MOLECULES
·
2024
·Vol. 29
·期 7
·1600
·
IF 4.2
Wenwen Long,Mingyue You,Jieli Li,Yan Wang,Dan Wang,Xueping Tao,Li Rao,Zhining Xia,Qifeng Fu
Enhancing the pH-independence and controlling the magnitude of electroosmotic flow (EOF) are critical for highly efficient and reproducible capillary electrophoresis (CE) separations. Herein, we present a novel capillary modification method utilizing sulfonated periodate-induced polydopamine (SPD) coating to achieve pH-independent and highly reproducible cathodic EOF in CE. The SPD-coated capillaries were obtained through post-sulfonation treatment of periodate-induced PDA (PDA-SP) coatings adhered on the capillary inner surface. The successful immobilization of the SPD coating and the substantial grafting of sulfonic acid groups were confirmed by a series of characterization techniques. The excellent capability of PDA-SP@capillary in masking silanol groups and maintaining a highly robust EOF mobility was verified. Additionally, the parameters of sulfonation affecting the EOF mobilities were thoroughly examined. The obtained optimum SPD-coated column offered the anticipated highly pH-independent and high-strength cathodic EOF, which is essential for enhancing the CE separation performance and improving analysis efficiency. Consequently, the developed SPD-coated capillaries enabled successful high-efficiency separation of aromatic acids and nucleosides and rapid cyclodextrin-based chiral analysis of racemic drugs. Moreover, the SPD-coated columns exhibited a long lifetime and demonstrated good intra-day, inter-day, and column-to-column repeatability.
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高影响因子
Advanced Energy Materials
·
2018
·Vol. 8
·期 18
·1703489
·
IF 21.875
Fulin Yang,Yuanmeng Zhao,Yeshuang Du,Yongting Chen,Gongzhen Cheng,Shengli Chen,Wei Luo
The search for Pt-free electrocatalysts exceeding pH-universal hydrogen evolution reaction (HER) activities when compared to the state-of-the-art commercial Pt/C is highly desirable for the development of renewable energy conversion systems but still remains a huge challenge. Here a colloidal synthesis of monodisperse Rh 2 P nanoparticles with an average size of 2.8 nm and their superior catalytic activities for pH-universal HER are reported. Significantly, the Rh 2 P catalyst displays remarkable HER performance with overpotentials of 14, 30, and 38 mV to achieve 10 mA cm −2 in 0.5 m H 2 SO 4 , 1.0 m KOH, and 1.0 m phosphate-buffered saline, respectively, exceeding almost all the documented electrocatalysts, including the commercial 20 wt% Pt/C. Density functional theory calculations reveal that the introduction of P into Rh can weaken the H adsorption strength of Rh 2 P to nearly zero, beneficial for boosting HER performance.
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高影响因子
LANGMUIR
·
2025
·
IF 3.9
Lijuan Zhu,Chun Feng,Pengao Yu,Yuchi Guo,Zongxue Yu,Xiaofeng Bai,Yuji Li
This article prepared a multifunctional anticorrosion superhydrophobic dual-layer coating with pH-response behavior. By modification of ZIF-8 with low surface energy substance stearic acid, and then loading the corrosion inhibitor 2-amino-5-mercapto-1,3,4-thiadiazole (AMT), a superhydrophobic nanocontainer encapsulating the corrosion inhibitor was prepared. The first layer of the smart coating was applied by using a brushing technique, while the second layer of the superhydrophobic coating was achieved through a spraying method. This composite coating exhibits both pH-responsive behavior and superhydrophobic properties. An electrochemical impedance spectroscopy test was conducted by immersing the composite coating in a 3.5 wt % NaCl solution. The results indicated that the dual-layer superhydrophobic anticorrosion composite coating, designated as ZST/EP-S, maintained the highest low-frequency impedance value after 40 days of immersion, which was 4 orders of magnitude greater than that of pure EP and 1 order of magnitude higher than the smart anticorrosion coating ZST/EP. This demonstrates a significant enhancement in corrosion resistance for the dual-layer superhydrophobic anticorrosion composite coating. Scratch test and UV–vis light experiments verified the successful release of corrosion inhibitor AMT.
