DYES AND PIGMENTS
·
2024
·
IF 4.1
Jie Hu,Hengju Zhou,Xinyao Wang,Shiqiang Cui,Shouzhi Pu
In order to overcome the influences of external environment on the properties photochromic compounds and expend their applications fields, various photochromic microcapsules have been prepared. However, the effects of wall materials on the properties of photochromic compounds need to be further studied. In this study, two photochromic microcapsules were prepared with polyurethane/chitosan as wall materials and a diarylethene molecular as core material. The properties such as photochromism, fatigue resistance, the sealing, and thermal stability of the microcapsules were studied, and the effects of the wall materials on the photochromic properties of the diarylethene were also investigated. Furthermore, the prepared microcapsules have been successfully applied to cotton fabrics of photochromic smart textiles.
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MACROMOLECULAR BIOSCIENCE
·
2025
·
IF 4.1
Zihan Ma,Chengde Liu,Yizheng Li,Xigao Jian
The implant-soft tissue interface is critical for successful integration. However, developing multifunctional coatings that combine antibacterial action, strong interfacial adhesion, and regenerative capacity remains a significant challenge. This study presents a novel hydrogel coating for surface modification of phthalazinone-naphthalene-based Poly(phthalazinone ether ketone) (PPEK) implants. The coating consists of an MgO nanoparticle-embedded, photocrosslinked gelatin/chitosan hydrogel functionalized with NHS groups. XPS and 1 H NMR analyses confirmed that NHS groups mediate covalent bonding. This bonding occurs with amine moieties on both plasma-activated PPEK implants and soft tissues, substantially improving interfacial adhesion. The coating demonstrated dual functionality: broad-spectrum antibacterial activity and sustained Mg 2 ⁺ release. The released Mg 2 ⁺ exhibited multiphase bioeffects. These bioeffects include enhanced migration of L929 fibroblasts, HUVECs, and HaCaT keratinocytes; stimulated HUVEC tubulogenesis; and upregulated extracellular matrix synthesis. Both in vitro and in vivo assessments revealed synergistic acceleration of collagen deposition and angiogenesis. This synergy facilitates rapid soft tissue regeneration. Subcutaneous implantation models demonstrated dual integration mechanisms: NHS-driven covalent adhesion and Mg 2 ⁺-mediated bioactive remodeling via cellular activation. These results position the MgO-integrated nanocomposite hydrogel as a multifunctional therapeutic coating. It simultaneously addresses microbial resistance, interfacial stability, and tissue regeneration for optimized implant-soft tissue integration. The design paradigm merges physicochemical bonding with ion-modulated bioactivity. This approach offers a strategic solution for complex interface engineering in biomedical implants.
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高影响因子
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
·
2025
·
IF 1.6
Wang Weiran,He Hui,Wang Zhifen
In this study, two new, highly selective, acid-resistant and reusable functionalized magnetic chitosan-based composites (FOS@C-DTPA and FOS@C-PBTCA) were successfully prepared. The adsorption performance of the composites was systematically evaluated through controlled variations in solution pH, exposure time, and starting uranium content, while the underlying mechanisms for uranium uptake were analyzed using kinetic models and thermodynamic equilibrium studies. In the multi-ion competition experiments, a high degree of selectivity for U(VI) was demonstrated; good cyclic regeneration performance was shown in both cycling experiments. XPS analysis combined with complementary characterization techniques demonstrated that uranium adsorption was predominantly caused by surfaces complexation between U(VI) ions and the composite material’s abundant functional groups rich in carbon, nitrogen, and oxygen on the composite material. At pH 5, FOS@C-PBTCA demonstrated an adsorption capacity of 303.53 mg·g −1 , while FOS@C-DTPA achieved 487.39 mg·g −1 at pH 6. The proposed approach aims to achieve efficient and selective uranium extraction by leveraging an anion-assisted synergistic mechanism, enabled through the rational design of acid-resistant and recyclable magnetic composite adsorbents.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2021
