JOURNAL OF CONTROLLED RELEASE
·
2022
·
IF 11.467
Jiamei Li,Yang Zhou,Jiaqi Liu,Xiaotong Yang,Kai Zhang,Lei Lei,Haili Hu,Huilin Zhang,Liang Ouyang,Huile Gao
As an endogenous gasotransmitter , CO has achieved tremendous advances in cancer treatment through selectively killing cancer cells. However, the application of CO in tumor immunotherapy has not been reported and the tumor targeting delivery is still a tremendous challenge. Herein, thermosensitive boronic acid group-containing CO prodrug was synthesized and fabricated with tannic acid (TA) and iron (Fe) to form metal-phenolic networks, and then loaded with near-infrared (NIR) photothermal agent IR820 to form [email protected] III TA for combinational therapy of CO and photothermal therapy . Ferroptosis can also be enhanced due to the Fe 3+ incorporation. After TA reduced Fe 3+ into Fe 2+ , Fe 2+ might lead to intracellular Fenton reaction. Furthermore, in combination with CTLA-4 blockade immunotherapy, [email protected] III TA remarkably inhibited breast tumor growth, suppressed the lung metastasis and improved the antitumor immune response. To summarize, [email protected] III TA provides a potential novel option for CO/photothermal/immune synergistic therapy with enhanced ferroptosis through simple compositions and facile synthesis process.
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PubMed
高影响因子
FUEL
·
2022
·
IF 8.035
Haijian Qin,Huaibiao Wang,Qing Xia,Chunzhi Zheng,Xiaonan Zhang,You Wu,Lei Peng,Fengli Yang,Songjian Zhao
Small size cobalt nanoparticles are highly dispersed on different crystalline forms of Ta 2 O 5 (amorphous, T, M, H) by impregnation method, which is then introduced to catalytic oxidation of CO. The experimental results show that Co 3 O 4 /M-Ta 2 O 5 exhibits the highest CO conversion efficiency compared with Co 3 O 4 loaded on amorphous-, T-, and H-Ta 2 O 5 , and the pure Co 3 O 4 and M-Ta 2 O 5 . The temperature of 90 % CO conversion rate is approximately 170 °C at the high space velocity of 780,000 h −1 . Besides, the effect of oxygen concentration, space velocity, CO concentration, as well as different ratio of Co: Ta on CO conversion have been studied. Moreover, XRD , SEM, TGA , BET and H 2 -TPR characterizations reveal that Co 3 O 4 is uniformly distributed and does not change the structure crystalline of Ta 2 O 5 , and there is strong interaction between cobalt active component and Ta 2 O 5 support, which might be beneficial for CO conversion. Furthermore, the reaction mechanism has been investigated by X-ray photon spectroscopy and in-situ diffuse reflectance infrared Fourier transform spectroscopy (DRIFTs), which suggest that Co 3+ is the active component and lattice oxygen as well as adsorbed oxygen play a critical role in CO oxidation.
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高影响因子
RSC Advances
·
2023
·Vol. 13
·期 9
·5667-5673
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IF 3.9
Bin Li,Haibo Qin,Ming Ma,Xiaojia Xu,Mengjing Zhou,Wenrui Hao,Zhigang Hu
In this paper, betaine (Bet) was used as a hydrogen bond acceptor (HBA), and acrylic acid (AA) and acrylamide (AM) were used as hydrogen bond donors (HBD) and mixed to form a deep eutectic solvent (DES). Different concentrations of β-cyclodextrin (β-CD) were dispersed in the DES, and a novel β-CD/P(AA-co-AM) hydrogel was prepared by frontal polymerization (FP). The characteristic structure and morphology of the hydrogels were analyzed using Fourier transform infrared (FTIR) spectroscopy and scanning electron microscopy (SEM), and the properties of the hydrogels were investigated. The results show that the mechanical properties of the hydrogel were improved by β-CD acting as a second cross-linking agent in the polymerization process, thus increasing the cross-link density of the hydrogel. Because the carboxyl groups contained in the acrylic acid dissociate under alkaline conditions, the composite hydrogel shows excellent pH responsiveness under alkaline conditions. Tetracycline hydrochloride was used as a drug model to test the drug loading and drug release performance of the hydrogels. With the increase of β-CD content, the loading capacity of the hydrogels for tetracycline hydrochloride gradually increased. The data of drug release indicated that the hydrogel has good drug delivery performance and has promising applications in drug delivery systems and other areas.