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高影响因子
SURFACE & COATINGS TECHNOLOGY
·
2024
·
IF 5.3
Shurong Zheng,Guangyao Dai,Qimei Xue,Ruiqi Liang,Wancheng Zhu,Changhao Wang,Yashao Chen
Biodegradable magnesium alloy (MgA) is a promising candidate material for orthopedic implants due to its excellent biocompatibility and mechanical properties. However, its poor corrosion resistance, susceptibility to infection, and differences in mechanical properties with human tissues always hinder its application in biomedical fields. Therefore, the construction of MgA surface with good corrosion resistance, excellent antimicrobial properties, and suitable mechanical properties is highly desired for its clinical applications. Herein, we have designed micro/nano composited structures containing pH-responsive hydrogel micropatterns and inorganic nanomaterials onto the surface of MgA (MgA-MgO-HANRs-Micropatterns) to improve its biological activities. Firstly, a MgO film was prepared on the surface of MgA using micro-arc oxidation method. Then, hydroxyapatite nanorods (HANRs) were grown on the MgO film using microwave-assisted hydrothermal method. Further, using UV light and photomasking technique, 2-hydroxyethyl methacrylate (HEMA) and 2,2-dimethylacryloyloxy-1-ethoxypropane (DMAEP) were polymerized on the surface of HANRs with loading of antibacterial agent carvacrol to construct pH-responsive hydrogel-carvacrol micropatterns at different sizes. The hydrophilicity, antimicrobial, antifouling and biocompatibility of MgA-MgO-HANRs-Micropatterns are significantly enhanced in comparison with MgA. In bacterial infections and inflammatory environments at pH = 5.0, the micropatterned hydrogel coating releases carvacrol due to ketone bond cleavage, which enhances the antimicrobial capacity of the MgA samples. Compared with MgA, the corrosion current density of MgA-MgO-HANRs-5 μm is reduced by four orders of magnitude and could be maintained even immersing in the simulated body fluids for 30 days. In addition, the bactericidal rates of MgA-MgO-HANRs-5 μm against S. aureus and E. coli are 96 % and 89 %, respectively, and the sample shows long-term and stable antimicrobial performance with the ability to kill nearly 75 % of S. aureus and 82 % of E. coli after 14 days of immersion.
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2024
·
IF 4.3
Zhe Li,Xiaohui Wang,Xiuli Fu,Jinhua Liu,Yuanan Liu,Hongxin Zhang
The pH and O 2 are the two important parameters to evaluate environmental conditions, healthcare, and industrial processes. Herein, we developed a ratiometric fluorescent capillary-based dual-functional sensor for simultaneous monitoring of pH and O 2 fluctuations. The fluorescent sensor consists of a pH sensing unit and an O 2 sensing unit on both ends of the capillary inner wall. The ratiometric fluorescent pH sensing unit includes pH-sensitive probe HPTS and the reference dye Ce6, while the O 2 sensing unit is composed of O 2 -sensitive probe RuDP and the reference dye C6. Under single-wavelength excitation at 430 nm, the ratiometric fluorescent dual-functional sensor exhibits highly sensitive, selective and reproducible responses to both pH and O 2 . As for practical aqueous samples, the results about pH and O 2 levels obtained by our sensor are considerable consistent with commercial devices. Meanwhile, the dynamic changes of pH and O 2 levels during glucose catalysis by glucose oxidase can be detected in real-time and accurately. The dual-functional ratiometric fluorescent capillary transducer provides a significant potential platform for environmental monitoring and medical diagnosis.
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高影响因子
JOURNAL OF CHEMICAL PHYSICS
·
2024
·Vol. 161
·期 5
·
IF 3.1
Li Xiaoping,Ma Lijing,Zhou Yu,Lu Xinlong,Jing Li,Jing Dengwei
Regarding the rheological properties of fluids, certain nanoparticles can markedly modify the rheological behavior of low surface tension solutions by interacting with surfactant molecules. In this work, a low surface tension fluid with cetyltrimethylammonium chloride was prepared, and the silica nanoparticles were uniformly dispersed into it by ultrasonic dispersion. By adjusting the size, shape, and concentration of nanoparticles, the fluid behavior can be changed from Newtonian to non-Newtonian with finely tuned viscosity and characterized by a shear-thinning rheological behavior. In addition, this work explored how variations in environmental temperature and solution pH affect the rheological responses of the low surface tension suspension system. The experimental findings revealed that increasing the temperature substantially decreases the system’s viscosity and induces a shear-thickening behavior. It is particularly significant that, under extreme pH conditions (either strongly acidic or alkaline), the viscosity of the nanoparticle suspensions was markedly enhanced at a particle concentration of 10 000 ppm. This interesting result coincided with a notable reduction in the zeta potential and an increase in the average particle size, suggesting an intensified aggregation of particles within the suspension system. A mechanism detailing the interaction between silica nanoparticles and surfactant micelles was proposed. This work indicates that the incorporation of nanoparticles into surfactant solutions offers a powerful approach to modulating fluid rheology across various conditions.
