INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2023
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IF 8.2
Wenqi Song,Tiantian Xu,Liwei Qian,Sufeng Zhang,Chaoli Wang,Yuzhen Zhao,Zemin He,Valentin Nica,Zongcheng Miao
With the trend of sustainable development and the complex medical environment, there is a strong demand for multimodal antibacterial cellulose wound dressing (MACD) with photothermal therapy (PTT). Herein, a novel MACD fabrication strategy with PTT was proposed and implemented through graft polymerization of an imidazolium ionic liquid monomer containing iron complex anion structure. The fabricated hydrogels exhibited excellent antibacterial properties because of the efficient photothermal conversion ability (68.67 %) of ionic liquids and the intrinsic structural characteristic of quaternary ammonium salts. The antibacterial ratio of cellulosic hydrogel dressings to S. aureus and E. coli could reach 99.57 % and 99.16 %, respectively. Additionally, the fabricated hydrogels demonstrated extremely low hemolysis rates (<5 %) and excellent cell viability (~>85 %). Furthermore, in vivo antibacterial experimental results proved that the fabricated antibacterial dressings could significantly accelerate wound healing. Therefore, the proposed strategy would provide a new method of designing and preparing high-performance cellulose wound dressings.
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ACS Nano
·
2023
·
IF 17.1
Min Wei,Jingwen Bai,Xiao Shen,Kangliang Lou,Yiyang Gao,Ruichan Lv,Peiyuan Wang,Xiaolong Liu,Guojun Zhang
Breast-conserving surgery (BCS) is the standard of care for early breast cancer patients, while the high ratio of reoperation is still a challenge due to inaccurate margin assessments. In patients with locally advanced or advanced breast cancer, radiotherapy is an important treatment for local control or improvement of quality of life. However, enhancing sensitization to radiotherapy is an unmet medical need. To solve the above clinical predicaments, a glutathione (GSH) exhausting virus-like silicon dioxide nanoprobe with Gd coating and folic acid (FA) modification is designed. After loading ICG in the mesopores, the VGd@ICG-FA probe efficiently targets tumor cells with high resolution, due to its virus-like morphology and folate acid anchoring. Especially, the fabricated nanoprobe enables the identification of tiny cancers and navigates precise surgery under NIR-II fluorescence imaging. Moreover, after the nanoprobes enter into the cytoplasm of cancer cells, tetrasulfide linkages in the silica framework are broken under the triggering of high GSH concentrations. In turn, the broken framework exhausts GSH to disrupt intracellular reactive oxygen species (ROS) homeostasis, and Gd produces more ROS under radiotherapy, further activating ferroptosis, and resulting in the enhancement of radiotherapy in breast cancer. Therefore, our nanoprobe exhibits tremendous potential as a NIR-II fluorescence imaging agent with no systematic side effects for precise cancer surgery and nanotherapeutics for boosting radiation sensitivity in future clinical translation of breast cancer.
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Journal of Materials Chemistry B
·
2023
·Vol. 11
·期 25
·5898-5909
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IF 7
Mei Yang,Jun Yao,Borui Su,Nini Xin,Ting Zhou,Mingze Zeng,Chengheng Wu,Dan Wei,Jing Sun,Hongsong Fan
As nanozymes, carbon dots (CDs) have attracted increasing attention due to their remarkable properties. Besides general enzyme activity, their photoluminescence and photothermal properties have been explored rarely, whereas their synergistic effects might produce CDs-based nanozymes of high performance. Here, iron-doped CDs (Fe-CDs) with tunable fluorescence and enhanced peroxidase-like activity were designed to develop a novel “three-in-one” multifunctional platform to provide dual-mode/dual-target detection and near infrared (NIR)-assisted antibacterial ability. This proposed strategy for a H2O2 test exhibited a wide linear relationship with a low limit of detection (LOD) of 0.16 μM (colorimetric) and 0.14 μM (ratiometric fluorescent). Furthermore, due to the nature of cholesterol being oxidized to H2O2 by cholesterol oxidase, sensitive and selective detection of cholesterol was realized, and the LOD was 0.42 μM (colorimetric) and 0.27 μM (ratiometric fluorescent), surpassing that reported previously. This result suggested that Fe-CDs could be used for dual-mode quantification of large family of H2O2-producing metabolites, thereby paving the way for developing multi-mode sensing strategies based on nanozymes. Moreover, this platform showed synergistic effects for antibacterial application, indicating great prospects for bacterial killing as well as wound disinfection and healing. Hence, this platform could contribute to the construction of multifunctional CDs with high performance.
