INTERNATIONAL JOURNAL OF PHARMACEUTICS
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2022
·
IF 6.51
Weiqin Wang,Xuefeng Li,Fanli Shi,Zhenhai Zhang,Huixia Lv
In this study, γ-cyclodextrins (γ-CD) and epigallocatechin-3-gallate (EGCG) were designed to form an inclusion complex (EGCG-γ-IC) for ulcerative colitis (UC) treatment. The drug-excipient combined therapeutic potential of γ-CD and EGCG was verified, when stability and compliance were also achieved. EGCG-γ-IC effectively inhibited the secretions of NO, TNF-α, and IL-6 and the intracellular ROS in RAW264.7 cells. The effectiveness of EGCG-γ-IC in treating DSS-induced acute UC in mice was observed including improving the histological conditions of the colon, reducing the levels of IL-1β, IL-6, and TNF-α in serum, and restoring MPO , GSH, and sIgA levels in intestinal tissues. Moreover, EGCG-γ-IC had a more prominent effect on regulating bacterial dysbiosis caused by DSS than EGCG and γ-CD alone. Therefore, EGCG-γ-IC designed here displayed UC treating capacity with safety in the long-term application and promised an industrial production potential due to its excellent storage stability.
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Biomaterials Science
·
2020
·Vol. 8
·期 21
·5955-5968
·
IF 6.183
Fangying Yu,Yun Zhu,Yupeng Liu,Guoxi Qiu,Xuwei Shang,Tingting Meng,Hong Yuan,Fuqiang Hu
The active targeting strategy has achieved inspiring progress for drug accumulation in tumor therapy; however, the insufficient expression level of many potential receptors poses challenges for drug delivery. Poly-γ-glutamic acid (γ-pGluA), a naturally occurring anionic biopolymer, showed high affinity with tumor-associated gamma-glutamyl transpeptidase (GGT), which localized on the cell surface and exhibited intracellular redox homeostasis-dependent expression pattern; thus, GGT was utilized for mediating endocytosis of nanoparticles. Herein, GGT-targeting nanopolyplexes (γ-pGluA-CSO@Fe3+, PCFN) consisting of cationic chitosan and GGT-targeting γ-pGluA blended with iron ion were constructed to load reactive oxygen species-induced menadione (MA) and doxorubicin, which were utilized to investigate the mechanism of GGT up-regulation. Briefly, the pretreated PCFN/MA induced an intracellular oxidative stress environment, which facilitated adjusted up-regulated GGT expression and boosted tumor targeting. Subsequently, the destroyed redox homeostasis sensitized tumors for synergistic therapy. The innovative strategy of augmenting active targeting by disturbing intracellular redox homeostasis offers insight for the application of γ-pGluA-derived nanopolyplexes.
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高影响因子
Journal of Materials Chemistry B
·
2018
·Vol. 6
·期 20
·3315-3330
·
IF 4.776
Linlong Li,Xincui Shi,Zongliang Wang,Yu Wang,Zixue Jiao,Peibiao Zhang
Large-scale cell culture for cell expansion in tissue engineering is currently a major focus of research. One method to achieve better cell amplification is to utilize microcarriers. In this study, different amounts of poly(γ-benzyl-L-glutamate) (PBLG) (from 11 wt% to 50 wt%) were grafted on mesoporous hydroxyapatite (MHA) by the in situ ring opening polymerization of γ-benzyl-L-glutamate N-carboxyanhydride (BLG-NCA), and biodegradable and biocompatible PBLG-g-MHA microcarriers were directly fabricated using the oil-in-water (O/W) solvent-evaporation technique for bone tissue engineering. The amount of grafted PBLG could be controlled by adjusting the feed ratio of MHA and BLG-NCA. The relationships between sphere morphology and graft amount or solution concentration were explored. Furthermore, cytological assays were performed to evaluate the biological properties of the PBLG-g-MHA microcarriers. For a solution concentration of 3% (w/v) and PBLG graft amounts of 33 wt% and 50 wt%, the microspheres could be harvested with optimal spherical shapes. In vitro cell culture revealed that the PBLG-g-MHA microspheres had favorable properties for cell proliferation and significantly enhanced the osteogenic differentiation of MC3T3-E1 cells and bone matrix formation.