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高影响因子
ACS Nano
·
2025
·
IF 16
Wei Liu,Anyang Wang,Jihan Zhang,Shixiang Yu,Maolin Wang,Shuheng Tian,Haoyi Tang,Ziwen Zhao,Xiao Ren,Yuzheng Guo,Ding Ma
Constructing subnanometric electrocatalysts is an efficient method to synergistically accelerate H2O dissociation and H+ reduction for pH-universal hydrogen evolution reaction (HER) for industrial water electrolysis to produce green hydrogen. Here, we construct a subnanometric Pt/α-MoC catalyst, where the α-MoC component can dissociate water effectively, with the rapid proton release kinetics of Pt species on Pt/α-MoC to obtain a good HER performance at high current densities in all-pH electrolytes. Quasi-in situ X-ray photoelectron spectroscopy analyses and density functional theory calculations confirm the highly efficient water dissociation capability of α-MoC and the thermodynamically favorable desorption process of hydrolytically dissociated protons on Pt sites at the high current density. Consequently, Pt/α-MoC requires only a low overpotential of 125 mV to achieve a current density of 1000 mA cm–2. Moreover, a Pt/α-MoC-based proton exchange membrane water electrolysis device exhibits a low cell voltage (1.65 V) and promising stability over 300 h with no performance degradation at an industrial-level current density of 1 A cm–2. Notably, even at a current of 100 A, the cell voltage remains low at 2.15 V, demonstrating Pt/α-MoC’s promising potential as a scalable alternative for industrial hydrogen production. These findings elucidate the synergistic mechanism of α-MoC and atomically dispersed Pt in promoting efficient HER, offering valuable guidance for the design of electrocatalysts in high current density hydrogen.
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高影响因子
LUMINESCENCE
·
2024
·Vol. 39
·期 12
·e70055
·
IF 3.2
Jiarui Si,Yikang Liu,Yuanfei Jiang,Yutong Chen,Anmin Chen,Mingxing Jin
The fluorescence quenching behavior of rhodamine 6G (R6G) by graphene oxide (GO) under varying pH conditions was investigated. Utilizing steady-state fluorescence spectroscopy, single-photon counting, and ultrafast time-resolved absorption spectroscopy, we explored the quenching efficiency at pH values of 3, 7, and 11. Our findings reveal that GO effectively quenches R6G fluorescence across all tested pH levels, with the most significant quenching observed at pH 7. This quenching efficiency is attributed to optimal electrostatic interactions and efficient charge transfer between GO and R6G at neutral pH. At pH 3, the quenching efficiency is moderately reduced due to partial protonation of GO, which weakens electrostatic interactions but maintains hydrogen bonding. At pH 11, the quenching efficiency is lowest, likely due to increased electrostatic repulsion and reduced charge transfer resulting from deprotonation of GO. Ultrafast time-resolved absorption spectroscopy further confirmed the dynamic nature of the quenching process, showing distinct differences in relaxation kinetics across the pH spectrum. This study highlights the critical role of pH in modulating the quenching mechanisms of GO and R6G, providing valuable insights for the design of pH-sensitive fluorescence sensing systems.
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高影响因子
ACS Applied Nano Materials
·
2024
·
IF 5.3
Sifang Zhao,Fengjiao Chen,Xianwu Chen,Hongze Liang,Hui Tan,Lingling Zhao
The tumor microenvironment is characterized by several hallmarks such as an acidic pH and high glucose levels in tumor tissues and increased expression of specific proteins and/or sugars on the surface of tumor cells. These unique hallmarks of tumors can be considered in the design of multifunctional drug delivery nanosystems to improve the efficiency of tumor therapy through targeted drug delivery and specific drug release in the tumor tissue. In this study, phenylboronic acid-modified pH- and glucose-responsive polymer micelles were designed for the targeted delivery of anticancer drugs. The polymeric micelles demonstrated prolonged and pH/glucose-triggered drug release and enhanced cellular internalization by B16F10 cells through a receptor-mediated endocytosis pathway. The polymeric micellar system could inhibit the proliferation of B16F10 cells with IC50 values lower than those of unmodified micelles. In addition, the polymeric micellar system could markedly suppress cell migration, colony formation, and invasion and promote the apoptosis of B16F10 cells, indicating good anticancer efficiency in vitro. Therefore, this polymeric nanocarrier provides a potential platform for targeted anticancer therapy.
