Materials Today Bio
·
2026
·
IF 10.2
Zhiyang Huang,Xiong Cai,Yibo Ying,Jiamen Shen,Zhenwen Xie,Jiali Lv,Yuchao Zhang,Yujun Mo,Hongli Lv,Lihua Luo,Xiaojun Cai,Sipin Zhu,Ping Wu,Zhouguang Wang
Spinal cord injury (SCI) initiates a cascade of pathological events in which neuroinflammation and hypoxia critically impair functional recovery. Although exogenous carbon monoxide (CO) exhibits anti-inflammatory potential, its translation has been hindered by the lack of a safe and effective delivery strategy. Here, we report the development of a multifunctional therapeutic platform (COPH), composed of CO-releasing molecules-401 (CORM-401) as the CO donor, peptide dendrimer nanogels (PDNs) as the carrier, and hyaluronic acid (HA) as a microglia-targeting ligand. COPH selectively accumulates in microglia, where it responds to elevated reactive oxygen species (ROS) by releasing CO and simultaneously scavenging excessive ROS. In vitro and in vivo studies demonstrate that COPH suppresses pro-inflammatory mediators such as IL-1β and CD86 via inhibition of the NF-κB/p65 pathway, while promoting M1-to-M2 microglial polarization. Moreover, CO released from COPH alleviates local hypoxia by modulating hemoglobin-oxygen binding dynamics, thereby enhancing oxygen availability to neurons and vascular cells in ischemic regions. Through activation of the Nrf2/HO-1 antioxidant pathway, COPH further mitigates oxidative stress and reduces neuronal apoptosis. Collectively, these findings highlight COPH as a targeted CO delivery system that attenuates inflammation, relieves hypoxia, and protects neurons after SCI, providing a promising strategy for CO-based therapeutics in neurotrauma.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Environmental Science-Nano
·
2026
·
IF 5.1
Hui Dong,Bo Su,YanXi Cheng,Saikat Ghosh,Nihar Ranjan Pradhan,Bo Pan,Baoshan Xing
The co-assembly of humic acid (HA)-coated maghemite nanoparticles (H-GFeNPs) and bovine serum albumin (BSA)-modified maghemite nanoparticles (B-GFeNPs) and sequestration of NO₃⁻ within the colloidal crystals were investigated. The π-π interaction between aromatic moieties of the adsorbed BSA and HA controlled the co-assembly process. The 1:1 binary mixture of H-GFeNPs and B-GFeNPs at pH 4 showed screw dislocation-driven growth of colloidal crystals, especially at higher concentrations of NO₃⁻. But, at pH 7, the binary mixture in the presence of NO₃⁻ produced spherical dendritic nanostructures and hierarchical growth of dendrites. However, at higher levels of NO3-, the binary mixture produced 2D cubic lattice and rocksalt-like 3D colloidal crystals. In addition, we also detected the growth of dendrites, ubiquitous in rocksalt-type crystal growth, specifically in an unsaturated environment. The binding of NO₃⁻ to the hydrophobic and positively charged residues of the protein, supplemented by the loss of α-helix and reduced radius of gyration (Rg), possibly favored crystal growth. Signatures of the NO3- specific Raman bands within the colloidal crystals discerned the sequestration of the highly mobile contaminant ion within the crystalline domain. Therefore, potentially diminishes the atmospheric emission of high global warming potential (GWP) oxides of N produced via denitrification.
✓ 已验证
DOI
高影响因子
ADVANCED POWDER TECHNOLOGY
·
2018
·Vol. 30
·期 2
·302-310
·
IF 2.943
Bingbing Liu,Yuanbo Zhang,Jia Wang,Juan Wang,Zijian Su,Guanghui Li,Tao Jiang
Investigations on the MnO 2 -Fe 2 O 3 system roasted in air has been reported in our previous work. This study further investigated the MnO 2 -Fe 2 O 3 system roasted under CO-CO 2 atmosphere. Extensive investigations were concentrated on the reduction of simplex iron oxides or manganese oxides, and little attention were paid on the reduction of MnO 2 -Fe 2 O 3 system regarding to interactive reactions between them. In this work, it was found that spinel-type Mn x Fe 3−x O 4 with high magnetism formed easily under CO-CO 2 atmosphere. The reduction and thermodynamic analyses of pure MnFe 2 O 4 were also researched to better understand the reduction behaviors of MnO 2 -Fe 2 O 3 system. Phase study showed that a series of Mn-Fe composite oxides, including Mn x Fe 3−x O 4 and (MnO) y (FeO) 1−y , generated during the reduction of MnO 2 -Fe 2 O 3 system. Mn x Fe 3−x O 4 was readily generated under CO content of 2.5–25 vol% at 1000 °C. With further increase of CO content, Mn x Fe 3−x O 4 was reduced to (MnO) y (FeO) 1−y and then to MnO and metallic iron. Reduction of manganese oxides, iron oxides and manganese ferrites happened concurrently during the reduction of MnO 2 -Fe 2 O 3 system. And the reduction of MnO 2 , Fe 2 O 3 , Fe 3 O 4 and MnFe 2 O 4 were compared by TG and thermodynamic analyses. In addition, the morphology evolution and magnetism change of the MnO 2 -Fe 2 O 3 system reduced under different CO contents were also studied.
