EUROPEAN JOURNAL OF PHARMACOLOGY
·
2026
·
IF 5.7
Ying Huang,Jiale Li,Yingzhou Qin,Bo Qie,Qianqian Wang,Cuijuan Liu,Yimin Zhu
A cyclic peptide binding with TIM-3, TBP1, was screened by a novel CX 12 C cyclic peptide display library base on bacterial surface display. • TBP1 effectively disrupted TIM-3 interactions with CEACAM-1 and PtdSer. • TBP1 restored the function of exhausted T cells in vitro . • TBP1 synergized with anti-PD-1 antibody, improving anti-tumor immunity in vivo . Immune checkpoint blockade (ICB) therapies, particularly antibodies blocking, the programmed cell death protein 1 (PD-1)/programmed cell death-ligand 1 (PD-L1), have shown clinical success but remain limited by suboptimal response rates, often due to insufficient immune activation. T-cell immunoglobulin and mucin domain-containing protein-3 (TIM-3), a non-redundant immune checkpoint frequently co-expressed with PD-1, drives severe T-cell exhaustion in solid tumors and contributes to resistance against anti-PD-1/PD-L1 therapy. Thus, dual blockade of TIM-3 and PD-1 may restore more effective anti-tumor immunity. Compared to antibodies, low-molecular-weight peptides offer advantages in combination therapy, including better tissue penetration, lower immunogenicity, improved tolerability and low production costs. Cyclic peptides, in particular, provide enhanced biological activity and proteolytic stability. Here, we present TBP1, a cyclic peptide identified via a bacterial surface display library, which binds TIM-3 with high affinity and specificity. Competitive blocking assays and molecular docking confirmed that TBP1 effectively disrupts TIM-3 interactions with Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM-1) and Phosphatidylserine (PtdSer). In vitro , TBP1 restored exhausted T-cell function by disrupting the TIM-3/CEACAM-1 interaction. In CT26 tumor-bearing mice, TBP1 synergized with an anti-PD-1 antibody, enhancing anti-tumor immunity by promoting CD4 + T cell infiltration and IL-2 secretion. These findings identify TBP1 as a novel TIM-3-targeting cyclic peptide and support its potential application in combination immune checkpoint blockade. Download: Download high-res image (372KB) Download: Download full-size image
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高影响因子
JOURNAL OF SOLID STATE CHEMISTRY
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2026
·
IF 3.2
Zubair Maroof,Jingrui Li,Zhihang Zhang,Haomiao Li,Zhongshi Hu,Zhaoxin Wu,Bo Jiao
Novel 1D lead bromide perovskitoid with [PbBr 5 ] 3− square pyramids. • Cyclic amine cation enables stable 1D corner-sharing inorganic chains. • Five-coordinated geometry separates electron and hole transport pathways. • Electrostatic-sprayed detector exhibits high sensitivity and low detection limit. Low-dimensional hybrid organic-inorganic perovskitoids have demonstrated substantial potential for direct X-ray detection owing to exceptional X-ray attenuation, high activation energy for ion migration and good environmental stability. However, the influence of organic cations, especially the nitrogen heterocycle-based organic cations, on lead bromide perovskitoid properties remains insufficiently explored. Herein, we synthesized a one-dimensional lead bromide perovskitoid, (1,2-Pmpz)PbBr 4 , employing 2-(1-piperazinyl) pyrimidine as the organic cation. (1,2-Pmpz)PbBr 4 exhibits a novel perovskitoid structure in the triclinic
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高影响因子
APPLIED SURFACE SCIENCE
·
2026
·
IF 6.6
Qi Zhang,Dongsheng He,Wei Xu,Yanhong Fu,Yuan Tang,Zhili Li,Wanqing Li,Jiayu Ma,El-Sayed R.E. Hassan
