APPLIED SURFACE SCIENCE
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2021
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IF 6.707
Huimin Sun,Xiuting Li,Ziyang Hu,Chenjie Gu,Dong Chen,Jun Wang,Bin Li,Tao Jiang,Xingfei Zhou
As a typical membrane matrix with attractive flexibility, paper has exhibited great feasibility to serve as surface-enhanced Raman scattering (SERS) substrate in the environmental monitoring and surveillance. In this research, we have designed and fabricated a distinctive hydrophilic-hydrophobic SERS substrate utilizing several ordinary papers loaded with Ag nanowires (Ag NWs). Remarkable SERS activities with an enhancement factor (EF) up to 2.63 × 10 6 was successfully achieved in the assembly Ag NWs with the optimal amount of nanotips and overlaps. The hydrophilic-hydrophobic strategy could contribute to anchoring microdroplets and thus enrich analytes to improve the homogeneity of substrate with a low relative standard deviation of 10.6%. Furthermore, the sophisticated SERS substrate was also applied in the in-situ detection of trace furazolidone on fish under the interference of malachite green and the reliable recovery rates were demonstrated as well.
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JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY
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2021
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IF 2.262
Miao Qin,Xia Zhou,Jun Zhu,Mutian Ma,Hongyan Wang,Liangbao Yang
We herein report the preparation, optical properties, and use of gold nanorods for the detection and analysis of additives and impurities in weight-loss healthcare products. Gold nanorods with different aspect ratios were synthesized by controlling the silver nitrate content. The resulting self-assembled gold nanorods, combined with a portable Raman spectrometer, were used as surface-enhanced Raman scattering substrates to analyze and detect phenolphthalein and sibutramine hydrochloride in a simulated aqueous solution. The obtained results indicate the high sensitivity and stability of this detection method owing to the use of gold nanorod substrates prepared from 100 μL silver nitrate. Therefore, the proposed detection method has potential for promoting the application of Raman spectroscopy in the detection of such drugs.
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OPTICS EXPRESS
·
2021
·Vol. 29
·期 9
·13968-13977
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IF 3.894
Yuhang Song,Yuhang Song,Yuhang Song,Qin Wang,Qin Wang,Qin Wang,Ying Luo,Ying Luo,Wenxi Cao,Wenxi Cao,Zijin Cao,Zijin Cao,Changchun Yan,Changchun Yan,Aixia Lu,Aixia Lu,Aixia Lu,Caiqin Han,Caiqin Han,Caiqin Han
A silver nano-tripod (AgNT) structure with a high-density “hot spots” distribution was fabricated by a tilting angle deposition technique. The electric field simulation distribution showed that the electric field enhancement of the AgNT structures is optimal when the tilting angle is 72°. Such AgNT substrates were successfully obtained experimentally when the included angle between the silver vapor and the normal of the sample platform was set to 86°. R6G and CV were used as probe molecules to investigate the SERS activity of AgNT, which revealed that the detection limits of AgNT for R6G and CV were 2.24×10−8 M and 4.01×10−8 M, the relative standard deviations (RSDs) were 4.26% and 4.44%, and the enhancement factors (EFs) were 9.58×106 and 1.16×107, respectively. The AgNT substrates with simple preparation and high distribution density of “hot spots” illustrate a good application prospect in environmental monitoring.
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Micro & Nano Letters
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2020
·Vol. 15
·期 15
·1126-1129
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IF 0.975
Jun Wang,Aifeng Ning
Various sizes and morphologies of noble metal/zinc oxide hybrid materials have promising applications in surface-enhanced Raman scattering (SERS). Generally, organic agents used during the synthesis of metal nanoparticles will inexorably induce organic pollution on the surface of SERS substrate, resulting in a negative effect on detection sensitivity. Herein, a stable and clean 3D flower-like ZnO/Ag hierarchical microstructure SERS substrate was designed and fabricated via a simple photocatalytic method. This synthetic strategy does not involve usage of any organic agents, which ensures the cleanness and free of impurities interferences. As anticipated, the as-fabricated 3D flower-like ZnO/Ag SERS substrates with high surface-to-volume ratio increased numerous hot spots, and exhibited excellent detection sensitivity to Rhodamine 6G. A linear relationship between the Raman intensity and the concentration of Rhodamine 6G ranging from 10 −11 to 10 −4 M was realised. This work demonstrated a performance-enhanced SERS sensor based on microflower-like ZnO@Ag hybrids, which provides a potential method to develop highly sensitive and stable SERS sensor for organic molecules detection.