✓ 已验证
DOI
高影响因子
JOURNAL OF MATERIALS RESEARCH
·
2026
·
IF 2.9
Zhang Zhiwei,Nie Yuhang,Zhang Lianke,Wei Zhiqiang,Li Dandan,Qin Haiying,Ni Hualiang,Li Yangyang,He Junjing
Atomically dispersed catalysts, characterized by their high atom utilization efficiency and distinct catalytic activity, exhibit advantages in reducing fuel cell costs. Herein, we synthesized Co/N/C atomic catalysts by acid leaching of CoO/N/C prepared through carbothermal shock. The resulting Co/N/C-130 demonstrates outstanding performance for the oxygen reduction reaction (ORR) in alkaline media. It displays a half-wave potential ( E 1/2 ) of 0.82 V and a Tafel slope of 47.1 mV dec −1 . Furthermore, it exhibits excellent stability with a positive E 1/2 shift of 6 mV after 40,000 cycles. When applied as a cathode catalyst in a direct borohydride fuel cell (DBFC), Co/N/C-130 achieves a maximum power density of 396 mW cm −2 at 60 °C. Long-term durability test at 50 mA cm −2 reveals a power retention of 90.8% after 24 h and 76.3% after 50 h. These results demonstrate that Co/N/C-130 atomic catalyst is a highly efficient and durable non-precious metal catalyst for ORR. Graphical abstract
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF FLUORESCENCE
·
2026
·
IF 3.4
Su Qian,Huang Li,Zhang Youjin,Yang Zhiyong
Carbon dots (CDs) have been broadly employed in many fields due to their excellent fluorescence property, especially in pharmaceutical analysis. Herein, we developed a simple and rapid method to prepare the phosphorus-nitrogen (P, N) co-doped carbon dots via a 3-minute 50-second microwave-assisted synthesis, using N-butyldiethanolamine as the carbon source with phosphoric acid accelerating the CDs formation reaction. The prepared CDs (termed CD1) were characterized by TEM, FT-IR, XPS, XRD and fluorescence spectroscopy. P, N co-doped CDs exhibited notable water solubility, a quantum yield of 19.7% and good photobleaching resistance. Taking advantage of their superior fluorescence, these CDs served as a bright-blue probe for tigecycline detection through fluorescence quenching. The sensor displayed excellent selectivity and anti-interference ability against common coexisting drugs (e.g., voriconazole, ceftazidime, amikacin). Under optimized conditions, a wide linear range (1-936 µM) between F 0 / F and Tigecycline concentration was established, with a correlation coefficient (R) of 0.984, and the detection limit (LOD) was calculated to be 1.10 µM. Furthermore, we clarified the fluorescence quenching mechanism of CD1 toward tigecycline, which was attributed to the internal filtration effect (IFE). Thus, this work demonstrated a novel P, N co-doped CD-based sensing strategy for rapid tigecycline monitoring.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nano-Micro Letters
·
2026
·Vol. 18
·期 1
·227
·
IF 36.3
Li Na,Cheng Weiren,Liu Yuying,Liu Ruiqi,Feng Sihua,Wang Huijuan,Lv Liyang,Liu Chenglong,Ma Jin,Wang Chao,Yan Wensheng
Monodisperse and substitute Co were doped into edge-sharing [IrO 6 ] octahedra of Ca 2 IrO 4 model catalyst, which usually present the intrinsic and strong stability for acid oxygen evolution reaction (OER)
The optimized Janus Co–Ir local structure triggers spin balance effect with optimal e g 1 orbital and uneven t 2g orbital despite the large crystal field of Ir, which co-promote the OER activity with a relatively stable crystal structure.