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高影响因子
OPTICAL MATERIALS
·
2023
·
IF 3.9
Qijing Zheng,Chunyan Guan,Zhenghuan Wan,Ru Fu,Jinyu Yang
Pure phase orthorhombic Er 3+ and Yb 3+ co-doped La 14 W 8 O 45 up-conversion luminescent materials were successfully prepared by the hydrothermal method combined with calcination treatment. The structures, morphology, and optical properties of the samples were analyzed by X-ray powder diffractometer (XRD), scanning electron microscope (SEM), ultraviolet–visible diffuse reflectance spectroscopy (UV–Vis DRS), and up-conversion photoluminescence spectroscopy (UPL) with a 980 nm laser. XRD results indicated that the obtained samples are single-phase orthorhombic Er 3+ and Yb 3+ co-doped La 14 W 8 O 45 crystals. SEM results showed that the prepared sample exhibits an irregular and melted polyhedral-like morphology with agglomeration in submicron size of particles approximately 50–200 nm. UV–vis DRS results revealed that the La 14 W 8 O 45 crystal is a direct semiconductor with an optical band gap of 3.84 eV. The prepared Er 3+ and Yb 3+ co-doped La 14 W 8 O 45 crystals exhibit strong up-conversion emission peaks at about 526 nm, 548 nm, and 660 nm under 980 nm laser excitation. The intensity of up-conversion luminescence is affected by the Er 3+ doping concentration, and concentration quenching will be observed due to the cross-relaxation (CR) process when the Er 3+ doping content is above 1%. The pumping power dependence of the luminescence indicated that the up-conversion emissions of samples are excited by a two-photon absorption process. The color coordinates of the samples are located in the green light region.
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高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2022
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IF 8.025
Zhimeng Chen,Tiantian Wen,Xueyuan Wang,Lin Yang,Zhongjie Wang,Yanru Qin,Yixue Hu,Tianyu Zhang,Dongna Wang,Amin Liu,Liefeng Zhang,Meng Lei,Yongqiang Zhu
Herein, a cyclodextrin derivative (R6RGD-CMβCD) with tumor target and a carboxymethyl chitosan derivative (M2pep-CMCS) with tumor-associated macrophages 2 (TAM2) target were successfully synthesized, respectively. DOX-loaded nanoparticles (R6RGD-CMβ [email protected] NPs, RCNP DOX ) and R848-loaded nanoparticles ( [email protected] NPs, MCNP R848 ) were prepared. Furthermore, the RCNP DOX and MCNP R848 exhibited good DOX and R848 absorption. Meanwhile, the synergetic cell toxicity of RCNP DOX and MCNP R848 was found. Additionally, RCNP DOX + MCNP R848 nanoparticles greatly promoted the expression levels of cleaved Caspase3, which indicated that the nanoparticles could induce cell apoptosis. At the same time, the immunohistochemical images exhibited that RCNP DOX + MCNP R848 group could effectively transform the phenotype of tumor-associated macrophages. Importantly, in vivo experiments revealed that RCNP DOX + MCNP R848 NPs exerted excellent anticancer effects in tumor-bearing mice. To summarize, RCNP DOX + MCNP R848 NPs are effective anticancer treatment combining chemotherapy and immunotherapy, M2pep-CMCS and R6RGD-CMβCD are good delivery materials.