·
IF 4.539
Zhe Li,Xiaoxia Jiang,Ziheng Yao,Fucai Chen,Lin Zhu,Hongning Liu,Liangshan Ming
In this study, cellulose nanocrystals (CNC)/chitosan (CS)/glutaraldehyde (Glu) ternary composites were synthesized using cross-linking method with different CNC/CS ratios (1:1, 2:1, 3:1, 4:1, w/w). The composites were firstly characterized using various techniques, such as SEM , FT-IR, isothermal nitrogen adsorption/desorption and TGA . They were further used as solid stabilizers for the preparation of O/W Pickering emulsions. The appearance of emulsions, size and zeta potential and rheological properties of the droplets were investigated. The results showed that the cross-linked biopolymer composites had high surface area, variable morphology and special three-dimensional networks, and showed good emulsifying capacity. Furthermore, the droplet size and zeta potential of emulsions as functions of pH (2–12), temperature (4–60 °C) and ion strength (0–1000 mM) were studied, and the results confirmed that the emulsions prepared with CNC/CS composites had good physical stability at different varying conditions. This study suggested that CNC/CS composites could significantly improve the emulsifying capacity and therefore had great potential for application in the pharmaceutical and food sciences.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2017
·
IF 3.671
Zhaotong Cong,Yanbin Shi,Yang Wang,Yanhong Wang,Jing’e Niu,Nana Chen,Haoyue Xue
In this study, we present a novel cross-linked unimolecular micelle based on chitosan. For controlling drug delivery via oral administration, emodin (EMO) encapsulated micelles were loaded into sodium alginate hydrogel matrix to construct the pH-sensitive hydrogel/micelle composites. The optimized formulation of micelle that consists of 8.06% CaCl 2 , 1.71% chitosan and 26.52% β-GP was obtained by the combination of Box-Behnken experimental design and response surface methodology. The morphological analysis showed that the micelles exhibited a smaller diameter of about 80 nm in aqueous solution, but dilated to 100–200 nm in hydrogel owing to the formation of polyelectrolyte complexes. The physical characteristics in simulated digestive fluids were investigated, demonstrating that the ratio of hydrogel to micelle distinctly affected swelling, degradation and in vitro drug release behaviors. The hydrogel/micelle (1:1) exhibited a sustained-release profile, while hydrogel/micelle (3:1) exhibited a colon-specific profile. Their corresponding release mechanisms revealed that the release of drug from these two formulations followed a complex process, in which several mechanisms were involved or occurred simultaneously. These results demonstrated that the pH-sensitive hydrogel/micelle composites constructed with biocompatible materials can be a promising sustained-release or site-specific drug delivery system for instable or hydrophobic drugs.
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高影响因子
ELECTROANALYSIS
·
2020
·Vol. 33
·期 3
·723-732
·
IF 2.544
Lincai Peng,Yingjie Luo,Hongping Xiong,Shun Yao,Minghui Zhu,Hang Song
A novel enzymatic biosensing platform toward glucose is achieved with nanocomposite of magnetic nanoparticles (Fe 3 O 4 −CS−CD) and multi-walled carbon nanotubes (MWCNTs). The synergistic effect of chitosan, β-cyclodextrin and MWCNTs can facilitate electron transfer between enzyme and electrode based on the promoting results of the cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). The new biosensors exhibited direct electron transfer (DET) from enzyme to electrode after glucose oxidase (GOx) was immobilized on the modified electrode with the nanocomposite. Consequently, the enzymatic glucose biosensor displayed a considerably wide linear range (40 μM to 1.04 mM) with a high sensitivity of 23.59 μA mM −1 cm −2 , low detection limit of 19.30 μM, good selectivity, reproducibility and repeatability for detecting glucose. In addition, the current response still retained at 93.4 % after 25 days. Furthermore, the practical application of glucose biosensor was test in human serum samples with satisfactory accuracy, demonstrating promising and practical potential in biomedical diagnostics.
