FASEB JOURNAL
·
2024
·Vol. 38
·期 17
·e70019
·
IF 4.4
Yuxue Xu,Yue Peng,Xiaojun Wu,Feixue Ni,Daxi Sun,Pengfei Zhang,Yang Yang,Miao Yan,Jia Mi,Geng Tian
Non-proliferative diabetic retinopathy (NPDR) is the early stage of diabetic retinopathy (DR) and is a chronic oxidative stress-related ocular disease. Few treatments are approved for early DR. This study aimed to investigate the pathogenic mechanisms underlying the retinal micro-vasculopathy induced by diabetes and to explore an early potential for treating early DR in a mouse model. The mouse model of type 1 diabetes was established by intraperitoneal injection of streptozotocin (STZ, 180 mg/kg), which was used as the early DR model. The body weight and blood glucose mice were measured regularly; The retinal vascular leakage in the early DR mice was determined by whole-mount staining; Label-free quantitative proteomic analysis and bioinformatics were used to explore the target proteins and signaling pathways associated with the retinal tissues of early DR mice; To detect the effects of target protein on endothelial cell proliferation, migration, and tube formation, knockdown and overexpression of VEGF-B were performed in human retinal vascular endothelial cells (HRECs); Western blotting was used to detect the expression of target proteins in vitro and in vivo; Meanwhile, the therapeutic effect of VEGF-B on vascular leakage has also been evaluated in vitro and in vivo. The protein expressions of vascular endothelial growth factor (VEGF)-B and the Rho GTPases family member CDC42 were reduced in the retinal tissues of early DR. VEGF-B upregulated the expression of CDC42/ZO1/VE-cadherin and prevented hyperglycemia-induced vascular leakage in HRECs. Standard intravitreal VEGF-B injections improved the retinal vascular leakage and neurovascular response in early DR mice. Our findings demonstrated, for the first time, that in diabetes, the retinal vessels are damaged due to decreased VEGF-B expression through downregulation of CDC42/ZO1/VE-cadherin expression. Therefore, VEGF-B could be used as a novel therapy for early DR.
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DOI
PubMed
高影响因子
Journal of Materials Chemistry C
·
2024
·Vol. 12
·期 47
·19086-19093
·
IF 5.7
Xiaowei Zhu,Wei Liu,Guobin Zhu,Siyu Xiong,Deqin Chen,Xiuyun Lei,Laijun Liu,Chunchun Li
The present study reports on entropy-engineered perovskite ceramics (Ca1/3Sr1/3Ba1/3)(SnxTi1−x)O3 (CSBTO-xSn) with varying Sn-doping levels (x = 0.1, 0.2, 0.3), achieved through synergistic compositional design in both the A-sites and B-sites of the perovskite. Increasing the Sn-doping content induces a transition in configuration entropy from medium to high values. Notably, at an optimal composition of x = 0.1, the ceramic exhibits exceptional energy storage characteristics including an ultrahigh recoverable energy density (Wrec) of 5.05 J cm−3 and a high efficiency (η) of 82.56% at an electric field strength (Eb) of 540 kV cm−1 over a wide temperature range spanning from 30 to 100 °C and frequencies ranging from 1 Hz to 200 Hz. Furthermore, this ceramic demonstrates remarkable charge–discharge properties with a discharge energy density (Wdis) of 2.94 J cm−3 and a rapid discharge rate of t0.9 ∼ 67 ns. This study underscores the effectiveness of entropy engineering as a viable approach for developing advanced energy storage capacitors.
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高影响因子
INTERNATIONAL JOURNAL OF POLYMER ANALYSIS AND CHARACTERIZATION
·
2019
·
IF 1.426
Yan Zhang,Qihang Zhou,Yujian Liu
Polymethylene-b-poly(ethylene glycol) (PM-b-PEG) with different block length ratio was synthesized by a combination of polyhomologation and coupling reaction. The effect of hydrophilic and hydrophobic block length on the crystallization process and self-assembly behavior of PM-b-PEG was self-assembled were investigated. The results showed that with the increase of methylene units, the crystallization temperature of PM block raised from 54.59 °C to 70.93 °C gradually, while that of the PEG block reduced from 17.54 °C to 15.23 °C. In addition, the amphiphilic PM-b-PEG was self-assembled into star-like micelles in water, and its diameter extended from 98.2 nm to 151.9 nm as the block length of hydrophobic PM increased from 30 to 70. And the micelles also exhibit super stability when the concentration of copolymer precursor is 0.50 ∼ 0.90 mg/ml and the storage temperature lies in the range of 25 ∼ 60 °C.