Different from the slowly kinetics of adsorbates evolution mechanism on Ca 2 IrO 4 , superoxide path mechanism occurs on Co doped Ca 2 IrO 4 based on the assignment of *OO on dual active sites of Ir and Co.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MICROBIOLOGICAL RESEARCH
·
2026
·
IF 8.5
Wei Zhao,Jingying Hu,Jitong Lin,Yanhong Lou,Hui Wang,Quangang Yang,Hongjie Di,Haojie Feng,Yuping Zhuge,Hong Pan
Co-contamination of agricultural soils with cadmium (Cd) and oxytetracycline (OTC) from organic fertilizers and wastewater irrigation threatens food safety. A pot experiment was conducted to examine the responses of soil and pak choi ( Brassica rapa subsp. chinensis ) to combined Cd (2/5 mg kg −1 ) and OTC (1/10/30 mg kg −1 ) exposure. Soil available Cd was primarily governed by the Cd addition level (F = 886.70, p < 0.001), but its response to OTC was concentration-dependent (F = 53.39, p < 0.001): available Cd increased by 2.89–3.11-fold with rising OTC under the Cd2 background but decreased under the Cd5 background, whereas the Cd bioconcentration factor was consistently lower in Cd5- than Cd2-treated soils ( p < 0.001), largely independent of OTC. The combined pollution reshaped bacterial communities and drove co-enrichment of antibiotic resistance genes (e.g., sul 1, sul 2, tet G, tet C) and the mobile genetic element int I1, whose abundance under Cd5 was up to 3.13-fold higher than under Cd2 in rhizosphere soils. The O10 treatments (Cd2O10 and Cd5O10) exhibited the highest comprehensive toxicity, with soil enzymatic IBR values reaching 3.79 and leaf IBR values reaching 7.9 × 10 −4 , alongside fewer negative microbial co-occurrence correlations and reduced network modularity. Under these high-toxicity conditions, the stress-tolerant genera Cupriavidus (Cd2O10) and Nocardiopsis (Cd5O10) were selectively enriched in root endophytes, and plant antioxidant defense responses (SOD, POD, GSH) were activated. Structural equation modeling indicated that Cd contamination directly and indirectly governed the edible safety of pak choi (λ = 0.75, p < 0.001). These findings reveal non-linear, dose-dependent risk patterns under Cd–OTC co-contamination and suggest microbial-assisted mitigation strategies for co-contaminated agricultural soils, providing insights for pollution control without compromising productivity.
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
·
2023
·
IF 2.7
Xuening Han,Jie Li,Hao Wu,Kai Sun,Yixin Chen,Lijun Jia,Huaiwu Zhang,Pengjie Zhang,Chunyang Wu
In this paper, the Bi-In co-substituted YIG ferrite materials composed of Y 3− x Bi x Fe 4.55 In 0.45 O 12 ( x = 0.0–1.0 with a step of 0.2) were synthesized by a conventional solid-state route. Samples with different Bi 3+ ion contents were sintered at different temperatures. The phase formation, microstructure, dielectric and magnetic properties of samples were investigated by X-ray diffraction (XRD), scanning electron microscopy (SEM), impedance analyzer, vibrating sample magnetometer (VSM), and ferromagnetic resonance (FMR). The results showed that Bi 3+ ion substitution could reduce the sintering temperature, increase the bulk density ( d b ), improve the dielectric constant ( ε' = 22.26@100 MHz at × = 1.0) and keep a high saturation magnetization ( 4πM S = 1700–1850 Gs), but led to the increase of the FMR linewidth ( ΔH = 316.21 Oe at × = 1.0).
✓ 已验证
产品关联
DOI
高影响因子
APPLIED SURFACE SCIENCE
·
2023
·
IF 6.7
Dan Wang,Jiangli Gu,Hanlin Wang,Mingzhuang Liu,Yichun Liu,Xintong Zhang
The sluggish surface reaction kinetic is the bottleneck limiting the photoelectrochemical (PEC) water oxidation of BiVO 4 photoanode, especially for the porous structured BiVO 4 with high surface area. Here, Co-based metal–organic frameworks (MOFs) were modified on porous BiVO 4 photoanode followed by calcining in the N 2 atmosphere, forming BiVO 4 -MOF-N 2 photoanode. The MOF-derived heterostructural cocatalysts significantly enhanced the photocurrent density of BiVO 4 -MOF-N 2 , reaching 2.32 mA·cm −2 (1.23 V vs RHE), about 1.15 times that of BiVO 4 -MOF and 2.64 times that of pristine BiVO 4 . The comparative study of BiVO 4 -MOF-N 2 , BiVO 4 -MOF, and pristine BiVO 4 photoanodes suggested that the Co-MOF-derived heterostructural cocatalyst had a much stronger effect on promoting the surface reactions than pure MOF. The BiVO 4 -MOF-N 2 photoanode had the highest charge transfer efficiency of 63.1 % at 1.3 V vs RHE and the lowest charge transfer resistivity compared with BiVO 4 and BiVO 4 -MOF. Both Co-active centers and conductive carbon matrix contributed to the enhanced charge transfer of BiVO 4 -MOF-N 2 photoanode. A MOF-loading-time dependent PEC performance of BiVO 4 photoanode also indicated that the intermediate charge transfer process from BiVO 4 to active centers strongly affected the final charge transfer and PEC performances. This work provides new insights into the design of high-performance photoelectrochemical electrodes based on heterostructural cocatalysts.
