and its effects on intracellular bacterial replication are less known. Here, we identify MCT1 and MCT4 as bidirectional transporters of itaconate. In addition to modulating itaconate concentration as transporters at the plasma membrane, MCT1 and MCT4 function as itaconate transporters at Salmonella -containing vacuole (SCV). Upon Salmonella infection, MCT1 and MCT4 transport itaconate into SCV facilitated by RAB32. Itaconate is also secreted out of cells through MCT1 and MCT4 as the infection persists. The suppression of MCT1 and MCT4-dependent itaconate secretion increases the overall concentration of itaconate and the proportion of itaconate-targeted Salmonella intracellularly, consequently inhibiting Salmonella replication. Our study thus offers valuable insights into itaconate transport during bacterial infection and provides proof of principle for the development of itaconate-dependent therapeutic strategies.
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