[C 8 mim]Br selectively floats quartz (88.13%) over fluorapatite (4.43%) at pH 7.01. • Binary mixture flotation with [C 8 mim]Br achieves a P 2 O 5 grade of 31.49% with 91.59% recovery, confirming superior selectivity over conventional DDA. • [C 8 mim] + selectively adsorbs on quartz via electrostatic attraction with Si-O − sites and C–H···O hydrogen bonding with silanol groups, while fluorapatite lacks these active sites. • Short-chain imidazolium ionic liquids serve as promising collectors for reverse flotation desilication of phosphate ores, offering a new reagent strategy for phosphate mineral processing. The reverse flotation separation of quartz from fluorapatite using 1-octyl-3-methylimidazolium bromide ([C 8 mim]Br) ionic liquid as a novel collector was investigated, with dodecylamine (DDA) employed as a benchmark. Micro-flotation tests showed that [C 8 mim]Br selectively collected quartz (88.13%) with negligible flotation of fluorapatite (4.43%) at pH 7.01 and 50 mg/L, demonstrating superior selectivity over DDA. Binary mixture flotation (fluorapatite: quartz = 1:1) achieved a P 2 O 5 grade of 31.49% with a recovery of 91.59%. Zeta potential and contact angle measurements revealed that [C 8 mim]Br increased the zeta potential of quartz by 14.05 mV and enhanced its contact angle from 19.41° to 79.75°, while exerting minimal influence on fluorapatite. Microcalorimetry demonstrated that the adsorption heat of [C 8 mim]Br on quartz (0.237 J/g) was significantly higher than that on fluorapatite (1.6 × 10 −3 J/g). FTIR and XPS analyses indicate that [C 8 mim]Br is adsorbed on the quartz surface mainly through electrostatic attraction between the imidazolium cation and deprotonated Si-O − sites. The optimized configuration obtained from DFT calculations shows that C-H···O hydrogen bonds exist between the protons at the C4/C5 positions of the imidazole ring and surface oxygen atoms (H···O = 1.971 Å, C-H···O = 141°), whereas no stable adsorption configuration is obtained on the fluorapatite surface. These findings demonstrate that [C 8 mim]Br is a promising selective collector for the reverse flotation desilication of siliceous-calcareous phosphate ores. [C8mim] + adsorbed on the quartz surface through electrostatic attraction with deprotonated Si-O − sites, supplemented by hydrogen bonding between the C–H proton and surface silanol groups. In contrast, the fluorapatite surface lacks such active sites for anchoring of [C8mim]+, which accounts for the selective separation. Download: Download high-res image (120KB) Download: Download full-size image
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高影响因子
VETERINARY RESEARCH
·
2026
·Vol. 57
·期 1
·175
·
IF 3.8
Jiang Luyao,Yang Fan,Wu Jiayan,Li Zhengliang,Zhu Xiemin,Pan Hao,Zhang Shaotong,Pan Haochun,Wang Hang,Yao Jingting,Yan Ping,Gao Qingqing,Huan Changchao,Gao Song,Jiao Xinan,Liu Xiufan
Host defense peptides (HDPs) possess both direct bacteriocidal and immunomodulatory activities. In this study, chicken cathelicidin-1 (cCATH-1) and chicken cathelicidin-3 (cCATH-3) were selected based on their markedly different minimum inhibitory concentrations (MICs) against avian pathogenic Escherichia coli (APEC) strains, with MICs of cCATH-1 being 4- to 16-fold lower than those of cCATH-3. However, following intraperitoneal challenge with APEC strain E058 (4 × 10⁶ CFU/mouse), 80% of cCATH-3 treated mice survived while 20% of cCATH-1 treated mice survived. Flow cytometry (FC) revealed significantly lower peripheral blood Ly6C high monocytes but higher peritoneal Ly6C high macrophages in cCATH-3-treated mice at 4 and 8 h post-treatment. Peritoneal CCL3 secretion was significantly upregulated in cCATH-3 treated mice at 8 h post-treatment. Upon knockout of macrophages, the protection of cCATH-3 in mice against APEC E058 challenge was markedly abolished. In vitro, peritoneal macrophages treated with cCATH-3 showed stronger bacteriocidal activity than those treated with cCATH-1. Mouse CCL-3 (mCCL3)-specific antibody neutralize the effect of mCCL3 on macrophages chemotaxis in vitro. mCCL3-specific antibody administration resulted in 0% survival in cCATH-3-treated mice versus 60% survival in cCATH-3-treated mice administered with mock antibody, while cCATH-1-treated mice showed 0% survival administered with either mCCL3-specific antibody or mock antibody after APEC E058 strain challenge. In summary, cCATH-3 provides robust protection against APEC infection compared with cCATH-1 in mice, partially through CCL3-mediated macrophage chemotaxis and enhanced bacteriocidal activity in activated macrophages, revealing a novel mechanism of avian cathelicidins and supporting HDPs as alternatives to antibiotics for controlling avian colibacillosis.
