Collagen and Leather
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2026
·Vol. 8
·期 1
·8
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IF 10.1
Pu Haoliang,Xiao Hanzhong,Wang Yujia,Huang Xin,Shi Bi
The next-generation on-skin devices are expected to provide identical textural characteristics to skin for accomplishing comfortable long-term wearability. Cattle hide is mainly consisted of type I collagen, which is therefore an ideal collagenous-matrix platform for developing skin-like on-skin devices. However, the raw cattle hide has a high water content that leads to poor wearability. Herein, we developed the skin-like wearable (SW) platform via a brand-new inter-fiber spacer-aided (IFS-aided) drying of cattle hide, where an amphiphilic nonionic surfactant that was capable of thoroughly infiltrating into the 3D hierarchical network of collagen fibers (CFs) was employed to work as the inter-fiber spacer to avoid the sticking of CFs during drying. Moreover, the inter-fiber spacer was easily eluted after drying for obtaining the collagenous matrix with highly dispersed fiber structure. The as-developed SW-platform exhibited ideal wearability by exhibiting full-protein nature, outstanding softness (6.808 mm), exceptional water-vapor permeability (5950 g·m -2 ·d -1 ) and high thermal stability. The hierarchical fiber structure with sufficient inter-fiber space endowed the SW-platform with reversible cross-scale deformations of CFs at both the nanoscale and microscale, which demonstrated its promising application in developing the skin-like and eco-friendly e-skins with outstanding sensing capability and flexible display function. Graphical
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JOURNAL OF NANOBIOTECHNOLOGY
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2026
·Vol. 24
·期 1
·250
·
IF 15
Zhu Jiankang,Zhang Yun,Li Bingjun,Jin Xin,Liu Chuxuan,Li Linchuan,Li Luyu,Zhang Hongyu,Zhang Guangyong
Background High reactive oxygen species (ROS) concentration displays dual functions, potentially promoting both tumor cell death and driving tumor-associated macrophage (TAM) polarization towards the M1-type to elicit a series of antitumor immune responses, positioning ROS as ideal tumor therapeutic molecules. However, sustained efficacy and precise ROS targeting at tumor sites retains numerous challenges. In this study, we present the synthesis of a nanoplatform, ZIF-8@XOR, comprising Xanthine oxidoreductase (XOR) with high intracellular enzymatic activity for high-level ROS generation and ZIF-8, a versatile zeolite imidazolate framework-8 carrier with high tumor site loading and targeting efficiency. Results: Our results revealed that ZIF-8@XOR targets tumor cells and elicits intracellular ROS both in vitro and in vivo, inducing tumor cell death. Moreover, intracellular ROS elicitation in TAM supports macrophage polarization towards the M1-type. In vivo, tumor-associated antigen pool generation from ROS-induced apoptosis of tumor cells further stimulates increased infiltration and macrophage activation in the tumor microenvironment. This, in turn, leads to increased tumor infiltration of CD8 + T cells with a cytokine profile, indicating cytotoxic effects and suggesting a successfully induced adaptive anti-tumor response. Conclusion: The hereby-presented newly developed nanomaterial could serve as a promising novel tool for gastric cancer immunotherapy. Graphical
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RESPIRATORY RESEARCH
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2026
·Vol. 27
·期 1
·103
·
IF 5.7
Ge Shaobo,Li Rui,Li Yuer,Liu Jin,Yao Shiyuan,Zhang Rui,Sun Yuanliang,Zhang Tao,Zhang Jie,Zhang Ming