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PubMed
高影响因子
Nano Research
·
2022
·Vol. 16
·期 6
·8405-8410
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IF 10.269
Cao Renfei,Cui Yangfeng,Huang Gang,Liu Wanqiang,Liu Jianwei,Zhang Xinbo
Li-O 2 batteries with extremely high specific energy density have been regarded as a kind of promising successor to current Li-ion batteries. However, the high charge overpotential for the decomposition of Li 2 O 2 discharge product reduces the energy efficiency and triggers a series of side reactions that cause the Li-O 2 batteries to have a limited lifetime. Herein, Co-doped C 3 N 4 (Co-C 3 N 4 ) photocatalysts were designed by an in situ thermal evaporation method to take advantage of the photo-assisted charging technology to conquer the shortcomings of Li-O 2 batteries encountered in the charge process. Different from the commonly used photocatalysts, the Co-C 3 N 4 photocatalysts perform well no matter with and without illumination, owing to the Co doping induced conductivity and electrocatalytic ability enhancement. This makes the Co-C 3 N 4 reduce the charge and discharge overpotentials and improve the cycling performance of Li-O 2 batteries (from 20 to 106 cycles) without illumination. While introducing illumination, the performance can be further improved: Charge voltage reduces to 3.3 V, and the energy efficiency increases to 84.84%, indicating that the Co-C 3 N 4 could behave as a suitable photocathode for Li-O 2 batteries. Besides, the low charge voltage and the continuous illumination together weaken the corrosion of the Li anode, making the long-term high-efficiency operation of Li-O 2 batteries no longer just extravagant hope.
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高影响因子
PHYSICA B-CONDENSED MATTER
·
2022
·
IF 2.988
Xianzhi Zeng,Haoyi Wu,Junhao Peng,Chuanlong Wang,Guangting Xiong,Yahong Jin,Yihua Hu
The improvement of luminescent properties is important for expanding the application of long afterglow phosphor (LAP). Here, the melilite-type Sr 1·97 MgSi 2 O 7 : Eu 2+ 0.01 , Dy 3+ 0.02 LAP was studied with Bi 3+ as the second co-dopant. Both photoluminescence (PL) and thermoluminescence (TL) were improved in terms of intensity and afterglow lifetime when the doping concentration of Bi 3+ exceeded 2.5 mol%, and the optimized point was 3.5 mol%. As compared to the case of Eu 2+ - Dy 3+ double doping, the improved PL of Eu 2+ - Dy 3+ - Bi 3+ triple doping samples was attributed to better photon absorption . The improved TL and afterglow were attributed to the synergistic strengthening density of the traps by Bi 3+ and the deepening of trapping by Dy 3+ , if their distance was sufficient close. As a result, both TL and afterglow optimized at a concentration of 2 mol% Dy 3+ - 3.5 mol% Bi 3+ coupling.
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高影响因子
JOURNAL OF FOOD ENGINEERING
·
2022
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IF 6.203
Zhongyu Yang,David Julian McClements,Xinwen Peng,Zhenlin Xu,Man Meng,Long Chen,Zhengyu Jin
Composite nanoparticles composed of zein and carboxymethyl cellulose (CMC) designed for the co-delivery of resveratrol and quercetin were prepared using antisolvent precipitation. At a mass ratio of zein-to-CMC of 2:1, composite nanoparticles with small average diameters (217 nm) could be formed. These nanoparticles had good thermal stability and did not aggregate or sediment when stored at pH 3.0–6.0. Encapsulation of quercetin and resveratrol simultaneously within the composite nanoparticles significantly improved their antioxidant activities . This study suggests that composite nanoparticles may have good physical and chemical stability, which may increase their application as co-delivery systems for bioactive components. As a result, they may be useful for personalized nutritional applications where combinations of bioactive compounds need to be orally administered.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2022
·
IF 16.744
Yu Jiang,Marhoun Ferhat,Wenhao Fan,Shaoping Chen,Yachao Wang,Jie Chen,Rasha Abdullah Ahmed Al-Yusufi,Chaochao Dun
Additional cation doping is one of the potential strategies to enhance the thermoelectric (TE) performance of Mg 3 Sb 2 -based materials with precise regulation of interaction between cations and the host. In this work, using Mg 3 Sb 1.5 Bi 0.5 as an example, we confirmed that co-doping rare-earth elements with Y and La is capable to simultaneously improve its power factor and suppress the thermal conductivity : Y is an effective n -type dopant to regulate the optimal carrier concentration, while La doping can modulate the band structure and increase the effective mass that related to the improved Seebeck coefficient . A promising power factor of 18.3 μW cm -1 K -2 is obtained after co-doping. Meanwhile, the lattice thermal conductivity is dramatically reduced to 0.39 W m -1 K -1 at 750 K thanks to the extra defect scattering introduced by Y and La. As a result, a peak figure of merit ( zT ) of 1.76 and a competitive average zT of 1.1 among 300–750 K are achieved in Mg 3.2 Y 0.04 La 0.01 Sb 1.5 Bi 0.5 . The synergistic effect stemming from dual-cations doping provides profound insights for controllable host-dopant design and modulation toward high-efficient n-type TE materials .