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EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
·
2023
·
IF 6.7
Jianv Wang,Jing Jia,Qingqing He,Yang Xu,Hongye Liao,Xia Xiong,Li Liu,Changzhen Sun
Recent advancements in tumour-targeted therapies and immunotherapy offer hope to patients with various malignancies. However, the uncontrolled growth and metastatic infiltration of malignant tumours remain a huge therapeutic challenge. Therefore, this study aimed to develop an integrated multifunctional diagnostic and treatment reagent IR-251 that can not only be used for tumour imaging but also to inhibit tumour growth and metastasis. Besides, our results showed that IR-251 targeted and damaged the mitochondria in cancer cells via organic anion-transporting polypeptides . Mechanistically, IR-251 induced ROS overproduction by inhibiting PPARγ and then inhibiting the β-catenin signalling pathway and downstream protein molecules related to the cell cycle and metastasis. Moreover, the excellent anti-tumour proliferation and metastasis ability of IR-251 were verified in vitro/in vivo . And histochemistry staining revealed that IR-251 inhibited tumour proliferation and metastasis, which showed no significant side effect. In conclusion, this novel, multifunctional, mitochondria-targeting near-infrared fluorophore probe IR-251 has great potential in achieving accurate tumour imaging and inhibiting tumour proliferation and metastasis, and the underlying mechanism of action of IR-251 is mainly via the PPARγ/ROS/β-catenin pathway.
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CHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 15.1
Yi Xing,Mengyun Zhou,Xiangmei Liu,Minghang Qiao,Liping Zhou,Tailin Xu,Xueji Zhang,Xin Du
Chemodynamic therapy (CDT), which catalyzes the production of highly toxic reactive oxygen species (ROS), has been widely used in tumor therapy in the past five years. However, most of the current nanomaterials for CDT are difficult to penetrate into the tumor effectively due to the lack of motility, resulting in an unsatisfactory CDT effect. Herein, bioinspired jellyfish-like carbon/manganese nanomotors (JCMNs) are designed to achieve hydrogen peroxide (H 2 O 2 ) and NIR light dual-propulsion for the enhanced CDT therapy. Based on the jellyfish-like asymmetric structure, the manganese component can catalyze H 2 O 2 to generate chemical concentration gradient, propelling JCMNs to dynamically generate ROS in cells by self-diffusiophoresis. In addition, the carbon component of JCMNs can absorb near-infrared (NIR) light to produce a temperature gradient, driving JCMNs to enhance tumor penetration by self-thermophoresis. The combination of chemical and NIR light propulsions significantly improves the efficiency of tumor CDT, revealing that it should be a reasonable strategy to promote the development of nanobiomedicine by endowing nanosystems with propulsion capacity.
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SCIENCE OF THE TOTAL ENVIRONMENT
·
2023
·
IF 9.8
Meiqing Zhu,Long Sun,Xina Liu,Xiaohui Pang,Fugang Fan,Xiaofan Yang,Rimao Hua,Yi Wang
Hg 2+ poses a great threat to human health and the environment due to its bioaccumulation and permanent damage. Herein, a reversible CHEF-based near-infrared fluorescent probe 2-(3-((E)-4-((E)-4-(diethylamino)-2- hydroxybenzylidene)amino)styryl)-5,5-dimethylcyclohex-2-en-1-ylidene)propanedinitrile ( DHEY ) capable of specifically recognizing Hg 2+ was constructed. DHEY exhibits advantages of large Stokes shift (157 nm), excellent selectivity , high sensitivity (LOD = 3.2 μg/L), and fast response efficiency (<3 min). Interestingly, DHEY can also realize rapid and effective detection of Hg 2+ after being recycled 7 times. The successful recovery of trace Hg 2+ in different environmental water samples fully demonstrates the potential of DHEY for actual applications. In particular, DHEY enables real-time observation of the distribution and translocation pattern of exogenous Hg 2+ in HeLa cells and zebrafish. This work provides important theoretical support for investigating the fate of heavy metal ions in the environment using fluorescence techniques.
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ADVANCED MATERIALS
·
2023
·Vol. 35
·期 26
·2211432
·
IF 29.4
Xiaojun He,Yuna Qian,Chenglin Wu,Jiayao Feng,Xiaoshuai Sun,Qinxiang Zheng,Xiaokun Li,Jianliang Shen
Bacterial infections, such as bacterial keratitis (BK) and subcutaneous abscess, pose significant challenges to global healthcare. Innovative and new antibacterial agents and antibacterial strategies are in demand to control infections in this era of high drug resistance. Nanotechnology is gradually emerging as an economically feasible and effective anti-infection treatment. High-entropy MXenes (HE MXenes) are used to confer desirable properties with exposed active sites to high-entropy atomic layers, whose potential application in the field of biomedicine remains to be explored. Herein, monolayer HE MXenes are fabricated by implementing transition metals with high entropy and low Gibbs free energy to fill the gap in the biocatalytic performance of non-high-entropy MXenes. HE MXenes are endowed with extremely strong oxidase mimic activity ( K m = 0.227 m m ) and photothermal conversion efficiency (65.8%) in the second near-infrared (NIR-II) biowindow as entropy increases. Subsequently, HE MXenes realize NIR-II-enhanced intrinsic oxidase mimic activity for killing methicillin-resistant Staphylococcus aureus and rapidly removing the biofilm. Furthermore, HE MXenes can effectively treat BK and subcutaneous abscess infection induced by methicillin-resistant Staphylococcus aureus as nanotherapeutic agents with minuscule side effects. Overall, monolayer HE MXenes demonstrate promising clinical application potential in the treatment of drug-resistant bacterial infections and promote the healing of infected tissues.