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CHEMICAL ENGINEERING JOURNAL
·
2018
·
IF 6.735
Jinxin Liu,Runrun Wu,Runxin Gu,Fengxian Qiu,Jianming Pan
Fabrication of chitosan-based composites without tedious procedures and significant biological hazard arising from using glutaraldehyde in the Schiff base reaction is highly needed. An environmentally friendly chitosan tablet is fabricated using Fe 3+ -mediated chitosan complexes via metallo-supramolecular chemistry. The structural properties of the material were investigated by SEM, FTIR, Raman and XRD, and the results indicated that Fe 3+ could chelate with chitosan via a “hide-and-seek” strategy to form well crosslinked polymer network. Moreover, the swelling behavior of the chitosan tablet showed that maximum swell ability achieved at pH 7.4. In addition, the chitosan tablet displayed pH-stimulated release properties, and its construct (i.e. chitosan-Fe 3+ complexes) was released efficiently at pH 1.0. Furthermore, the cytotoxicity experiments confirmed that chitosan tablet was compatible with human cell. Based on these results, we demonstrate here that the obtained chitosan tablet would be an oral iron supplementation potentially for treatment of iron deficiency anemia (IDA).
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CURRENT MOLECULAR MEDICINE
·
2018
·Vol. 18
·期 6
·383-391
·
IF 2.254
Li Yue,Lin Yan,Liufu Chun,Tu Jiawei,Yang Chaopin,Chen ZhiYi
Objective: To study transfection efficiency of folate-modified chitosan (FACS) nanoparticles as a non-viral vector delivering pEGFP-C3plasmid (FA-CS/P) to 293T cells with or without the combination of ultrasound and microbubble. Method: pEGFP-C3 was used as a reporter gene and
FA-CS nanoparticles, which were prepared by complex coagulation method, were used as biological carriers. Transfection efficiency to 293T cells mediated by FA-CS/P nanoparticles, ultrasound (US) and microbubble (MB) was assessed by fluorescence microscopy and flow cytometry. Result: FA-CS/P
nanoparticles have a particle size of 355.1 nm and zeta potential of 10.4 mV. Significant green fluorescence could be observed in CS/P group, FA-CS/P group, US+MB/P group, US+FA-CS/P group, Liposome 2000 (L) group under an inverted fluorescence microscope, while for US+MB+FA-CS/P group, only
scattered fluorescence was observed. Result of flow cytometry showed that the transfection rate of US+MB+FA-CS/P group was (2.0±0.2)%, which was significantly lower than other groups (P<0.05). CCK-8 experiments showed that cell vitality of US+MB+FA-CS/P was groups (P<0.05). CCK-8
experiments showed that cell vitality of US+MB+FA-CS/P was (64.1±4.6)%, which was also lower than other groups (P<0.05). Conclusion: In this study, FA-CS was successfully synthesized. FA-CS could combine with pEGFP-C3 effectively forming nanoparticles with nanoparticle size,
well dispersion, high encapsulation efficiency and no significant toxicity to cells. The application of ultrasound increased the transfection rate of FA-CS/P. However, while being exposed to ultrasound and microbubble, the transfection rate of FA-CS/P decreased obviously, may indicate that
there was no synergistic effect for gene transfection by the combination of ultrasound, folate modified chitosan and microbubbles.
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Chemistry-An Asian Journal
·
2013
·Vol. 9
·期 1
·319-327
·
IF 4.572
Xiaoxi Hu,Yun Wang,Bo Peng
Graphical Doff my cap : pH-Responsive chitosan-capped mesoporous silica nanoparticles were synthesized by using a facile strategy and served as nanocapsules for site-specific drug loading and release. Herein, we present a straightforward synthesis of pH-responsive chitosan-capped mesoporous silica nanoparticles (MSNs). These MCM-41-type MSNs could be used as nanocapsules to accommodate guest molecules. Subsequently, (3-glycidyloxypropyl)trimethoxysilane was grafted onto the surface of the MSNs, which served as a bridge to link between MSNs and chitosan, which is ubiquitous in nature and commercially available. Owing to the pH-responsive and biocompatible features of chitosan, the loading and release of an anti-cancer drug, doxorubicin hydrochloride, were carried out in vitro, in which the composite chitosan-capped MSNs (CS-MSNs) showed excellent environmental response. As the pH value of the media decreased, the degree of drug release correspondingly increased. Moreover, thanks to the perfect biocompatibility of chitosan, the CS-MSNs exhibited lower cytotoxicity than that of the naked MSNs in an MTT assay. In addition, the in vitro kill potency against MCF-7 breast-cancer cells was enhanced over time, as well as with increasing concentration of the drug-loaded CS-MSNs. These results indicate that CS-MSNs are promising candidates for pH-responsive drug delivery in cancer therapy.