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RSC Advances
·
2015
·Vol. 5
·期 65
·52369-52381
·
IF 3.84
Zhanchao Liu,Zhaoyong Hu,Yan Liu,Minjia Meng,Liang Ni,Xiangguo Meng,Guoxing Zhong,Fangfang Liu,Yanmin Gao
Utilising a general protocol for making surface-imprinted core–shell microparticles via a RAFT-mediated approach, we developed a Cu(II) imprinted polymer with a novel magnetic nanosphere, γ-Fe2O3@meso-SiO2, as support. Attributed to the controlled/living polymerization mechanism of the RAFT polymerization process, the Cu(II) imprinted polymer prepared by RAFT polymerization (IIP-RAFT) presented a more well-defined morphology, more mono-dispersed properties, and much higher magnetic responsiveness, compared to the Cu(II) imprinted polymer prepared by traditional free-radical polymerization (IIP-TP). Moreover, in the static saturation binding experiments, a higher binding capacity of IIP-RAFT (210 mg g−1) than IIP-TP (145 mg g−1) was also found. Afterwards, a series of adsorption experiments were carried out to systematically evaluate the adsorption performance of the as-prepared IIP-RAFT. And the results showed that IIP-RAFT exhibited excellent selectivity, good reusability and desirable dynamic adsorption behavior, and could be an ideal candidate for SPE sorbents for the removal of Cu(II) in real wastewater.
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JOURNAL OF ALLOYS AND COMPOUNDS
·
2024
·
IF 5.8
Jiacheng Xu,Shun Wang,Chenyun Zhang,Jing Zhang,Lihua Xu,Yue Shi,Guoqiang Xu,Shuiliang Yao
Catalyst surface active oxygen species have an important influence on plasma catalytic oxidation . However, the reaction process of CO and O 3 migration and transformation on the catalyst surface during discharge at different temperature is still unclear. In this study, β- and γ -MnO 2 are selected to unveil the roles of different oxygen species under in-plasma catalysis configuration at different temperature in CO oxidation. Operando TPR-DRIFTS-MS is used to reveal CO and O 3 oxidation pathways. The results show that O 3 can react with CO at room temperature, and O 3 is also converted to other reactive oxygen species on the catalyst surface. As the temperature increases, the oxygen species of the catalyst itself (Mn O and Mn-O-Mn) can react with CO to form oxygen vacancies (Mn-□-Mn and Mn=□). Mn-□-Mn are beneficial for O 2 decomposition and promotes the regeneration of Mn O and Mn-O-Mn. The carbonate covered on the surface of the catalyst is the rate-determining step of CO oxidation. It is hoped that Mn-based catalysts with more reactive oxygen species and oxygen defects will be prepared to facilitate low-temperature CO oxidation under plasma conditions.
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Surfaces and Interfaces
·
2024
·
IF 5.7
Bo Wang,Cheng Zhang,Bo Huang,Haoguang Wang,Xinrui Miao,Wenli Deng
A facile approach to prepare superhydrophobic fabric with high adhesive ability towards water droplets was developed via a simple dip-coating method. Immersing the cotton fabric (CF) into the γ-Fe 2 O 3 /epoxy resin/lauric acid (FEL) suspension for several minutes, followed by heat curing at 80 °C for 2 h, the superhydrophobic fabric (CF-FEL) was obtained. The quality ratio of γ-Fe 2 O 3 to epoxy resin effect on superhydrophobicity of°F-FEL was discussed. The water contact angle was 156° when 0.15 g γ-Fe 2 O 3 particles were applied. Based on the sticky water adhesion, the CF-FEL could be utilized to realize the transportation of water droplet without mass loss. Meanwhile, due to the capillary force and stagger fibers, the CF-FEL exhibited excellent separation flux and efficiency to separate heavy oil/water mixtures. The mechanical durability of the CF-FEL was also evaluated through tape peeling and rubbing test, which further indicated the feasibility of practical application. Moreover, the CF-FEL showed superior flame retardancy because it inherited the thermal stability property of epoxy resin and γ-Fe 2 O 3 particles. Thus, the prepared CF-FEL is multifunctional and the preparation method is facile and environmentally friendly.