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高影响因子
COMPOSITES PART A-APPLIED SCIENCE AND MANUFACTURING
·
2022
·
IF 9.463
Sinan Zheng,Zhihui Zeng,Jing Qiao,Yue Liu,Jiurong Liu
The C/MnO/Co nanocomposite fibers were prepared via a facile electrospinning and subsequent carbonization process. Co acting as the magnetic nanoparticles and MnO nanoparticles serving as impedance modulator were introduced, effectively inhibiting the agglomeration of carbon fibers during annealing. This optimizes the microstructure and significantly improves the microwave absorption performance of the nanocomposites with diameters of 250–350 nm and rough surface morphologies . The nanocomposite fibers with equal MnO and Co molar contents exhibited the minimum reflection loss of − 71.7 dB at a frequency of 14.1 GHz and an absorber thickness of 2.3 mm, and the effective absorption bandwidth reached at 6.3 GHz at a thickness of 2.6 mm. The high microwave absorption performance can be attributed to the synergistic coactions of conduction loss, magnetic loss, interfacial polarization, and multiple scatterings derived from the rational design of the constituents and microstructure of the nanocomposites.
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高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2022
·Vol. 57
·期 2
·1302-1313
·
IF 4.682
He Fupo,Qiu Chao,Wang Yao,Lu Teliang,Ye Jiandong
The aim of this study was to fabricate silicon/gallium co-substituted tricalcium phosphate bioceramics having the ability to promote osteoblast activities as well as hinder osteoclast activities. The silicon/gallium co-substituted tricalcium phosphates were synthesized with a solid-state reaction route, and their bioceramics were prepared by the process of molding and sintering. The bioceramics were characterized employing X-ray fluorescence spectroscopy, X-ray diffraction and scanning electron microscopy. Porosity and compressive strength tests, and experiments for in vitro cell response evaluation were performed. The results manifested that silicon/gallium co-substitution promoted transition of β-tricalcium phosphate to α-tricalcium phosphate and additionally gave rise to new phases of silicocarnotite and Ca 2 SiO 4 . In contrast to a single gallium substitution, the silicon/gallium co-substitution retarded the densification process but retained the high mechanical strength of bioceramics, and maintained the inhibitory effect of gallium on the osteoclast activities. The tricalcium phosphate bioceramics with substitutions of 2.5 mol% gallium and 10 mol% silicon possessed considerable mechanical strength, enhanced osteoblast activities and restrained osteoclast activities, so they were expected to efficiently reconstruct the bone defects in the environment of osteoporosis.
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高影响因子
CHEMICAL PHYSICS LETTERS
·
2022
·
IF 2.719
Peng Yong,Sheng Wang,Xu Zhang,Haibo Pan,Shuifa Shen
Shape controlled preparation and doping are important means to improve the gas sensitivity of metal oxide semiconductor materials. In this work, pure and Co-doped In 2 O 3 porous hollow hexagonal cylinders were successfully prepared using metal–organic frameworks (MOFs) MIL-68(In) as self-sacrificial template. The size of the MIL-68(In) hexagonal cylinder is uniform, and the In 2 O 3 obtained after pyrolysis better inherits the shape of the MIL-68(In), but becomes hollow, and the cylinder surfaces are porous. The product has a large specific surface area (46.52 m 2 /g), and the doping of Co significantly increases the oxygen vacancy of the material. The Co-doped sample obtained by pyrolysis at 500℃ has excellent gas sensing performances to ethanol gas, its sensitivity to 100 ppm ethanol gas at 210 ℃ is 14.6, response/recovery time is 21 s and 107 s, and the sensing selectivity to ethanol is also good.
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高影响因子
危险品化学品经营许可证（带存储）