Journal of Natural Medicines
·
2017
·Vol. 72
·期 2
·390-398
·
IF 1.982
Lu Jianrao,Yi Yang,Pan Ronghua,Zhang Chuanfu,Han Haiyan,Chen Jie,Liu Wenrui
Renal ischemia reperfusion injury (RIRI) refers to the irreversible damage for renal function when blood perfusion is recovered after ischemia for an extended period, which is common in clinical surgeries and has been regarded as a major risk for acute renal failures (ARF) that is accompanied with unimaginably high morbidity and mortality. Hypoxia during ischemia followed by reoxygenation via reperfusion serves as a major event contributing to cell apoptosis, which has been widely accepted as the vital pathogenesis in RIRI. Preventing apoptosis in renal tubular epithelial cell has been considered as effective method for blocking RIRI. In this paper, we established a hypoxia/reoxygenation (H/R) injury model in human proximal tubular epithelial HK-2 cells. Here, we found increased SPHK1 levels in H/R injured HK-2 cells, which could be significantly down regulated after berberine treatment. Berberine has been reported to exert a protective effect on H/R-induced apoptosis of HK-2 cells. So, in our present study, we planned to investigate whether SPHK1 participated in the anti-apoptosis process of berberine in H/R injured HK-2 cells. Our study confirmed the protective effect of berberine against H/R-induced apoptosis in HK-2 cells through promoting cells viability, inhibiting cells apoptosis, and down-regulating p-P38, caspase-3, caspase-9 as well as SPHK1, while up regulating the ratio of Bcl-2/Bax. However, SPHK1 overexpression in HK-2 cells induced severe apoptosis, which can be significantly ameliorated with additional berberine treatment. We concluded that berberine could remarkably prevent H/R-induced apoptosis in HK-2 cells through down-regulating SPHK1 expression levels, and the mechanisms included the suppression of p38 MAPK activation and mitochondrial stress pathways.
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ZEITSCHRIFT FUR NATURFORSCHUNG SECTION A-A JOURNAL OF PHYSICAL SCIENCES
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2017
·Vol. 73
·期 2
·99-103
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IF 1.432
Lu Pan,Xiaozhan Yang,Chaoyue Xiong,Dashen Deng,Chunlin Qin,Wenlin Feng
A series of new red-orange emission phosphors Na 2 BaMg(PO 4 ) 2 :Pr 3+ were synthesised by a high-temperature solid-state reaction. The crystal structure and photoluminescence properties of these samples were characterised by X-ray diffraction and spectroscopic measurements. This compound holds P 3̅ m 1 space group of the trigonal system with the lattice parameters of hexagonal cell a =0.5304(3) nm and c =0.6989(3) nm. The phosphor emits the strongest peak at 606 nm when excited by 449 nm. The average Commission Internationale de l’Eclairage chromaticity coordinates calculated for the phosphors are (0.52, 0.46). The results demonstrate the potential application of these phosphors in solid-state lighting and other fields.
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INORGANIC CHEMISTRY COMMUNICATIONS
·
2024
·
IF 4.4
Jianbo Ding,Ce Xu,Xianghong Li,Bingguang Zhang,Dingguo Tang
A cyclometalated ruthenium complex ( 1 ) using 2-phenylbenzimidazole as a C,N-ligand was developed as a colorimetric chemosensor to detect Ag + ions. Upon the addition of Ag + ions, the absorption spectra of complex 1 demonstrated no change in CH 3 CN solution. However, an excellent solution color change from dark-green to purple and absorption spectral change with a blue-shift of 27 nm (from 612 to 585 nm) were clearly observed after Ag + ions were added to the solution of 1 with 2-fold of fluoride (denoted as 1 + F − ). When Ag + ions were replaced by other common metal ions, the solution color changed from green to red. Therefore, the solution of 1 + F − can be used to distinguish Ag + from the other common metal ions. The absorption intensity at 612 nm exhibited a good linear correlation for the detection of Ag + ion from 0 to 4 µM with a detection limit of 0.34 µM. According to the absorption and 1 HNMR spectral changes of complex 1 , the reaction mechanism is proposed to be as a coordination between silver ion and the deprotonated nitrogen in imidazole. However, the interactions of other metal ions with 1 + F − are related to a proton transfer process.