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APPLIED SURFACE SCIENCE
·
2020
·
IF 6.182
Jie Chen,Meizhen Huang,Lili Kong
In this work, we have developed a sensitive, flexible, cost-effective Ag/Nanocellulose fibers SERS substrate (Ag@NCF substrate) which is suitable for in-situ food safety detection. NCFs build nanoporous networks as flexible templates. Ag nanoparticles time-efficiently, in-situ grow on the cross fibers, forming sensitive Ag clusters, providing a high density of ‘hot-spot’, further resulting in a significant enhancement of electromagnetic fields. The lowest distinguishable level of Rhodamine 6G is 10 −9 M and simplified models correspondingly reveal a high sensitivity of Ag@NCF substrate. In additions, the Ag@NCF film facilitates a simple, direct, in-situ ‘paste-test’ method for hazardous residue detection on actual food samples. The sensitive Ag@NCF substrates achieve ppb-level detection of pesticide and veterinary drug by a self-developed portable Raman spectrometer. The estimated LOD is low to 0.05 ppm for thiram, 0.09 ppm for thiabendazole, 0.0014 ppm for malachite green and 0.069 ppm for enrofloxacin, respectively. And hazardous residues could be directly detected on pear and fish by the Ag@NCF substrates. These results reveal that Ag@NCF substrate cooperated with portable Raman system is suitable for sensitive, in-situ, on-site pesticides and veterinary drugs detection on fruit or seafood and remains great potentials to expand to other on-site, in-situ applications.
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ANALYTICA CHIMICA ACTA
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2020
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IF 5.977
Yue Zhang,Linfang Li,Ye Gao,Xinnan Wang,Lei Sun,Wei Ji,Yukihiro Ozaki
Urinary 5-hydroxyindole-3-acetic acid (5-HIAA) is a marker for diagnosis of patients with carcinoid tumors. In clinical practice, a simple colorimetric assay has widely been utilized for urinary 5-HIAA via its reaction with 1-nitroso-2-naphthol (NNa) in nitrous acid medium. However, this colorimetric assay has been criticized for lack of specificity. Herein, we proposed a novel SERS-based method for selective detection of urinary 5-HIAA by the use of a modified nitrosonaphthol reaction, in which hydrochloric acid is substituted for nitric acid to control the reaction conditions. This slight modification is crucial to be able to detect the cationic products in the acidic reaction mixture, because the chloride-aggregated Ag colloids not only create enormous hot spots for SERS enhancement, but also improve the chemical stability of nanostructured Ag substrates in acidic environment. Under optimized conditions, the present method can detect 5-HIAA within 12 min at concentrations as low as 1.2 ng/mL, which is 1000 times lower than that of conventional colorimetric method . And more importantly, the present method exhibits specific response toward 5-HIAA against other metabolites with similar structures in the urine. The relative standard deviation (RSD) of the present method is less than 5%, suggesting the acceptable reproducibility. The recoveries ranging from 89.6% to 106.3% were obtained for spiked human urine samples with RSD of 3.7–4.9%. Furthermore, several healthy person’s urine samples were also analyzed using the present method, and experimental results are in compliance with the levels recorded in a healthy population. On the basis of these results we can conclude that the present SERS-based method can provide a valuable alternative to conventional colorimetric assay for clinical diagnosis, evaluating prognosis, and monitoring of treatment in carcinoid tumors.
