MICROCHIMICA ACTA
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2021
·Vol. 188
·期 5
·1-9
·
IF 5.833
An Xuanxuan,Chen Ruchun,Chen Qizhen,Tan Qin,Pan Shuang,Liu Hui,Hu Xiaoli
A MnO 2 nanosheet-assisted ratiometric fluorescence probe based on carbon quantum dots (CQDs) and o-phenylenediamine (OPD) has been developed for the detection of the anticancer drug 6-mercaptopurine (6-MP). CQDs with strong fluorescence are synthesized via the one-step hydrothermal method. MnO 2 nanosheets as an oxidase-mimicking nanomaterial directly oxidize OPD into 2,3-diaminophenazine (DAP) which has a fluorescence emission at 570 nm, whereas the fluorescence of CQDs at 445 nm is then reduced by the DAP through the inner filter effect (IFE) under a single excitation wavelength (370 nm). After adding 6-MP, MnO 2 nanosheets can be reduced to Mn 2+ and lose their oxidase-like property, blocking the IFE with the fluorescence decrease of DAP and fluorescence increase of CQDs. The novel ratiometric fluorescence probe exhibits considerable sensitivity toward 6-MP and linear response is in the 0.46–100.0 μmol L −1 concentration range with the detection limit of 0.14 μmol L −1 . Furthermore, the probe shows good selectivity when exposed to a series of interfering other organic and inorganic compounds, and biomolecules and can be applied to the detection for 6-MP in human serum samples and pharmaceutical tablets. Satisfactory recoveries of 6-MP in human serum samples are in the range 96.1–110.9% with the RSD of 1.4 to 3.2%. The amount of 6-MP is successfully estimated as 49.3 mg in pharmaceutical tablet with the RSD of about 2.2%. Graphical abstract
研究领域:
分析化学
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药物分析
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生物医学工程
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PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2021
·
IF 13.273
Min Zhang,Baolong Li,Yu Du,Gaojian Zhou,Yanyan Tang,Yanfen Shi,BiYu Zhang,Zhou Xu,Qingli Huang
The preparation and construction of novel nanostructures as targeting theranostic is of great significance for diagnosis and treatment of tumor. Herein, a novel PANI/ [email protected] @MnO 2 (PPAuMns) yolk-shell enzymatic theranostic agent was fabricated firstly via in situ deposition of Au nanoparticles (Au NPs) and reduction of KMnO 4 on the surface of PANI/PPy nanocomposites. In addition to high biocompatible and biodegraded performance, PPAuMns possessed amazing tumor microenvironment (TME)-responsive O 2 generation capacity, magnetic resonance imaging (MRI) property, enzymatic activity and excellent photothermal conversion effect. Chemotherapeutics doxorubicin and folic acid (FA) were further loaded and decorated on it for targeted tumor therapy. Experiments in vitro and in vivo indicated that DOX-loaded [email protected] demonstrated excellent synergistic anti-tumor effect combining chemotherapy (CT), chemo-dynamic therapy (CDT) and photothermal therapy (PTT). This work offers a paradigm to design and construct tumor diagnosis and therapy platforms employing TME-responsive synergistic strategy of photothermal ablation, chemo-dynamic and chemotherapy.