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RENEWABLE ENERGY
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2024
·
IF 9
Cuicui Wu,Meng Wang,Yunming Fang
The productive motivation of high-energy-density fuels from sustainable feedstocks has been prompted by environmental concerns and resource scarcities. To address this demand, here, the energy-rich C10 cycloalkanes were first afforded with biomass-derived 2-cyclopentenone (2CPE). Initially, bio-based 2CPE can be converted to tricyclo-diketones by (2 + 2) cycloaddition under UV irradiation or zeolite catalysis. The UV-light photocatalysis for dimerization of 2CPE to diketol-cycloadducts disclosed outstanding advantages of cost-effectiveness and feasibility than traditional zeolite-catalyzed manner, with a yield of 53.61 % at ambient temperature for 2 h. Despite the potential for high dimer yield (77.28 %) under thermo-catalysis of H-ZSM-5 zeolite, the reaction conditions (120 °C, 18 h) were found to be suboptimal. Subsequently, diketol-cycloadducts were selectively and efficiently hydrodeoxygenated to provide cyclopentane-based hydrocarbons using a Huang-Minlon methodology with a yield of 97.04 %, where the target components were directly distilled during the reaction. Specifically, the as-synthesized C10 cycloalkane mixture originated from 2CPE possess high density of 0.96 g mL −1 , large volumetric heat net of combustion (NHOC) of 40.02 MJ L −1 , along with low freezing point of −49 °C. These properties suggest that the bio-liquid cycloalkanes can be used as a standalone high-energy fuel or as a blending agent to enhance the performance of conventional jet fuels.
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MICROCHEMICAL JOURNAL
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2024
·
IF 4.9
Ziwen Song,Qiqi Huang,Shizhao Zhang,Songlin Luo,Mengdie Su,Xin Yang,Shaopeng Wang,Liwei Wang
2-Aminophenol (2-AP) is an organic compound with antibacterial and antioxidant properties in cosmetics, detergents, dyes, and pharmaceuticals. In particular, human health and the environment can be significantly threatened when the concentration of phenolic substances in water reaches 0.1005 mg/L. Hence, there is an urgent need to develop a prompt and accurate analyzing method of 2-AP. To this end, Cu-MOF material was employed as a substrate, and its conductivity and catalytic properties were then enhanced by incorporating Tp-BD-DBd COF within the pores. This COF@MOF composite incorporation, named Tp-COF@Cu-BDC, introduced not only extensive π-conjugated systems but also the mutual electron-donating amino and carboxylate electron-withdrawing groups that may help improve the adsorption capability of 2-AP. Consequently, an increase in conductivity of the Tp-COF@Cu-BDC composite was achieved compared with the MOF monomer. At the same time, the fabricated sensor exhibited a broad detection range (2–250 μM), a low detection limit (0.597 μM), remarkable anti-interference capabilities, and a high recovery rate for 2-AP. Furthermore, the recovery experiment results have proved the actual samples’ detection capability based on our electrochemical sensor. Thus, it can be inferred that the COF@MOF composite-based electrochemical sensor is a highly effective platform for detecting 2-AP in environmental settings.
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Batteries-Basel
·
2025
·Vol. 11
·期 3
·83
·
IF 4.8
Yongli Tong,Baoqian Chi,Yu Jiang,Xiang Wu
It is crucial for energy storage devices to construct electrode materials with excellent performance. However, enhancing energy density and cycling stability for supercapacitors is a significant challenge. We successfully synthesized CoNi2S4@Ni(OH)2nanosheets on the surface of Ni foam substrate by a two-step hydrothermal approach. The obtained products exhibit a remarkable areal capacitance of 1534 F g−1at a current density of 1 A g−1. Moreover, even after 10,000 cycles, the specific capacitance remains 90% of its initial value, highlighting the exceptional long-term stability and durability. Furthermore, an asymmetric supercapacitor (ASC) device incorporating the CoNi2S4@Ni(OH)2material shows remarkable electrochemical performance. It delivers an energy density of 58.5 mW h g−1at a power density of 2700 W kg−1. The outstanding performance mainly arises from the selection of materials, the design of the structure, and the synergistic interaction between the materials. The result suggests that this material holds great potential as an energy storage material.