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APPLIED SURFACE SCIENCE
·
2020
·
IF 6.182
Li Wang,Daqing Yu,Baoquan Huang,Ziyuan Ou,Li Tao,Lili Tao,Zhaoqiang Zheng,Jun Liu,Yibin Yang,Aixiang Wei,Yu Zhao
Two-dimensional (2D) transition metal dichalcogenides materials have recently been explored as possible substrates for surface-enhanced Raman spectroscopy (SERS). However, in comparison to the conventional noble-metal-based counterpart, most of the 2D materials have very small area for SERS measurement, which is a big limitation toward practical applications. Herein, we presented our study of SERS using substrate-scale continuous ReS 2 monolayer films on flexible mica substrate. We demonstrated that the charge transfer between the target molecules and the atomically thin ReS 2 can be modulated by the underlying substrate of ReS 2 , resulting in greatly different suppressing level of FL background. Kelvin probe force microscopy revealed a large difference of surface potential between ReS 2 /SiO 2 and ReS 2 /mica, suggesting that the strong FL quenching of molecular on ReS 2 /mica might be attributed to the inert surface of layered mica. The large-area ReS 2 monolayer films on mica show a detection limit of R6G molecule around 10 −7 M and a robust SERS performance after an exposure in air for one month and repeated bending for 1000 times. Our work explores the practical application of 2D ReS 2 for molecular detection via SERS technique.
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TALANTA
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2020
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IF 5.339
Kaiqiang Wang,Da-Wen Sun,Hongbin Pu,Qingyi Wei
The development of flexible and robust plasmonic substrates has become a hot research topic in simplifying and extending the application of surface-enhanced Raman scattering (SERS) technique for real-world analysis. In this work, a facile method to fabricate an Au@Ag nanoparticle array sandwiched between the adhesive acrylic polymer tape and polyethene terephthalate (PET) film (T/Au@Ag/PET) as a high-performance SERS chip was reported for nondestructive detection of thiram on fruit peels. For this SERS chip, the ordered Au@Ag nanoparticle array formed by the self-assembly method was closely-packed, which generated high‐density sub‐3‐nm gaps and could produce high reproducible and sensitive SERS enhancement effects. The measurement of crystal violet with the limit of detection of 7.24 × 10 −10 M was realized by targeting Raman shift at 1177 cm −1 . Moreover, the excellent flexible feature of acrylic polymer tape enabled the substrate to withstand a tensile strain value of 20% for three cycles without significantly losing its SERS activity. By covering with a PET film, the SERS chip could maintain 87% SERS activity after storage for 60 days in the air environment, and could well withstand the influence of harsh conditions such as high temperature and ultrasound treatments. As a proof of the concept, the SERS tape was directly used to detect thiram on apple, tomato, and cucumber peels via a simple sampling-and-detection procedure, and the detection limit of 5 ng/cm 2 was achieved. The T/Au@Ag/PET SERS chip should hold a promising candidate for food safety analysis in the future.
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SENSORS AND ACTUATORS B-CHEMICAL
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2020
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IF 7.1
Xinyu He,Chuang Ge,Xiangquan Zheng,Bin Tang,Li Chen,Shunbo Li,Li Wang,Liqun Zhang,Yi Xu
The rapid detection of alpha-fetoprotein (AFP) in serum is of great significance in the early diagnosis of hepatocellular carcinoma (HCC). A novel six-channel microfluidic SERS chip integrated with Ag/Au nanocomposites (NCs) for rapid SERS identification of AFP in serum was proposed in this work. Automatic injection was realized by negative pressure formed by specially designed PDMS module on the SERS chip. The serum samples originating from 60 HCC patients and 60 healthy people were measured by SERS on the designed microchip under the optimized conditions. The SERS spectra of serum samples from normal people and patients were collected and analyzed by Principal Component Analysis (PCA) which separated the characteristic Raman peaks of AFP of the two groups into two distinct clusters. Linear Discriminate Analysis (LDA) based on the PCA generated features differentiated the patients’ sera SERS spectra from the normal sera SERS spectra with a classification accuracy of 96.25% and a blind sample test accuracy of 95%. It is shown that the proposed microfludic SERS chip for AFP SERS test in serum can rapidly and efficiently identify HCC patients. It is of great research value and practical prospect in the fields of disease diagnosis and screening.
