Crystals
·
2021
·Vol. 11
·期 7
·769
·
IF 2.589
Yazhou Qin,Binjie Wang,Yuanzhao Wu,Jiye Wang,Xingsen Zong,Weixuan Yao
Bimetallic nanoparticles have received extensive attention due to their unique physical and chemical properties, including enhanced optical properties, chemical stability, and better catalytic activity. In this article, we have successfully achieved the controllable preparation of Ag@Au nanoparticles via a seed-mediated growth method. By regulating the amount of seeds—silver nanospheres—we realized that Ag@Au nanoparticles gradually changed from spherical to a sea-urchin-like structure. The structure and composition of the prepared nanoparticles were characterized via scanning electron microscopy (SEM), transmission electron microscopy (TEM), energy-dispersive X-ray spectroscopy (EDS), and high-angle circular dark field scanning transmission electron microscopy (HAADF-STEM). In addition, we use the prepared Ag@Au nanoparticles as a substrate material for highly sensitive surface-enhanced Raman spectroscopy (SERS). Using 4-aminothiophenol (4-ATP) as the test molecule, we explored the SERS enhancement effects of Ag@Au nanoparticles with different structures. Furthermore, we used Ag@Au nanoparticles for SERS to detect the drug fentanyl, and realized the label-free detection of fentanyl, with the lowest detection concentration reaching 10−7M. This research not only provides a method for preparing bimetallic Ag@Au nanoparticles with different structures, but also provides a reference for the application of Ag@Au nanoparticles in the field of detection technology.Keywords:Ag@Au nanoparticle;core–shell structure;sea-urchin-like structure;SERS;fentanyl
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CERAMICS INTERNATIONAL
·
2021
·
IF 4.527
Tianran Wang,Peitao Dong,Chushu Zhu,Weiye Gao,Pengxing Sha,Yulie Wu,Xuezhong Wu
As an emerging label-free detection technology, surface-enhanced Raman scattering (SERS) has been used for biological detection, food safety, and environmental pollution owing to its high sensitivity, specificity and rapid response. However, traditional SERS substrates are unstable, prone to agglomeration, and demonstrate low productivity and high production cost. In this work, hybrids of a two-dimensional electron gas (2DEG) Ti 3 C 2 T x monolayer and Au nanorods (AuNRs) were fabricated via self-assembly. Ti 3 C 2 T x :AuNRs ratios were prepared, and each hybrid's SERS activity was evaluated through 4-aminothiophenol (pATP) detection. The Ti 3 C 2 T x /AuNRs-1 substrate exhibited the weakest SERS performance, whereas the Ti 3 C 2 T x /AuNRs-3 substrate had the best SERS activity enhancement, with a pATP limit of detection (LOD) of 10 −9 M. When 30 sites on substrates were selected for SERS detection, the relative standard deviation (RSD) was found to be only 7.18 %, revealing the good performance sensitivity and high reproducibility of the Raman signal. The sensitivity of Ti 3 C 2 T x /AuNRs-3 was also assessed with respect to a hazardous chemical, 1,2-bis (4-pyridyl) ethylene (BPE), revealing an LOD of 10 −12 M. For thiram, the LOD of Ti 3 C 2 T x /AuNRs-3 was 10 −8 M, which is considerably lower than the 1 ppm industry safety standard. A relative standard deviation RSD of 7.94 % indicates the high reproducibility and uniformity of the Raman signal of thiram for Ti 3 C 2 T x /AuNRs-3. Compared with the LODs of 10 −5 M and 10 −6 M for commercial substrates T-SERS and Au nanorod arrays (AuNRAs), respectively, the 10 −8 M LOD of our synthesized Ti 3 C 2 T x /AuNRs indicates good sensitivity. Three kinds of pesticides were detected by Ti 3 C 2 T x /AuNRs, and only Raman signal of thiram can be found, revealing the good selectivity for thiram. These results for Ti 3 C 2 T x /AuNRs suggest its potential to serve as a novel SERS platform.
