FOOD CHEMISTRY
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2026
·
IF 10.4
Mingzhu Liu,Xueyan He,Bo Peng,Jin Wu,Zunquan Zhao,Jialei Bai,Jingran Sun,Yanjun Fang
Highly mimetic enzymatic Mn₃O₄/gold nanoparticle (AuNP) composites were prepared, which catalyze the oxidation of tert-butylhydroquinone (TBHQ) to red 2-tert-butyl-1,4-benzoquinone (TBBQ) for TBHQ detection. Absorbance at 487 nm (A₄₈₇) correlates linearly with TBHQ concentrations in the range of 0.52–50 μg/mL, with a limit of detection (LOD) of 0.063 μg/mL, and a limit of quantification (LOQ) of 0.21 μg/mL. TBBQ quenches the fluorescence of copper/iodine-doped carbon dots (Cu,I-CDs) at 500 nm via the inner filter effect (IFE), forming an “on-off” fluorescence probe for TBHQ. TBHQ concentration correlates linearly with the fluorescence intensity difference (F₀ − F) in the range of 0.31–54 μg/mL, with an LOD of 0.054 μg/mL and an LOQ of 0.18 μg/mL. This study uses a dual-mode detection approach to determine TBHQ in various food samples, with recovery rates ranging from 82.5% to 103.0%. The method is sensitive, accurate, cost-effective, and suitable for the rapidly analyzing of TBHQ in food.
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ACS Applied Materials & Interfaces
·
2026
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IF 8.2
Qianjun Su,Hui Duan,Qiyan Li,Mengdan Zhang,Pan Liu,Huixue Chen,Weili Li,Ping Liu,Chunlin Chen,Ruiyuan Liu,Pengfei Li
Persistent infection with high-risk HPV in women can progress to cervical intraepithelial neoplasia and even cervical cancer. This study investigated the cytotoxic and immunomodulatory effects of the TBTCN-TDG photodynamic therapy (PDT) probe in treating HPV-associated cervical lesions. The TBTCN-TDG probe was designed by integrating a donor-acceptor-π-acceptor 1 (D-A-π-A1) structure (TBTCN) with TDG, a moiety targeting Galectin-1, and its targeting ability in HPV-positive SiHa cells was confirmed. The in vitro results demonstrated that TBTCN-TDG combined with light treatment significantly inhibited SiHa cell proliferation, increased apoptosis, and activated immune responses by stimulating dendritic cells, macrophages, and NK cells, through enhanced NF-κB pathway signaling. In vivo, this targeted photosensitizer exhibited substantial therapeutic effects under laser excitation, as evidenced by TUNEL staining, which showed increased apoptosis in lesions. Immune analysis indicated that TBTCN-TDG enhanced NK cell viability and elevated the levels of pro-inflammatory cytokines under laser excitation, such as TNF-α, IFN-γ, and IL-6, confirming immune response activation. In conclusion, the combination of TBTCN-TDG and PDT effectively targets cells infected with HPV, enhances immune responses, and suppresses HPV infection. This suggests a novel therapeutic strategy for photodynamic immunotherapy in patients with cervical high-risk HPV infections.
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ACS Applied Materials & Interfaces
·
2026
·Vol. 18
·期 33
·44984-45002
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IF 7.8
Wang Shuaihang,Ji Zhonghao,Shen Ding,Liu Siyu,Hao Jingbin,Cheng Qi,Jia Bao,Guo Liang,Shang Jie,Chen Kai,Han Meng
Currently, the repair of bone defects faces multiple challenges, including insufficient angiogenesis and limited osteogenic differentiation capacity, which pose significant obstacles to treatment. In this study, a ternary composite scaffold composed of PCL-nHA-nMgO (PHM) was fabricated using 3D printing technology. After surface modification with a photothermal polydopamine (PDA) coating, a PHM@PDA composite scaffold was obtained. Metformin (Met) and PDA were loaded into GelMA hydrogels to produce GPM hydrogels. The GPM hydrogels were then packed into the PHM@PDA composite scaffolds, resulting in near-infrared region-I (NIR-I)-responsive PHM@PDA/GPM composite scaffolds. The outer GPM layer serves as a three-dimensional in vivo-like microenvironment, providing physical transport channels for cellular nutrient exchange. Upon stimulation by NIR-I, the scaffold enables the dynamic release of Mg 2+ and Met, upregulates the expression of the VEGF and KDR, accelerates vascular network reconstruction, and creates a mild microenvironment conducive to cell proliferation. Furthermore, by activating the PI3K/AKT signaling pathway, it promotes the expression of osteogenesis-related factors (such as transcription factor Sp7, alkaline phosphatase, and osteocalcin), thereby accelerating the osteogenic differentiation process. In vivo animal experiments, micro-CT and tissue staining confirmed that, under near-infrared light (NIR-I) stimulation, this scaffold significantly increased bone mineral density, trabecular bone thickness, and trabecular bone count and demonstrated excellent angiogenic effects. In summary, this NIR-I-responsive composite scaffold can meet the dual requirements of reconstructing the vascular network and promoting osteogenic differentiation, enabling personalized precision therapy and offering a promising new treatment strategy for complex bone defects where vascular regeneration and osteogenic differentiation are challenging.