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Nano Today
·
2023
·
IF 17.4
Jiahuan Xu,Liang Chen,Sujun Ding,Xinyue Dai,Yanfei Dai,Yu Chen,Xuejun Ni
Two-dimensional (2D) transition metal carbides/nitrides (MXenes) have been extensively applied in biomedicine . However, the potential of MXene-based nanomedicine in sonodynamic therapy (SDT) has been rarely explored. Here, under the guidance of theoretical calculation, Nb 2 C MXenes are engineered as a high-performance sonocatalyst/sonosensitizer through mild in-situ self-oxidation. The work function values of Nb 2 C MXenes with different oxidation degrees are calculated to determine the optimized conditions to construct efficient Schottky heterojunction in the self-oxidized Nb 2 C MXenes. Experimentally, the niobium oxide clusters are homogeneously self-generated in-situ in Nb 2 C MXenes to form efficient Schottky barriers after the mild hydrothermal oxidation. The results reveal that the Schottky heterojunction can accelerate the separation of sono-triggered electron-hole pairs and inhibit their recombination, which profoundly augments the reactive oxygen species (ROS) generation efficiency of the in-situ self-oxidized Nb 2 C MXenes (denoted as Nb 2 C-Ox) under ultrasound (US) irradiation. The mild oxidation also allows the Nb 2 C-Ox to inherit the high photothermal performance of Nb 2 C MXenes in the second near-infrared (NIR-II) window. Accordingly, the developed Nb 2 C MXene-originated sonocatalyst/sonosensitizer can achieve high therapeutic efficacy based on the sonodynamic effect and NIR-II photonic hyperthermia. Therefore, this work proposes a theoretical calculation-oriented strategy to design and fabricate new MXene-based sonocatalysts/sonosensitizers for biomedical applications .
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BIOMACROMOLECULES
·
2019
·
IF 5.667
Baoxuan Huang,Jia Tian,Dawei Jiang,Yun Gao,Weian Zhang
Photodynamic therapy (PDT) is a promising treatment modality for cancer treatment owing to its minimally invasive nature and negligible drug resistance. However, the disadvantages of conventional photosensitizers including universal aggregation-caused quenching (ACQ) effect or nonselective activation are still major hurdles for PDT clinical application. Herein, a new strategy for flexible manipulating photosensitizers in effective quenching and quick recovery of photoactivation is presented by introducing porphyrin units into upper critical solution temperature (UCST) block copolymer decorated gold nanorods (AuNR-P(AAm-co-AN-co-TPP)-b-PEG). The UCST block copolymer can achieve a self-quenching effect to make the porphyrin photosensitizers in the “Off” state by π–π stacking and hydrogen bonding interactions at physiological temperature, which greatly minimizes the nonselective phototoxicity of the photosensitizers to meet the requirement of phototherapy protected from sunlight. After the immigration of AuNR-P(AAm-co-AN-co-TPP)-b-PEG nanoparticles into the tumor tissue and the internalization by cancer cells, the UCST polymer chains can be extended under the local heating of AuNRs by NIR light irradiation, and then porphyrin photosensitizers are turned “On” to dramatically boost the PDT efficiency. Therefore, the process of PDT could be well manipulated in the “Off/On” state by the hybrid nanoplatform with UCST block copolymers and AuNRs, which will open new horizons for clinical treatments of PDT.