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高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2024
·
IF 8
Siyi Li,Kexin Li,Xianfeng Gong,Pengfei Yan,Shaoping Sun
Multifunctional polymeric micelles, which possess capabilities for tracking, bioimaging, stimuli-responsive drug release and tumor targeting, are essential in facilitating the effective delivery of anticancer drugs. Hence, a novel copolymer (CD-CS-Bio-TPAA, CCBT) was synthesized with biotin and hydroxypropyl-β-cyclodextrin conjugated chitosan as the hydrophilic segment and aggregation-induced emission (AIE) featured tetraphenylethene derivative (TPAA) as the hydrophobic segment. Interestingly, under acidic conditions, CCBT exhibited color-tunable AIE behavior as a result of the cleavage of benzoic imine bonds in TPAA molecules, transitioning from red to yellow. Furthermore, CCBT could also self-assemble into polymeric micelles and be used as drug carriers to encapsulate paclitaxel (PTX) (PTX/CCBT PMs) for self-indicating cancer therapy. In vitro release experiments demonstrated that PTX/CCBT PMs could release drugs specifically under acidic conditions. Fluorescence imaging experiments demonstrated that CCBT PMs exhibited excellent cell imaging capabilities and could be tracked due to their unique color-changing behavior. Moreover, PTX/CCBT PMs exhibited notable cytotoxic effects on MCF-7 cells and showed selective internalization by MCF-7 cells through biotin receptor-mediated active targeting. In vivo antitumor experiments confirmed that PTX/CCBT PMs possessed remarkable tumor-inhibiting effects and low systemic toxicity. This work suggested that PTX/CCBT PMs provided new ideas for self-indicating breast cancer treatment.
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JOURNAL OF ALLOYS AND COMPOUNDS
·
2024
·
IF 5.8
Pei Yu,Fengting Luo,Shijian Chen
Rational designing Mo-based heterojunction catalysts as hydrogen evolution catalysts is seriously significant for the widespread utilization of hydrogen energy. Here, the ingenious hierarchical construction of MoP 2 /MoS 2 nanowires was delivered with high conductivity of porous MoP 2 and abundant active sites of defect-rich MoS 2 . Under synergistic effect of two materials, this catalyst achieves a dramatically optimized electronic structure to boost hydrogen evolution in all-pH range. The optimal MoP 2 /MoS 2 /CC nanoreactor showed overpotentials of 47.11, 60.16, and 89.83 mV to drive −10 mA cm −2 and Tafel slopes of 51.69, 52.04, and 73.79 mV dec −1 in acidic, alkaline, and neutral media, respectively. This finding may provide an effective approach for elevating the pH-universal electrocatalytic performance in order to achieve industrial hydrogen evolution.
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Surfaces and Interfaces
·
2024
·
IF 5.7
Xinyu Jiang,Fengtong Ju,Zhe Wu,Qiuyu Jing,Wenjing Lv,Yongchao Lai,Xiaomei Li
As a molecular-specific and highly sensitive technology, surface-enhanced Raman spectroscopy (SERS) is well-suited to meet the analytical demands of a multidisciplinary range of fields. Nevertheless, the fabrication of SERS substrates that are inexpensive, reproducible, and controllable represents a significant challenge. In this study, a straightforward, reproducible, and controllable strategy was proposed for the fabrication of high-sensitivity SERS substrates based on self-limiting surface reactions. The preparation of the self-confined nanogaps (sCN-Ag) substrate was achieved through the dealloying process of Cu-Ag alloy wires. In this process, the interior nanogaps were self-confined by AgCl produced in situ, thus facilitating the control of "hot spots" on a nanoscale. The sCN-Ag substrate, which can be readily activated by the removal of AgCl with NH₃·H₂O, exhibited high sensitivity, spatial uniformity, and good thermal stability in pH sensing. This self-limiting strategy, which integrates the advantages of controllability, reproducibility, and mass production, is expected to further promote the development and application of SERS.
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