Background Oxidative stress contributes to airway mucus hypersecretion in the pathogenesis of chronic obstructive pulmonary disease (COPD). Although reactive oxygen species modulator 1 (ROMO1) is involved in mitochondrial oxidative stress, its role in airway mucus hypersecretion in COPD remains unclear. Methods The protein expression of ROMO1 and mucin5AC (MUC5AC) in human airway epithelium was determined by immunohistochemistry. The effects of ROMO1 on mitochondrial injury and MUC5AC expression in cigarette smoke extract (CSE)-treated airway epithelial cells were evaluated by a series of experimental techniques, including real-time PCR, western-blot and immunofluorescent staining. Results Protein expression of ROMO1 and MUC5AC was significantly elevated in the airway epithelium of COPD patients compared with the controls. The mRNA and protein expression of ROMO1 and MUC5AC were significantly increased in concentration- and time-dependent manners when airway epithelial cells were treated with CSE. ROMO1 silencing significantly suppressed 7.5% CSE-induced mitochondrial structure damage, mitochondrial membrane potential loss, intracellular ATP depletion, mitochondrial reactive oxygen species production, signal transducer and activator of transcription 6 (STAT6) phosphorylation, and MUC5AC expression in airway epithelial cells. Moreover, pretreatment with either a mitochondrial-targeted antioxidant or STAT6 inhibitor significantly inhibited the up-regulated expression of p-STAT6/STAT6 and MUC5AC in airway epithelial cells stimulated with 7.5% CSE. Conclusion Our findings suggest that ROMO1 contributes to airway mucus hypersecretion in COPD by mediating MUC5AC expression in airway epithelial cells via the mitochondrial ROS-STAT6 pathway, thereby highlighting its potential clinical value as a therapeutic target.
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INFLAMMATION RESEARCH
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2026
·Vol. 75
·期 1
·79
·
IF 6.2
Zhao Junyong,Luo Xiaolin,Wang Zelan,Luo Wenjian,Wu Shaofa,Ma Xingyu,Liu He,Chen Yang,Pi Shixian,Zhang Jiawen,Zhang Jihang,Liu Chuan,Bi Xianjin,Qin Zhexue
Aims Vascular calcification (VC) predicts cardiovascular risk in diabetes, chronic kidney disease (CKD) and atherosclerosis patients and is closely linked to the osteogenic transdifferentiation of vascular smooth muscle cells (VSMCs). Our previous work revealed that cGAS-STING signalling pathway in VSMCs increases CKD-associated atherosclerotic plaque vulnerability and recent studies elucidated the involvement of STING in vascular calcification, but its upstream modulation mechanism remains to be elucidated. Methods and results DNA damage and robust upregulation of STING occurred in high phosphate (Pi)-stimulated VSMCs, calcified aortic tissues from 1,25(OH) 2 VitD 3 (VitD 3 )-overloaded mice and radial arteries from CKD patients, and these changes were accompanied by the activation of the cGAS‒STING signalling pathway. STING deficiency alleviated vascular calcification in CKD model mice. STING knockdown suppressed calcium deposition and the expression of osteogenic transdifferentiation markers in VSMCs, whereas the overexpression of STING or its agonist 2′,3′-cGAMP exacerbated VC. Mechanistically, Brd4 was identified as a critical epigenetic regulator of Pi-induced DNA damage, STING activation and VC. Furthermore, the N6-methyladenosine (m6A) modification of STING mRNA was significantly increased in Pi-stimulated VSMCs, increasing its stability. Brd4 depletion decreased the m6A modification of STING and accelerated its degradation. The m6A modification of STING was mediated by the core methyltransferase Mettl3, whose transcription was regulated by Brd4. Finally, C-176 showed translational potential by effectively suppressing vascular calcification and osteogenesis markers expression in both VitD 3 -overloaded mice and Pi-stimulated VSMCs. Conclusions Our study elucidated the interplay between Brd4-mediated epigenetic and Mettl3-dependent epitranscriptomic mechanisms governs STING m6A modification and STING may be a potential therapeutic target for vascular calcification.