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高影响因子
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
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2025
·
IF 8.3
Hengyi Wang,Yong-Fei Li,Xueli Niu,Peiyun Dai,Mingyu Dou,Guang Yang,Fatao Gong,Hongjie Zhu,Hua Yang,Jianmin Dou
Due to the consumption of traditional fossil fuels, human society faces global energy shortages and increasing environmental pollution problems. To address water pollution caused by the abuse of antibiotics and to promote green hydrogen production. In this paper, a Bi 2 WO 6 /CdS S-scheme heterojunction was prepared to realize the photocatalytic levofloxacin (LEV) degradation coupled with hydrogen production reaction. Under the introduction of [Co(bpy) 3 Cl 2 ] (CoBpy) as a molecular photosensitizer, the hydrogen production activity of Bi 2 WO 6 /CdS increased remarkably to 5395.9 μmol g −1 h −1 , meanwhile, the degradation rate of LEV could reach 87.5 %, which was much higher than that of the pure phase material and exhibited excellent stability over five cycles. The enhanced photocatalytic activity originates from the S-scheme heterojunction mechanism that enables the oxidizing and reducing abilities of the material to be fully exploited, meanwhile the sensitization of CoBpy further optimizes the charge transfer pathway, which realizes the combination of visible-light-driven wastewater treatment and green hydrogen production. Our findings provide an efficient and safe approach to environmental remediation and green energy production for a sustainable energy future.
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高影响因子
Frontiers in Nutrition
·
2024
·
IF 4
Wang Yi,Hu Yaozhong,Niu Zhenhua,Zhang Xuejiao,Fan Dancai,Ji Xuemeng,Lv Huan,Wang Shuo,Zhao Yanrong
Single nutrient likes polyphenol or dietary fiber have been exhaustively investigated to validate their positive intervention in health or disease. Meanwhile, the common interaction of inner systems with the nutrient complex has not been well elucidated, which raises the scientific issue of the modulatory effect of the nutrient complex on immunity. The representative prebiotics of epigallocatechin-3-gallate (EGCG), ginseng extract, and polydextrose (PDX) were selected on behalf of the classification of polyphenol, flavone or polysaccharides, and dietary fiber to generally cover the daily food intake in this study to explore their intervention in inflammation and macrophage polarization. The intervention of selected nutrients on inflammation and macrophage polarization has been evaluated against macrophages to unveil their comprehensive effects. The synergistic effect of selected nutrients was demonstrated by inhibiting M1 macrophage polarization and the promotion of M2 macrophage polarization. Then, the nutrient formula was set up to verify the intervention effect, and the results revealed the significant inhibition of cell inflammation and the effect on cell proliferation through promoting the cell cycle in the G2 phase. The nutrient complex could inhibit M1 macrophage polarization to inhibit M1-mediated inflammation and promote M2 macrophages for anti-inflammatory effect and enhance cell phagocytosis. Moreover, the varied intervention effects of the nutrient complex with different formulas could be summarized. In general, the formula containing EGCG, ginseng extract, and PDX was demonstrated to possess an enhanced immunomodulatory effect on cell inflammation and macrophage polarization, which could potentially inspire the investigation of complex nutrients in health and diseases.
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产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Haijie Cai,Xingyu Wang,Jingting Han,Yayao Song,Jingwen Wang,Zhaomin Gao,Tianjun Ni,Yongheng Zhu
Gas sensors for detecting foodborne pathogen biomarkers offer a promising approach to enhance food safety monitoring. However, sensors based on conventional sensing materials often lack the requisite sensitivity for trace-level pathogen metabolites. Herein, PdPt/ZnO hollow concave nanocages are rationally designed through a surface-tailored strategy to achieve rapid and ultrasensitive detection of the Listeria monocytogenes biomarker 3-hydroxy-2-butanone at ultralow concentrations. The representative 1%PdPt/ZnO-based sensor exhibits superior sensing properties: high response (R a /R g = 92.8@5 ppm), rapid response/recovery kinetics (14/15 s), ultralow detection limit (20 ppb), excellent selectivity, and over 30-day stability at an operating temperature of 150 °C. The combination of ex-situ / in-situ characterization and DFT calculations reveals that the hollow concave nanocage morphology synergistically activated by PdPt bimetallic sites dramatically increases active site density, accelerates oxygen diffusion, and lowers the reaction energy barrier, thereby enabling the efficient adsorption and conversion of oxygen species and 3-hydroxy-2-butanone. Crucially, the sensor enables rapid response of Listeria monocytogenes in actual food samples and distinguishes it from other foodborne pathogens, demonstrating its significant potential for accurate, real-time, and non-invasive monitoring of Listeria monocytogenes contamination.