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高影响因子
POLYMERS FOR ADVANCED TECHNOLOGIES
·
2018
·Vol. 29
·期 6
·1684-1696
·
IF 2.137
Xiaoyu Chen,Xiaomeng Wu,Zhongyong Fan,Qinghua Zhao,Qing Liu
The macroinitiator of poly(1,3-trimethylene carbonate) (PTMC) with number-average molecular weight ( ) of 9.6 × 10 3 g mol −1 was synthesized by ring-opening polymerization at 120°C. Then, the novel terpolymer P(TMC- b -( L LA- ran -GA)) consisting of PTMC homopolymer segment attached with various monomer molar ratios of L -lactide ( L LA) and glycolide (GA) random copolymerization block was prepared with about 5.0 × 10 4 g mol −1 by ring-opening polymerization in bulk at 140°C. The tailored molecular structures of P(TMC- b -( L LA- ran -GA)) were characterized by 1 H nuclear magnetic resonance, 13 C NMR, FTIR, and gel permeation chromatography, and chain microstructure analysis was performed in detail with 13 C NMR spectroscopy. The effect of GA units on the thermal and crystallization behaviors, mechanical properties, as well as biodegradability of terpolymers was investigated by differential scanning calorimetry, wide-angle X-ray diffraction, stress-strain measurements, and in vitro tests in comparison with corresponding poly(trimethylene carbonate- block - L -lactide) copolymer P(TMC- b - L LA). The results show that amorphous PTMC segments have a significant effect on condensed state behavior of the terpolymers, and the incorporation of GA units strongly decreases the crystallinity and crystallization ability of L LA segment within terpolymers because of more random L LA-GA sequence and shorter average L LA block length. Meanwhile, the toughness of materials is greatly improved, and in vitro degradation is also accelerated. Peripheral vascular stents were 3D printed for the first time and met the requirements for application. The results show totally biodegradable terpolymers with unique molecular structure, and modifiable properties are promising new biomaterials with advanced performance for biomedical application.
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高影响因子
Inorganic Chemistry Frontiers
·
2021
·Vol. 8
·期 15
·3716-3722
·
IF 6.569
Siru Guo,Wenbin Zhang,Rong Yang,Min Zhang,Zhihua Yang,Shilie Pan
The first borate featuring a three-dimensional B–O anionic network with edge-sharing (ES) [BO4] units, Pb2.28Ba1.72B10O19 (PbBaBO), has been synthesized under ambient pressure. The squeezing effect of the 2∞[B10O19] bilayer structure on the intra-layer co-edge [BO4] leads to an extremely long B–B distance and quite small internal O–B–O angles in the [B2O6] ring.
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高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2013
·
IF 2.206
Yan-Ling Luo,Li-Li Chen,Yan Miao,Feng Xu
Novel AB4-type polyurethane (PU) micelle-like amphiphilic block copolymers consisting of hydroxyl-functionalized carboxyl-terminated poly(butadiene-co-acrylonitrile) (f-CTBN) as the hydrophobic cores and methoxy poly(ethylene glycol) (MPEG) as the hydrophilic branched blocks were synthesized via esterification, followed by coupling reaction. Their chemical structure and molecular weight were characterized by FTIR, NMR, and SEC measurements. The block copolymers could easily self-assemble to form core–shell micelle nanoparticles in various media. The micelles bear a critical micelle concentration (CMC) in a range from 0.740 to 6.310 mg L–1 and were very stable even in PBS solutions. The TEM and DLS findings revealed that the micelles were almost spherical and narrow-size-distribution, with TEM mean diameters from 13 to 24 nm, and average hydrodynamic diameter about 124–151 nm. All these depended on chain lengths and compositional ratios of hydrophilic MPEG blocks. The drug loading and in vitro release indicated that the self-assembled micelle nanoparticles could effectively load hydrophobic prednisone, with encapsulation capacity of about 27–30%, and the drug release from the nanoparticles was dependent on MPEG chain lengths and the molar ratios of f-CTBN to MPEG. Cytotoxicity assays disclosed that the as-prepared block copolymer micelle nanoparticles exhibit good biocompatibility and could be employed as potential drug controlled release carriers.