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Science Signaling
·
2026
·Vol. 19
·期 948
·
IF 7
Qian Zhang,Yuedan Zhu,Yi Chen,Wenhao Hou,Aolong Sun,La Yan,Xingzhu Liu,Yu Yuan,Chaoxin Gao,Junfeng Xie,Rui Zhang,Haiyang Chen
Aging impairs intestinal stem cell (ISC) function, disrupting epithelial homeostasis and regenerative repair. Loss of ISC quiescence promotes intestinal dysfunction and contributes to organismal aging. Here, we report an epitranscriptomic mechanism through which a decrease in adenosine-to-inosine (A-to-I) RNA editing by the adenosine deaminase ADAR in ISCs during aging disrupts a conserved signaling axis that maintains ISC quiescence. In Drosophila melanogaster , ISC-specific loss of dADAR triggered hyperproliferation and tissue aging, whereas dADAR overexpression reduced age-related gut dysfunction and extended life span. Intestinal injury induced a decrease in dADAR, which was necessary for tissue regeneration, and in the zinc finger protein dZn72D, which stabilized dADAR to support intestinal homeostasis during aging. dADAR edited transcripts encoding the RNA binding protein Pumilio (dPUM) to generate an isoform that inhibited translation of two components of the mitogen-activated protein kinase (MAPK), dEGFR and dERK, thereby maintaining ISC quiescence. The abundance of ADAR2 and of the dZn72D ortholog ZFR decreased in human colonic crypts with aging and in mouse colon after injury, suggesting that attenuation of ADAR activity may play a conserved role in ISC aging and in facilitating colonic regeneration. Our work identifies a conserved mechanism of epitranscriptomic regulation that safeguards tissues and the decay of ADAR-mediated RNA editing as a form of age-related epigenetic information loss that disrupts ISC homeostasis.
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CHEMICAL ENGINEERING JOURNAL
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2026
·
IF 12.5
Junyi Feng,Jiwei Zhang,Mengyi Tang,Xiaodan Zhang,Xiaoshuang Chen,Xuesong Feng,Kaifa Du,Wei Li,Huayi Yin,Bowen Deng,Dihua Wang
Efficient capture and separation of Cs + from nuclear wastewater remains a central challenge in nuclear chemical engineering. Here, a solvent-free solid-state conversion strategy is developed to directionally transform natural kaolinite into sodalite under thermally driven solid-state conditions, yielding a Cs + -selective capture material with intrinsic ion-sieving properties. The resulting sodalite exhibits a high Cs + adsorption capacity of up to 242.96 mg/g in weakly acidic solutions and reaches adsorption equilibrium within approximately 50 min, demonstrating fast uptake kinetics. Isotherm and kinetic analyses demonstrate that Cs + adsorption proceeds via a monolayer, chemisorption-dominated process governed by ion exchange. Multiscale characterization combined with theoretical calculations reveals that Cs + capture arises from the synergistic effects of size-matched pore confinement and spatially confined ion-exchange sites within the sodalite framework. These findings establish kaolinite-derived sodalite as a viable inorganic platform for the efficient separation and long-term management of radionuclides in nuclear wastewater.
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CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Xin Qi,Zhuo Chen,Xiaotong He,Jiu-Qiang Xiong
The global challenge of antibiotic contamination calls for a comprehensive approach that integrates various technological, economic, and social factors to design effective, and sustainable solutions. Microalgae-based biotechnologies offer a sustainable and efficient approach to mitigating residual antibiotics while curbing the spread of antibiotic resistance genes. In this study, we found that the widely distributed microalgal species Chlamydomonas reinhardtii can efficiently degrade tetracycline, oxytetracycline (OTC), and doxycycline. Despite this promising result, the enzymatic mechanisms underlying this degradation process remain largely unknown. Taking OTC as a model chemical, we demonstrated that neither cytochrome P450 enzymes nor primary amine oxidase in C. reinhardtii were essential for OTC degradation using enzyme inhibition assays. Further identification and characterization of a novel tropinone reductase I (TRI) demonstrated that this enzyme catalyzes the demethylation of OTC, achieving a remarkable removal efficiency of 93.10% within 24 h. Additionally, informative analysis of metagenomic and metatranscriptomic databases revealed a widespread distribution and transcriptional activity of genes encoding TRI homologs across diverse environmental settings. The widespread distribution and transcriptional activity of TRI homologs suggest potential for TRI-mediated OTC degradation in diverse marine settings. These fundamental understandings of enzymatic catalysis processes not only provide critical insights into improving environmental management strategies, but also offer new lights on the unknown global impacts of novel phytoplankton enzymes.