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JOURNAL OF ALLOYS AND COMPOUNDS
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2016
·
IF 3.014
Yong Cui,Zhe Zhang,Xu Du,Wei Liu,Shi Liu,Yulin Deng,Xiaogu Huang,Gang Wang
Hybrid solution process is a powerful liquid deposited strategy merging the advantage of molecular precursor solution and nanocrystals ink. A novel hybrid solution approach is presented to fabricate Cu(In,Ga)(S,Se) 2 (CIGSSe) absorber layer using fully dissolved CIGS precursor solution and the CIGS nanocrystals. Such attractive strategy could significantly improve the single deposited thickness and enhance the quality of as-prepared CIGS film compared with the pure CIGS molecular precursor solution and the CIGS nanocrystals ink. Photovoltaic absorber layers based on CIGSSe chalcopyrite structure show the high-quality microstructural performance and are incorporated into solar cells with power conversion efficiency of 10.19%. The high performance of resulted optoelectronic devices represents a chance to extend the hybrid solution process to other inorganic semiconductor thin film solar cells.
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CHEMICO-BIOLOGICAL INTERACTIONS
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2016
·
IF 2.618
Xiaonan Zhang,Kang Chen,Bo Wei,Xingwang Liu,Zeming Lei,Xizhuang Bai
Glucocorticoid-induced osteoporosis (GIOP) is the primary cause of secondary osteoporosis and the existing therapeutic strategies are limited. The aim of this study is to evaluate the effects of ginsenosides (GS) Rg3 on dexamethasone (DEX)-induced osteoporosis in vivo and in vitro. GIOP rat was established by DEX injection for 5 weeks and treated by GS Rg3 10 or 20 mg/kg. Body weight and bone mineral density (BMD) of rats were measured at the beginning and the end of the experiment. Histological changes of femurs were observed using HE staining. The in vitro model was established on primary osteoblasts induced by DEX. CCK-8 assay was used to test the cell viability. Bone metabolism markers in serum or primary osteoblasts were detected using biochemical kits. Real time PCR and western blot were used to measure nuclear factor-kappa B ligand (RANKL), osteoprotegerin (OPG), bone morphogenic protein-2 (BMP-2), BMP receptor 1A (BMPR1A) and Runx2 expression. The results demonstrated that GS Rg3 prevented DEX-induced body weight and BMD reduction, enhanced secretion of bone formation markers and decreased bone resorption markers. In addition, GS Rg3 was found to prevent the suppression of BMP-2/BMPR1A/Runx2 signals induced by DEX both in GIOP rats and primary osteoblasts. Inhibition of BMP-2 by noggin completely blocked the bone-alkaline phosphatase-secretion-promoted effect of GS Rg3 in vitro. These data suggest that GS Rg3 attenuates GIOP through regulating BMP-2 signaling pathway. This study provides a potential drug candidate for GIOP therapy.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2016
·Vol. 27
·期 6
·5735-5740
·
IF 1.798
Liu Chang,Liu Yunfei,Lyu Yinong,Lyu Chongguang
Octahedra-like NaNd(MoO 4 ) 2 microcrystals with tetragonal scheelite-type structure were successfully synthesized by a low cost molten salt method using halons (NaCl or NaBr) as flux. The as-prepared products were characterized by powder X-ray diffractometer, field emission-scanning electron microscope and photoluminescence spectrometer (PL). The results show that the reaction parameters including calcining temperature, reaction time, and the type of salt play important roles on the morphologies and sizes of the NaNd(MoO 4 ) 2 microcrystals. The excitation spectra of the NaNd(MoO 4 ) 2 octahedron-like crystals were observed with a maximum peak at 585 nm (λ em = 1066 nm). The emission spectra were recorded under excitation wavelength of 585 nm and exhibit the strongest peak at 1066 nm. In addition, the results revealed the size effect on the PL intensity of NaNd(MoO 4 ) 2 crystals, that the PL intensity of microcrystals is higher than that of nanocrystals. These imply that NaNd(MoO 4 ) 2 microcrystals have potential application in the field of solid state laser materials.