研究领域:
纳米技术
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生物医学工程
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癌症治疗
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材料科学
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医学成像
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DOI
高影响因子
ACS Biomaterials Science & Engineering
·
2020
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IF 4.152
Jing Wang,Qiaoyun Lu,Chenyuan Weng,Xiaoyun Li,Xiaoqiang Yan,Wei Yang,Bingzhi Li,Xuemin Zhou
In this research, we attempted to develop a sensitive colorimetric sensing strategy for the detection of acid phosphatase (ACP) based on MnO2 nanosheets and explored its applications in screening and evaluating inhibitors of ACP. The MnO2 nanosheets exhibit intrinsic biomimetic oxidase activity, which can catalyze the oxidation of the colorless 2,2′-azino-bis(3-ethylbenzthiazoline-6-sulfonate) diammonium salt (ABTS) into green oxidized ABTS (oxABTS). Upon the introduction of ACP, l-ascorbic acid-2-phosphate can be dephosphorylated to ascorbic acid, which arouses the disintegration of MnO2 nanosheets into Mn2+ ions. This disintegration weakens the enzyme mimicking activity of the MnO2 nanosheets, leading to the impediment of the oxidation of ABTS. Conversely, in the absence of ACP, the ABTS is rapidly oxidized by MnO2, leading to a significant colorimetric signal change. The absorbance difference at 420 nm displayed a linear relationship with the concentration of ACP ranging from 0.075 to 0.45 mU·mL–1, generating a detection limit of 0.046 mU·mL–1. In the inhibition assays, this sensing platform provided simple detection for parathion-methyl (PM), a representative inhibitor of ACP. The facile evaluation of the inhibitory effect of PM, including its IC50 toward ACP, was also realized.
研究领域:
分析化学
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生物化学
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纳米技术
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DOI
PubMed
高影响因子
Acta Pharmaceutica Sinica B
·
2021
·
IF 11.614
Xinping Kuai,Yuefei Zhu,Zheng Yuan,Shengyu Wang,Lin Lin,Xiaodan Ye,Yiping Lu,Yu Luo,Zhiqing Pang,Daoying Geng,Bo Yin
Tumor-targeted immunotherapy is a remarkable breakthrough, offering the inimitable advantage of specific tumoricidal effects with reduced immune-associated cytotoxicity. However, existing platforms suffer from low efficacy, inability to induce strong immunogenic cell death (ICD), and restrained capacity of transforming immune-deserted tumors into immune-cultivated ones. Here, an innovative platform, perfluorooctyl bromide (PFOB) nanoemulsions holding MnO 2 nanoparticles (MBP), was developed to orchestrate cancer immunotherapy, serving as a theranostic nanoagent for MRI/CT dual-modality imaging and advanced ICD. By simultaneously depleting the GSH and eliciting the ICD effect via high-intensity focused ultrasound (HIFU) therapy, the MBP nanomedicine can regulate the tumor immune microenvironment by inducing maturation of dendritic cells (DCs) and facilitating the activation of CD8 + and CD4 + T cells. The synergistic GSH depletion and HIFU ablation also amplify the inhibition of tumor growth and lung metastasis. Together, these findings inaugurate a new strategy of tumor-targeted immunotherapy, realizing a novel therapeutics paradigm with great clinical significance.
研究领域:
癌症治疗
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纳米技术
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医学成像
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免疫学
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生物医学工程
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DOI
PubMed
高影响因子
WATER ENVIRONMENT RESEARCH
·
2026
·Vol. 98
·期 4
·e70380
·
IF 2.8
Shifeng Li,Yan Zhou,Shiyu Wang,Shuhua Yao,Min Xiao
Arsenic contamination in water, particularly from highly toxic arsenite (As(III)), continues to pose a significant global public health challenge due to its high mobility and resistance to conventional treatment methods. This study presents an innovative core-shell β-FeOOH@MnO 2 nanocomposite, which synergistically integrates MnO 2 nanosheets to oxidize As(III) into adsorptive arsenate (As(V)) and β-FeOOH to facilitate the efficient uptake of As(V). This approach addresses common limitations such as particle aggregation and suboptimal adsorption observed in pure MnO 2 systems. The nanocomposite, synthesized by hydrothermal methods, exhibits a doubled surface area of 172.95 m 2 /g, offering numerous active sites and mesopores conducive to rapid mass transfer. Under optimized conditions (pH 3.0, 0.4-g/L dosage), the nanocomposite achieved 98.39% removal of As(III) and a maximum adsorption capacity of 50.26 mg/g at 25°C, following pseudo-second-order kinetics and endothermic chemisorption. Characterization techniques, including X-ray diffraction (XRD), transmission electron microscopy (TEM), and X-ray photoelectron spectroscopy (XPS), confirmed the synergistic mechanism, wherein MnO 2 oxidizes As(III) through the reduction of Mn 4+ to Mn 3+ , and the resulting As(V) is adsorbed by β-FeOOH. This advancement offers a cost-effective and efficient solution for improved arsenic remediation in water treatment applications. Graphical A core-shell β-FeOOH@MnO 2 nanocomposite effectively removes toxic arsenite by oxidizing mobile As(III) to adsorptive As(V) and adsorbing it, achieving high removal efficiency.