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JOURNAL OF NANOBIOTECHNOLOGY
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2026
·Vol. 24
·期 1
·245
·
IF 15
Zhao Xian-Sheng,Zhang Li-Ping,Wang Geng,Yang Qu-Yang,Cheng Xiu-Jun,Wu Chang-Yue,Wu Dan,Dong Can-Bin,Yang Yu-Tian,Wang Yi-Fan,Cai Xiu-Jun,Zhu Ning-Wen
Infectious wounds induce a cycle of bacterial proliferation, oxidative stress accumulation, and dysregulated macrophage polarization, collectively hindering tissue repair. Conventional wound dressings typically address these pathological factors in isolation, resulting in suboptimal therapeutic outcomes. Here, we report the design of a biocompatible multifunctional hydrogel (GAPC). This system integrates self-assembled Proanthocyanidin/Chlorhexidine nanoparticles into a dual-network GelMA/ADM scaffold. Consequently, the hydrogel exhibits simultaneous antibacterial activity, ROS scavenging, and immunomodulatory capacity. In vitro, GAPC hydrogel has superb antibacterial, antioxidant, and anti-inflammatory effects. On the other hand, GAPC hydrogel promotes M1-to-M2 macrophage transition and preserved cellular viability under oxidative stress. Furthermore, in vivo it accelerated infected burn wound closure, enhanced collagen remodeling, and stimulated neovascularization. Collectively, GAPC hydrogel interrupts the “infection-oxidative stress-inflammation” loop, offering a safe and promising option for managing infected wounds. Graphical
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KOREAN JOURNAL OF CHEMICAL ENGINEERING
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2026
·
IF 3.4
Jiang Pengfei,Hao Yifan,Jia Mingxi,Liu Cun
Hydrogen peroxide (H 2 O 2 ) is a key reactive oxygen species involved in physiological regulation and pathological processes, and its accurate quantification is essential for bioanalysis and disease-related studies. Herein, we report the synthesis of a series of Cu-Fe oxide nanozymes via a simple antisolvent crystallization strategy and systematically investigate their peroxidase-like catalytic activity toward colorimetric H 2 O 2 detection. By tuning the Cu/Fe molar ratio, the catalytic activity of the nanozymes can be effectively regulated, with Cu 2 FeO x exhibiting the highest peroxidase-like activity toward 3,3′,5,5′-tetramethylbenzidine (TMB) oxidation in the presence of H 2 O 2 under acidic conditions and enabling sensitive colorimetric detection of H 2 O 2 over a linear range of 10–200 µM with a detection limit of 0.572 µM. Furthermore, the proposed sensing platform demonstrates satisfactory selectivity and reproducibility, and is successfully applied to the determination of H 2 O 2 released into cell culture supernatants after chemical stimulation. This work highlights the potential of composition‑regulated Cu-Fe oxide nanozymes as robust artificial enzymes for colorimetric H 2 O 2 sensing and provides insights into their application in bioanalytical systems.
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Journal of Food Measurement and Characterization
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2026
·
IF 3.6
Zhang Longqian,Wang Fang,Gao Yuan,Xu Zhenrong,Shu Jie,Wang Junke,Zhang Li
Smartphones have become ideal platforms for portable colorimetric analysis due to their widespread availability, cost-effectiveness, and advanced imaging capabilities. However, most existing smartphone-based detection methods are susceptible to inconsistent lighting conditions and often rely on external computational resources, which limits their practical application in scenarios like food quality control and environmental monitoring. To overcome these limitations, a fully on-device smartphone colorimetry system integrated with machine learning (ML) is presented. Leveraging the characteristic color transition from light pink to deep purple, the system captures sample images using the built-in smartphone camera and processes them via a custom-developed Android application. To tackle lighting interference, a foundational dataset of 1134 images was constructed under seven controlled lighting conditions using two smartphone models. On the two primary training devices, XGBoost demonstrated the best predictive accuracy ( \(\varvec{R^{2} = 0.9968, \textrm{RMSE} = 0.0044, \textrm{MAPE} = 2.87\%}\) ) among four trained ML models. Furthermore, robust cross-device generalization was successfully validated on two additional unencountered models via an adaptive calibration protocol. The system offers a wide working range (0.045–0.250 mg/L), a low detection limit (0.015 mg/L), and maintains high analytical reliability under diverse lighting scenarios. The system’s practical applicability was demonstrated through the quantification of nitrite in processed meat samples and water. Furthermore, the entire workflow from automatic region-of-interest identification to concentration prediction is performed locally on the smartphone without requiring internet connectivity, ensuring operational autonomy and data privacy. This portable, low-cost, and user-friendly system demonstrates strong potential as a practical tool for on-site food safety screening and environmental surveillance.