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RSC Advances
·
2016
·Vol. 6
·期 25
·20761-20771
·
IF 3.289
Weiwei Zhang,Delong Zhang,Xiaoshan Fan,Guangyue Bai,Yuming guo,Zhiguo Hu
Four new Y-shaped miktoarm amphiphilic copolymers were synthesized by ring-opening polymerization (ROP) and click chemistry. The structure of these copolymers was determined by nuclear magnetic resonance (NMR), Fourier transform infrared spectroscopy (FT-IR) and gel permeation chromatography (GPC). The stereocomplexes were prepared by an evaporation method and confirmed by FT-IR, differential scanning calorimetry (DSC) and X-ray diffraction (XRD). Further the aggregation behaviors of these synthesized polymers and their stereocomplexes were studied by fluorescence spectroscopy (PL), transmission electron microscopy (TEM) and light scattering (LS). Their critical micelle concentrations (CMC) obtained by PL were 0.005 mg mL−1 for MPEG1.9k–(scPLA4.5k)2 and 0.039 mg mL−1 for MPEG5k–(scPLA4.5k)2. The aggregation morphologies of homochiral copolymers were worm-like aggregates, while for the stereocomplexes, the spherical micelles were visually observed. The biocompatibility of these copolymers and their stereocomplexes was evaluated with relatively lower cytotoxicity. Finally, the release of doxorubicin (DOX) encapsulated into the micelles in buffer at pH 5.4 was faster than that at pH 7.4. This study demonstrates that the DOX-loaded stereocomplex micelles could be a potential carrier for cancer treatments.
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Journal of Energetic Materials
·
2017
·
IF 1.557
Xi Li,Qiu-han Lin,Xin-Ying Zhao,Zhi-Wei Han,Bo-liang Wang
Thermal techniques (differential scanning calorimetry (DSC) and the vacuum stability test (VST)), according to STANAG 4147, and non-thermal techniques (Fourier transform infrared (FTIR) spectrometry and X-ray diffractometry (XRD)) were used to examine compatibility issues for 2,4,6,8,10,12-hexanitrohexaazaisowurtzitane (CL-20) with a selection of insensitive explosives, including nitroguanidine (NQ), 2,4,6-trinitrotoluene (TNT), 2,6-diamino-3,5-dinitropyridine-1-oxide (ANPyO), 2,4,6-triamino-1,3,5-trinitrobenzene (TATB), 3-nitro-1,2,4-triazol-5-one (NTO) and 2,6-diamino-3,5-dinitropyrazine-1-oxide (LLM-105). DSC measurements showed that ANPyO, TATB, NTO and LLM-105 were compatible with CL-20. The compatibility of CL-20/NQ, CL-20/TNT, CL-20/ANPyO, CL-20/TATB, CL-20/NTO and CL-20/LLM-105 mixtures was further explored using the VST, which revealed that all the selected insensitive explosives were compatible with CL-20. Possible chemical interactions were suspected for CL-20/TATB from the FTIR results and for CL-20/NTO from XRD analysis. In summary, ANPyO and LLM-105 demonstrated the optimal compatibility with CL-20.
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Journal of Energy Chemistry
·
2015
·
IF 2.352
Xianxiang Liu,Hui Ding,Qiong Xu,Wenzhou Zhong,Dulin Yin,Shengpei Su
A mild and simple process for the effective oxidation of 5-hydroxymethylfurfural (HMF) into 2,5-diformylfuran (DFF) has been developed using NaNO 2 as the oxidant. Some important reaction parameters were investigated to optimize the oxidation of HMF into DFF. It was found that the reaction solvent was very crucial for this reaction. Trifluoroacetic acid was the best solvent for the oxidation of HMF into DFF by NaNO 2 . Under the optimal reaction condition, almost quantitative HMF conversion and high DFF yield of 90.4% were obtained after 1 h at room temperature.
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