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高影响因子
EUROPEAN JOURNAL OF PHARMACOLOGY
·
2026
·
IF 5.7
Xu-Jiao Song,Lu Bai,Xin-Ran Dong,Han Zhang,Yi-Bing Chen,Yuan-Lu Cui
3-Methylindole (3-MI) administered intranasally establishes a non-invasive, ethically sound depression model. • Targets the olfactory pathway to replicate core pathological features of depression. • Novel depression model based on the “olfactory dysfunction-neuroinflammation-hippocampal injury” cascade. Olfactory dysfunction has been closely linked to depression. However, the olfactory bulbectomy (OBX) model, a commonly employed animal model of depression, presents significant limitations, including poor alignment with clinical etiology and an elevated risk of mortality. In this study, we introduced an innovative, non-invasive model of depression by inducing olfactory dysfunction via the intranasal administration of a thermosensitive poloxamer gel containing 3-methylindole (3-MI) loaded in hydroxypropyl-β-cyclodextrin (HP-β-CD). This method specifically targets the olfactory pathway, thereby enhancing the model's safety and reliability. Through behavioral assessments, histopathological examination, transmission electron microscopy (TEM), immunohistochemistry, and neurotransmitter analyses, we found that the intranasal administration of the 3-MI gel significantly impaired olfactory sensitivity, damaged the olfactory epithelium, and induced inflammation and oxidative stress within the olfactory bulb. These alterations resulted in depressive-like behaviors, mitochondrial dysfunction, and apoptosis in the hippocampus, as well as reduced neurotransmitter release and metabolism in brain tissues. Treatment with mecobalamin or fluoxetine effectively alleviated olfactory dysfunction and depressive symptoms, respectively. Mecobalamin restored olfactory function and ameliorated depressive pathologies. Importantly, fluoxetine substantiated the model's predictive validity by reversing depressive and neurochemical deficits, although its efficacy in improving olfactory function was limited. Compared with the OBX and chronic unpredictable mild stress (CUMS) models, the intranasal 3-MI gel administration approach avoids both invasive surgery and prolonged stress exposure, aligning with animal welfare principles through minimized distress. These findings affirm the dual utility of this approach as both an effective and ethically optimized method for modeling depression. Schematic illustration of 3-MI/HP-β-CD-ATG for nose-to-brain delivery, inducing depression via olfactory dysfunction. Download: Download high-res image (331KB) Download: Download full-size image
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PubMed
高影响因子
Laser & Photonics Reviews
·
2026
·
IF 9.7
Yi Zhang,Weibin Chen,Yuhang Kuang,Tao Hu,Ming Zhao,Zhiguo Xia,Xinping Zhang
Laser phosphor display is promising for next-generation high-quality display technology due to its high brightness, wide color gamut, and low speckle. However, the lack of high performance narrow-band green emitters with robust laser resistance remains a critical bottleneck. Herein, we develop RbSr 4 (BO 3 ) 3 :Eu 2+ (RSBO:Eu 2+ ) as a narrow-band green emitter, which exhibits an emission peak at 526 nm with a narrow full width at half maximum of only 50 nm under blue light excitation. The highly dense and rigid host framework effectively suppresses lattice relaxation and electron–phonon coupling despite Eu 2+ occupying multiple cation sites in RSBO. Highly stable RSBO:Eu 2+ was further embedded into a low-melting P 2 O 5 -Al 2 O 3 -B 2 O 3 -Na 2 O glass matrix to fabricate a phosphor-glass composite (RSBO:Eu-PGC), demonstrating good thermal stability and a high saturation threshold exceeding 40 W/mm 2 . The corresponding rotating phosphor wheel maintained a low surface temperature of 79.9°C under 40 W/mm 2 blue-laser irradiation, effectively mitigating thermal degradation. A prototype laser display system using a rotating wheel integrating RSBO:Eu-PGC and K 2 SiF 6 :Mn 4+ -PGC achieved a wide color gamut of 107% National Television System Committee (NTSC) standard, which highlights the great potential of narrow-band green-emitting RSBO:Eu-PGC for laser phosphor display applications.