✓ 已验证
产品关联
DOI
高影响因子
INORGANIC CHEMISTRY
·
2023
·
IF 4.6
Hao Chen,Hui-Bin Huang,Hai-Hong Li,Shui-Zhong Zhao,Li-Dong Wang,Jia Zhang,Sheng-Liang Zhong,Cheng-Feng Lao,Li-Ming Cao,Chun-Ting He
Remodeling the active surface through fabricating heterostructures can substantially enhance alkaline water electrolysis driven by renewable electrical energy. However, there are still great challenges in the synthesis of highly reactive and robust heterostructures to achieve both ampere-level current density hydrogen evolution reaction (HER) and oxygen evolution reaction (OER). Herein, we report a new Co/CeO2 heterojunction self-supported electrode for sustainable overall water splitting. The self-supporting Co/CeO2 heterostructures required only low overpotentials of 31.9 ± 2.2, 253.3 ± 2.7, and 316.7 ± 3 mV for HER and 214.1 ± 1.4, 362.3 ± 1.9, and 400.3 ± 3.7 mV for OER at 0.01, 0.5, and 1.0 A·cm–2, respectively, being one of the best Co-based bifunctional electrodes. Electrolyzer constructed from this electrode acting as an anode and cathode merely required cell voltages of 1.92 ± 0.02 V at 1.0 A·cm–2 for overall water splitting. Multiple characterization techniques combined with density functional theory calculations disclosed the different active sites on the anode and cathode, and the charge redistributions on the heterointerfaces that can optimize the adsorption of H and oxygen-containing intermediates, respectively. This study presents the tremendous prospective of self-supporting heterostructures for effective and economical overall water splitting.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CRYSTENGCOMM
·
2023
·Vol. 25
·期 6
·981-987
·
IF 3.1
Nan Li,Minghao Shi,Wei Zhan,Wenjing Shen,Mianmian Wu,Guifang Sun,Qingfei Li,Jiangquan Ma
Ru-based catalysts are potential substitutes for Pt in the hydrogen evolution reaction (HER). It is worth noting that the Se ions in RuSe2 can modulate the electronic structure of the Ru metal, thus effectively improving the HER kinetics of RuSe2. However, single electronic structure modulation is hard to complete due to the electron deficiency of active Ru atoms. Herein, we prepare and design a novel RuSe2/Co–N–C (RuSe2 nanospheres supported on Co–N–C nanosheets) electrocatalyst with two-electron modulation by a hydrothermal and thermal annealing method. Benefiting from the uniform distribution of RuSe2 nanospheres on Co–N–C nanosheets and Co–N–C nanosheets acting as additional electron donors to make up for the electron deficiency of the Ru metal, RuSe2/Co–N–C exhibits excellent HER performance with a low overpotential of 26.4 mV at 10 mA cm−2 and a low Tafel slope of 53.2 mV dec−1. This work offers an effective method for the synthesis of high catalytic performance electrocatalysts by constructing an interaction between the carrier and the active metal.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2022
·
IF 9.965
Huaiwei Zhang,Yifan Chen,Liang Bao,Jing-yuan Ge
The green synthesis process of photocatalytic ammonia production has received more and more attentions. Herein, a Z-scheme heterojunction with all-solid-state structures is constructed, in which carbon dots can act as electron transferring mediators. The photocatalytic measurement shows that the modified photocatalysts exhibit much higher activities, in which the ammonia production rates can reach above 232 µmol·g cal -1 ·h −1 under the light irradiation. The improved catalytic properties can be credited to the significantly increased number of photoinduced oxygen vacancies, the excellent visible-light adsorption abilities and photogenerated electron-hole separation efficiencies for the carbon dots bridged heterostructures. More hydroxyl and superoxide radicals can be simultaneously produced in the composites. This work provides reasonable guidance for applications in photocatalytic ammonia synthesis and a promising construction strategy of efficient Z-scheme photocatalysts.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）