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JOURNAL OF ALLOYS AND COMPOUNDS
·
2021
·
IF 5.316
Yazhou Qin,Yuanzhao Wu,Binjie Wang,Jiye Wang,Weixun Yao
Compared with silver nanoparticles, gold nanoparticles have excellent chemical resistance and biocompatibility, while silver nanoparticles have more excellent local surface plasmon resonance characteristics than gold. In this article, we developed a simple method for growing island-shaped gold nanoparticles on the surface of silver nanowires (NWs), so that the prepared Ag@Au NWs have both the advantages of Au and Ag without their disadvantages. Furthermore, by changing the reaction parameters, we achieved the regulation of the density of island-shaped gold nanoparticles on the Ag NWs surface, thereby optimizing its LSPR performance. We use the prepared Ag@Au NWs as the base material for highly sensitive Surface enhanced Raman scattering (SERS) detection. By using 4-aminothiophenol (4-ATP) as the test molecule to explore the uniformity of the prepared SERS substrate, the detection limit of 4-ATP reached 10 -9 M. And 10 points were randomly selected for testing and the RSD was 7.4%, indicating the Ag@Au NWs SERS substrates had excellent uniformity. Furthermore, we have achieved highly sensitive SERS detection of 5 tropane alkaloids including L -Hyoscyamine, Anisodamine, Scopolamine Hydrobromide, scopolamine methyl bromide and scopolamine butyrate bromide. The limit of detection is 10 -9 M, 10 -10 M, 10 -9 M, 10 -9 M and 10 -10 M. Furthermore, by analyzing the obtained SERS spectra, we realized the differentiation of 5 kinds of tropane alkaloids by their characteristic peaks.
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ChemSusChem
·
2021
·Vol. 15
·期 13
·e202101983
·
IF 8.928
Yanan Wei,Yunlei Zhang,Yao Chen,Fang Wang,Yu Cao,Wen Guan,Xin Li
Graphical Saving face : Catalytic performance of Au/CeO 2 with different exposed CeO 2 crystal faces for oxidation of 5-hydroxymethlfurural to 2,5-furandicarboxylic acid is dependent on the oxygen vacancy (V O ) concentration. Higher V O concentration of Au/rod-CeO 2 (110) is more beneficial for adsorption of oxygen and formation of active oxygen species than Au/cube-CeO 2 (100) and Au/oct-CeO 2 (111). Developing an efficient catalyst to upgrade 5-hydroxymethylfurfural (HMF) to high-value-added downstream chemicals is of great significance in biomass conversion. Nanorod (110)-, nanocube (100)-, and nanooctaheron (111)-CeO 2 -supported Au nanoparticles were prepared to investigate the intrinsic effect of CeO 2 crystal faces on the oxidation of HMF to 2,5-furandicarboxylic acid (FDCA). The experimental results and density functional theory calculation revealed that the concentration of oxygen vacancy (V O ) for exposed specific crystal faces was crucial to the oxygen adsorption ability, and Au/nanorod-CeO 2 with the highest V O concentration promoted the formation of more oxygen active species (superoxide radical) on CeO 2 (110) crystal face than (100) and (111) crystal faces. Besides, the higher V O concentration could provide a strong adsorption ability of HMF, greatly boosting the activation of HMF. Thus, these results led to a superior catalytic activity for HMF oxidation over Au/nanorod-CeO 2 (FDCA yield of 96.5 %). In-situ Fourier-transform (FT)IR spectroscopy uncovered the HMF oxidation pathway, and the possible catalytic mechanism was proposed. The deep insight into the role of regulation for crystal faces provides a basis for the rational design of highly active facets for the oxidation of HMF and related reactions.
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CERAMICS INTERNATIONAL
·
2021
·
IF 4.527
Yu Liang,Wei Li,Xuan Wang,Run Zhou,Hao Ding
TiO 2 –ZnO/Au ternary heterojunction nanocomposite was fabricated by producing TiO 2 nanosheets first using solvent-thermal method followed by Au deposition and ZnO deposition respectively. The TiO 2 nanosheets provide a relatively large surface area for the good dispersion of ZnO nanoparticles and Au particles and sufficient contact with the medium, which contribute to the excellent photocatalytic performances of TiO 2 –ZnO/Au heterojunction composite. The phases and structures, morphologies, surface and optical properties of the ternary heterojunction composite are well-characterized. Subsequently, the photocatalytic hydrogen generation of TiO 2 –ZnO/Au is evaluated under visible light irradiation. TiO 2 –ZnO/Au ternary heterojunction composite has efficient light absorption ability and excellent performances in photocatalytic hydrogen generation (1068 μmol/g under the irradiation of visible light for 4 h) and antibacterial properties (reaching 98.2%). TiO 2 –ZnO/Au ternary heterojunction nanocomposite has a large potential to be used in areas such as interior wall coating.