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高影响因子
ChemCatChem
·
2026
·Vol. 18
·期 5
·e70637
·
IF 4.1
Yintao Song,Hang Zheng,Mengyuan Huang,Quanwei Deng,Luhui Lin,Yaqi Shi,Jiacheng Li,Chenting Yang,Lu Lin,Changlong Wang,Xing Tang
We have developed a highly efficient and stable non-noble metal-based heterogeneous catalyst for the selective oxidation of HMF to DFF. Mixed oxide catalysts with different Mn/Ni molar ratios were synthesized using the urea precipitation method. The Mn 6.6 NiO X catalyst exhibited a 95.33% HMF conversion rate and a 99.39% DFF selectivity under the conditions of 110°C, 2 h, 1 MPa O 2 , and N,N -dimethylformamide. Experimental results indicate that the introduction of NiO can effectively regulate the crystal structure of MnO 2 , forming an amorphous Mn─O─Ni interface, which significantly increases the specific surface area (SSA) of the catalyst while reducing the binding energy of surface lattice oxygen (O L ), promoting the generation of oxygen vacancies (O V ), and thereby enhancing the adsorption and activation capabilities of O 2 . Combined adsorption experiments and kinetic analysis revealed that Ni species preferentially anchor the hydroxymethyl group in HMF molecules, enhancing reaction selectivity. Further experiments demonstrated that the Mn 6.6 NiO x catalyst, under certain conditions, could achieve an HMF conversion rate of 87.52% and a DFF selectivity of 85.81% even at a high substrate concentration of 10 wt% HMF.
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Small
·
2016
·Vol. 12
·期 40
·5564-5571
·
IF 8.315
Ming Zhong,Donghui Yang,Chenchao Xie,Zhang Zhang,Zhen Zhou,Xian-He Bu
Manganese oxides (MnO x ) are promising anode materials for lithium ion batteries, but they generally exhibit mediocre performances due to intrinsic low ionic conductivity, high polarization, and poor stability. Herein, yolk–shell nanorods comprising of nitrogen-doped carbon (N–C) coating on manganese monoxide (MnO) coupled with zinc manganate (ZnMn 2 O 4 ) nanoparticles are manufactured via one-step carbonization of α -MnO 2 /ZIF-8 precursors. When evaluated as anodes for lithium ion batteries, MnO@ZnMn 2 O 4 /N–C exhibits an reversible capacity of 803 mAh g −1 at 50 mA g −1 after 100 cycles, excellent cyclability with a capacity of 595 mAh g −1 at 1000 mAg −1 after 200 cycles, as well as better rate capability compared with those non-N–C shelled manganese oxides (MnO x ). The outstanding electrochemical performance is attributed to the unique yolk–shell nanorod structure, the coating effect of N–C and nanoscale size.