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NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
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2026
·
IF 4
Fu Xingqian,Liu Wei,Zhang Yongxiang,Wu Qihong,Long Gang,Zhai Yifa,Song Chao,Yang Po
The pathophysiology of osteoarthritis (OA), a common degenerative joint disease, is complicated. The significance of autophagy irregularities and iron metabolism issues in OA has garnered a lot of interest in recent years, with “Ferritinophagy” mediated by NCOA4 acting as a crucial link between the two and potentially a novel therapeutic target. The purpose of this research is to determine whether resveratrol, a naturally occurring substance, protects cartilage via controlling the ferritinophagy network. Using differential analysis, weighted gene co-expression network analysis, and other machine learning methods, this study combined transcriptome data from several omics studies and screened OA core ferritinophagy-related genes. Use molecular docking and molecular dynamics simulations to assess resveratrol’s binding mechanism and stability to core targets. The CCK-8 technique was employed in vitro to assess cell survival and identify the ideal resveratrol intervention concentration in an inflammatory model of human articular chondrocytes caused by IL-1β. Using Western blot (WB) to determine the expression of 8 key proteins including NCOA4, GPX4, and LC3. Transmission electron microscopy is used to observe the mitochondrial ultrastructure. NCOA4 protein location and expression were verified using immunofluorescence. Bioinformatics analysis successfully screened key genes such as DDIT4, CTSB, BNIP3, CDKN1A, and NCOA4. Molecular docking and molecular dynamics simulations demonstrate that resveratrol can stably bind to core proteins such as BNIP3 and NCOA4. Resveratrol has been shown in vitro to dramatically increase cell survival and reverse the aberrant expression of important ferritinophagy proteins brought on by IL-1β, upregulating GPX4 and CDKN1A and downregulating NCOA4, LC3-II/I, and BNIP3. The results of transmission electron microscopy demonstrated that resveratrol successfully reduced aberrant autophagosome aggregation and mitochondrial damage. Resveratrol can considerably reduce the unusually high expression of NCOA4, as further demonstrated by immunofluorescence. This study reveals the molecular mechanism by which resveratrol inhibits NCOA4-mediated ferroptophagy, thereby regulating downstream autophagy and ferroptosis processes, and alleviating chondrocyte damage in OA. This provides a new perspective for elucidating the cartilage protective effect of resveratrol and lays a solid theoretical and experimental foundation for developing OA treatment strategies targeting ferritinophagy.
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CELLULAR & MOLECULAR BIOLOGY LETTERS
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2026
·Vol. 31
·期 1
·33
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IF 12.2
Ding Ying,Feng Ziyang,Chen Guanjun,Liu Yunqing,Zhu Yuxing,Cao Ke
Background Anaplastic thyroid cancer (ATC) is a highly aggressive malignancy with rapid progression and poor prognosis. Although N1-methyladenosine (m 1 A) modification has been implicated in cancer development, the specific role of tRNA m 1 A modification in ATC remains unclear. Methods An integrated multi-omics approach is employed, including m 1 A-MAP-tRNA-seq, tRNA-seq, RNA-seq, and Ribo-seq, complemented by functional assays such as tRNA aminoacylation assay, puromycin intake assay, and L-HPG staining. Additional experiments involved polysome profiling qRT-PCR, codon-switch assay, endoplasmic reticulum (ER)-tracker and TPE-MI staining, transmission electron microscopy, ChIP-qPCR, dual-luciferase reporter assay, and BODIPY staining to elucidate the underlying mechanism. Results TRMT6/TRMT61A is significantly upregulated in ATC. The complex promotes tumor cell proliferation and metastasis by enhancing the aminoacylation of specific tRNAs, thereby facilitating global protein translation. Elevated translation led to the accumulation of unfolded proteins in the ER, which activates the IRE1α–XBP1s pathway. Notably, m 1 A modification also increased IRE1α translation, further amplifying the pathway. Activation of the IRE1α–XBP1s pathway upregulates DGAT1 expression, which promotes triglyceride synthesis. Conclusions Together, these findings reveal a previously unrecognized mechanism by which TRMT6/TRMT61A drives ATC progression through translational and metabolic reprogramming, identifying TRMT6/TRMT61A as a promising therapeutic target in ATC. Graphical abstract