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ANALYTICAL CHEMISTRY
·
2021
·
IF 6.986
Guanglei Li,Jia Hao,Wenli Li,Fangyuan Ma,Tuotuo Ma,Wei Gao,Yiting Yu,Dan Wen
Wearable biosensors for real-time and non-invasive detection of biomarkers are of importance in early diagnosis and treatment of diseases. Herein, a high-performance wearable biosensing platform was proposed by combining a three-dimensional hierarchical porous Au hydrogel-enzyme electrode with high biocompatibility, activity, and flexibility and soft-MEMS technologies with high precision and capability of mass production. Using glucose oxidase as the model enzyme, the glucose sensor exhibits a sensitivity of 10.51 μA mM–1 cm–2, a long durability over 15 days, and a good selectivity. Under the mechanical deformation (0 to 90°), it is able to maintain an almost constant performance with a low deviation of <1.84%. With the assistance of a wireless or a Bluetooth module, this wearable sensing platform achieves real-time and non-invasive glucose monitoring on human skins. Similarly, continuous lactic acid monitoring was also realized with lactate oxidase immobilized on the same sensing platform, further verifying the universality of this sensing platform. Therefore, our work holds promise to provide a universal, high-performance wearable biosensing platform for various biomarkers in sweat and reliable diagnostic information for health management.
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DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
·
2019
·
IF 2.367
Jian Wang,Yamin Zhang,Lei Liu,Zilin Cui,Xiaolong Liu,Lianjiang Wang,Yang Li,Qiang Li
Chemotherapy has been widely used for treatment to malignant cancer, such as hepatocellular carcinoma (HCC). Chemotherapeutic effect was not often efficient to achieve totally tumor ablation due to the poor cellular uptake and drug resistance. To address these problems, a novel nanoplatform was constructed based on nontoxic mesoporous silica nanoparticles (MSNs) for a combined chemo/photothermal therapy to enhance tumor cell accumulation and promote toxicity of chemotherapeutic drugs. Prepared MSNs were consisted of Au nanoshell for photothermal conversion and a first-line anti-HCC drug-sorafenib (SO) for chemotherapy. The SO-Au-MSNs could help SO accumulate more in hepatic cancer cells. Under near infrared irradiation, SO-Au-MSNs exerted a high cell inhibition rate which could be attributed to the enhanced toxicity of SO under hyperthermia and synergistic chemo/photothermal therapy. SO-Au-MSNs showed a good compatibility as well as efficient cell cytotoxicity. Overall, SO-Au-MSNs would be a promising candidate for further enhancing the antitumor effect on HCC.
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CANADIAN JOURNAL OF CHEMICAL ENGINEERING
·
2019
·Vol. 98
·期 3
·767-774
·
IF 1.61
Yuchao Li,Yun Tian,Yanxia Zheng,Tingting Ge,Zhongjun Fu,Tiantian Jiao,Ming Wang,Haofei Huang,Cuncun Zuo
A series of Zr-doped CeO 2 nanorods supported by Au nanoparticle catalysts with different morphologies were prepared for methyl methacrylate (MMA) synthesis via direct oxidation esterification of methacrolein (MAL) with methanol. Catalytic activities under mild conditions (0.3 MPa; 80°C) were evaluated in the kettle reactor. Different characterization methods, such as XRD, Raman, N 2 adsorption, ICP, TEM, SEM, XPS, and H 2 -TPR techniques, were applied to study the relationship between catalytic activity and structural characteristics, especially the form of Zr doped into the lattice of CeO 2 and the promotion mechanism of selective oxidation. The influence of Au supported on Ce 0.6 Zr 0.4 O 2 nanorods (Au/CZ-R) was also discussed. The results exhibited that the highest catalytic activity for the oxidative esterification with a MAL conversion of 99% and a MMA selectivity of 74% was achieved. The MMA synthesis performance correlated well with the surface oxygen vacancies, in particular for the active oxygen species around the Au particles.
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ACS Applied Materials & Interfaces
·
2019
·
IF 8.456
Lifeng Hang,Hailiang Li,Tao Zhang,Dandan Men,Cong Zhang,Peng Gao,Qianling Zhang
Recently, the chemodynamic therapy (CDT) has been widely reported and applied to tumor therapy. However, only low level hydroxyl radicals (•OH) generated by the endogenous hydrogen peroxide alone are insufficient to kill the cancer cells. To overcome the insufficient therapeutic effect, this study reports a novel CDT based on Fenton catalyst Au@Prussian blue nanocubes (Au@PB NCs), subsequently encapsulated with doxorubicin (Dox). The in vitro and in vivo results indicate that the Dox-Au@PB NCs can take synergistic effects on tumor suppressor by CDT. In addition, Au@PB NCs possess high X-ray computed tomography contrast enhanced efficiency about ∼27.13 HU·mL·mg–1. This study highlights a great potential of the Dox-Au@PB NCs for tumor diagnosis and CDT.