研究领域:
材料科学
·
能源存储与转换
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DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2019
·
IF 8.355
Zimo Lou,Jiang Xu,Jiasheng Zhou,Kunlun Yang,Zhen Cao,Yizhou Li,Yuanli Liu,Liping Lou,Xinhua Xu
Atomic H* has been regarded as the key active species for the electrocatalytic hydrodechlorination (ECH), and the electrode design and operation conditions are related to the atomic H* generation. However, there is limited understanding of how the operation parameters affect the atomic H* generation and utilization. Due to the fact that Pd was inefficient in water dissociation step, MnO 2 was combined with Pd to construct a novel Pd/MnO 2 /Ni foam cathode. Cyclic voltammetry confirmed that Pd/MnO 2 /Ni foam cathode with MnO 2 load of 0.51 mg cm −2 possessed the highest atomic H* generation and ECH activity. Excessive Pd load (>0.44 mg cm −2 ) was detrimental to ECH because of the side hydrogen evolution reaction (HER). Operation conditions (e.g. applied current and electrolyte concentration) would directly affect the cathode potential, which was an important indicator of the atomic H* generation. The optimal cathode potential was determined to be −0.85 V when the applied current was 10 mA in this study. The electrolyte concentration of 10–15 mM was able to provide sufficient atomic H* for ECH, while excessive input of electrolyte would favor HER but inhibit ECH. ECH at acidic and neutral/alkaline solution underwent different pathways for atomic H* generation and further affect the utilization of atomic H*. After 120 min reaction, >70% of atomic H* could be selectively used for ECH at initial pH of 4.0 and 5.0, while only ∼37% was used for ECH at initial pH of 7.0. This work correlated the reactivity of electrode with the atomic H* and cathode potential, which would provide strategies for ECH catalyst design and operation optimization.
研究领域:
环境科学
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电化学
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DOI
高影响因子
Journal of Analysis and Testing
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2026
·
IF 9.4
Huang Shan,Liu Xinqi,Huang Aoxiang,Zhuo Yongxiu,Huang Tiantian,Fang Yi,Wei Fuxiang,Xiao Qi
As one of the most extensively applied herbicides globally, glyphosate (GLY) is frequently detected in food and water matrices, raising substantial concerns regarding its potential harm to human health. Addressing this challenge calls for analytical platforms that offer both reliable performance and operational convenience. In this work, a GLY-responsive nanoenzyme was developed by hybridizing Zr-based metal–organic frameworks (Zr-MOF) with manganese dioxide (MnO 2 ). The system capitalizes on the strong chelation between GLY and metal centers, which destabilizes the nanozyme structure and consequently modulates its catalytic activity toward colorimetric readout. The resulting composite enables precise quantification of GLY in solution and can be readily incorporated into paper substrates to support visual, user-friendly sensing. In solution format, the assay achieves a linear response over 0.001–10 mg/mL with a limit of detection (LOD) of 0.9 μg/mL, whereas the paper-based counterpart operates within 0.05–20 mg/mL and affords an LOD of 0.03 mg/mL, making it well-suited for cost-effective field applications. Both detection formats were validated using GLY-spiked fruit and water samples. Recovery rates fell between 90.5% and 110% for the solution-based method, and between 95.3% and 105% for the paper-based strips, with relative standard deviations (RSDs) of less than 15% and 7%, respectively, indicating satisfactory accuracy and reproducibility. Overall, this work presents a versatile strategy that bridges high analytical precision with straightforward operation, meeting the demands of both routine monitoring and point-of-use testing by non-professionals.
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高影响因子
ACS Applied Bio Materials
·
2023
·
IF 4.7
Wen-Xing Zhang,Ze-Lei Zhou,Qi-Yan Lv,Xiejie Song,Junyang Chen,Chang-Bin Niu,Hui-Fang Cui
Cancer starvation/photothermal combined tumor therapy (CST/PTT) has attracted great interest attributed to their mutual compensation and synergistically enhanced effect. However, the very low O2 supply in the tumor microenvironment (TME) greatly limits the CST efficiency of glucose oxidase (GOx). Additionally, the easy degradation in blood circulation and significant off-target effects are big challenges for clinical applications of the GOx-based CST. In this study, a drug delivery system (DDS) with specific tumor-targeted GOx delivery, near-infrared (NIR) light and TME responsive O2 generation, NIR-responsive glucose consumption, high GOx loading, and efficient NIR photothermia was developed. Positively charged AuNRs@MnO2@SiO2 nanoparticles (named AMS+ NPs) were synthesized. GOx was covalently loaded with a high loading ratio of 36.0%. Finally, a thermosensitive biomimetic hybrid membrane composed of a thermosensitive lipid (TSL) membrane, red blood cell membrane (RBCM), and 4T1 cancer cell membrane (CCM) was coated on the NPs through a double-layer strategy. The AMS+-G@TSL@[RBC-CC-TSL]M NPs consumed 32.7 times glucose at 50 °C as that at 37 °C and generated 4.9 times O2 upon NIR laser irradiation. The thermosensitive biomimetic NPs showed an efficient targeting capability to the homotypic 4T1 cancer cells/tumors accompanied by good biocompatibility, macrophage evading capability, high cancer cell cytotoxicity, and excellent antitumor efficacy. The tumor growth inhibition ratio with NIR laser irradiation reached 92.8%. The AMS+-GOx@TSL@[RBC-CC-TSL]M NPs provide a smart, efficient, safe, PTT/CST combined DDS for highly efficient tumor therapy.