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Nature Communications
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2026
·
IF 18.1
Lei Ying,Zhan Xu,Chen Chao,Liu Yuxin,Wang Ying,Liu Ping
Effective host defense against pathogens requires coordinated behavioral and immune responses, yet the mechanisms that couple epithelial sensing to these systemic defenses remain poorly understood. Here, we identify a proton-mediated gut-to-neuron signaling pathway that orchestrates host defense in C. elegans . Intestinal pathogens stimulate mechanosensitive Ca 2+ influx into intestinal epithelial cells (IECs) through the TRP channel GON-2, activating the Na + /H + exchanger NHX-6 via the calmodulin CMD-1 to drive basolateral proton release. These protons activate cholinergic motor neurons through the acid-sensing ion channel ASIC-1, enhancing cholinergic transmission to promote both pathogen avoidance and intestinal innate immunity. Notably, mouse NHE1 and ASIC1a can functionally substitute for their nematode counterparts. Together, these findings demonstrate a role for proton signaling in gut-to-neuron communication, revealing a potentially conserved mechanism that links epithelial sensing to neuroimmune defense.
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Nano-Micro Letters
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2026
·Vol. 18
·期 1
·302
·
IF 38.5
Lu Bokai,Jin Guangkai,Cui Yuhong,Zhang Tianyi,Liu Shujuan,Ye Qian,Liu Xuqing,Zhou Feng
Catechol-functionalized carbon dots chemically anchor onto MXene nanosheets, enhancing interfacial polarization and enabling impedance matching optimization through glycerol-regulated gel polarity.
A flexible organic hydrogel absorber was constructed via synergistic integration of a dual-crosslinked polymer network and conductive MXene/carbon dots (CDs) hybrid fillers.
The MXene/CDs hydrogel exhibits outstanding performance (RL min = −47.9 dB, 3.5 GHz bandwidth at 3.1 mm) together with improved mechanical robustness.
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ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
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2026
·
IF 0
Kim Sung-Jin,Zhang Lingling
This study presents a transformative zero-waste paradigm for up-cycling steel slag (SS) which is an abundant industrial waste, by strategically deconstructing it into two valuable products. The established process involves the targeted sulfuric acid leaching of SS to separate its major components: iron ions and calcium. The iron-rich leachate serves as a precursor for the plant-mediated synthesis of α-Fe 2 O 3 /SiO 2 nanocomposites using Gingko biloba leaf extract, while the solid residue is transformed into gypsum (CaSO 4 ·2H 2 O), a huge applicable material in construction and agriculture. Optimization of methylene blue (MB) adsorption using the Taguchi method achieved an experimental equilibrium capacity of 37.03 mg/g under the investigated conditions. The adsorption behavior was best described by the pseudo-second-order kinetic model and the Freundlich isotherm model, indicating dominant chemisorption on a heterogeneous surface. The Freundlich constants ( K F = 75.5 (mg/g)(L/mg) 1/n and n = 2.04) confirmed strong adsorption affinity and favorable adsorption characteristics. A Langmuir monolayer capacity of 102.04 mg/g was estimated from model fitting. Density functional theory (DFT) and molecular mechanics simulations provided atomistic-level confirmation of a strong, exothermic interaction between methylene blue (MB) and the Fe 2 O 3 surface, albeit moderated in an aqueous environment. Furthermore, the nanocomposite showed remarkable stability, retaining over 70% of its removal efficiency after five consecutive adsorption-desorption cycles. This study establishes a comprehensive “waste-to-wealth” pipeline beyond simple waste modification and demonstrates a viable circular economy model simultaneously designed to control the solid waste management and water pollution.
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