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FOOD RESEARCH INTERNATIONAL
·
2015
·
IF 2.818
Yujia Liu,Dandan Liu,Li Zhu,Qian Gan,Xueyi Le
Liposome, a promising delivery system with phospholipid bilayer, could improve the water solubility of curcumin, which is a polyphenolic natural product with many bioactivities. However, the instability of liposome limits its development in application. In this study, the chitosan was used to protect the structure stability of phospholipid bilayer of curcumin liposome and control the sustained release rate of curcumin further. The temperature stability and phase transition were studied by differential scanning calorimetry. When curcumin molecule was embedded in phospholipid bilayer, the pre-transition temperature (50.40 °C) and main phase transition temperature (61.47 °C) decreased about 10 °C compared to it without curcumin, and phospholipid bilayer fluidity was increased. The pre-transition temperature was disappeared after chitosan coated on the surface of curcumin liposome. The thermal stability test and X-ray diffraction also indicate that high temperature could change the structure of liposome and chitosan could protect the curcumin from damage and leak. The in vitro release study showed that the cumulative release rate got faster with temperature increased and chitosan could decrease the release rate. These results may guide the potential application of chitosan-coated liposome as a carrier of curcumin in nutraceutical and functional foods.
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REACTIVE & FUNCTIONAL POLYMERS
·
2014
·
IF 2.822
Dengke Yin,Hua Wu,Chaoxu Liu,Jun Zhang,Ting Zhou,Jingjing Wu,Ying Wan
Chitosan–polylactide (CH–PLA) copolymers with various polylactide percentages changing from around 14 to 40 wt% were synthesized. CH–PLAs were then blended with type-II collagen to fabricate layered collagen/CH–PLA scaffolds that are potentially suitable for the applications in articular cartilage repair. Based on combinatorial processing techniques involving layer-superposition, thermal melting and freeze-drying, two types of stratified collagen/CH–PLA scaffolds were built. The content of collagen inside the scaffolds altered from the top layer to the bottom layer in a trend contrary to that of chitosan. One of them was fabricated using tripolyphosphate (TPP) as a single crosslinker and another type of scaffold was constructed via a dual-crosslinking pathway using TPP and genipin as two crosslinkers in a designated order. These collagen/CH–PLA scaffolds were found to have graded average pore-size and porosity, gradient swelling index and layer-dependent compressive modulus. The resulting scaffolds were thus partially similar to the articular cartilage extracellular matrix in composition , structure and property. In vitro cell culture on some optimized collagen/CH–PLA scaffolds for a period of time up to 3 weeks showed that the scaffolds were able to well support the growth of the seeded cells, suggesting that these collagen/CH–PLA scaffolds have promising potential for articular cartilage repair.
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CARBOHYDRATE POLYMERS
·
2018
·
IF 5.158
Ting Wu,Weiping Liao,Wei Wang,Jie Zhou,Weiguo Tan,Weibing Xiang,Jinglin Zhang,Lina Guo,Tao Chen,Dong Ma,Weiye Yu,Xiang Cai
Lung-targeted genipin-crosslinked deacetylated chitosan (GEN-CS)/isoniazid (INH)/rifampin (RMP) nanogel particles (NGPs) were prepared as a treatment for tuberculosis caused by multidrug-resistant Mycobacterium tuberculosis (MTB) to surmount the undesirable side effects and decrease the cytotoxicity of INH and RMP when being against MTB. The size, morphology, in vitro release property, long-term antibacterial performance, stability, in vitro cytotoxicity, in vivo toxicity, and in vivo release property of GEN-CS/INH/RMP NGPs inhalation powder were investigated. The results showed that the GEN-CS/INH/RMP NGPs inhalation powder exhibited extended antibacterial activity because of its long-term release of INH and RMP. A simplex GEN-CS/INH/RMP NGPs pulmonary dose led to the therapeutic drug concentration of 40%–60% in lung and other organs (＜5%) for 24 h. Furthermore, this GEN-CS/INH/RMP NGPs lyophilized inhalation powder displayed lung-targeted property and lower in vivo toxicity. These results suggested that this GEN-CS/INH/RMP NGPs inhalation powder would be a more useful dosage form than separate dose of INH or RMP for MTB.
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