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高影响因子
RARE METALS
·
2023
·Vol. 43
·期 3
·1153-1166
·
IF 8.8
Lu Li-Wen,Luo Hui,Li Guang-Xu,Li Yun,Wang Xin-Hua,Huang Cun-Ke,Lan Zhi-Qiang,Zhou Wen-Zheng,Guo Jin,Ismail Mohammad,Liu Hai-Zhen
The Li-Mg-B-H composite (2LiBH 4 + MgH 2 ) has a high capacity of 11.4 wt% as a hydrogen storage material. However, the slow kinetics and poor cycling stability severely restrict its practical applications. In this work, a layered Nb 2 C MXene was first synthesized and then introduced to tailor the kinetics and cycling stability of the Li-Mg-B-H composite. The milled 2LiH + MgB 2 composites were initially hydrogenated to obtain the 2LiBH 4 + MgH 2 composites. The 2LiBH 4 + MgH 2 + 5 wt% Nb 2 C can release 9.0 wt% H 2 in 30 min at 400 °C, while it is only 2.7 wt% for the undoped 2LiBH 4 + MgH 2 . The dehydrogenation activation energies of MgH 2 and LiBH 4 are 123 and 154 kJ·mol −1 respectively for the 5 wt% Nb 2 C-doped composite, lower than the undoped composite (164 and 165 kJ·mol −1 ). The 2LiBH 4 + MgH 2 + 5 wt% Nb 2 C possesses excellent cycling stability, with the reversible capacity only slightly reduced from 9.4 wt% for the 1st cycle to 9.3 wt% for the 20th cycle. Nb 2 C keeps stable in the composite and acts as an efficient catalyst for the Li-Mg-B-H composite. It is believed that both the layered structure and the active Nb element contribute to the enhanced hydrogen storage performances of the Li-Mg-B-H composite. This work confirms that the Nb 2 C MXene with layered structure has a significant enhancing impact on the Li-Mg-B-H hydrogen storage materials, which is different from the bulk NbC. Graphical abstract
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高影响因子
Analytical Methods
·
2014
·Vol. 6
·期 21
·8627-8632
·
IF 1.938
Jinjiao Shi,Ligang Chen
In this study, we investigated the possibility of reverse micelles which were used for the determination of rhodamine B in lipsticks followed by high performance liquid chromatography (HPLC). The reverse micelle of surfactant sodium 1,4-bis(2-ethylhexoxy)-1,4-dioxobutane-2-sulfonate (AOT) was formed in n-hexane. First, the samples were preprocessed by reverse micelle extraction, and then rhodamine B was extracted from the mixture with methanol by back-extraction. The effects of different parameters including the concentration of surfactant, pH, amount of potassium chloride, ultrasonic time and type of organic solvents were evaluated and optimized during reverse micelle formation. The limit of detection of rhodamine B was 0.01 μg g−1. The intra-day and inter-day precisions expressed as relative standard deviations were 3.6% and 4.5%, respectively. The recovery of rhodamine B obtained was 95.0%. The reverse micelle method proposed for the determination of rhodamine B in real samples of lipsticks has the advantages of simplicity, speed, high precision, low detection limit and the use of inexpensive equipment.
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高影响因子
CERAMICS INTERNATIONAL
·
2025
·
IF 5.6
Xinyu Ping,Xiaoyu Pan,Bin Meng,Qingqing Yang,Wenlong Zhang
The dielectric performance of BaTiO 3 -based ceramic capacitors must be improved for further miniaturization and integration of energy storage devices. This study combines two optimization strategies, the grain refinement and high-entropy effect, to design BaTiO 3 -based high-entropy nanocrystalline ceramics: Ba(Ti 0.2 Zr 0.2 Nb 0.2 Y 0.2 Sn 0.2 )O 3 (HEO1) and Ba(Ti 0.2 Zr 0.2 Nb 0.2 Yb 0.2 Hf 0.2 )O 3 (HEO2). These ceramics were synthesized using fast hot-pressing sintering (FHPS), yielding HEO1-FHPS and HEO2-FHPS samples, both of which exhibit a pure perovskite structure, similar to that of samples fabricated via conventional solid-state sintering (CS), namely HEO1-CS and HEO2-CS. The relative densities of the HEO1-FHPS (96.18 %) and HEO2-FHPS (98.34 %) samples are higher than those of HEO1-CS (95.47 %) and HEO2-CS (95.40 %). In addition, the grain sizes of HEO1-FHPS (0.092 μm) and HEO2-FHPS (0.084 μm) are notably smaller than those of HEO1-CS (2.48 μm) and HEO2-CS (2.91 μm). The high relative density and small grain size of HEO1 and HEO2 improve their maximum permittivity, increase the Curie temperature and enhance dielectric stability. Furthermore, compared with HEO1-CS and HEO2-CS, HEO1-FHPS and HEO2-FHPS exhibit higher critical electric field strengths (359 and 389 kV/cm), greater recoverable energy densities (0.40 and 0.88 J/cm 3 ) and improved energy storage efficiencies (69.6 % and 70.4 %). These findings provide a promising approach for developing BaTiO 3 -based ceramics with enhanced dielectric performance.