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NEW JOURNAL OF CHEMISTRY
·
2019
·Vol. 44
·期 4
·1313-1319
·
IF 3.069
Xu Yang,Kunhao Yang,Li Wu,Jingkui Yang,Yujian He
Magnetic nanoparticles containing multiform heteroatoms on their surface have great potential for metal-ion recovery with a high throughput. In this study, a novel adsorbent (Fe3O4@CPTES@PEG) was developed to adsorb Au(III) from aqueous solution, which was synthesized by functionalizing Fe3O4 magnetic nanoparticles with poly(ethylene glycol) via a simple two-step reaction. Various techniques including Fourier transform infrared spectroscopy (FT-IR), thermal gravimetric analysis (TGA), vibrating sample magnetometry (VSM), transmission electron microscopy (TEM) and X-ray diffraction spectroscopy (XRD) were used to characterize the adsorbent, demonstrating that poly(ethylene glycol) was successfully grafted onto the Fe3O4 magnetic nanoparticles. Batch experiments were performed to investigate the effects of the initial concentration of Au(III), contact time and coexisting ions on the absorption of Au(III) from an aqueous solution at pH = 1.0. Simultaneously, the adsorption process was well-fitted with the Langmuir and pseudo-second-order models. The as-synthesized core–shell structured Fe3O4@CPTES@PEG showed a high performance towards Au(III) adsorption with the maximum adsorption capacity of about 83 mg g−1. Significantly, the material exhibited highly selective adsorption toward Au(III) in the presence of coexisting ions (Fe(III), Mn(II), Pb(II), Cd(II), Cu(II), Cr(III), Al(III), Mg(II), Zn(II) and Au(III)). Also, the material could be regenerated using ferrous sulfate, and exhibited excellent reutilization for at least three times without significant loss in its adsorption capacity after a simple post-treatment. Therefore, the proposed method shows enormous potential for practical applications in the selective separation and enrichment of Au(III) from aqueous solution at pH = 1.0.
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MICROCHIMICA ACTA
·
2019
·Vol. 186
·期 2
·1-8
·
IF 5.479
He Baoshan,Yan Sasa
A signal-on aptasensor is described for the voltammetric determination of kanamycin (KANA). Au@Pt core-shell nanoparticles with large surface and good electrical conductivity were synthetized and act as both a conductive material and as the carrier for complementary strands (CS2) and thionine (TH). In the presence of KANA, the electrochemical response of TH changes due to hybridization between CS1 immobilized on the electrode and the Au@Pt-CS2/TH system. The peak current increases linearly with the logarithm of the KANA concentration in the range from 1 pM to 1 μM, and the limit of detection is 0.16 pM. The sensor was characterized in terms of selectivity, reproducibility and stability, and satisfactory results were obtained. It was also utilized for the determination of KANA in (spiked) chicken samples. The recoveries (95.8–103.2%) demonstrate the potential of the method for KANA detection in real samples.
A signal-on aptasensor for kanamycin (KANA) was developed by using Au@Pt core-shell nanoparticles as nanocarrier for probe aptamer and as a sensing probe.
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BIOSENSORS & BIOELECTRONICS
·
2019
·
IF 9.518
Xiaoxue Fu,Junlin He,Chengli Zhang,Jun Chen,Yilin Wen,Jia li,Weiran Mao,Hangtian Zhong,Jiahao Wu,Xingduo Ji,Chao Yu
In this work, an aptamer was used as the target capturing agent and a trimetallic signal amplification strategy based on [email protected] and AuPtRu NPs was demonstrated for the sensitive detection of TSP-1. Herein, the synthesized AuPtRu nanocomposite (AuPtRu NPs) not only acts as the catalyst for catalyzing hydrogen peroxide but also acts as a nanocarrier for capturing the -NH 2 termination single strand DNA (S1) to obtain the signal probe (SP, AuPtRu nanocomposite/S1). Then, SP was efficiently linked into TSP-1 aptamers with the addition of complementary linking strands to form M1 (SP/aptamer). The [email protected] nanocomposites were obtained by in situ reduction and used as GCE electrode modification materials. The -NH 2 -modified capture probe (CP) DNA was immobilized on the surface of [email protected] nanocomposites for hybridizing SP. In the presence of the target TSP-1, the aptamer recognizes the target and binds strongly so that SP is released from the prepared M1 and then hybridized with CP. When the detection solution contains an electrochemical matrix of H 2 O 2 , AuPtRu NPs can oxidize H 2 O 2 to obtain an enhanced signal. Furthermore, the proposed aptasensor has a very low LOD of 0.13 fg mL −1 TSP-1 in the detection range of 1 fg mL −1 to 10 ng mL −1 . Moreover, the proposed platform also has application implications for other potential targets.
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