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高影响因子
ENVIRONMENTAL TECHNOLOGY
·
2021
·
IF 3.247
Xiaoman Li,Longsheng Yi,Qinglin Zhu,Lihua Zhao,Yuanhong Xu,Miao Liu,Tao Liu,Qian Wu
In this study, coal fly ash supported MnO2 (CFA@MnO2) was synthesized as heterocatalyst for the activation of peroxymonosulfate to degrade Acid Red 73 (AR73). The synthesized catalyst was characterized by X-Ray Fluorescence Spectrometer (XRF), X-ray powder diffraction (XRD), Scanning electron microscope (SEM), X-ray photoelectron spectroscopy (XPS) and Brunauer–Emmett–Teller (BET). The composite of CFA@MnO2 possesses a large surface area of 74.59 m2/g. In the catalytic experiment, CFA@MnO2 exhibits excellent catalytic performance with 99.13% AR73 removed within 40 min with a high kinetic rate constant of 0.124 min−1, 5.49 times higher than that of pure MnO2. The operating parameters of CFA@MnO2-based fenton catalytic system were discussed, including MnO2 loading, solution pH, PMS dosage and temperature. The catalyst maintained a relatively high removal rate (>85%) over 5 cycles and degradation intermediates are detected on the catalyst surface after cycled via XPS analysis. The degradation mechanism was investigated by quenching experiments and Electron Paramagnetic Resonance technology. The surface-bound ·OH and SO4·− are considered as the main active radicals in the degradation process. The composite of CFA@MnO2 provides a low-cost and efficient alternative for the catalytic oxidation of organic pollutants.
研究领域:
环境科学
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化学工程
·
材料科学
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DOI
PubMed
高影响因子
Journal of Cleaner Production
·
2021
·
IF 9.297
Kai-Qiang He,Chun-Gang Yuan,Yang-Hong Jiang,Yan Li,Xue-Lei Duan,Qi Guo
Some sorbents have been developed for arsenic (As) compounds capture from flue gas . However, most of the conventional sorbents have cost constraints and can cause secondary pollution due to the leaching of arsenic after use. To solve this problem, a new and highly efficient adsorbent for gaseous arsenic was successfully developed in this paper with excellent immobilization performance and low-cost. A series of Mn-supported attapulgite (ATP) composites were fabricated, characterized, and investigated for arsenic capture. The modification of ATP with Mn not only considerably enhanced the adsorption efficiency but also stabilized the adsorbed As in the spent sorbents. SO 2 in flue gas promoted the adsorption performance through As-sulfate binding, whereas NO was beneficial for the oxidation of As(III) to As(V) on the surface of Mn-modified ATP. The incorporation of Mn with ATP generated abundant hydroxylate (OH − ) from hydration and accelerated the formation of As-sulfate compounds, which was beneficial for physical encapsulation. The results of the toxicity characteristic leaching procedure and sequential extraction test revealed that adsorbed As could be considerably immobilized by the sorbent with low leaching ability. Mn modification changed more As into inert fractions and consequently inhibited release from spent sorbents, which considerably reduced the risks of secondary pollution. The developed composite can be potentially used as a new efficient sorbent for gaseous arsenic capture in flue gas.
研究领域:
环境科学
·
材料科学
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高影响因子
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