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2025
·
IF 9
Bingning Wang,Yeshuang Wang,Zhen Wang,Song Yang,Chao Yang,Jiawei Kou,Huiling Fan,Ju Shangguan
In this study, we report a simple strategy to enhance the low-temperature catalytic performance of γ-Al 2 O 3 for carbonyl sulfide (COS) hydrolysis by regulating the dissociation of H 2 O. Specifically, tetrabutylphosphonium chloride (TBuPC), an ionic liquid, was introduced onto γ-Al 2 O 3 via ultrasonic impregnation. There was a strong interaction between Cl in TBuPC and Al sites in tetrahedral interstices of γ-Al 2 O 3 , and Al sites in octahedral interstices were acted as main adsorption sites of H 2 O. Additionally, the hydrogen bond Cl···H-O lowered the dissociation energy of H 2 O on Al sites in octahedral interstices of γ-Al 2 O 3 , leading to the generation of abundant basic –OH groups, which served as active sites for COS adsorption and hydrolysis. Consequently, 3TBuPC/γ-Al 2 O 3 achieved 100 % COS conversion at 60 °C, which was 2.05 times higher than that of γ-Al 2 O 3 . The catalytic mechanism of COS hydrolysis over 3TBuPC/γ-Al 2 O 3 involved the following steps: (1) H 2 O was adsorbed on the γ-Al 2 O 3 surface and dissociated, generating H* and basic –OH groups; (2) COS was adsorbed on the –OH sites, forming the intermediate HSCO 2 - ; (3) HSCO 2 - reacted with H* to release CO 2 and H 2 S. This significant enhancement provides a new insight for the design and development of low-temperature hydrolysis catalysts.
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FUEL
·
2025
·
IF 7.5
Xinglin Wen,Yonglu Yang,Yong Pan,Jitao Hu,Xiaoyue Wan,Yanhui Yang,Sébastien Leveneur,Juncheng Jiang
The hydrogenation of 2,4-dinitrotoluene (2,4-DNT) into 1-methyl-2,4-cyclohexanediamine (2,4-MCHD), a significant yet underutilized raw material for the synthesis of methylcyclohexane diisocyanate (HTDI) with exceptional properties, represents one of the most promising reactions for the development of diisocyanate chemical processes. In this study, we developed a highly efficient and stable heterogeneous catalytic system for the direct hydrogenation of 2,4-DNT to 2,4-MCHD using Li-modified γ-Al 2 O 3 supported Ru nanoclusters (Li-modified-Ru/γ-Al 2 O 3 ). Under mild reaction conditions, we successfully inhibited side reactions, such as deamination, achieving a selectivity exceeding 95% for 2,4-MCHD, while the conversion of 2,4-DNT surpassed 99%. Kinetic studies revealed that the hydrogenation of 2,4-DNT in this system occurs as a tandem reaction, with the hydrogenation of the benzene ring identified as the rate-determining step. Investigations into the structure–activity relationship indicated that the valence state of the Ru nanocluster, the acid-base properties of the catalyst, the modification by Li, and the synergistic effects of various elements within the catalyst are critical factors contributing to the high activity and stability of the Li-modified-Ru/γ-Al 2 O 3 catalyst for the hydrogenation of 2,4-DNT to produce 2,4-MCHD. This work represents the first example of the direct hydrogenation of dinitroaromatic compounds to yield diamino aliphatic compounds and provides a solid foundation for understanding such reaction systems.
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JOURNAL OF ORGANIC CHEMISTRY
·
2020
·
IF 4.335
Xiao-Yu Zhan,Hua Zhang,Yu Dong,Jian Yang,Shuai He,Zhi-Chuan Shi,Lei Tang,Ji-Yu Wang
The B(C6F5)3-catalyzed chemoselective hydrosilylation of α,β- and α,β,γ,δ-unsaturated ketones into the corresponding non-symmetric ketones in mild reaction conditions is developed. Nearly 55 substrates including those bearing reducible functional groups such as alkynyl, alkenyl, cyano, and aromatic heterocycles are chemoselectively hydrosilylated in good to excellent yields. Isotope-labeling studies revealed that hexafluoro-2-propanol also served as a hydrogen source in the process.