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FOOD CHEMISTRY
·
2026
·
IF 10.4
Jing Wen,Jingyang Wang,Huining Lai,Zhengang Zhao
Pomelo peel, a major byproduct of pomelo processing, was utilized to isolate rhamnogalacturonan-I (RG-I) pectin via a novel approach combining low-concentration alkaline extraction with dielectric barrier discharge (DBD) plasma treatment, followed by characterization. The extracted pectin (DAP) was characterized by its esterification degree, monosaccharide composition, molecular weight, X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), triple-helix structure, and scanning electron microscopy (SEM). Results revealed that DBD increased its RG-I content while preserving its overall structure. Additionally, the effects of DAP, oil phase, CaCO₃ concentration, and glucono-δ-lactone (GDL) concentration on the properties of the resulting emulsion gel were investigated. In vitro release studies indicated that the emulsion gel followed the Korsmeyer-Peppas model, demonstrating controlled-release behavior. After simulated in vitro digestion, 70% of the encapsulated naringenin available for release in intestine. This study provides a theoretical foundation for the green extraction of RG-I pectin from pomelo peel and application in delivery systems.
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Pharmaceutics
·
2026
·Vol. 18
·期 6
·634
·
IF 6.9
Yan Lin,Xian Zhang,Fulin Bi,Guangji Wang,Jin Yang
Background/Objectives:Despite the presumption of bioequivalence for BCS Class I drugs due to their high solubility and permeability, recent evidence indicates that those with rapid systemic elimination exhibit heightened vulnerability toCmaxnon-equivalence, primarily attributable to intrasubject variability in gastrointestinal transit and absorption kinetics. It is well known that gastric emptying is a significant physiological-dependent factor. But, does the formulation affect gastric emptying?Methods:Using zidovudine as a model drug, formulations containing sodium carboxymethyl starch (CMS-Na), pregelatinized starch, hydroxypropyl methylcellulose (HPMC), and lactose were investigated for their effects on gastric emptying kinetics, and the impact of excipient-mediated gastric emptying prolongation on pharmacokinetic parameters was also evaluated.Results:Relative to AZT alone (Cmax= 13,350 ng/mL; gastric %ID = 11.3%), co-administration with CMS-Na, pregelatinized starch, or HPMC significantly prolonged gastric retention (%ID: 23.4%, 30.5%, and 40.8% at 22.5 min) and reducedCmaxin rats by 47.8%, 34.4%, and 35.1%, respectively, with no effect on intestinal permeability. Viscosity positively correlated with gastric emptying delay.Conclusions:Our rat findings provide new possible mechanistic evidence that certain viscosity-modifying excipients can delay gastric emptying and reduceCmaxof zidovudine, a rapidly eliminated BCS Class I drug, with potential implications for biowaiver risk assessment. Gastric emptying is not only a physiological-dependent variation but also, in cases where common excipients may significantly delay gastric emptying, a formulation-dependent rate-limiting step. For such drugs, excipient-induced gastric emptying delay poses an underappreciated risk to the biowaiver approach, necessitating more prudent regulatory assessment that encompasses the dynamic interplay among sequential rate processes governing drug disposition.
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Journal of CO2 Utilization
·
2018
·
IF 5.503
Xue-Dong Li,Yu Cao,Ran Ma,Liang-Nian He
Efficient CuI/1,10-phen-catalyzed three-component cascade reaction of propargylic alcohols, CO 2 , and 2-aminoethanols has been firstly developed for the thermodynamically favourable preparation of 2-oxazolidinones. In the presence of commercially available CuI, 1,10-phen (1,10-phenanthroline) and t -BuOK, the cascade reaction afforded the desired products in good to excellent yields with a broad substrate scope (14 examples). The predicted copper complex Cu 2 I 2 (phen) 2 in situ formed from CuI and 1,10-phen could activate the triple bond through coordination. The isolation of α-alkylidene cyclic carbonate as the reaction intermediate suggests that the carboxylative cyclization of propargylic alcohol with CO 2 , followed by ring-opening reaction, is involved in the one-pot three-component cascade reaction.