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高影响因子
Chinese Journal of Natural Medicines
·
2026
·Vol. 24
·期 2
·227-236
·
IF 7.5
Rakotomalala Manda Heriniaina,Xia Chen,Yulian Wu,Wenfeng Liao,He Fei,Peipei Wang,Kan Ding
Pancreatic cancer, specifically pancreatic ductal adenocarcinoma (PDAC), ranks among the most prevalent malignancies and is a leading cause of cancer-related mortality worldwide. Therefore, there is an urgent need to identify novel anti-pancreatic cancer agents. This study reports a newly identified homogeneous polysaccharide, designated ESPPW, isolated from Arthrospira platensis ( A. platensis ). The molecular weight of ESPPW is estimated at 356 kDa, and it consists predominantly of glucose and rhamnose, with minor amounts of mannose, glucuronic acid, galacturonic acid, galactose, xylose, arabinose, and fucose. ESPPW inhibits the proliferation and migration of PDAC cells both in vitro and in vivo . Mechanistic investigations reveal that ESPPW induces apoptosis through activation of caspase-3 and is associated with upregulation of the tumor-suppressor protein p53. Notably, treatment with 2.8 nmol·L −1 of ESPPW leads to significant time-dependent downregulation of galectin-3 (Gal-3) and glypican-6 (GPC-6). These findings are corroborated by immunohistochemical analysis of tumor xenograft tissues. Furthermore, overexpression of Gal-3 and GPC-6 reverses the pro-apoptotic effect of ESPPW, as indicated by restored cycle regulatory proteins (CDK2) expression. In conclusion, these data demonstrate that ESPPW suppresses PDAC cell growth by promoting apoptosis and disrupting the functional activity of Gal-3 and GPC-6.
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DOI
PubMed
高影响因子
JOURNAL OF SOLID STATE CHEMISTRY
·
2019
·
IF 2.291
Lulu Huang,Jun Guo,Zhen-Hua Ge,Yehua Jiang,Jing Feng
The In 2 O 3 (ZnO) 3 + x mol%Ga 2 O 3 ( x = 0, 0.1, 0.3, 0.5, 1) ceramics were synthesized by a solid-state reaction process. The effect of Ga doping on the thermoelectric properties of the In 2 O 3 (ZnO) 3 ceramics was studied. The phase structure and microstructure of all the bulk samples were checked by X-ray diffraction (XRD) and field emission scanning electron microscopy (FESEM), respectively. Additionally, the minimum thermal conductivity of 1.45 Wm −1 K −1 at 973 K is obtained for 0.5% Ga-doped sample, which is 35% lower than that of the pristine sample. The significantly decreased thermal conductivity for Ga 2 O 3 -doped sample is due to the enhanced scattering of phonons , which is derives from the point defects caused by Ga-doping and the introduction of the second phase. As a result, the In 2 O 3 (ZnO) 3 +0.5 mol% Ga 2 O 3 sample achieved the highest ZT value of 0.23 at 973 K.
研究领域:
材料科学
·
热电学
·
陶瓷
·
固态化学
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高影响因子
ACS Applied Materials & Interfaces
·
2019
·
IF 8.456
Xingwei Liu,Xiaoyu Jiang,Faping Zhong,Xiangming Feng,Weihua Chen,Xinping Ai,Hanxi Yang,Yuliang Cao
Sodium-ion batteries (SIBs) have been viewed as a promising candidate for grid-scale energy storage systems owing to their low cost and abundant Na resources. However, insufficient safety and poor cycling performance of current SIBs are hampering their implementation. Herein, we develop a symmetric SIB by employing Na3V2(PO4)3 as both cathode and anode along with the nonflammable triethyl phosphate dissolving 0.9 M NaClO4 as the electrolyte. The symmetric SIB demonstrates a superior rate capability (35.1 mA h g–1 at 32 C) and excellent cycling performance with a capacity retention of 88.9% after 500 cycles at 2 C. This work demonstrates a new avenue to construct safe and long-cycle-life SIBs with a simple electrode manufacturing process.
研究领域:
储能
·
电化学
·
材料科学
·
电池技术
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DOI
高影响因子
危险品化学品经营许可证（带存储）