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高影响因子
JOURNAL OF ORGANIC CHEMISTRY
·
2018
·
IF 4.805
Zhen-Hua Li,Zhi-Jiang Jiang,Qiao-Ling Shao,Jin-Jing Qin,Qiang-Feng Shu,Wen-Hao Lu,Wei-Ke Su
A one-pot cascade heterocyclization strategy has been developed for the synthesis of 2,4-dichloro-substituted pyrano[2,3-d]pyrimidines and furo[2,3-d]pyrimidines from linear γ- and β-ketomalononitriles using triphosgene and triphenylphosphine oxide. The reaction afforded synthetic useful products with moderate to good yields, bypassing the conventional harsh conditions of chlorination. The mechanistic study revealed that the reaction proceeded with a non-isocyanate route, and the second step may conduct in a triphenylphosphine oxide-catalyzed manner.
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高影响因子
JOURNAL OF CHROMATOGRAPHY A
·
2022
·
IF 4.601
Yuting Li,Luhan Wang,Minhua Qian,Shengda Qi,Lei Zhou,Qiaosheng Pu
ABSTRACT γ-Hydroxybutyric acid (GHB), a neurotransmitter or neuromodulator in the human central nervous system, is often abused in drug-facilitated sexual assaults due to its euphoric and sedative effects. While the analysis of GHB has received continuous attention, its inherent characteristics pose challenges. In the current study, capillary electrophoresis (CE) with capacitively coupled contactless conductivity detection (C 4 D) was built, and Good's buffers were evaluated as the background electrolytes for CE separation and C 4 D detection. On this basis, a simple and efficient CE-C 4 D method was developed for GHB analysis. Through theoretical discussion and experimental optimization, the separation of GHB and related positional isomers α-hydroxybutyric acid (AHB) and β-hydroxybutyric acid (BHB) was achieved within 4 min using 150 mM 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid (HEPES) as the running buffer. Under the optimized condition, the relative standard deviations of migration time and peak area were less than 1.1% and 4.5%, indicating good precision. The C 4 D signal of GHB showed a good linear relationship with GHB concentration in the range of 3-300 µM with a determination coefficient of 0.9997, and the detection limit was calculated to be 0.37 µM based on the signal-to-noise ratio of three. Furthermore, liquid-liquid extraction (LLE) and solid-phase extraction (SPE) were comparatively studied for sample matrix purification. Combined with the optimized SPE procedure, the developed CE-C 4 D method has been successfully applied for the determination of exogenous GHB in spiked beverages and endogenous GHB in human urine.
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JOURNAL OF PHYSICS D-APPLIED PHYSICS
·
2024
·Vol. 57
·期 32
·325302
·
IF 3.1
Siyi Xu,Danyi Li,Wenrui Wang,Lin Lin,Ying Sun,Jihao Li,Linfan Li
A large amount of toxic smoke and heat generated by the combustion of ethylene vinyl acetate copolymer (EVA) poses a significant threat to human fire escape evacuation. This work aims to use γ-ray to prepare e-MXene@Ag hybrid flame-retardant materials by the method of in-situ reduction, and EVA composites are prepared by melt blending to reduce the smoke and toxic gases produced during combustion significantly. Compared with pure EVA, the total heat release, total smoke release, and the production rate of CO and CO2 produced by the combustion of EVA composite with 1 wt% e-MXene@Ag1.0 decreased by 30.3%, 33.3%, 18.2%, and 20.1% respectively. The fire hazard reduction of EVA composite materials was due to the physical barrier, catalytic carbonization and adsorption of the e-MXene@Ag1.0 hybrid. In addition, e-MXene@Ag1.0 can also further increase the mechanical properties of EVA composites due to its own 'multi-contact point limit structure'.
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