研究领域:
有机化学
·
催化
·
二氧化碳利用
·
合成方法学
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2022
·
IF 5.518
Xiao-han Pan,Jian-hua Zu,Jing-jie Diao,Yi Xue,Si-yu Liu
The aim of current work was to explore a new material for the fast, efficient and selective recovery of precious metal silver (Ag(I)) from electroplating effluents to alleviate its high consumption and mitigate its environmental pollution. In this study, the sulfydryl-rich covalent organic framework (COF-SH) was prepared by solvothermal method . Its Ag(I) adsorption performance was evaluated by batch adsorption experiments that the effects of initial Ag(I) concentration, ratio of adsorption dosage to solution volume, adsorption time and reacting temperature were studied. The isothermal data fitted well with the Langmuir model and the maximum adsorption capacity at 298 K was up to 609.89 mg/g. The adsorption rate was very fast almost achieving adsorption equilibrium within 16 min. The adsorption rate and adsorption capacity increased with the increase in reaction temperature. The perfect fitting with pseudo-second-order kinetic model indicated the adsorption process was dominated by chemisorption process. Weber–Morris intraparticle diffusion model divided the adsorption process into three stages and temperature had a positive correlation with the first stage, external surface diffusion . The thermodynamic fitting results suggested that the adsorption process was endothermic, disordered and spontaneous. In terms of application, COF-SH achieved highly selective adsorption of Ag(I) in simulated electroplating wastewater with coexistence of multiple metal ions , especially at high acidity (≥1 M HNO 3 ), and the increase in concentration of competing ions had no affects. In addition, 1 M HNO 3 + 0.3 M thiourea (TU) could be used as desorption agent with 100% Ag(I) desorbed from the adsorbed adsorbent COF-SH-Ag.
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ACS Applied Nano Materials
·
2022
·
IF 6.14
Yingsha Wang,Shanshan Cheng,Meili Liu,Jia Liu,Shouting Zhang,Wenping Hu
Developing a peroxidase-like activity modulator to accurately regulate peroxidase-like activity has always been the primary challenge to be addressed. External stimulation can effectively modulate the electronic structure of metal-centered active sites, which optimizes the chemical reaction path and changes the peroxidase-like activity. Herein, in a weak acidic environment (pH = 6.0), we found that the electron transfer may occur between silver nanoparticles (Ag NPs) anchored on the surface of reduced graphene oxide/poly(ethylene glycol) (rGO/PEG) nanosheets and added mercury(II) (Hg2+), which can induce the formation of mercurous ions (Hg(I), Hg22+). Hg(I) with regulatory catalytic performance can stimulate the expression of the active sites of Ag NPs via optimizing the electronic structure so that the adsorbed H2O2 molecules can efficiently produce reactive oxygen intermediates (•OH and •O2–) and be stabilized on the surface of Ag NPs. Meanwhile, density functional theory (DFT) calculations showed that the generated Hg(I) significantly reduced the Gibbs free energy of the chemical reaction and provided a pathway for electron transfer, which effectively enhanced the peroxidase-like activity. Based on this finding, a visual colorimetric sensor was constructed to detect Hg2+ with a detection limit of 19.7 nM in the range of 0.02–5.0 μM. Finally, we confirmed that the developed rGO/PEG/Ag nanohybrids can quantitatively detect Hg2+ in the environment. This method is reliable and has potential advantages in the environmental application field.
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SOLVENT EXTRACTION AND ION EXCHANGE
·
2022
·
IF 3.695
Huifang Xing,Liangrong Yang,Lu Wang,Mengfang Li,Jiemiao Yu,Diannan Lu,Gang Ye,Huizhou Liu
The effect of ion species and concentration on the extraction percent of Cs+ by 1,3-Diisopropoxycalix [4] arenecrown-6 (BPC6) in octanol/water solvent extraction system has been studied by molecular dynamics simulations and experiments. The results show that the anionic species play an important role on the enhancement of the extraction percent of Cs+. Specifically, the order in which anions promote the extraction percent is different at different total anion concentrations. At a relatively low anion concentration of 0.5 M, the extraction percent follows the sequence: ClO4−> I−> NO3−> Br−> Cl−> SO42−> F−. At a relatively high concentration of 2 M, the extraction percent of Cs+ follows the following sequence: I−> ClO4−> Br−~ NO3−> Cl−> SO42−> F−. It is indicated that the extraction percent is dominated by the anion’s interface propensity, which is the probability of anion distribution in the interface compared to the water phase. However, at low concentration of anions, strong coordination effect of NO3− promotes the extraction effect compared to Br−. At the high anion’s concentration, the stronger salting-out capacity of Br− leads to a considerable increase of extraction percent. In addition, the cations also slightly affect the extraction percent. The extraction percent is affected by both cations’ concentration and the salt-out effect. On this basis, a neutral Cs+ extraction system has been established, and one stage extraction percent could reach 62.5%.
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