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FOOD CHEMISTRY
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2020
·
IF 6.306
Huirong He,Da-Wen Sun,Hongbin Pu,Lunjie Huang
Aflatoxin B1 (AFB1) as the most toxic mycotoxin in contaminated food can greatly threaten human health, and sensitive and selective detection of AFB1 is thus highly desired. An ultrasensitive surface-enhanced Raman spectroscopy (SERS) aptasensor was developed for AFB1 detection in peanut oil samples. SH-cDNA modified Fe 3 O 4 @Au nanoflowers acted as capture probes, SH-Apt modified [email protected] nanospheres and commercial Cy3-Apt were used as reporter probes. Strong SERS signals of reporter probes were produced due to the recognition of AFB1 aptamer and its complementary strand (SH-cDNA). With the preferred binding of AFB1 aptamer to AFB1, reporter probes were released from capture probes, causing a linear decrease in SERS intensity. Therefore an ultralow detection limit of 0.40 pg·mL −1 in a wide linear range of 0.0001–100 ng·mL −1 was obtained and the sensibility of this SERS aptasensor was higher than that of the Cy3-Apt based SERS aptasensor. In addition, an excellent selectivity in interfering toxins and satisfactory recoveries of 96.6–115% in peanut oil samples were obtained, proving this aptasensor is a promising analytical tool in AFB1 detection.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2020
·Vol. 412
·期 13
·3063-3071
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IF 3.637
Li Hongmei,Yue Xiaxia,Gao Ningning,Tang Jun,Lv Xiaoyi,Hou Junwei
Clopidol is one of the most widely used anti-coccidiosis drugs. Its residues in poultry products and the environment pose a serious threat to human health. In this work, microwave-assisted synthesis of magnetic ionic liquid/gold nanoparticles (MIL-Au NPs) as the SERS substrates were first designed for sensitive and reliable determination of clopidol residue in egg samples. The experiment shows that MIL(1-methyl-3-hexyl imidazole ferric tetrachloride ([C 6 mim]FeCl 4 )) and microwave play a key role in the dispersion and morphology of Au NPs. Under the optimal conditions, the as-prepared MIL-Au NPs were applied to the SERS detection of clopidol in methanol and egg solution and its detection limits can be as low as to 0.5 μg/kg (equal to 0.5 ppb) in both solutions. The standard curves with regression coefficients of 0.9298 and 0.93496 were constructed in the linear range of 100–1000 ppb and 0.5–50 ppb for clopidol in egg solutions. Moreover, satisfactory recoveries (97.5–103.2%) were obtained for egg samples. The developed SERS method provides a way for quantitation of clopidol and can be applied for the convenient, reliable, and highly sensitive detection of antibiotic residues in food and environment, which has great potential in food safety and biological monitoring.
Graphical abstract
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Journal of Food Measurement and Characterization
·
2020
·Vol. 14
·期 4
·2021-2029
·
IF 1.648
Hussain Abid,Pu Hongbin,Sun Da-Wen
Surface-enhanced Raman spectroscopy (SERS) with cysteamine modified silver-coated gold nanoparticles (Au@Ag-CysNPs) was presented for fast screening of oxamyl and thiacloprid in liquid samples of milk. Concentrations at different levels were detected ranging from 0.5 to 10 ppm by choosing 500–1600 cm −1 spectral range. A strongest Raman peak at 679 cm −1 was ascribed to oxamyl, whereas a band at 1095 cm −1 was associated with thiacloprid in milk samples. The morphology and average size of core-shell nanoparticles (Au@AgNPs) and Au@Ag-CysNPs were acquired by High-resolution transition electron microscopy images and dynamic light scattering. Images showed that Au@AgNPs which had a core size of 28 nm and a shell of 6 nm thickness was modified with 6 nm cysteamine hydrochloride successfully. High coefficient of determination (R 2 ) values of 0.9968 and 0.9875 was calculated for oxamyl and thiacloprid with the limits of detection of 0.031 ppm and 0.023 ppm, respectively. The current novel nanoparticle was easy to prepare and was suitable to serve as a sensitive substrate for SERS detection applications, which could be employed for assessing other accidental contaminants in other food matrices in future studies.
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危险品化学品经营许可证（带存储）