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高影响因子
RESEARCH ON CHEMICAL INTERMEDIATES
·
2025
·
IF 3.5
Zhang Yu,Xiao Xinyan,Wang Fei,Lu Ting,Cheng Xia
Photocatalytic degradation of dye wastewater has great potential due to its eco-friendly, simple, and solar energy-based characteristics. In this work, an energy-saving and convenient precipitation method was explored to compound two classical photocatalyst materials BiOBr and CAU-17. The Z-scheme heterojunction decreases the agglomeration of the BiOBr nanosheets and addresses the issue of the low photogenerated carrier participation rate of CAU-17. The solvothermal method was used to prepare CAU-17 nanorods, and then BiOBr nanosheets were grown on them at room temperature to fabricate BiOBr/CAU-17 composites. The samples were characterized by XRD, SEM, TEM, XPS, DRS, PL, EIS, and other techniques. The photodegradation performance was tested using Rhodamine B (RhB) as the model pollutant. The 80% BiOBr/CAU-17 composite (0.1 g/L) exhibited a degradation rate of 99.41% for RhB under simulated sunlight in 60 min, with an apparent rate constant of 0.0631 min⁻ 1 , which is 3.45 times faster than pure BiOBr and 315.5 times faster than CAU-17. Free radical capture and EPR tests confirmed that · O 2 ⁻ and h⁺ were the main active species in the process, and a reasonable photocatalytic mechanism is proposed. Additionally, cyclic tests are conducted to confirm the stability and durability of the composite, proving the potential of BiOBr/CAU-17 composites for efficient and sustainable photocatalytic applications.
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高影响因子
Materials Today Energy
·
2025
·
IF 8.6
Jinwu Hu,Yunqin Hu,Mingyue Li,Shiyu Hong,Shaozhen Wang,Caihong Fang
Herein, we synthesized new 3D flower-like boron doped PtCe nanoalloys formed by nanosheets with ultra-thin thickness (B-PtCe NSs) using a convenient one-pot method without any surfactants. The self-supporting 3D architecture overcomes the commonly closely packed and overlapping problems of conventional 2D nanosheets. The ultrathin feature of the petals provides large active areas, facilitating mass and electron transfer rates. Specifically, the synergistic effect between different components effectively modifies the electronic structures and upshifts the d -band center. The B-PtCe NSs therefore exhibited superior electrocatalytic performance to methanol and ethanol oxidation reactions (MOR/EOR). Specifically, the mass/specific activities of B-PtCe NSs were 2.75 ± 0.050 A·mg Pt −1 /27.58 ± 0.50 A·m −2 , which are 3.85/2.12 times higher than those of commercial Pt/C catalysts (0.71 ± 0.011 A·mg Pt −1 /12.96 ± 0.20 A·m −2 ) toward MOR, respectively. The ultrathin B-PtCe NSs also exhibited superior mass/specific activity of 2.12 ± 0.04 A·mg Pt −1 /21.11 ± 0.40 A·m −2 to EOR. Furthermore, the B-PtCe NSs exhibit higher electrocatalytic stability owing to their special morphological feature and promoted anti-CO properties. More importantly, the B-PtCe also demonstrates superior mass activities of 0.159, 0.851, 2.23, and 2.71 A·mg Pt −1 to the electrooxidation reactions of glucose, isopropanol, glycerol, and ethylene glycol. We unraveled the improved mechanism though density functional theory calculations.
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DOI
高影响因子
Asian Journal of Organic Chemistry
·
2025
·
IF 2.7
Xin-Yi Huang,Lan-Ying Han,Man-Yu Wang,Lu Li,Su-Yun Shi,Cheng-Hua Jin
A series of amides ( 19a – i ) and another of sulfonamides ( 21a – g ) containing the imidazo[2,1-b][1,3,4]thiadiazole moiety were synthesized and evaluated for their antimicrobial activities. Most of these compounds showed good antibacterial activities (MIC = 4–64 µg/mL). Compounds 21c (MIC = 4 µg/mL) and 21g (MIC = 4 µg/mL) exhibited strongest antibacterial activities that are comparable to that of the positive control gatifloxacin, along with low cytotoxicity (as measured against human LO2 cells) and no hemolysis, even at ultrahigh concentration (200 µM). These results indicate that these compounds show promise for further development as antibacterial agents.
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高影响因子
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