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CHEMICAL ENGINEERING JOURNAL
·
2019
·
IF 8.355
Yanjuan Huang,Yali Jiang,Zhanghong Xiao,Yifeng Shen,Liangfeng Huang,Xiaoyu Xu,Gaofei Wei,Congjun Xu,Chunshun Zhao
Strategies utilizing reactive oxygen species (ROS) to cause cell death are widely practiced for cancer therapy, including photodynamic therapy (PDT) and chemodynamic therapy (CDT). However, the efficiency of PDT alone is greatly hindered by tumor hypoxia, laser penetration depth and the relatively low oxidation performance of 1 O 2 and its subsequent products H 2 O 2 . Meanwhile, CDT is limited by the deficiency of endogenous H 2 O 2 in cancer cells. If the ROS, produced in PDT process, served as the substrate in CDT, the total ROS production would be greatly enhanced. However, the increased ROS could be scavenged by the overexpressed glutathione (GSH) in cancer cells, impairing the effect of PDT and CDT. Thus, in this study, a self-reinforcing ferric pyrophosphate based nanoagent (FeP-ZnPc) for synergetic NIR-triggered photo/chemodynamic therapy with glutathione depletion ability was constructed. The constructed FeP-ZnPc exhibited “triple use”: PDT, CDT and GSH depletion function. Upon internalized into cancer cells, the FeP-ZnPc could release Fe 3+ which underwent a redox reaction with GSH, resulting in GSH depletion and the production of Fe 2+ . Upon laser, Zinc phthalocyanine (ZnPc) in the FeP-ZnPc could generate ROS for PDT directly. Moreover, the elevated ROS particularly H 2 O 2 could serve as the substrate of CDT, accelerating the Fenton reaction process, producing the strongest oxidants, hydroxyl radical ( OH) and leading to ROS burst to expedite cell death. This combination strategy of enhancing ROS production and inhibiting ROS elimination could eventually break down the redox homeostasis and enhance the ROS-mediated cancer therapy.
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JOURNAL OF HAZARDOUS MATERIALS
·
2019
·
IF 7.65
Yuefa Jia,Shiping Li,Haoxuan Ma,Jianzhi Gao,Gangqiang Zhu,Fuchun Zhang,Jun Young Park,Sangwon Cha,Jong-Seong Bae,Chunli Liu
To fully utilize the solar light, photocatalyst with broad spectrum response from UV to near-infrared (NIR) is desirable. In this work, ternary mixed valent Bi 2 O 4 -Bi 4 O 7 -BiO 2-x with rich oxygen vacancy has been synthesized through one-pot hydrothermal treatment of NaBiO 3 . The results showed that through adjusting the hydrothermal conditions, oxygen vacancy-rich Bi 2 O 4 -Bi 4 O 7 -BiO 2-x nanocomposites with much higher efficiency than single or mixed bismuth oxides (Bi 2 O 4 , Bi 4 O 7 , BiO 2-x and Bi 4 O 7 -BiO 2-x ,) can be synthesized for photocatalytic degradation of bisphenol A (BPA) under UV, visible, and NIR light irradiation. In addition, the liquid chromatography-mass spectrometer (LC–MS) characterization demonstrated that BPA was oxidized to 4-isopropenyphenol first and the rings were opened sequentially under NIR light irradiation. Further detection of reactive species indicated that holes, O 2 − , and OH were the main oxidizing species in the degradation system. The experimental observations and density functional theory (DFT) calculations suggested that both type-II and the Z-scheme charge transfer with oxygen vacancies as electrons and holes mediators were formed at the interfaces of Bi 2 O 4 , Bi 4 O 7 , and BiO 2-x , resulting in a very efficient separation of photogenerated charge carriers in the composite. This work adds to the growing potential of mixed valent bismuth oxides based photocatalysts and is expected to accelerate the pace of the development of new-generation photocatalysts with high efficiency utilizing full-spectrum solar light.
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CHEMISTRY-A EUROPEAN JOURNAL
·
2018
·Vol. 24
·期 51
·13676-13680
·
IF 5.16
Huishan Shang,Qiumei Di,Muwei Ji,Bing Bai,Jiajia Liu,Wenxing Chen,Meng Xu,Hongpan Rong,Jia Liu,Jiatao Zhang
Graphical Tunable nanocrystals . Ternary I-III-VI 2 (AgInS 2 ) colloidal nanocrystals (NCs) with precise control of the composition (from In 3+ doping to ternary composition) and good NIR fluorescence performance (800–1000 nm) have been synthesized by facile low-temperature in situ conversion of colloidal Ag 2 S nanoparticles. In 3+ ions were inserted into the crystal lattice of Ag 2 S NCs at a relatively low temperature as dopant with ternary AgInS 2 NCs obtained at a higher temperature following a phase transition (see figure). Focusing on ternary I-III-VI 2 colloidal nanocrystals (NCs) synthesized with precise control of the composition (from doping to ternary composition) and NIR fluorescence performance, monodisperse binary In 3+ -doped Ag 2 S NCs and ternary AgInS 2 NCs have been achieved successfully by facile low-temperature in situ conversion of colloidal Ag 2 S nanoparticles. In 3+ ions were inserted into the crystal lattice of Ag 2 S NCs at a relatively low temperature as dopant and ternary AgInS 2 NCs were obtained at a higher temperature following a phase transition. These doped Ag 2 S and AgInS 2 NCs based on different indium precursor concentrations were explored with respect to the position and intensity of the near-infrared photoluminescent emission at different doping levels and crystal phase evolution.
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